CA2941445A1 - Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes - Google Patents
Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes Download PDFInfo
- Publication number
- CA2941445A1 CA2941445A1 CA2941445A CA2941445A CA2941445A1 CA 2941445 A1 CA2941445 A1 CA 2941445A1 CA 2941445 A CA2941445 A CA 2941445A CA 2941445 A CA2941445 A CA 2941445A CA 2941445 A1 CA2941445 A1 CA 2941445A1
- Authority
- CA
- Canada
- Prior art keywords
- methoxy
- trifluoromethyl
- chloro
- phenyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/021775 WO2015134039A1 (en) | 2014-03-07 | 2014-03-07 | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2941445A1 true CA2941445A1 (en) | 2015-09-11 |
Family
ID=50391464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2941445A Abandoned CA2941445A1 (en) | 2014-03-07 | 2014-03-07 | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3114123B1 (https=) |
| JP (1) | JP6303031B2 (https=) |
| CN (1) | CN106414434B (https=) |
| AU (1) | AU2014385276B2 (https=) |
| CA (1) | CA2941445A1 (https=) |
| ES (2) | ES2887011T3 (https=) |
| MX (1) | MX367852B (https=) |
| WO (1) | WO2015134039A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2944572T3 (es) | 2016-03-15 | 2023-06-22 | Univ London Queen Mary | Procedimiento de tratamiento de la obesidad |
| JP6809278B2 (ja) * | 2017-02-17 | 2021-01-06 | Jnc株式会社 | 重合性液晶化合物、重合性液晶組成物および液晶重合膜 |
| JP2021517142A (ja) | 2018-03-15 | 2021-07-15 | アクザム ソシエタ ペル アチオニ | 置換ピラゾールｆｆａ４／ｇｐｒ１２０受容体作動薬 |
| CN118040044B (zh) * | 2023-11-07 | 2024-09-13 | 南昌大学 | 一种电解液与锂离子电池 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999011255A1 (en) * | 1997-08-28 | 1999-03-11 | Ono Pharmaceutical Co., Ltd. | Peroxisome proliferator-activated receptor controllers |
| JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| GB0405033D0 (en) * | 2004-03-05 | 2004-04-07 | Karobio Ab | Novel pharmaceutical compositions |
| NZ592603A (en) * | 2008-10-21 | 2013-02-22 | Metabolex Inc | Aryl gpr120 receptor agonists and uses thereof |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| CN105209446A (zh) * | 2013-03-14 | 2015-12-30 | 詹森药业有限公司 | 用于治疗ii型糖尿病的gpr120激动剂 |
-
2014
- 2014-03-07 CN CN201480078670.3A patent/CN106414434B/zh not_active Expired - Fee Related
- 2014-03-07 MX MX2016011630A patent/MX367852B/es active IP Right Grant
- 2014-03-07 JP JP2016573458A patent/JP6303031B2/ja not_active Expired - Fee Related
- 2014-03-07 AU AU2014385276A patent/AU2014385276B2/en not_active Ceased
- 2014-03-07 CA CA2941445A patent/CA2941445A1/en not_active Abandoned
- 2014-03-07 ES ES18169025T patent/ES2887011T3/es active Active
- 2014-03-07 WO PCT/US2014/021775 patent/WO2015134039A1/en not_active Ceased
- 2014-03-07 ES ES14714057.8T patent/ES2673578T3/es active Active
- 2014-03-07 EP EP14714057.8A patent/EP3114123B1/en not_active Not-in-force
- 2014-03-07 EP EP18169025.6A patent/EP3409671B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2887011T3 (es) | 2021-12-21 |
| CN106414434B (zh) | 2019-12-31 |
| EP3409671B1 (en) | 2021-07-21 |
| JP6303031B2 (ja) | 2018-03-28 |
| MX2016011630A (es) | 2016-11-29 |
| JP2017507189A (ja) | 2017-03-16 |
| EP3114123B1 (en) | 2018-04-25 |
| AU2014385276A1 (en) | 2016-09-01 |
| EP3409671A1 (en) | 2018-12-05 |
| ES2673578T3 (es) | 2018-06-22 |
| WO2015134039A1 (en) | 2015-09-11 |
| EP3114123A1 (en) | 2017-01-11 |
| MX367852B (es) | 2019-09-09 |
| CN106414434A (zh) | 2017-02-15 |
| AU2014385276B2 (en) | 2019-01-17 |
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| JP2019094341A (ja) | Ｇｐｒ１２０アゴニストとして有用なベンゾ縮合ヘテロ環式誘導体 | |
| CA2941445A1 (en) | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes | |
| CA2905729C (en) | Bicyclic pyrrole derivatives useful as agonists of gpr120 | |
| CA2941442C (en) | Bicyclic pyrrole derivatives useful as agonists of gpr120 | |
| HK40005165A (en) | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes | |
| HK40005165B (en) | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes | |
| HK1233634A1 (en) | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes | |
| HK1233634B (zh) | 异噻唑衍生物作为用於治疗ii型糖尿病的gpr120激动剂 | |
| HK1230597A1 (en) | Bicyclic pyrrole derivatives useful as agonists of grp120 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190306 |
|
| FZDE | Discontinued |
Effective date: 20230911 |