CA2938807A1 - Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer - Google Patents
Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer Download PDFInfo
- Publication number
- CA2938807A1 CA2938807A1 CA2938807A CA2938807A CA2938807A1 CA 2938807 A1 CA2938807 A1 CA 2938807A1 CA 2938807 A CA2938807 A CA 2938807A CA 2938807 A CA2938807 A CA 2938807A CA 2938807 A1 CA2938807 A1 CA 2938807A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- expression
- biomarkers
- subject
- biomarker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 148
- 201000011510 cancer Diseases 0.000 title claims description 103
- 238000004393 prognosis Methods 0.000 title claims description 78
- 230000004044 response Effects 0.000 title description 18
- 239000004037 angiogenesis inhibitor Substances 0.000 title description 13
- 238000002405 diagnostic procedure Methods 0.000 title description 6
- 239000000090 biomarker Substances 0.000 claims abstract description 628
- 230000014509 gene expression Effects 0.000 claims abstract description 440
- 238000000034 method Methods 0.000 claims abstract description 273
- 239000003814 drug Substances 0.000 claims abstract description 97
- 238000011282 treatment Methods 0.000 claims abstract description 92
- 206010061535 Ovarian neoplasm Diseases 0.000 claims abstract description 81
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 71
- 230000001772 anti-angiogenic effect Effects 0.000 claims abstract description 39
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims abstract description 19
- 230000004083 survival effect Effects 0.000 claims description 91
- 206010033128 Ovarian cancer Diseases 0.000 claims description 86
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 81
- 239000002246 antineoplastic agent Substances 0.000 claims description 79
- 229940127089 cytotoxic agent Drugs 0.000 claims description 79
- 102100023915 Insulin Human genes 0.000 claims description 73
- 229960000397 bevacizumab Drugs 0.000 claims description 69
- -1 Tivozinib Chemical compound 0.000 claims description 67
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims description 59
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims description 59
- 102100031611 Collagen alpha-1(III) chain Human genes 0.000 claims description 57
- 101000993285 Homo sapiens Collagen alpha-1(III) chain Proteins 0.000 claims description 57
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 54
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims description 54
- 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 claims description 49
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 claims description 49
- 101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 claims description 46
- 102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 claims description 46
- 238000012360 testing method Methods 0.000 claims description 44
- 108010072582 Matrilin Proteins Proteins 0.000 claims description 42
- 102100024337 Collagen alpha-1(VIII) chain Human genes 0.000 claims description 41
- 101000909492 Homo sapiens Collagen alpha-1(VIII) chain Proteins 0.000 claims description 41
- 229910052697 platinum Inorganic materials 0.000 claims description 41
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims description 35
- 229940121849 Mitotic inhibitor Drugs 0.000 claims description 35
- 101000831866 Homo sapiens Transmembrane protein 45A Proteins 0.000 claims description 34
- 102100024186 Transmembrane protein 45A Human genes 0.000 claims description 34
- 206010009944 Colon cancer Diseases 0.000 claims description 29
- 230000000973 chemotherapeutic effect Effects 0.000 claims description 29
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 29
- 229930012538 Paclitaxel Natural products 0.000 claims description 28
- 229960004562 carboplatin Drugs 0.000 claims description 28
- 229960001592 paclitaxel Drugs 0.000 claims description 28
- 190000008236 carboplatin Chemical compound 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 27
- 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 claims description 26
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 claims description 26
- 101000825086 Homo sapiens Transcription factor SOX-11 Proteins 0.000 claims description 25
- 102100022415 Transcription factor SOX-11 Human genes 0.000 claims description 25
- 102100039435 C-X-C motif chemokine 17 Human genes 0.000 claims description 19
- 101000889048 Homo sapiens C-X-C motif chemokine 17 Proteins 0.000 claims description 19
- 239000003112 inhibitor Substances 0.000 claims description 17
- 101000635777 Homo sapiens Receptor-transporting protein 4 Proteins 0.000 claims description 16
- 102100030854 Receptor-transporting protein 4 Human genes 0.000 claims description 16
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 16
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 16
- 101000575378 Homo sapiens Microfibrillar-associated protein 2 Proteins 0.000 claims description 14
- 102100025599 Microfibrillar-associated protein 2 Human genes 0.000 claims description 14
- 108091006277 SLC5A1 Proteins 0.000 claims description 14
- 102000058090 Sodium-Glucose Transporter 1 Human genes 0.000 claims description 14
- 230000003247 decreasing effect Effects 0.000 claims description 13
- 230000037361 pathway Effects 0.000 claims description 11
- 229940100198 alkylating agent Drugs 0.000 claims description 10
- 239000002168 alkylating agent Substances 0.000 claims description 10
- 230000000340 anti-metabolite Effects 0.000 claims description 10
- 229940100197 antimetabolite Drugs 0.000 claims description 10
- 239000002256 antimetabolite Substances 0.000 claims description 10
- 239000003972 antineoplastic antibiotic Substances 0.000 claims description 9
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 9
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 9
- 101100274957 Mus musculus Col1a1 gene Proteins 0.000 claims description 8
- 229940123237 Taxane Drugs 0.000 claims description 8
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims description 7
- 230000002491 angiogenic effect Effects 0.000 claims description 7
- 230000002519 immonomodulatory effect Effects 0.000 claims description 7
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims description 6
- 108010047761 Interferon-alpha Proteins 0.000 claims description 6
- 102000006992 Interferon-alpha Human genes 0.000 claims description 6
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims description 6
- 239000005536 L01XE08 - Nilotinib Substances 0.000 claims description 6
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims description 6
- 229960002412 cediranib Drugs 0.000 claims description 6
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims description 6
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims description 6
- 229960002633 ramucirumab Drugs 0.000 claims description 6
- 238000007637 random forest analysis Methods 0.000 claims description 6
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 6
- 229940120638 avastin Drugs 0.000 claims description 5
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims description 4
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims description 4
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 4
- 229960004942 lenalidomide Drugs 0.000 claims description 4
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims description 4
- 229960001796 sunitinib Drugs 0.000 claims description 4
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims description 4
- 229960003433 thalidomide Drugs 0.000 claims description 4
- KCOYQXZDFIIGCY-CZIZESTLSA-N (3e)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one Chemical compound C1CN(C)CCN1C1=CC=C(N\C(N2)=C/3C(=C4C(F)=CC=CC4=NC\3=O)N)C2=C1 KCOYQXZDFIIGCY-CZIZESTLSA-N 0.000 claims description 3
- JRMGHBVACUJCRP-BTJKTKAUSA-N (z)-but-2-enedioic acid;4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline Chemical compound OC(=O)\C=C/C(O)=O.COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 JRMGHBVACUJCRP-BTJKTKAUSA-N 0.000 claims description 3
- XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 claims description 3
- 102400000068 Angiostatin Human genes 0.000 claims description 3
- 108010079709 Angiostatins Proteins 0.000 claims description 3
- 102000003916 Arrestin Human genes 0.000 claims description 3
- 108090000328 Arrestin Proteins 0.000 claims description 3
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 3
- 102400000730 Canstatin Human genes 0.000 claims description 3
- 101800000626 Canstatin Proteins 0.000 claims description 3
- 102100031186 Chromogranin-A Human genes 0.000 claims description 3
- 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims description 3
- 102100033780 Collagen alpha-3(IV) chain Human genes 0.000 claims description 3
- 108010079505 Endostatins Proteins 0.000 claims description 3
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 3
- 229960002833 aflibercept Drugs 0.000 claims description 3
- 108010081667 aflibercept Proteins 0.000 claims description 3
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims description 3
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims description 3
- AEULIVPVIDOLIN-UHFFFAOYSA-N cep-11981 Chemical compound C1=C2C3=C4CNC(=O)C4=C4C5=CN(C)N=C5CCC4=C3N(CC(C)C)C2=CC=C1NC1=NC=CC=N1 AEULIVPVIDOLIN-UHFFFAOYSA-N 0.000 claims description 3
- PIQCTGMSNWUMAF-UHFFFAOYSA-N chembl522892 Chemical compound C1CN(C)CCN1C1=CC=C(NC(=N2)C=3C(NC4=CC=CC(F)=C4C=3N)=O)C2=C1 PIQCTGMSNWUMAF-UHFFFAOYSA-N 0.000 claims description 3
- 229960002448 dasatinib Drugs 0.000 claims description 3
- 229950005778 dovitinib Drugs 0.000 claims description 3
- 229960001433 erlotinib Drugs 0.000 claims description 3
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 3
- 229940022353 herceptin Drugs 0.000 claims description 3
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical compound CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 claims description 3
- CPMDPSXJELVGJG-UHFFFAOYSA-N methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate Chemical compound OC=1NC2=CC(=CC=C2C=1C(=NC1=CC=C(C=C1)N(C(CN1CCN(CC1)C)=O)C)C1=CC=CC=C1)C(=O)OC CPMDPSXJELVGJG-UHFFFAOYSA-N 0.000 claims description 3
- 229950003968 motesanib Drugs 0.000 claims description 3
- RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 claims description 3
- LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 claims description 3
- 229960001346 nilotinib Drugs 0.000 claims description 3
- 229960000639 pazopanib Drugs 0.000 claims description 3
- 229950003647 semaxanib Drugs 0.000 claims description 3
- WUWDLXZGHZSWQZ-WQLSENKSSA-N semaxanib Chemical compound N1C(C)=CC(C)=C1\C=C/1C2=CC=CC=C2NC\1=O WUWDLXZGHZSWQZ-WQLSENKSSA-N 0.000 claims description 3
- 229940068117 sprycel Drugs 0.000 claims description 3
- 229940034785 sutent Drugs 0.000 claims description 3
- 229940069905 tasigna Drugs 0.000 claims description 3
- 229960000575 trastuzumab Drugs 0.000 claims description 3
- 108010075758 trebananib Proteins 0.000 claims description 3
