CA2941824C - Amides d'acide phenylamino-oxazole-4-carboxylique substitues en tant qu'inhibiteurs de la kinase tyk2 - Google Patents
Amides d'acide phenylamino-oxazole-4-carboxylique substitues en tant qu'inhibiteurs de la kinase tyk2 Download PDFInfo
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- CA2941824C CA2941824C CA2941824A CA2941824A CA2941824C CA 2941824 C CA2941824 C CA 2941824C CA 2941824 A CA2941824 A CA 2941824A CA 2941824 A CA2941824 A CA 2941824A CA 2941824 C CA2941824 C CA 2941824C
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- oxazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
L'invention concerne un composé qui est un amide de la formule (2) : ou un sel ou un stéréoisomère de celui-ci; où : R7 est choisi parmi chlore et fluor; R3, R4, R5 et R6 sont chacun indépendamment choisis parmi hydrogène, fluor et chlore; n est 0, 1 ou 2; Q1 est choisi parmi C(=O), S(=O) et SO2; A est absent ou représente NR2; R1 est choisi parmi : -hydrogène, -un groupe hydrocarboné non aromatique en C1-6 facultativement substitué; et -des noyaux carbocycliques et hétérocycliques non aromatiques à 3 à 7 chaînons contenant un ou deux chaînons de cycle hétéroatomes choisis parmi O, N et S, et des noyaux hétérocycliques bicycliques pontés de sept à neuf chaînons de cycle dont un ou deux sont des atomes d'azote, les noyaux carbocycliques et hétérocycliques et les noyaux hétérocycliques bicycliques pontés étant facultativement substitués; R2 est choisi parmi hydrogène et alkyle en C1-4; ou NR1R2 forme un noyau hétérocyclique contenant de l'azote non aromatique à 4 à 7 chaînons facultativement substitué contenant facultativement un second chaînon de cycle hétéroatome choisi parmi l'azote et l'oxygène; à condition que : (i) pas plus de deux parmi R3 à R6 sont autres qu'hydrogène; et (ii) lorsque R7 et R6 représentent tous deux fluor, alors l'un parmi R3 à R5 représente chlore ou fluor et/ou R1-A-Q1 est choisi parmi éthylsulfonyle et isopropylsulfonyle. L'invention concerne également des compositions pharmaceutiques contenant les composés et leurs utilisations thérapeutiques.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/068198 WO2015032423A1 (fr) | 2013-09-03 | 2013-09-03 | Composés pharmaceutiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2941824A1 CA2941824A1 (fr) | 2015-03-12 |
| CA2941824C true CA2941824C (fr) | 2020-08-25 |
Family
ID=49237179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2941824A Active CA2941824C (fr) | 2013-09-03 | 2013-09-03 | Amides d'acide phenylamino-oxazole-4-carboxylique substitues en tant qu'inhibiteurs de la kinase tyk2 |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP6239118B2 (fr) |
| KR (1) | KR102191084B1 (fr) |
| CN (1) | CN105793245B (fr) |
| AU (1) | AU2013399913B2 (fr) |
| BR (1) | BR112016004723B1 (fr) |
| CA (1) | CA2941824C (fr) |
| IL (1) | IL244380B (fr) |
| MX (1) | MX369974B (fr) |
| RU (1) | RU2652795C2 (fr) |
| SG (1) | SG11201601503SA (fr) |
| WO (1) | WO2015032423A1 (fr) |
| ZA (1) | ZA201602047B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| WO2019132654A1 (fr) * | 2017-12-27 | 2019-07-04 | Erasmus University Medical Center Rotterdam | Méthodes de traitement de la sarcoïdose |
| WO2020009566A1 (fr) * | 2018-07-04 | 2020-01-09 | Erasmus University Medical Center Rotterdam | Méthodes de traitement de la sarcoïdose |
| GB201816369D0 (en) * | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| JP2022537877A (ja) | 2019-04-30 | 2022-08-31 | セルジーン コーポレイション | アプレミラストおよびｔｙｋ２阻害剤を含む併用療法 |
| GB202005114D0 (en) | 2020-04-07 | 2020-05-20 | Sareum Ltd | Crystalline Forms of a Pharmaceutical Compound |
