CA2941929C - Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue - Google Patents

Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue Download PDF

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Publication number
CA2941929C
CA2941929C CA2941929A CA2941929A CA2941929C CA 2941929 C CA2941929 C CA 2941929C CA 2941929 A CA2941929 A CA 2941929A CA 2941929 A CA2941929 A CA 2941929A CA 2941929 C CA2941929 C CA 2941929C
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composition
reagent
cells
chelator
tag
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CA2941929A
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English (en)
French (fr)
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CA2941929A1 (en
Inventor
Tony K. Baker
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TRUCKEE APPLIED GENOMICS LLC
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TRUCKEE APPLIED GENOMICS LLC
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2941929A 2013-03-15 2014-03-14 Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue Active CA2941929C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798627P 2013-03-15 2013-03-15
US61/798,627 2013-03-15
PCT/US2014/029198 WO2014144682A1 (en) 2013-03-15 2014-03-14 Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue

Publications (2)

Publication Number Publication Date
CA2941929A1 CA2941929A1 (en) 2014-09-18
CA2941929C true CA2941929C (en) 2021-02-23

Family

ID=51528685

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2941929A Active CA2941929C (en) 2013-03-15 2014-03-14 Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue

Country Status (17)

Country Link
US (5) US9113623B2 (https=)
EP (2) EP2970878B1 (https=)
JP (1) JP6465857B2 (https=)
CN (2) CN112806352A (https=)
CA (1) CA2941929C (https=)
CY (1) CY1120801T1 (https=)
DK (1) DK2970878T3 (https=)
ES (1) ES2684582T3 (https=)
HR (1) HRP20181352T1 (https=)
HU (1) HUE039933T2 (https=)
LT (1) LT2970878T (https=)
PL (1) PL2970878T3 (https=)
PT (1) PT2970878T (https=)
RS (1) RS57900B1 (https=)
SI (1) SI2970878T1 (https=)
SM (1) SMT201800457T1 (https=)
WO (1) WO2014144682A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2970878T (lt) 2013-03-15 2018-11-12 Truckee Applied Genomics, Llc Vėžio ląstelių chirurginiu būdu pašalintame audinyje gyvybingumo palaikymo būdai ir reagenatai
US10053676B2 (en) 2014-11-25 2018-08-21 Bio-Rad Laboratories, Inc. Arginine improves polymerase storage stability
CN107333750A (zh) * 2017-06-11 2017-11-10 成都吱吖科技有限公司 一种长时血液细胞稳定剂
WO2021055170A1 (en) * 2019-09-17 2021-03-25 Longhorn Vaccines And Diagnostics, Llc Multipurpose compositions for collecting and transporting biological material
WO2022010916A1 (en) * 2020-07-07 2022-01-13 Truckee Applied Genomics, Llc Cell preservation reagents and methods of use
CN117063915B (zh) * 2023-08-17 2026-02-24 镜像绮点(上海)细胞技术有限公司 原代肿瘤细胞冻存液