- 108010012374 type IV collagen alpha3 chain Proteins 0.000 claims description 3
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims description 3
- 108010060757 vasostatin Proteins 0.000 claims description 3
- 229950000578 vatalanib Drugs 0.000 claims description 3
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 claims description 3
- 229940069559 votrient Drugs 0.000 claims description 3
- 102000055008 Matrilin Proteins Human genes 0.000 claims 8
- 230000002611 ovarian Effects 0.000 abstract description 9
- 239000000523 sample Substances 0.000 description 221
- 108090000623 proteins and genes Proteins 0.000 description 135
- 230000000692 anti-sense effect Effects 0.000 description 64
- 230000033115 angiogenesis Effects 0.000 description 57
- 238000003556 assay Methods 0.000 description 51
- 239000012472 biological sample Substances 0.000 description 48
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 46
- 210000001519 tissue Anatomy 0.000 description 46
- 238000004458 analytical method Methods 0.000 description 45
- 201000010099 disease Diseases 0.000 description 45
- 102100033670 Matrilin-3 Human genes 0.000 description 34
- 101150026651 63 gene Proteins 0.000 description 31
- 230000000875 corresponding effect Effects 0.000 description 30
- 238000002493 microarray Methods 0.000 description 30
- 150000007523 nucleic acids Chemical class 0.000 description 28
- 239000002299 complementary DNA Substances 0.000 description 25
- 210000004027 cell Anatomy 0.000 description 24
- 102000039446 nucleic acids Human genes 0.000 description 24
- 108020004707 nucleic acids Proteins 0.000 description 24
- 108020004999 messenger RNA Proteins 0.000 description 23
- 102000004169 proteins and genes Human genes 0.000 description 23
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 22
- 238000002790 cross-validation Methods 0.000 description 21
- 230000006870 function Effects 0.000 description 20
- 230000004547 gene signature Effects 0.000 description 20
- 102100024155 Cadherin-11 Human genes 0.000 description 19
- 101000762236 Homo sapiens Cadherin-11 Proteins 0.000 description 19
- 238000009396 hybridization Methods 0.000 description 19
- 229940079593 drug Drugs 0.000 description 18
- 230000000694 effects Effects 0.000 description 18
- 238000012549 training Methods 0.000 description 18
- 102100022976 B-cell lymphoma/leukemia 11A Human genes 0.000 description 17
- 102100036213 Collagen alpha-2(I) chain Human genes 0.000 description 17
- 101000903703 Homo sapiens B-cell lymphoma/leukemia 11A Proteins 0.000 description 17
- 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 description 17
- 238000011161 development Methods 0.000 description 17
- 230000018109 developmental process Effects 0.000 description 17
- 239000000047 product Substances 0.000 description 17
- 102100030446 Adenosine 5'-monophosphoramidase HINT1 Human genes 0.000 description 16
- 101000842270 Homo sapiens Adenosine 5'-monophosphoramidase HINT1 Proteins 0.000 description 16
- 101000880098 Homo sapiens Sushi repeat-containing protein SRPX Proteins 0.000 description 16
- 102100037352 Sushi repeat-containing protein SRPX Human genes 0.000 description 16
- 238000011269 treatment regimen Methods 0.000 description 16
- 101000666607 Homo sapiens Rho-related BTB domain-containing protein 3 Proteins 0.000 description 15
- 102100038342 Rho-related BTB domain-containing protein 3 Human genes 0.000 description 15
- 239000013610 patient sample Substances 0.000 description 15
- 101001091984 Homo sapiens Rho GTPase-activating protein 26 Proteins 0.000 description 14
- 102100035744 Rho GTPase-activating protein 26 Human genes 0.000 description 14
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- 238000002512 chemotherapy Methods 0.000 description 14
- 101000814514 Homo sapiens XIAP-associated factor 1 Proteins 0.000 description 13
- 102100039488 XIAP-associated factor 1 Human genes 0.000 description 13
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 description 13
- 230000012010 growth Effects 0.000 description 13
- 230000001023 pro-angiogenic effect Effects 0.000 description 13
- 102100034622 Complement factor B Human genes 0.000 description 12
- 101100382122 Homo sapiens CIITA gene Proteins 0.000 description 12
- 101001043321 Homo sapiens Lysyl oxidase homolog 1 Proteins 0.000 description 12
- 102100021958 Lysyl oxidase homolog 1 Human genes 0.000 description 12
- 102100026371 MHC class II transactivator Human genes 0.000 description 12
- 108700002010 MHC class II transactivator Proteins 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 12
- 101000840272 Homo sapiens Immunoglobulin lambda constant 3 Proteins 0.000 description 11
- 101000645296 Homo sapiens Metalloproteinase inhibitor 2 Proteins 0.000 description 11
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 description 11
- 102100029619 Immunoglobulin lambda constant 3 Human genes 0.000 description 11
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 description 11
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 102100025672 Angiopoietin-related protein 2 Human genes 0.000 description 10
- 101000693081 Homo sapiens Angiopoietin-related protein 2 Proteins 0.000 description 10
- 238000003491 array Methods 0.000 description 10
- 238000003018 immunoassay Methods 0.000 description 10
- 108091070501 miRNA Proteins 0.000 description 10
- 239000002679 microRNA Substances 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 102100037417 Dexamethasone-induced protein Human genes 0.000 description 9
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 9
- 101000806442 Homo sapiens Dexamethasone-induced protein Proteins 0.000 description 9
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 9
- 230000008901 benefit Effects 0.000 description 9
- 230000027455 binding Effects 0.000 description 9
- 238000001514 detection method Methods 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 230000003827 upregulation Effects 0.000 description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 8
- 102100032633 E3 ubiquitin-protein ligase SH3RF2 Human genes 0.000 description 8
- 238000002965 ELISA Methods 0.000 description 8
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 8
- 101000654568 Homo sapiens E3 ubiquitin-protein ligase SH3RF2 Proteins 0.000 description 8
- 230000034994 death Effects 0.000 description 8
- 231100000517 death Toxicity 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- 239000012634 fragment Substances 0.000 description 8
- 238000013178 mathematical model Methods 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- 102100030343 Antigen peptide transporter 2 Human genes 0.000 description 7
- 206010006187 Breast cancer Diseases 0.000 description 7
- 208000026310 Breast neoplasm Diseases 0.000 description 7
- 102100024823 DNA polymerase delta subunit 2 Human genes 0.000 description 7
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 7
- 101000909189 Homo sapiens DNA polymerase delta subunit 2 Proteins 0.000 description 7
- 101000601047 Homo sapiens Nidogen-1 Proteins 0.000 description 7
- 101000878215 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 description 7
- 101000600766 Homo sapiens Podoplanin Proteins 0.000 description 7
- 101000918141 Homo sapiens Protein eva-1 homolog C Proteins 0.000 description 7
- 102100037369 Nidogen-1 Human genes 0.000 description 7
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 description 7
- 102100036983 Peptidyl-prolyl cis-trans isomerase FKBP7 Human genes 0.000 description 7
- 102100037265 Podoplanin Human genes 0.000 description 7
- 102100029273 Protein eva-1 homolog C Human genes 0.000 description 7
- 108091006531 SLC28A3 Proteins 0.000 description 7
- 102100021470 Solute carrier family 28 member 3 Human genes 0.000 description 7
- 101800000849 Tachykinin-associated peptide 2 Proteins 0.000 description 7
- 238000001574 biopsy Methods 0.000 description 7
- 208000029742 colonic neoplasm Diseases 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 230000003828 downregulation Effects 0.000 description 7
- 208000005017 glioblastoma Diseases 0.000 description 7
- 230000028993 immune response Effects 0.000 description 7
- 108091046261 miR-198 stem-loop Proteins 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 230000004043 responsiveness Effects 0.000 description 7
- 238000010200 validation analysis Methods 0.000 description 7
- 102100028252 Brain acid soluble protein 1 Human genes 0.000 description 6
- 102100022145 Collagen alpha-1(IV) chain Human genes 0.000 description 6
- 102100028538 Guanylate-binding protein 4 Human genes 0.000 description 6
- 101000935689 Homo sapiens Brain acid soluble protein 1 Proteins 0.000 description 6
- 101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 description 6
- 101001058851 Homo sapiens Guanylate-binding protein 4 Proteins 0.000 description 6
- 238000011529 RT qPCR Methods 0.000 description 6
- 108091007416 X-inactive specific transcript Proteins 0.000 description 6
- 108091035715 XIST (gene) Proteins 0.000 description 6
- 239000012491 analyte Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000001627 detrimental effect Effects 0.000 description 6
- 238000007481 next generation sequencing Methods 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- WMLBMYGMIFJTCS-HUROMRQRSA-N (2r,3s,5r)-2-[(9-phenylxanthen-9-yl)oxymethyl]-5-purin-9-yloxolan-3-ol Chemical compound C([C@H]1O[C@H](C[C@@H]1O)N1C2=NC=NC=C2N=C1)OC1(C2=CC=CC=C2OC2=CC=CC=C21)C1=CC=CC=C1 WMLBMYGMIFJTCS-HUROMRQRSA-N 0.000 description 5
- 102100030346 Antigen peptide transporter 1 Human genes 0.000 description 5
- 206010055113 Breast cancer metastatic Diseases 0.000 description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 5
- 102100024426 Dihydropyrimidinase-related protein 2 Human genes 0.000 description 5
- 102100023226 Early growth response protein 1 Human genes 0.000 description 5
- 102100031546 HLA class II histocompatibility antigen, DO beta chain Human genes 0.000 description 5
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 description 5
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 5
- 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 description 5
- 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 description 5
- 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 description 5
- 101000840566 Homo sapiens Insulin-like growth factor-binding protein 5 Proteins 0.000 description 5
- 101000780205 Homo sapiens Long-chain-fatty-acid-CoA ligase 5 Proteins 0.000 description 5
- 101001131990 Homo sapiens Peroxidasin homolog Proteins 0.000 description 5
- 101000652794 Homo sapiens Protein shisa-4 Proteins 0.000 description 5
- 102100029225 Insulin-like growth factor-binding protein 5 Human genes 0.000 description 5
- 102100034318 Long-chain-fatty-acid-CoA ligase 5 Human genes 0.000 description 5
- 108010023335 Member 2 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 5
- 238000000636 Northern blotting Methods 0.000 description 5
- 102100034601 Peroxidasin homolog Human genes 0.000 description 5
- 102100030902 Protein shisa-4 Human genes 0.000 description 5
