CA2941824C - Substituted phenylamino-oxazole-4-carboxylic acid amides as tyk2 kinase inhibitors - Google Patents
Substituted phenylamino-oxazole-4-carboxylic acid amides as tyk2 kinase inhibitors Download PDFInfo
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- CA2941824C CA2941824C CA2941824A CA2941824A CA2941824C CA 2941824 C CA2941824 C CA 2941824C CA 2941824 A CA2941824 A CA 2941824A CA 2941824 A CA2941824 A CA 2941824A CA 2941824 C CA2941824 C CA 2941824C
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- oxazole
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 10
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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| WO2019132654A1 (en) * | 2017-12-27 | 2019-07-04 | Erasmus University Medical Center Rotterdam | Methods of treating sarcoidosis |
| WO2020009566A1 (en) * | 2018-07-04 | 2020-01-09 | Erasmus University Medical Center Rotterdam | Methods of treating sarcoidosis |
| GB201816369D0 (en) * | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| WO2020222773A1 (en) | 2019-04-30 | 2020-11-05 | Celgene Corporation | Combination therapies comprising apremilast and tyk2 inhibitors |
| GB202005114D0 (en) | 2020-04-07 | 2020-05-20 | Sareum Ltd | Crystalline Forms of a Pharmaceutical Compound |
| EP3944859A1 (de) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Verfahren zur behandlung von immuntoxizitäten, die durch immun-checkpoint-inhibitoren induziert werden |
| KR20240070634A (ko) | 2021-09-30 | 2024-05-21 | 브리스톨-마이어스 스큅 컴퍼니 | Tyk2 억제제에 대한 반응성을 결정하는 방법 |
| KR20240111312A (ko) | 2021-10-25 | 2024-07-16 | 카이메라 쎄라퓨틱스 인코포레이티드 | Tyk2 분해제 및 이의 용도 |
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| GB1497536A (en) * | 1973-12-17 | 1978-01-12 | Lilly Industries Ltd | 2-acylaminooxazoles methods for their preparation and their use |
| DE69924480D1 (en) * | 1998-05-05 | 2005-05-04 | Hoffmann La Roche | Pyrazolderivative als p-38 map kinase inhibitoren |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| CA2690141A1 (en) | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| JP2011518221A (ja) | 2008-04-21 | 2011-06-23 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｊａｎｕｓキナーゼの阻害剤 |
| US8344144B2 (en) | 2008-06-18 | 2013-01-01 | Merck Sharp & Dohme Corp. | Inhibitors of Janus kinases |
| AU2009268875A1 (en) | 2008-07-09 | 2010-01-14 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| EP2166006A1 (de) * | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-Arylpropionsäuren und -Derivate und pharmazeutische Zusammensetzungen, die diese enthalten |
| GB0820819D0 (en) * | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| MX2012010265A (es) | 2010-03-17 | 2012-10-01 | Hoffmann La Roche | Compuestos de imidazopiridina, composiciones y metodos de uso. |
| EP2588105A1 (de) | 2010-07-01 | 2013-05-08 | Cellzome Limited | Triazolopyridine als tyk2-hemmer |
| WO2013055645A1 (en) * | 2011-10-12 | 2013-04-18 | Array Biopharma Inc. | 5,7-substituted-imidazo[1,2-c]pyrimidines |
| DK3040336T3 (da) * | 2012-03-02 | 2020-06-22 | Sareum Ltd | Forbindelser til brug i behandling af TYK2 Kinase-medierede tilstande |
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| IL244380A0 (en) | 2016-04-21 |
| KR20160048883A (ko) | 2016-05-04 |
| SG11201601503SA (en) | 2016-03-30 |
| CA2941824A1 (en) | 2015-03-12 |
| JP2016529264A (ja) | 2016-09-23 |
| BR112016004723B1 (pt) | 2022-08-30 |
| KR102191084B1 (ko) | 2020-12-15 |
| IL244380B (en) | 2018-01-31 |
| MX369974B (es) | 2019-11-27 |
| JP6239118B2 (ja) | 2017-11-29 |
| AU2013399913A1 (en) | 2016-03-24 |
| CN105793245B (zh) | 2018-03-20 |
| RU2016111522A (ru) | 2017-10-09 |
| AU2013399913B2 (en) | 2018-03-15 |
| MX2016002738A (es) | 2016-08-11 |
| BR112016004723A2 (de) | 2017-08-01 |
| WO2015032423A1 (en) | 2015-03-12 |
| ZA201602047B (en) | 2020-12-23 |
| CN105793245A (zh) | 2016-07-20 |
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