| EP3944859A1 (fr) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Procédé de traitement des toxicités immunitaires induites par des inhibiteurs des points de contrôle immunitaire |
| WO2023055901A2 (fr) | 2021-09-30 | 2023-04-06 | Bristol-Myers Squibb Company | Méthodes de détermination de réactivité à des inhibiteurs de tyk2 |
| AU2022378463A1 (en) | 2021-10-25 | 2024-05-09 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1497536A (en) * | 1973-12-17 | 1978-01-12 | Lilly Industries Ltd | 2-acylaminooxazoles methods for their preparation and their use |
| EP1075467B1 (fr) * | 1998-05-05 | 2005-03-30 | F. Hoffmann-La Roche Ag | Derives de pyrazole tenant lieu d'inhibiteurs de p.38 map kinase |
| GB0709031D0 (en) * | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| WO2008156726A1 (fr) | 2007-06-20 | 2008-12-24 | Merck & Co., Inc. | Inhibiteurs des janus kinases |
| AU2009274454A1 (en) | 2008-04-21 | 2010-01-28 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| AU2009260389A1 (en) | 2008-06-18 | 2009-12-23 | Merck Sharp & Dohme Corp. | Inhibitors of Janus kinases |
| EP2310384B1 (fr) | 2008-07-09 | 2014-04-09 | Merck Sharp & Dohme Corp. | Inhibiteurs des kinases janus |
| EP2166006A1 (fr) * | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | Acides 2-aryl-propioniques et dérivés et compositions pharmaceutiques les contenant |
| GB0820819D0 (en) * | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| RU2012141536A (ru) | 2010-03-17 | 2014-04-27 | Ф. Хоффманн-Ля Рош Аг | Имидазопиридины, композиции и способы применения |
| US20130143915A1 (en) | 2010-07-01 | 2013-06-06 | Cellzome Limited | Triazolopyridines as tyk2 inhibitors |
| WO2013055645A1 (fr) * | 2011-10-12 | 2013-04-18 | Array Biopharma Inc. | Imidazo[1,2-c]pyrimidines 5,7-substituées |
| US20130231340A1 (en) * | 2012-03-02 | 2013-09-05 | Sareum Limited | Pharmaceutical compounds |
-
2013
- 2013-09-03 MX MX2016002738A patent/MX369974B/es active IP Right Grant
- 2013-09-03 BR BR112016004723-0A patent/BR112016004723B1/pt active IP Right Grant
- 2013-09-03 AU AU2013399913A patent/AU2013399913B2/en active Active
- 2013-09-03 SG SG11201601503SA patent/SG11201601503SA/en unknown
- 2013-09-03 CA CA2941824A patent/CA2941824C/fr active Active
- 2013-09-03 RU RU2016111522A patent/RU2652795C2/ru active
- 2013-09-03 JP JP2016537144A patent/JP6239118B2/ja active Active
- 2013-09-03 CN CN201380080517.XA patent/CN105793245B/zh active Active
- 2013-09-03 WO PCT/EP2013/068198 patent/WO2015032423A1/fr active Application Filing
- 2013-09-03 KR KR1020167007925A patent/KR102191084B1/ko active IP Right Grant
-
2016
- 2016-03-02 IL IL244380A patent/IL244380B/en active IP Right Grant
- 2016-03-29 ZA ZA2016/02047A patent/ZA201602047B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2652795C2 (ru) | 2018-05-03 |
| CA2941824A1 (fr) | 2015-03-12 |
| JP2016529264A (ja) | 2016-09-23 |
| BR112016004723A2 (fr) | 2017-08-01 |
| ZA201602047B (en) | 2020-12-23 |
| RU2016111522A (ru) | 2017-10-09 |
| JP6239118B2 (ja) | 2017-11-29 |
| CN105793245B (zh) | 2018-03-20 |
| KR102191084B1 (ko) | 2020-12-15 |
| MX2016002738A (es) | 2016-08-11 |
| CN105793245A (zh) | 2016-07-20 |
| WO2015032423A1 (fr) | 2015-03-12 |
| IL244380B (en) | 2018-01-31 |
| AU2013399913B2 (en) | 2018-03-15 |
| BR112016004723B1 (pt) | 2022-08-30 |
| AU2013399913A1 (en) | 2016-03-24 |
| SG11201601503SA (en) | 2016-03-30 |
| IL244380A0 (en) | 2016-04-21 |
| KR20160048883A (ko) | 2016-05-04 |
| MX369974B (es) | 2019-11-27 |
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