- 238000011226 adjuvant chemotherapy Methods 0.000 description 5
- 230000003321 amplification Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 229960004397 cyclophosphamide Drugs 0.000 description 5
- 238000002651 drug therapy Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 229960002949 fluorouracil Drugs 0.000 description 5
- 238000003364 immunohistochemistry Methods 0.000 description 5
- 238000010202 multivariate logistic regression analysis Methods 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 239000012188 paraffin wax Substances 0.000 description 5
- 230000007170 pathology Effects 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 238000010837 poor prognosis Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 238000003757 reverse transcription PCR Methods 0.000 description 5
- 238000011285 therapeutic regimen Methods 0.000 description 5
- 102100036516 Ectonucleoside triphosphate diphosphohydrolase 7 Human genes 0.000 description 4
- 102100037260 Gap junction beta-1 protein Human genes 0.000 description 4
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 description 4
- 101000852006 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 7 Proteins 0.000 description 4
- 101000954104 Homo sapiens Gap junction beta-1 protein Proteins 0.000 description 4
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 description 4
- 101000977638 Homo sapiens Immunoglobulin superfamily containing leucine-rich repeat protein Proteins 0.000 description 4
- 101000717450 Homo sapiens RCC1 and BTB domain-containing protein 1 Proteins 0.000 description 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 4
- 102100023538 Immunoglobulin superfamily containing leucine-rich repeat protein Human genes 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 102100020837 RCC1 and BTB domain-containing protein 1 Human genes 0.000 description 4
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 4
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 4
- 230000002596 correlated effect Effects 0.000 description 4
- 238000003795 desorption Methods 0.000 description 4
- 229960004679 doxorubicin Drugs 0.000 description 4
- 238000010195 expression analysis Methods 0.000 description 4
- 238000002866 fluorescence resonance energy transfer Methods 0.000 description 4
- 108091008053 gene clusters Proteins 0.000 description 4
- 238000011223 gene expression profiling Methods 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 238000010801 machine learning Methods 0.000 description 4
- 238000004949 mass spectrometry Methods 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000002974 pharmacogenomic effect Effects 0.000 description 4
- 230000000306 recurrent effect Effects 0.000 description 4
- 238000012552 review Methods 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- 238000001262 western blot Methods 0.000 description 4
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 3
- 108020005544 Antisense RNA Proteins 0.000 description 3
- 101000693933 Arabidopsis thaliana Fructose-bisphosphate aldolase 8, cytosolic Proteins 0.000 description 3
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 description 3
- 102100031168 CCN family member 2 Human genes 0.000 description 3
- 102100024436 Caldesmon Human genes 0.000 description 3
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 3
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 description 3
- 102100021633 Cathepsin B Human genes 0.000 description 3
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 3
- 102100033601 Collagen alpha-1(I) chain Human genes 0.000 description 3
- 102100027442 Collagen alpha-1(XII) chain Human genes 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 3
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 3
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 3
- 102100023528 Glucoside xylosyltransferase 2 Human genes 0.000 description 3
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 3
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 3
- 108010075704 HLA-A Antigens Proteins 0.000 description 3
- 108010058607 HLA-B Antigens Proteins 0.000 description 3
- 101000740785 Homo sapiens Bone marrow stromal antigen 2 Proteins 0.000 description 3
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 description 3
- 101000910297 Homo sapiens Caldesmon Proteins 0.000 description 3
- 101000898449 Homo sapiens Cathepsin B Proteins 0.000 description 3
- 101000861874 Homo sapiens Collagen alpha-1(XII) chain Proteins 0.000 description 3
- 101000641077 Homo sapiens Diamine acetyltransferase 1 Proteins 0.000 description 3
- 101000906420 Homo sapiens Glucoside xylosyltransferase 2 Proteins 0.000 description 3
- 101000840257 Homo sapiens Immunoglobulin kappa constant Proteins 0.000 description 3
- 101000595918 Homo sapiens Phospholipase A and acyltransferase 4 Proteins 0.000 description 3
- 101000864990 Homo sapiens Serine incorporator 5 Proteins 0.000 description 3
- 101000713305 Homo sapiens Sodium-coupled neutral amino acid transporter 1 Proteins 0.000 description 3
- 101000801701 Homo sapiens Tropomyosin alpha-1 chain Proteins 0.000 description 3
- 101000838463 Homo sapiens Tubulin alpha-1A chain Proteins 0.000 description 3
- 101000830565 Homo sapiens Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 description 3
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 description 3
- 101000723645 Homo sapiens Zinc finger protein 697 Proteins 0.000 description 3
- 102100029572 Immunoglobulin kappa constant Human genes 0.000 description 3
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
- 102100035200 Phospholipase A and acyltransferase 4 Human genes 0.000 description 3
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 102100023075 Protein Niban 2 Human genes 0.000 description 3
- 208000015634 Rectal Neoplasms Diseases 0.000 description 3
- 206010038389 Renal cancer Diseases 0.000 description 3
- 102100029726 Serine incorporator 5 Human genes 0.000 description 3
- 102100030100 Sulfate anion transporter 1 Human genes 0.000 description 3
- 102100033632 Tropomyosin alpha-1 chain Human genes 0.000 description 3
- 102100028968 Tubulin alpha-1A chain Human genes 0.000 description 3
- 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 description 3
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 3
- 108010083162 Twist-Related Protein 1 Proteins 0.000 description 3
- 102100030398 Twist-related protein 1 Human genes 0.000 description 3
- 101100022813 Zea mays MEG3 gene Proteins 0.000 description 3
- 102100028373 Zinc finger protein 697 Human genes 0.000 description 3
- 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 description 3
- 238000011122 anti-angiogenic therapy Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000013528 artificial neural network Methods 0.000 description 3
- 238000000668 atmospheric pressure chemical ionisation mass spectrometry Methods 0.000 description 3
- 238000001854 atmospheric pressure photoionisation mass spectrometry Methods 0.000 description 3
- 238000004422 calculation algorithm Methods 0.000 description 3
- 229960004117 capecitabine Drugs 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 229960001904 epirubicin Drugs 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000010230 functional analysis Methods 0.000 description 3
- 238000010209 gene set analysis Methods 0.000 description 3
- 238000007417 hierarchical cluster analysis Methods 0.000 description 3
- 238000001114 immunoprecipitation Methods 0.000 description 3
- 229950000038 interferon alfa Drugs 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229960004768 irinotecan Drugs 0.000 description 3
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 3
- 201000010982 kidney cancer Diseases 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 201000007270 liver cancer Diseases 0.000 description 3
- 201000005202 lung cancer Diseases 0.000 description 3
- 208000020816 lung neoplasm Diseases 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 238000011275 oncology therapy Methods 0.000 description 3
- 230000002018 overexpression Effects 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 238000003909 pattern recognition Methods 0.000 description 3
- 238000007781 pre-processing Methods 0.000 description 3
- 238000003908 quality control method Methods 0.000 description 3
- 206010038038 rectal cancer Diseases 0.000 description 3
- 201000001275 rectum cancer Diseases 0.000 description 3
- 230000011664 signaling Effects 0.000 description 3
- 238000011255 standard chemotherapy Methods 0.000 description 3
- 238000013517 stratification Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 230000006459 vascular development Effects 0.000 description 3
- 230000032665 vasculature development Effects 0.000 description 3
- 101150090724 3 gene Proteins 0.000 description 2
- 102100036438 Amyloid beta precursor protein binding family B member 2 Human genes 0.000 description 2
- 102100030762 Apolipoprotein L1 Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000212384 Bifora Species 0.000 description 2
- 102100028226 COUP transcription factor 2 Human genes 0.000 description 2
- 102100031457 Collagen alpha-1(V) chain Human genes 0.000 description 2
- 102100036217 Collagen alpha-1(X) chain Human genes 0.000 description 2
- 102100024203 Collagen alpha-1(XIV) chain Human genes 0.000 description 2
- 206010052358 Colorectal cancer metastatic Diseases 0.000 description 2
- 102100025849 Complement C1q subcomponent subunit C Human genes 0.000 description 2
- 102100037573 Dual specificity protein phosphatase 12 Human genes 0.000 description 2
- 102100033941 Ephrin-A5 Human genes 0.000 description 2
- 108010043939 Ephrin-A5 Proteins 0.000 description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 2
- 102100040936 FXYD domain-containing ion transport regulator 6 Human genes 0.000 description 2
- 102100036089 Fascin Human genes 0.000 description 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 2
- 102100035688 Guanylate-binding protein 1 Human genes 0.000 description 2
- 102100022599 Homeobox protein Hox-C6 Human genes 0.000 description 2
- 101100323521 Homo sapiens APOL1 gene Proteins 0.000 description 2
- 101000928680 Homo sapiens Amyloid beta precursor protein binding family B member 2 Proteins 0.000 description 2
- 101000860860 Homo sapiens COUP transcription factor 2 Proteins 0.000 description 2
- 101000941708 Homo sapiens Collagen alpha-1(V) chain Proteins 0.000 description 2
- 101000875027 Homo sapiens Collagen alpha-1(X) chain Proteins 0.000 description 2
- 101000909626 Homo sapiens Collagen alpha-1(XIV) chain Proteins 0.000 description 2
- 101000933636 Homo sapiens Complement C1q subcomponent subunit C Proteins 0.000 description 2
- 101001036287 Homo sapiens DNA-binding protein inhibitor ID-3 Proteins 0.000 description 2
- 101000924017 Homo sapiens Dual specificity protein phosphatase 1 Proteins 0.000 description 2
- 101000881110 Homo sapiens Dual specificity protein phosphatase 12 Proteins 0.000 description 2
- 101000893722 Homo sapiens FXYD domain-containing ion transport regulator 6 Proteins 0.000 description 2