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409826A (en) * 1993-06-08 1995-04-25 Coulter Corporation Preserved, non-infectious control cells prepared by the modulation or modification of normal cells
CA2250570A1 (en) * 1996-03-26 1997-10-02 Eli Lilly And Company Formulations of ob protein
US20010007673A1 (en) 1999-11-12 2001-07-12 Merrill Seymour Goldenberg Sustained-release delayed gels
US7569342B2 (en) 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
US20080064108A1 (en) 1997-12-10 2008-03-13 Tony Baker Urine Preservation System
WO1999029904A2 (en) 1997-12-10 1999-06-17 Sierra Diagnostics, Inc. Methods and reagents for preservation of dna in bodily fluids
AU1848602A (en) * 2000-12-04 2002-06-18 Lymphotec Inc. Cell-preservation liquid and method of preserving cells by using the liquid
KR20020066778A (ko) 2001-02-13 2002-08-21 한국과학기술연구원 체내 난흡수 물질의 흡수촉진용 조성물과 제형 및 그의제조방법
WO2008111981A1 (en) 2007-03-14 2008-09-18 Sierra Molecular Corporation Compositions, systems, and methods for preservation of macromolecules
WO2004052184A2 (en) * 2002-12-12 2004-06-24 Oncotech, Inc. Genes related to sensitivity and resistance to chemotherapeutic drug treatment
US8793895B2 (en) * 2006-02-10 2014-08-05 Praxair Technology, Inc. Lyophilization system and method
US8652782B2 (en) * 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8080645B2 (en) * 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
WO2008033936A2 (en) 2006-09-12 2008-03-20 Sierra Molecular Corporation Removal of molecular assay interferences for nucleic acids employing buffered solutions of chaotropes
WO2008052170A2 (en) 2006-10-27 2008-05-02 Sierra Molecular Corporation Penetratable septum cap
WO2008071384A1 (en) 2006-12-13 2008-06-19 Roche Diagnostics Gmbh Use of tde for the isolation of nucleic acids
KR20100015578A (ko) 2007-03-14 2010-02-12 시에라 몰레큘러 코포레이션 세포 및/또는 거대분자의 보존 및/또는 안정화를 위한 조성물, 시스템 및 방법
EP2217244A4 (en) * 2007-11-12 2011-08-31 Bipar Sciences Inc TREATMENT OF NUTRITIONAL CANCER AND EGG CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTITUMOROUS MEDICINES
US20100003748A1 (en) 2008-07-03 2010-01-07 Tony Baker Compositions, systems, and methods for stabilization of a cell and/or macromolecule
WO2010028156A2 (en) 2008-09-04 2010-03-11 Board Of Regents, The University Of Texas System Dual modality detection of apoptosis
US9133343B2 (en) * 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
CN102318597B (zh) * 2011-08-19 2013-04-03 张雪云 一种液基细胞保存液组合物及其制备方法
LT2970878T (lt) 2013-03-15 2018-11-12 Truckee Applied Genomics, Llc Vėžio ląstelių chirurginiu būdu pašalintame audinyje gyvybingumo palaikymo būdai ir reagenatai

Also Published As

Publication number Publication date
US20140272921A1 (en) 2014-09-18
PL2970878T3 (pl) 2019-01-31
CY1120801T1 (el) 2019-12-11
US9949474B2 (en) 2018-04-24
RS57900B1 (sr) 2019-01-31
WO2014144682A8 (en) 2015-08-13
PT2970878T (pt) 2018-10-09
SMT201800457T1 (it) 2018-11-09
HUE039933T2 (hu) 2019-02-28
EP2970878A4 (en) 2016-08-03
US20160235055A1 (en) 2016-08-18
CN105121629A (zh) 2015-12-02
HK1220481A1 (en) 2017-05-05
US20150327539A1 (en) 2015-11-19
CA2941929A1 (en) 2014-09-18
US9113623B2 (en) 2015-08-25
CN105121629B (zh) 2020-12-18
EP3581643A1 (en) 2019-12-18
US9565852B2 (en) 2017-02-14
US10772318B2 (en) 2020-09-15
EP2970878A1 (en) 2016-01-20
US20170215410A1 (en) 2017-08-03
JP2016512693A (ja) 2016-05-09
WO2014144682A1 (en) 2014-09-18
ES2684582T3 (es) 2018-10-03
JP6465857B2 (ja) 2019-02-06
SI2970878T1 (sl) 2019-02-28
HRP20181352T1 (hr) 2018-12-14
LT2970878T (lt) 2018-11-12
US20150230454A1 (en) 2015-08-20
EP2970878B1 (en) 2018-05-23
WO2014144682A4 (en) 2014-12-24
CN112806352A (zh) 2021-05-18
DK2970878T3 (en) 2018-09-03
US9445586B2 (en) 2016-09-20

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