CA2941154A1 - Optimal dosing of a cd19-antibody drug conjugate - Google Patents
Optimal dosing of a cd19-antibody drug conjugate Download PDFInfo
- Publication number
- CA2941154A1 CA2941154A1 CA2941154A CA2941154A CA2941154A1 CA 2941154 A1 CA2941154 A1 CA 2941154A1 CA 2941154 A CA2941154 A CA 2941154A CA 2941154 A CA2941154 A CA 2941154A CA 2941154 A1 CA2941154 A1 CA 2941154A1
- Authority
- CA
- Canada
- Prior art keywords
- dose
- sgn
- cd19a
- administered
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461976790P | 2014-04-08 | 2014-04-08 | |
| US61/976,790 | 2014-04-08 | ||
| PCT/US2015/024732 WO2015157297A1 (en) | 2014-04-08 | 2015-04-07 | Optimal dosing of a cd19-antibody drug conjugate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2941154A1 true CA2941154A1 (en) | 2015-10-15 |
Family
ID=54288332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2941154A Abandoned CA2941154A1 (en) | 2014-04-08 | 2015-04-07 | Optimal dosing of a cd19-antibody drug conjugate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20170182178A1 (enExample) |
| EP (1) | EP3129052B1 (enExample) |
| JP (1) | JP2017512801A (enExample) |
| KR (1) | KR20160141727A (enExample) |
| CN (1) | CN106170300A (enExample) |
| AU (1) | AU2015244004A1 (enExample) |
| CA (1) | CA2941154A1 (enExample) |
| EA (1) | EA201692016A1 (enExample) |
| IL (1) | IL247526A0 (enExample) |
| MX (1) | MX2016012258A (enExample) |
| SG (1) | SG11201607133QA (enExample) |
| WO (1) | WO2015157297A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018007592A1 (en) * | 2016-07-08 | 2018-01-11 | Genmab A/S | New dosage regimens for antibody drug conjugates based on anti-axl antibodies |
| JP7145891B2 (ja) * | 2017-06-14 | 2022-10-03 | アーデーセー セラピューティクス ソシエテ アノニム | 抗cd19 adcを投与するための投与レジメ |
| WO2019000327A1 (zh) * | 2017-06-29 | 2019-01-03 | 成都华创生物技术有限公司 | 一种trail类蛋白持续抑制肿瘤细胞生长的给药方法 |
| MY202687A (en) * | 2017-12-23 | 2024-05-15 | Uwell Biopharma Inc | Pharmaceutical chimeric receptor composition and method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213469A (zh) * | 2003-11-06 | 2017-09-29 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| DK2211904T3 (en) * | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| AU2011267106B2 (en) * | 2010-06-15 | 2015-05-14 | Genmab A/S | Human antibody drug conjugates against tissue factor |
| CA2815363C (en) * | 2010-10-22 | 2020-07-14 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
| EP2714738B1 (en) * | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
-
2015
- 2015-04-07 WO PCT/US2015/024732 patent/WO2015157297A1/en not_active Ceased
- 2015-04-07 EP EP15775944.0A patent/EP3129052B1/en not_active Not-in-force
- 2015-04-07 MX MX2016012258A patent/MX2016012258A/es unknown
- 2015-04-07 AU AU2015244004A patent/AU2015244004A1/en not_active Abandoned
- 2015-04-07 EA EA201692016A patent/EA201692016A1/ru unknown
- 2015-04-07 CA CA2941154A patent/CA2941154A1/en not_active Abandoned
- 2015-04-07 CN CN201580019099.2A patent/CN106170300A/zh active Pending
- 2015-04-07 US US15/129,727 patent/US20170182178A1/en not_active Abandoned
- 2015-04-07 SG SG11201607133QA patent/SG11201607133QA/en unknown
- 2015-04-07 JP JP2016559853A patent/JP2017512801A/ja active Pending
- 2015-04-07 KR KR1020167027123A patent/KR20160141727A/ko not_active Withdrawn
-
2016
- 2016-08-29 IL IL247526A patent/IL247526A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017512801A (ja) | 2017-05-25 |
| SG11201607133QA (en) | 2016-09-29 |
| EA201692016A1 (ru) | 2017-01-30 |
| WO2015157297A1 (en) | 2015-10-15 |
| EP3129052B1 (en) | 2020-06-03 |
| KR20160141727A (ko) | 2016-12-09 |
| AU2015244004A1 (en) | 2016-09-15 |
| US20170182178A1 (en) | 2017-06-29 |
| EP3129052A4 (en) | 2017-11-15 |
| MX2016012258A (es) | 2017-01-06 |
| EP3129052A1 (en) | 2017-02-15 |
| IL247526A0 (en) | 2016-11-30 |
| CN106170300A (zh) | 2016-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230190638A1 (en) | Anti-cd37 immunoconjugate and anti-cd20 antibody combinations | |
| Cura et al. | Phase I and pharmacokinetics study of crotoxin (cytotoxic PLA2, NSC-624244) in patients with advanced cancer | |
| US7794713B2 (en) | Compositions and methods for the treatment and prevention of hyperproliferative diseases | |
| JP6181273B2 (ja) | B細胞悪性腫瘍の症状の治療のための抗cd19メイタンシンノイドイムノコンジュゲート抗体の使用 | |
| Socinski et al. | Phase 1/2 study of the CD56-targeting antibody-drug conjugate lorvotuzumab mertansine (IMGN901) in combination with carboplatin/etoposide in small-cell lung cancer patients with extensive-stage disease | |
| US12144818B2 (en) | Method for treating cancer in a human patient by administering an anti-CD37 immunoconjugate using various dosing regimens | |
| EP3129052B1 (en) | Optimal dosing of a cd19-antibody drug conjugate | |
| Moore et al. | Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer | |
| RU2454245C2 (ru) | Фармацевтические композиции, способные вызывать апоптоз опухолевых клеток, для диагностики и лечения в-клеточной хронической лимфоцитарной лейкемии | |
| KR20170117045A (ko) | Cd19-adc 및 빈크리스틴을 사용하는 병용 치료법 | |
| JP6591665B2 (ja) | T−dm1難治性がん患者のsyd985処置 | |
| TW202116353A (zh) | 使用酞菁染料靶向分子結合物之治療方法 | |
| WO2006078336A2 (en) | Compositions and methods for the treatment and prevention of hyperproliferative diseases | |
| EP3487525A1 (en) | Combination therapy using a cd19-adc and rchp |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |
|
| FZDE | Discontinued |
Effective date: 20211123 |