- 101001021925 Homo sapiens Fascin Proteins 0.000 description 2
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 description 2
- 101001045154 Homo sapiens Homeobox protein Hox-C6 Proteins 0.000 description 2
- 101000961156 Homo sapiens Immunoglobulin heavy constant gamma 1 Proteins 0.000 description 2
- 101000961146 Homo sapiens Immunoglobulin heavy constant gamma 2 Proteins 0.000 description 2
- 101000961149 Homo sapiens Immunoglobulin heavy constant gamma 4 Proteins 0.000 description 2
- 101000840577 Homo sapiens Insulin-like growth factor-binding protein 7 Proteins 0.000 description 2
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 2
- 101001076431 Homo sapiens NF-kappa-B inhibitor zeta Proteins 0.000 description 2
- 101000611888 Homo sapiens Platelet-derived growth factor C Proteins 0.000 description 2
- 101000730607 Homo sapiens Pleckstrin homology domain-containing family G member 1 Proteins 0.000 description 2
- 101000771012 Homo sapiens Protein CMSS1 Proteins 0.000 description 2
- 101000822540 Homo sapiens Sterile alpha motif domain-containing protein 9-like Proteins 0.000 description 2
- 101000666429 Homo sapiens Terminal nucleotidyltransferase 5C Proteins 0.000 description 2
- 101000805613 Homo sapiens Vacuole membrane protein 1 Proteins 0.000 description 2
- 101000860430 Homo sapiens Versican core protein Proteins 0.000 description 2
- 101150088952 IGF1 gene Proteins 0.000 description 2
- 102100039345 Immunoglobulin heavy constant gamma 1 Human genes 0.000 description 2
- 102100039346 Immunoglobulin heavy constant gamma 2 Human genes 0.000 description 2
- 102100039347 Immunoglobulin heavy constant gamma 4 Human genes 0.000 description 2
- 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 description 2
- 102100025390 Integrin beta-2 Human genes 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 206010050513 Metastatic renal cell carcinoma Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 108010063737 Myristoylated Alanine-Rich C Kinase Substrate Proteins 0.000 description 2
- 102000015695 Myristoylated Alanine-Rich C Kinase Substrate Human genes 0.000 description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- 102100026009 NF-kappa-B inhibitor zeta Human genes 0.000 description 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- 102100040681 Platelet-derived growth factor C Human genes 0.000 description 2
- 102100032595 Pleckstrin homology domain-containing family G member 1 Human genes 0.000 description 2
- 102100029154 Protein CMSS1 Human genes 0.000 description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 2
- 102000039471 Small Nuclear RNA Human genes 0.000 description 2
- 102100022459 Sterile alpha motif domain-containing protein 9-like Human genes 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 102100038305 Terminal nucleotidyltransferase 5C Human genes 0.000 description 2
- 108020004566 Transfer RNA Proteins 0.000 description 2
- 102100038001 Vacuole membrane protein 1 Human genes 0.000 description 2
- 102100028437 Versican core protein Human genes 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 230000006481 angiogenic pathway Effects 0.000 description 2
- 230000002137 anti-vascular effect Effects 0.000 description 2
- 238000002820 assay format Methods 0.000 description 2
- 238000005251 capillar electrophoresis Methods 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 2
- 229960004316 cisplatin Drugs 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 238000011393 cytotoxic chemotherapy Methods 0.000 description 2
- 238000011334 debulking surgery Methods 0.000 description 2
- 230000009274 differential gene expression Effects 0.000 description 2
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 2
- 201000004101 esophageal cancer Diseases 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 description 2
- 229960005277 gemcitabine Drugs 0.000 description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 2
- 238000003365 immunocytochemistry Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000000370 laser capture micro-dissection Methods 0.000 description 2
- 238000001001 laser micro-dissection Methods 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 238000001325 log-rank test Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
- 229960000485 methotrexate Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000009099 neoadjuvant therapy Methods 0.000 description 2
- 238000004848 nephelometry Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 238000007899 nucleic acid hybridization Methods 0.000 description 2
- 239000002853 nucleic acid probe Substances 0.000 description 2
- 201000002528 pancreatic cancer Diseases 0.000 description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 238000011518 platinum-based chemotherapy Methods 0.000 description 2
- 239000000092 prognostic biomarker Substances 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 238000000575 proteomic method Methods 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 108020004418 ribosomal RNA Proteins 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000009097 single-agent therapy Methods 0.000 description 2
- 108091029842 small nuclear ribonucleic acid Proteins 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 201000011549 stomach cancer Diseases 0.000 description 2
- 238000012706 support-vector machine Methods 0.000 description 2
- 238000002626 targeted therapy Methods 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- 238000004879 turbidimetry Methods 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 description 1
- FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 description 1
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 1
- 101150084750 1 gene Proteins 0.000 description 1
- HJTAZXHBEBIQQX-UHFFFAOYSA-N 1,5-bis(chloromethyl)naphthalene Chemical compound C1=CC=C2C(CCl)=CC=CC2=C1CCl HJTAZXHBEBIQQX-UHFFFAOYSA-N 0.000 description 1
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 description 1
- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 1
- 102100026210 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Human genes 0.000 description 1
- GXAFMKJFWWBYNW-OWHBQTKESA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-3-cyclopropyl-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC2CC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GXAFMKJFWWBYNW-OWHBQTKESA-N 0.000 description 1
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 description 1
- WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 1
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
- 102100027399 A disintegrin and metalloproteinase with thrombospondin motifs 2 Human genes 0.000 description 1
- 108091005662 ADAMTS2 Proteins 0.000 description 1
- 102100039645 ADP-ribosylation factor-like protein 4A Human genes 0.000 description 1
- 102100030834 AT-rich interactive domain-containing protein 5A Human genes 0.000 description 1
- 102100036732 Actin, aortic smooth muscle Human genes 0.000 description 1
- 102100020963 Actin-binding LIM protein 1 Human genes 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102100026026 Acyl-CoA synthetase short-chain family member 3, mitochondrial Human genes 0.000 description 1
- 102100024394 Adipocyte enhancer-binding protein 1 Human genes 0.000 description 1
- 206010058897 Adnexa uteri mass Diseases 0.000 description 1
- 102100039702 Alcohol dehydrogenase class-3 Human genes 0.000 description 1
- 102100040357 Angiomotin-like protein 1 Human genes 0.000 description 1
- 108010049777 Ankyrins Proteins 0.000 description 1
- 102000008102 Ankyrins Human genes 0.000 description 1
- 102100031323 Anthrax toxin receptor 1 Human genes 0.000 description 1
- 102100031325 Anthrax toxin receptor 2 Human genes 0.000 description 1
- 102100036451 Apolipoprotein C-I Human genes 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 description 1
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 description 1
- 108010031480 Artificial Receptors Proteins 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 108010024976 Asparaginase Proteins 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 108091032955 Bacterial small RNA Proteins 0.000 description 1
- 241000005672 Baia Species 0.000 description 1
- 102100023006 Basic leucine zipper transcriptional factor ATF-like 2 Human genes 0.000 description 1
- 102100030686 Beta-sarcoglycan Human genes 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 102100025250 C-X-C motif chemokine 14 Human genes 0.000 description 1
- 102100032912 CD44 antigen Human genes 0.000 description 1
- 102000017925 CHRM3 Human genes 0.000 description 1
- 102100040527 CKLF-like MARVEL transmembrane domain-containing protein 3 Human genes 0.000 description 1
- 102100028228 COUP transcription factor 1 Human genes 0.000 description 1
- 101100205088 Caenorhabditis elegans iars-1 gene Proteins 0.000 description 1
- 102100038542 Calcium homeostasis modulator protein 6 Human genes 0.000 description 1
- 101001110283 Canis lupus familiaris Ras-related C3 botulinum toxin substrate 1 Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102100033377 Carbohydrate sulfotransferase 15 Human genes 0.000 description 1
- 102100033040 Carbonic anhydrase 12 Human genes 0.000 description 1
- 102100033041 Carbonic anhydrase 13 Human genes 0.000 description 1
- 102100035249 Carbonyl reductase [NADPH] 3 Human genes 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 102100035654 Cathepsin S Human genes 0.000 description 1
- 102100032230 Caveolae-associated protein 1 Human genes 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 description 1
- 208000030808 Clear cell renal carcinoma Diseases 0.000 description 1
- 102100034951 Coiled-coil domain-containing protein 69 Human genes 0.000 description 1
- 102100023708 Coiled-coil domain-containing protein 80 Human genes 0.000 description 1
- 102100022640 Collagen alpha-1(XV) chain Human genes 0.000 description 1
- 102100031544 Collagen alpha-1(XXVII) chain Human genes 0.000 description 1
- 102100031502 Collagen alpha-2(V) chain Human genes 0.000 description 1
- 102100039551 Collagen triple helix repeat-containing protein 1 Human genes 0.000 description 1
- 102100027309 Cyclic AMP-responsive element-binding protein 5 Human genes 0.000 description 1
- 102100031127 Cysteine/serine-rich nuclear protein 1 Human genes 0.000 description 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
- 102100036696 Cytochrome P450 27C1 Human genes 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 102100022286 DNA repair-scaffolding protein Human genes 0.000 description 1
- 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 description 1
- 101100317380 Danio rerio wnt4a gene Proteins 0.000 description 1
- 102100024352 Dedicator of cytokinesis protein 4 Human genes 0.000 description 1
- 102100030442 Derlin-3 Human genes 0.000 description 1
- 108010086291 Deubiquitinating Enzyme CYLD Proteins 0.000 description 1
- 102100022735 Diacylglycerol kinase alpha Human genes 0.000 description 1
- 102100024425 Dihydropyrimidinase-related protein 3 Human genes 0.000 description 1
- 102100032302 Diphosphoinositol polyphosphate phosphohydrolase NUDT4B Human genes 0.000 description 1
- 102100028555 Disheveled-associated activator of morphogenesis 1 Human genes 0.000 description 1
- 102100024364 Disintegrin and metalloproteinase domain-containing protein 8 Human genes 0.000 description 1
- 102100037844 Divergent protein kinase domain 1C Human genes 0.000 description 1
- 102100027085 Dual specificity protein phosphatase 4 Human genes 0.000 description 1
- 102100023228 Dynein axonemal intermediate chain 4 Human genes 0.000 description 1
- 102100036275 E3 ubiquitin-protein ligase RNF149 Human genes 0.000 description 1
- 102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 description 1
- 102100021659 ER membrane protein complex subunit 10 Human genes 0.000 description 1
- 102100039563 ETS translocation variant 1 Human genes 0.000 description 1
- 102100035087 Ectoderm-neural cortex protein 1 Human genes 0.000 description 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
- 108010009900 Endothelial Protein C Receptor Proteins 0.000 description 1
- 102000009839 Endothelial Protein C Receptor Human genes 0.000 description 1
- 102100040513 Endothelin-converting enzyme-like 1 Human genes 0.000 description 1
- 102100033183 Epithelial membrane protein 1 Human genes 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 102100021654 Extracellular sulfatase Sulf-2 Human genes 0.000 description 1
- 201000001342 Fallopian tube cancer Diseases 0.000 description 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 description 1
- 102100035049 Feline leukemia virus subgroup C receptor-related protein 2 Human genes 0.000 description 1
- 102100027634 Fibronectin type 3 and ankyrin repeat domains protein 1 Human genes 0.000 description 1
- 102100026546 Fibronectin type III domain-containing protein 1 Human genes 0.000 description 1
- 102100031813 Fibulin-2 Human genes 0.000 description 1
- 102100037564 Filamin-binding LIM protein 1 Human genes 0.000 description 1
- 102100037181 Fructose-1,6-bisphosphatase 1 Human genes 0.000 description 1
- 102100022629 Fructose-2,6-bisphosphatase Human genes 0.000 description 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 description 1
- 102100021200 G-protein coupled receptor 176 Human genes 0.000 description 1
- 102100028464 Galactose-3-O-sulfotransferase 4 Human genes 0.000 description 1
- 102100031351 Galectin-9 Human genes 0.000 description 1
- 102100021337 Gap junction alpha-1 protein Human genes 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 102100025945 Glutaredoxin-1 Human genes 0.000 description 1
- 102100040517 Golgi-associated kinase 1B Human genes 0.000 description 1
- 102100031153 Growth arrest and DNA damage-inducible protein GADD45 beta Human genes 0.000 description 1
- 102100031493 Growth arrest-specific protein 7 Human genes 0.000 description 1
- 102100028541 Guanylate-binding protein 2 Human genes 0.000 description 1
- 102100028539 Guanylate-binding protein 5 Human genes 0.000 description 1
- 102100031258 HLA class II histocompatibility antigen, DM beta chain Human genes 0.000 description 1
- 102100029966 HLA class II histocompatibility antigen, DP alpha 1 chain Human genes 0.000 description 1
- 108010050568 HLA-DM antigens Proteins 0.000 description 1
- 108010093061 HLA-DPA1 antigen Proteins 0.000 description 1
- 102100027385 Hematopoietic lineage cell-specific protein Human genes 0.000 description 1
- 102100031188 Hephaestin Human genes 0.000 description 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 description 1
- 102100026119 High affinity immunoglobulin gamma Fc receptor IB Human genes 0.000 description 1
- 102100029235 Histone-lysine N-methyltransferase NSD3 Human genes 0.000 description 1
- 102100027704 Histone-lysine N-methyltransferase SETD7 Human genes 0.000 description 1
- 102100028707 Homeobox protein MSX-1 Human genes 0.000 description 1
- 102100028798 Homeodomain-only protein Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000691589 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Proteins 0.000 description 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 1
- 101000886015 Homo sapiens ADP-ribosylation factor-like protein 4A Proteins 0.000 description 1
- 101000792952 Homo sapiens AT-rich interactive domain-containing protein 5A Proteins 0.000 description 1
- 101000929319 Homo sapiens Actin, aortic smooth muscle Proteins 0.000 description 1
- 101000783802 Homo sapiens Actin-binding LIM protein 1 Proteins 0.000 description 1
- 101000720147 Homo sapiens Acyl-CoA synthetase short-chain family member 3, mitochondrial Proteins 0.000 description 1
- 101000833122 Homo sapiens Adipocyte enhancer-binding protein 1 Proteins 0.000 description 1
- 101000959452 Homo sapiens Alcohol dehydrogenase class-3 Proteins 0.000 description 1
- 101000891169 Homo sapiens Angiomotin-like protein 1 Proteins 0.000 description 1
- 101000796095 Homo sapiens Anthrax toxin receptor 1 Proteins 0.000 description 1
- 101000796085 Homo sapiens Anthrax toxin receptor 2 Proteins 0.000 description 1
- 101000928628 Homo sapiens Apolipoprotein C-I Proteins 0.000 description 1
- 101000903615 Homo sapiens Basic leucine zipper transcriptional factor ATF-like 2 Proteins 0.000 description 1
- 101000703495 Homo sapiens Beta-sarcoglycan Proteins 0.000 description 1
- 101000858068 Homo sapiens C-X-C motif chemokine 14 Proteins 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 101000749433 Homo sapiens CKLF-like MARVEL transmembrane domain-containing protein 3 Proteins 0.000 description 1
- 101000860854 Homo sapiens COUP transcription factor 1 Proteins 0.000 description 1
- 101000741361 Homo sapiens Calcium homeostasis modulator protein 6 Proteins 0.000 description 1
- 101000943842 Homo sapiens Carbohydrate sulfotransferase 15 Proteins 0.000 description 1
- 101000867855 Homo sapiens Carbonic anhydrase 12 Proteins 0.000 description 1
- 101000867860 Homo sapiens Carbonic anhydrase 13 Proteins 0.000 description 1
- 101000737274 Homo sapiens Carbonyl reductase [NADPH] 3 Proteins 0.000 description 1
- 101000869049 Homo sapiens Caveolae-associated protein 1 Proteins 0.000 description 1
- 101000946601 Homo sapiens Coiled-coil domain-containing protein 69 Proteins 0.000 description 1
- 101000978383 Homo sapiens Coiled-coil domain-containing protein 80 Proteins 0.000 description 1
- 101000899935 Homo sapiens Collagen alpha-1(XV) chain Proteins 0.000 description 1
- 101000940372 Homo sapiens Collagen alpha-1(XXVII) chain Proteins 0.000 description 1
- 101000941594 Homo sapiens Collagen alpha-2(V) chain Proteins 0.000 description 1
- 101000746121 Homo sapiens Collagen triple helix repeat-containing protein 1 Proteins 0.000 description 1
- 101000710032 Homo sapiens Complement factor B Proteins 0.000 description 1
- 101000726193 Homo sapiens Cyclic AMP-responsive element-binding protein 5 Proteins 0.000 description 1
- 101000922196 Homo sapiens Cysteine/serine-rich nuclear protein 1 Proteins 0.000 description 1
- 101000714865 Homo sapiens Cytochrome P450 27C1 Proteins 0.000 description 1
- 101000825159 Homo sapiens DNA repair-scaffolding protein Proteins 0.000 description 1
- 101001052955 Homo sapiens Dedicator of cytokinesis protein 4 Proteins 0.000 description 1
- 101000842622 Homo sapiens Derlin-3 Proteins 0.000 description 1
- 101001044817 Homo sapiens Diacylglycerol kinase alpha Proteins 0.000 description 1
- 101001053501 Homo sapiens Dihydropyrimidinase-related protein 3 Proteins 0.000 description 1
- 101000590225 Homo sapiens Diphosphoinositol polyphosphate phosphohydrolase NUDT4B Proteins 0.000 description 1
- 101000915413 Homo sapiens Disheveled-associated activator of morphogenesis 1 Proteins 0.000 description 1
- 101000832767 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 8 Proteins 0.000 description 1
- 101000806090 Homo sapiens Divergent protein kinase domain 1C Proteins 0.000 description 1
- 101001057621 Homo sapiens Dual specificity protein phosphatase 4 Proteins 0.000 description 1
- 101000907302 Homo sapiens Dynein axonemal intermediate chain 4 Proteins 0.000 description 1
- 101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 description 1
- 101000896290 Homo sapiens ER membrane protein complex subunit 10 Proteins 0.000 description 1
- 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 description 1
- 101000877456 Homo sapiens Ectoderm-neural cortex protein 1 Proteins 0.000 description 1
- 101000967016 Homo sapiens Endothelin-converting enzyme-like 1 Proteins 0.000 description 1
- 101000850989 Homo sapiens Epithelial membrane protein 1 Proteins 0.000 description 1
- 101000820626 Homo sapiens Extracellular sulfatase Sulf-2 Proteins 0.000 description 1
- 101001022717 Homo sapiens Feline leukemia virus subgroup C receptor-related protein 2 Proteins 0.000 description 1
- 101000937169 Homo sapiens Fibronectin type 3 and ankyrin repeat domains protein 1 Proteins 0.000 description 1
- 101000913643 Homo sapiens Fibronectin type III domain-containing protein 1 Proteins 0.000 description 1
- 101001065274 Homo sapiens Fibulin-2 Proteins 0.000 description 1
- 101001028052 Homo sapiens Filamin-binding LIM protein 1 Proteins 0.000 description 1
- 101001028852 Homo sapiens Fructose-1,6-bisphosphatase 1 Proteins 0.000 description 1
- 101000823463 Homo sapiens Fructose-2,6-bisphosphatase Proteins 0.000 description 1
- 101001040723 Homo sapiens G-protein coupled receptor 176 Proteins 0.000 description 1
- 101001061348 Homo sapiens Galactose-3-O-sulfotransferase 4 Proteins 0.000 description 1
- 101001130151 Homo sapiens Galectin-9 Proteins 0.000 description 1
- 101000894966 Homo sapiens Gap junction alpha-1 protein Proteins 0.000 description 1
- 101000856983 Homo sapiens Glutaredoxin-1 Proteins 0.000 description 1
- 101000893979 Homo sapiens Golgi-associated kinase 1B Proteins 0.000 description 1
- 101001066164 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 beta Proteins 0.000 description 1
- 101000923044 Homo sapiens Growth arrest-specific protein 7 Proteins 0.000 description 1
- 101001058858 Homo sapiens Guanylate-binding protein 2 Proteins 0.000 description 1
- 101001058850 Homo sapiens Guanylate-binding protein 5 Proteins 0.000 description 1
- 101001009091 Homo sapiens Hematopoietic lineage cell-specific protein Proteins 0.000 description 1
- 101000993183 Homo sapiens Hephaestin Proteins 0.000 description 1
- 101000824104 Homo sapiens High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 description 1
- 101000913077 Homo sapiens High affinity immunoglobulin gamma Fc receptor IB Proteins 0.000 description 1
- 101000634046 Homo sapiens Histone-lysine N-methyltransferase NSD3 Proteins 0.000 description 1
- 101000650682 Homo sapiens Histone-lysine N-methyltransferase SETD7 Proteins 0.000 description 1
- 101000985653 Homo sapiens Homeobox protein MSX-1 Proteins 0.000 description 1
- 101000839095 Homo sapiens Homeodomain-only protein Proteins 0.000 description 1
- 101000840271 Homo sapiens Immunoglobulin lambda constant 2 Proteins 0.000 description 1
- 101000903806 Homo sapiens Inactive glycosyltransferase 25 family member 3 Proteins 0.000 description 1
- 101000852486 Homo sapiens Inositol 1,4,5-triphosphate receptor associated 2 Proteins 0.000 description 1
- 101001077600 Homo sapiens Insulin receptor substrate 2 Proteins 0.000 description 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
- 101000840572 Homo sapiens Insulin-like growth factor-binding protein 4 Proteins 0.000 description 1
- 101000840582 Homo sapiens Insulin-like growth factor-binding protein 6 Proteins 0.000 description 1
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 description 1
- 101001082058 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 2 Proteins 0.000 description 1
- 101001082063 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 5 Proteins 0.000 description 1
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 description 1
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 description 1
- 101000977636 Homo sapiens Isthmin-1 Proteins 0.000 description 1
- 101001050321 Homo sapiens Junctional adhesion molecule C Proteins 0.000 description 1
- 101001046971 Homo sapiens KN motif and ankyrin repeat domain-containing protein 4 Proteins 0.000 description 1
- 101001006886 Homo sapiens Krueppel-like factor 12 Proteins 0.000 description 1
- 101001139126 Homo sapiens Krueppel-like factor 6 Proteins 0.000 description 1
- 101001139115 Homo sapiens Krueppel-like factor 8 Proteins 0.000 description 1
- 101001054649 Homo sapiens Latent-transforming growth factor beta-binding protein 2 Proteins 0.000 description 1
- 101001054646 Homo sapiens Latent-transforming growth factor beta-binding protein 3 Proteins 0.000 description 1
- 101001130208 Homo sapiens Lipid droplet assembly factor 1 Proteins 0.000 description 1
- 101001044093 Homo sapiens Lipopolysaccharide-induced tumor necrosis factor-alpha factor Proteins 0.000 description 1
- 101000780208 Homo sapiens Long-chain-fatty-acid-CoA ligase 4 Proteins 0.000 description 1
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 description 1
- 101001012021 Homo sapiens Mammalian ependymin-related protein 1 Proteins 0.000 description 1
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 1
- 101000972143 Homo sapiens Maturin Proteins 0.000 description 1
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 description 1
- 101000972278 Homo sapiens Mucin-6 Proteins 0.000 description 1
- 101000928919 Homo sapiens Muscarinic acetylcholine receptor M3 Proteins 0.000 description 1
- 101000583841 Homo sapiens Muscleblind-like protein 2 Proteins 0.000 description 1
- 101001128456 Homo sapiens Myosin regulatory light polypeptide 9 Proteins 0.000 description 1
- 101000906927 Homo sapiens N-chimaerin Proteins 0.000 description 1
- 101000995801 Homo sapiens Neural proliferation differentiation and control protein 1 Proteins 0.000 description 1
- 101001128969 Homo sapiens Neuron navigator 1 Proteins 0.000 description 1
- 101000634537 Homo sapiens Neuronal PAS domain-containing protein 2 Proteins 0.000 description 1
- 101000603202 Homo sapiens Nicotinamide N-methyltransferase Proteins 0.000 description 1
- 101000601048 Homo sapiens Nidogen-2 Proteins 0.000 description 1
- 101000969031 Homo sapiens Nuclear protein 1 Proteins 0.000 description 1
- 101000722306 Homo sapiens Outer dense fiber protein 3B Proteins 0.000 description 1
- 101000736367 Homo sapiens PH and SEC7 domain-containing protein 3 Proteins 0.000 description 1
- 101000611892 Homo sapiens Platelet-derived growth factor D Proteins 0.000 description 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 description 1
- 101001067178 Homo sapiens Plexin-A4 Proteins 0.000 description 1
- 101000620009 Homo sapiens Polyunsaturated fatty acid 5-lipoxygenase Proteins 0.000 description 1
- 101000742006 Homo sapiens Prickle-like protein 2 Proteins 0.000 description 1
- 101000614347 Homo sapiens Prolyl 4-hydroxylase subunit alpha-2 Proteins 0.000 description 1
- 101000684673 Homo sapiens Protein APCDD1 Proteins 0.000 description 1
- 101000933604 Homo sapiens Protein BTG2 Proteins 0.000 description 1
- 101000979565 Homo sapiens Protein NLRC5 Proteins 0.000 description 1
- 101000804792 Homo sapiens Protein Wnt-5a Proteins 0.000 description 1
- 101000855004 Homo sapiens Protein Wnt-7a Proteins 0.000 description 1
- 101000613615 Homo sapiens Protein mono-ADP-ribosyltransferase PARP14 Proteins 0.000 description 1
- 101001062751 Homo sapiens Pseudokinase FAM20A Proteins 0.000 description 1
- 101000771401 Homo sapiens Putative aquaporin-7-like protein 3 Proteins 0.000 description 1
- 101000575037 Homo sapiens Putative homeobox protein Meis3-like 2 Proteins 0.000 description 1
- 101000908015 Homo sapiens Putative inactive carboxylesterase 4 Proteins 0.000 description 1
- 101000784192 Homo sapiens Putative inactive neutral ceramidase B Proteins 0.000 description 1
- 101000723969 Homo sapiens Putative protein ZBED10P Proteins 0.000 description 1
- 101000798007 Homo sapiens RAC-gamma serine/threonine-protein kinase Proteins 0.000 description 1
- 101000905936 Homo sapiens RAS guanyl-releasing protein 2 Proteins 0.000 description 1
- 101000742274 Homo sapiens RELT-like protein 1 Proteins 0.000 description 1
- 101000668168 Homo sapiens RNA-binding motif, single-stranded-interacting protein 3 Proteins 0.000 description 1
- 101001110313 Homo sapiens Ras-related C3 botulinum toxin substrate 2 Proteins 0.000 description 1
- 101000580043 Homo sapiens Ras-specific guanine nucleotide-releasing factor 2 Proteins 0.000 description 1
- 101001106787 Homo sapiens Refilin-B Proteins 0.000 description 1
- 101001075466 Homo sapiens Regulatory factor X-associated protein Proteins 0.000 description 1
- 101000637795 Homo sapiens SH3 domain and tetratricopeptide repeat-containing protein 2 Proteins 0.000 description 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 description 1
- 101000724404 Homo sapiens Saccharopine dehydrogenase Proteins 0.000 description 1
- 101000864786 Homo sapiens Secreted frizzled-related protein 2 Proteins 0.000 description 1
- 101001126009 Homo sapiens Secretory phospholipase A2 receptor Proteins 0.000 description 1
- 101000703089 Homo sapiens Set1/Ash2 histone methyltransferase complex subunit ASH2 Proteins 0.000 description 1
- 101000642345 Homo sapiens Sperm-associated antigen 16 protein Proteins 0.000 description 1
- 101000708620 Homo sapiens Spermine oxidase Proteins 0.000 description 1
- 101000651197 Homo sapiens Sphingosine kinase 2 Proteins 0.000 description 1
- 101000697502 Homo sapiens Stathmin-3 Proteins 0.000 description 1
- 101000641015 Homo sapiens Sterile alpha motif domain-containing protein 9 Proteins 0.000 description 1
- 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 description 1
- 101000585332 Homo sapiens Sulfotransferase 1C4 Proteins 0.000 description 1
- 101000692109 Homo sapiens Syndecan-2 Proteins 0.000 description 1
- 101000835665 Homo sapiens TRPM8 channel-associated factor 1 Proteins 0.000 description 1
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 description 1
- 101000794187 Homo sapiens Tetraspanin-18 Proteins 0.000 description 1
- 101000851436 Homo sapiens Thioredoxin-related transmembrane protein 4 Proteins 0.000 description 1
- 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 description 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 description 1
- 101000830710 Homo sapiens Torsin-4A Proteins 0.000 description 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 description 1
- 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 description 1
- 101000635958 Homo sapiens Transforming growth factor beta-2 proprotein Proteins 0.000 description 1
- 101000652736 Homo sapiens Transgelin Proteins 0.000 description 1
- 101000925985 Homo sapiens Translation initiation factor eIF-2B subunit epsilon Proteins 0.000 description 1
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 description 1
- 101000640723 Homo sapiens Transmembrane protein 131-like Proteins 0.000 description 1
- 101000801308 Homo sapiens Transmembrane protein 43 Proteins 0.000 description 1
- 101000795130 Homo sapiens Trehalase Proteins 0.000 description 1
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 description 1
- 101000679907 Homo sapiens Tumor necrosis factor receptor superfamily member 27 Proteins 0.000 description 1
- 101000606129 Homo sapiens Tyrosine-protein kinase receptor TYRO3 Proteins 0.000 description 1
- 101000708381 Homo sapiens U11/U12 small nuclear ribonucleoprotein 25 kDa protein Proteins 0.000 description 1
- 101000761740 Homo sapiens Ubiquitin/ISG15-conjugating enzyme E2 L6 Proteins 0.000 description 1
- 101000621529 Homo sapiens Vacuolar protein-sorting-associated protein 36 Proteins 0.000 description 1
- 101000622304 Homo sapiens Vascular cell adhesion protein 1 Proteins 0.000 description 1
- 101000997307 Homo sapiens Voltage-gated potassium channel subunit beta-2 Proteins 0.000 description 1
- 101000666295 Homo sapiens X-box-binding protein 1 Proteins 0.000 description 1
- 101000964613 Homo sapiens Zinc finger protein 154 Proteins 0.000 description 1
- 101000964590 Homo sapiens Zinc finger protein 175 Proteins 0.000 description 1
- 101000802323 Homo sapiens Zinc finger protein 548 Proteins 0.000 description 1
- 101000818832 Homo sapiens Zinc finger protein 608 Proteins 0.000 description 1
- 101000785609 Homo sapiens Zinc finger protein 655 Proteins 0.000 description 1
- 101000782300 Homo sapiens Zinc finger protein 827 Proteins 0.000 description 1
- 101000795753 Homo sapiens mRNA decay activator protein ZFP36 Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 108010044240 IFIH1 Interferon-Induced Helicase Proteins 0.000 description 1
- 101150030450 IRS1 gene Proteins 0.000 description 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 102100029620 Immunoglobulin lambda constant 2 Human genes 0.000 description 1
- 102100022966 Inactive glycosyltransferase 25 family member 3 Human genes 0.000 description 1
- 102100036343 Inositol 1,4,5-triphosphate receptor associated 2 Human genes 0.000 description 1
- 102100025092 Insulin receptor substrate 2 Human genes 0.000 description 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 description 1
- 102100029224 Insulin-like growth factor-binding protein 4 Human genes 0.000 description 1
- 102100029180 Insulin-like growth factor-binding protein 6 Human genes 0.000 description 1
- 108010078049 Interferon alpha-2 Proteins 0.000 description 1
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 description 1
- 102100027353 Interferon-induced helicase C domain-containing protein 1 Human genes 0.000 description 1
- 102100027303 Interferon-induced protein with tetratricopeptide repeats 2 Human genes 0.000 description 1
- 102100027356 Interferon-induced protein with tetratricopeptide repeats 5 Human genes 0.000 description 1
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 1
- 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 description 1
- 102100020873 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102100023539 Isthmin-1 Human genes 0.000 description 1
- 102100023429 Junctional adhesion molecule C Human genes 0.000 description 1
- 102100022904 KN motif and ankyrin repeat domain-containing protein 4 Human genes 0.000 description 1
- 102100027792 Krueppel-like factor 12 Human genes 0.000 description 1
- 102100020679 Krueppel-like factor 6 Human genes 0.000 description 1
- 102100020691 Krueppel-like factor 8 Human genes 0.000 description 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 102100027017 Latent-transforming growth factor beta-binding protein 2 Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 102100031359 Lipid droplet assembly factor 1 Human genes 0.000 description 1
- 102100021607 Lipopolysaccharide-induced tumor necrosis factor-alpha factor Human genes 0.000 description 1
- 102100034319 Long-chain-fatty-acid-CoA ligase 4 Human genes 0.000 description 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 description 1
- 108010075654 MAP Kinase Kinase Kinase 1 Proteins 0.000 description 1
- 101150033052 MAS5 gene Proteins 0.000 description 1
- 108091008065 MIR21 Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102100030031 Mammalian ependymin-related protein 1 Human genes 0.000 description 1
- 102100030417 Matrilysin Human genes 0.000 description 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 1
- 102100022448 Maturin Human genes 0.000 description 1
- 102100033115 Mitogen-activated protein kinase kinase kinase 1 Human genes 0.000 description 1
- 102100022493 Mucin-6 Human genes 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 102100030964 Muscleblind-like protein 2 Human genes 0.000 description 1
- 102100031787 Myosin regulatory light polypeptide 9 Human genes 0.000 description 1
- 102100023648 N-chimaerin Human genes 0.000 description 1
- 108010082699 NADPH Oxidase 4 Proteins 0.000 description 1
- 102100021872 NADPH oxidase 4 Human genes 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 102100034619 Neural proliferation differentiation and control protein 1 Human genes 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 102100031225 Neuron navigator 1 Human genes 0.000 description 1
- 102100029045 Neuronal PAS domain-containing protein 2 Human genes 0.000 description 1
- 108090000772 Neuropilin-1 Proteins 0.000 description 1
- 108090000770 Neuropilin-2 Proteins 0.000 description 1
- 101150067565 Nfatc1 gene Proteins 0.000 description 1
- 102100038951 Nicotinamide N-methyltransferase Human genes 0.000 description 1
- 102100037371 Nidogen-2 Human genes 0.000 description 1
- 102100034404 Nuclear factor of activated T-cells, cytoplasmic 1 Human genes 0.000 description 1
- 102100021133 Nuclear protein 1 Human genes 0.000 description 1
- MSHZHSPISPJWHW-UHFFFAOYSA-N O-(chloroacetylcarbamoyl)fumagillol Chemical compound O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)NC(=O)CCl)CCC21CO2 MSHZHSPISPJWHW-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102100025285 Outer dense fiber protein 3B Human genes 0.000 description 1
- 102100036231 PH and SEC7 domain-containing protein 3 Human genes 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 108010043958 Peptoids Proteins 0.000 description 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 102100040682 Platelet-derived growth factor D Human genes 0.000 description 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 description 1
- 102100034385 Plexin-A4 Human genes 0.000 description 1
- 102100022364 Polyunsaturated fatty acid 5-lipoxygenase Human genes 0.000 description 1
- 102100038629 Prickle-like protein 2 Human genes 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102100040478 Prolyl 4-hydroxylase subunit alpha-2 Human genes 0.000 description 1
- 102100023735 Protein APCDD1 Human genes 0.000 description 1
- 102100026034 Protein BTG2 Human genes 0.000 description 1
- 102100023432 Protein NLRC5 Human genes 0.000 description 1
- 102100020729 Protein Wnt-7a Human genes 0.000 description 1
- 101800000618 Protein kinase C delta type catalytic subunit Proteins 0.000 description 1
- 102100023068 Protein kinase C-binding protein NELL1 Human genes 0.000 description 1
- 102100034433 Protein kinase C-binding protein NELL2 Human genes 0.000 description 1
- 102100040848 Protein mono-ADP-ribosyltransferase PARP14 Human genes 0.000 description 1
- 102100021004 Protein sidekick-1 Human genes 0.000 description 1
- 102100030553 Pseudokinase FAM20A Human genes 0.000 description 1
- 201000008183 Pulmonary blastoma Diseases 0.000 description 1
- 102100029407 Putative aquaporin-7-like protein 3 Human genes 0.000 description 1
- 102100025549 Putative homeobox protein Meis3-like 2 Human genes 0.000 description 1
- 102100023322 Putative inactive carboxylesterase 4 Human genes 0.000 description 1
- 102100021030 Putative inactive neutral ceramidase B Human genes 0.000 description 1
- 102100028242 Putative protein ZBED10P Human genes 0.000 description 1
- 238000001190 Q-PCR Methods 0.000 description 1
- 102100032314 RAC-gamma serine/threonine-protein kinase Human genes 0.000 description 1
- 102100023488 RAS guanyl-releasing protein 2 Human genes 0.000 description 1
- 102100038200 RELT-like protein 1 Human genes 0.000 description 1
- 102100039689 RNA-binding motif, single-stranded-interacting protein 3 Human genes 0.000 description 1
- 108091007335 RNF149 Proteins 0.000 description 1
- 102100022129 Ras-related C3 botulinum toxin substrate 2 Human genes 0.000 description 1
- 102100027555 Ras-specific guanine nucleotide-releasing factor 2 Human genes 0.000 description 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 description 1
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 1
- 206010038111 Recurrent cancer Diseases 0.000 description 1
- 102100021327 Refilin-B Human genes 0.000 description 1
- 102100021258 Regulator of G-protein signaling 2 Human genes 0.000 description 1
- 101710140412 Regulator of G-protein signaling 2 Proteins 0.000 description 1
- 102100021043 Regulatory factor X-associated protein Human genes 0.000 description 1
- 102100027611 Rho-related GTP-binding protein RhoB Human genes 0.000 description 1
- 101150054980 Rhob gene Proteins 0.000 description 1
- 102100032022 SH3 domain and tetratricopeptide repeat-containing protein 2 Human genes 0.000 description 1
- 102100029198 SLAM family member 7 Human genes 0.000 description 1
- 101100344462 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YDJ1 gene Proteins 0.000 description 1
- 102100028294 Saccharopine dehydrogenase Human genes 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 102100030054 Secreted frizzled-related protein 2 Human genes 0.000 description 1
- 102100029392 Secretory phospholipase A2 receptor Human genes 0.000 description 1
- 102100030733 Set1/Ash2 histone methyltransferase complex subunit ASH2 Human genes 0.000 description 1
- 108010029176 Sialic Acid Binding Ig-like Lectin 1 Proteins 0.000 description 1
- 102100032855 Sialoadhesin Human genes 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 102100036373 Sperm-associated antigen 16 protein Human genes 0.000 description 1
- 102100032800 Spermine oxidase Human genes 0.000 description 1
- 102100027662 Sphingosine kinase 2 Human genes 0.000 description 1
- 102100028052 Stathmin-3 Human genes 0.000 description 1
- 102100034291 Sterile alpha motif domain-containing protein 9 Human genes 0.000 description 1
- 102100028847 Stromelysin-3 Human genes 0.000 description 1
- 102100029863 Sulfotransferase 1C4 Human genes 0.000 description 1
- 102100032891 Superoxide dismutase [Mn], mitochondrial Human genes 0.000 description 1
- 102100026087 Syndecan-2 Human genes 0.000 description 1
- 102000003718 TNF receptor-associated factor 5 Human genes 0.000 description 1
- 108090000001 TNF receptor-associated factor 5 Proteins 0.000 description 1
- 102100026351 TRPM8 channel-associated factor 1 Human genes 0.000 description 1
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 description 1
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 description 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 102100030175 Tetraspanin-18 Human genes 0.000 description 1
- 102100036923 Thioredoxin-related transmembrane protein 4 Human genes 0.000 description 1
- 108091046915 Threose nucleic acid Proteins 0.000 description 1
- 206010043515 Throat cancer Diseases 0.000 description 1
- 102100036034 Thrombospondin-1 Human genes 0.000 description 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 101710183280 Topoisomerase Proteins 0.000 description 1
- 102100024605 Torsin-4A Human genes 0.000 description 1
- 102100023234 Transcription factor MafB Human genes 0.000 description 1
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 description 1
- 102100030737 Transforming growth factor beta-2 proprotein Human genes 0.000 description 1
- 102100031013 Transgelin Human genes 0.000 description 1
- 102100034267 Translation initiation factor eIF-2B subunit epsilon Human genes 0.000 description 1
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
- 102100033853 Transmembrane protein 131-like Human genes 0.000 description 1
- 102100033530 Transmembrane protein 43 Human genes 0.000 description 1
- 102100029677 Trehalase Human genes 0.000 description 1
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 description 1
- 102100022202 Tumor necrosis factor receptor superfamily member 27 Human genes 0.000 description 1
- 102100039127 Tyrosine-protein kinase receptor TYRO3 Human genes 0.000 description 1
- 102100031474 U11/U12 small nuclear ribonucleoprotein 25 kDa protein Human genes 0.000 description 1
- 102100024250 Ubiquitin carboxyl-terminal hydrolase CYLD Human genes 0.000 description 1
- 102100024843 Ubiquitin/ISG15-conjugating enzyme E2 L6 Human genes 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 102100022960 Vacuolar protein-sorting-associated protein 36 Human genes 0.000 description 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 229940122803 Vinca alkaloid Drugs 0.000 description 1
- 102100034074 Voltage-gated potassium channel subunit beta-2 Human genes 0.000 description 1
- 101150010310 WNT-4 gene Proteins 0.000 description 1
- 102000052548 Wnt-4 Human genes 0.000 description 1
- 108700020984 Wnt-4 Proteins 0.000 description 1
- 102000043366 Wnt-5a Human genes 0.000 description 1
- 102100038151 X-box-binding protein 1 Human genes 0.000 description 1
- 102100040784 Zinc finger protein 154 Human genes 0.000 description 1
- 102100040810 Zinc finger protein 175 Human genes 0.000 description 1
- 102100034641 Zinc finger protein 548 Human genes 0.000 description 1
- 102100021354 Zinc finger protein 608 Human genes 0.000 description 1
- 102100026494 Zinc finger protein 655 Human genes 0.000 description 1
- 102100035804 Zinc finger protein 823 Human genes 0.000 description 1
- 102100035802 Zinc finger protein 827 Human genes 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 229960000548 alemtuzumab Drugs 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 229960002932 anastrozole Drugs 0.000 description 1
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 description 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000003705 background correction Methods 0.000 description 1
- 229960000997 bicalutamide Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000008236 biological pathway Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000000091 biomarker candidate Substances 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229960001467 bortezomib Drugs 0.000 description 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
- 238000000339 bright-field microscopy Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000007475 c-index Methods 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000003392 chemiluminescence resonance energy transfer Methods 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 229960002436 cladribine Drugs 0.000 description 1
- 238000013145 classification model Methods 0.000 description 1
- 206010073251 clear cell renal cell carcinoma Diseases 0.000 description 1
- 229960000928 clofarabine Drugs 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229960000684 cytarabine Drugs 0.000 description 1
- 108010057085 cytokine receptors Proteins 0.000 description 1
- 102000003675 cytokine receptors Human genes 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 238000003066 decision tree Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 239000012502 diagnostic product Substances 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000005315 distribution function Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000011209 electrochromatography Methods 0.000 description 1
- 238000010201 enrichment analysis Methods 0.000 description 1
- 229930013356 epothilone Natural products 0.000 description 1
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 229960001842 estramustine Drugs 0.000 description 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229960000255 exemestane Drugs 0.000 description 1
- 201000001343 fallopian tube carcinoma Diseases 0.000 description 1
- 230000012953 feeding on blood of other organism Effects 0.000 description 1
- 201000010255 female reproductive organ cancer Diseases 0.000 description 1
- 238000011354 first-line chemotherapy Methods 0.000 description 1
- 238000009093 first-line therapy Methods 0.000 description 1
- 229960000961 floxuridine Drugs 0.000 description 1
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 1
- 229960000390 fludarabine Drugs 0.000 description 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
- 229960002074 flutamide Drugs 0.000 description 1
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
- 235000008191 folinic acid Nutrition 0.000 description 1
- 239000011672 folinic acid Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229960002584 gefitinib Drugs 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 229960000908 idarubicin Drugs 0.000 description 1
- 229960002411 imatinib Drugs 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229960003521 interferon alfa-2a Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000001871 ion mobility spectroscopy Methods 0.000 description 1
- 238000005040 ion trap Methods 0.000 description 1
- 238000000534 ion trap mass spectrometry Methods 0.000 description 1
- 238000001948 isotopic labelling Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 229960003881 letrozole Drugs 0.000 description 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 description 1
- 229960001691 leucovorin Drugs 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 238000010841 mRNA extraction Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 238000001531 micro-dissection Methods 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 229960001156 mitoxantrone Drugs 0.000 description 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 238000007837 multiplex assay Methods 0.000 description 1
- NJHLGKJQFKUSEA-UHFFFAOYSA-N n-[2-(4-hydroxyphenyl)ethyl]-n-methylnitrous amide Chemical compound O=NN(C)CCC1=CC=C(O)C=C1 NJHLGKJQFKUSEA-UHFFFAOYSA-N 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229960002653 nilutamide Drugs 0.000 description 1
- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 108091027963 non-coding RNA Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 201000011330 nonpapillary renal cell carcinoma Diseases 0.000 description 1
- 238000002966 oligonucleotide array Methods 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 208000015124 ovarian disease Diseases 0.000 description 1
- 238000009595 pap smear Methods 0.000 description 1
- 230000003076 paracrine Effects 0.000 description 1
- 238000010239 partial least squares discriminant analysis Methods 0.000 description 1
- 238000010238 partial least squares regression Methods 0.000 description 1
- 229960005079 pemetrexed Drugs 0.000 description 1
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 description 1
- 229960002340 pentostatin Drugs 0.000 description 1
- FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 201000002524 peritoneal carcinoma Diseases 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 201000002511 pituitary cancer Diseases 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 230000026341 positive regulation of angiogenesis Effects 0.000 description 1
- 230000027317 positive regulation of immune response Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000009443 proangiogenesis Effects 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000005173 quadrupole mass spectroscopy Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010833 quantitative mass spectrometry Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000001004 secondary ion mass spectrometry Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 229940043517 specific immunoglobulins Drugs 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 108010045815 superoxide dismutase 2 Proteins 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960005026 toremifene Drugs 0.000 description 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461937224P | 2014-02-07 | 2014-02-07 | |
| US61/937,224 | 2014-02-07 | ||
| GB1409479.1 | 2014-05-28 | ||
| GBGB1409479.1A GB201409479D0 (en) | 2014-05-28 | 2014-05-28 | Molecular diagnostic test for cancer |
| PCT/GB2015/050352 WO2015118353A1 (en) | 2014-02-07 | 2015-02-09 | Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2938807A1 true CA2938807A1 (en) | 2015-08-13 |
Family
ID=51177582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2938807A Abandoned CA2938807A1 (en) | 2014-02-07 | 2015-02-09 | Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10280468B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3102700A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017506506A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20160117606A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106164296A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015213844A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016018044A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2938807A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201409479D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015118353A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11568982B1 (en) | 2014-02-17 | 2023-01-31 | Health at Scale Corporation | System to improve the logistics of clinical care by selectively matching patients to providers |
| US10650325B2 (en) * | 2015-07-31 | 2020-05-12 | Microsoft Technology Licensing, Llc | Deterministic message distribution |
| US10496691B1 (en) * | 2015-09-08 | 2019-12-03 | Google Llc | Clustering search results |
| US11243206B2 (en) * | 2016-09-28 | 2022-02-08 | The Catholic University Of Korea Industry-Academic Cooperation Foundation | Gender-specific markers for diagnosing prognosis and determining treatment strategy for renal cancer patients |
| JP6899848B2 (ja) * | 2016-12-28 | 2021-07-07 | 公益財団法人がん研究会 | 抗ｖｅｇｆｒ−２抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット |
| CN107301328B (zh) * | 2017-05-19 | 2021-04-06 | 浙江工业大学 | 基于数据流聚类的癌症亚型精准发现与演化分析方法 |
| KR102396784B1 (ko) | 2017-06-13 | 2022-05-13 | 보스턴진 코포레이션 | 분자 기능적 프로파일을 생성하고, 시각화하고, 분류하는 시스템 및 방법 |
| JP6977965B2 (ja) * | 2017-10-26 | 2021-12-08 | 公立大学法人福島県立医科大学 | 卵巣癌組織型鑑別方法 |
| CN110880356A (zh) * | 2018-09-05 | 2020-03-13 | 南京格致基因生物科技有限公司 | 对卵巢癌进行筛查、诊断或风险分级的方法和装置 |
| US12325879B2 (en) * | 2018-10-31 | 2025-06-10 | Regents Of The University Of Minnesota | Methods for predicting a response to bevacizumab or platinum-based chemotherapy or both in patients with ovarian cancer |
| US11610679B1 (en) | 2020-04-20 | 2023-03-21 | Health at Scale Corporation | Prediction and prevention of medical events using machine-learning algorithms |
| CN112164474B (zh) * | 2020-07-14 | 2024-05-24 | 中国矿业大学 | 一种基于自表达模型的药物敏感性预测方法 |
| US12094582B1 (en) | 2020-08-11 | 2024-09-17 | Health at Scale Corporation | Intelligent healthcare data fabric system |
| US12080428B1 (en) | 2020-09-10 | 2024-09-03 | Health at Scale Corporation | Machine intelligence-based prioritization of non-emergent procedures and visits |
| AU2022245322A1 (en) * | 2021-03-25 | 2023-10-05 | Oncxerna Therapeutics, Inc. | Targeted therapies in cancer |
| US20240115699A1 (en) * | 2021-06-04 | 2024-04-11 | Cedars-Sinai Medical Center | Use of cancer cell expression of cadherin 12 and cadherin 18 to treat muscle invasive and metastatic bladder cancers |
| CN113667752A (zh) * | 2021-09-09 | 2021-11-19 | 菲思特(上海)生物科技有限公司 | 一种用于柔红霉素代谢标志物的检测试剂盒及其检测方法和应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| ATE173767T1 (de) | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| US6998234B2 (en) | 2000-11-03 | 2006-02-14 | Oncotech, Inc. | Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells |
| RS20160203A1 (sr) | 2003-05-30 | 2016-10-31 | Genentech Inc | Tretman sa anti-vegf antitelima |
| US7659062B2 (en) | 2003-06-03 | 2010-02-09 | The Board of Trustee of the University of Arkansas System | Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors |
| EP2395112B1 (en) | 2003-12-31 | 2017-02-15 | The Penn State Research Foundation | Methods for predicting and overcoming resistance to chemotherapy in ovarian cancer and for predicting colon cancer occurrence |
| US20080113874A1 (en) | 2004-01-23 | 2008-05-15 | The Regents Of The University Of Colorado | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| EP2163650B1 (en) | 2004-04-09 | 2015-08-05 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| MXPA06013079A (es) | 2004-05-14 | 2007-10-08 | Ludwig Inst Cancer Res | Identificacion y caracterizacion de un subconjunto de glioblastomas sensibles al tratamiento con imatinib. |
| WO2006008526A2 (en) | 2004-07-23 | 2006-01-26 | Astrazeneca Ab | Method of predicting the responsiveness oa a tumor to erbb receptor drugs |
| CA2586201A1 (en) | 2004-11-03 | 2006-05-11 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
| US7862995B2 (en) * | 2004-12-10 | 2011-01-04 | Targeted Molecular Diagnostics | Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor |
| EP1937837A2 (en) | 2005-07-29 | 2008-07-02 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies |
| US8445198B2 (en) | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| EP1963862A4 (en) | 2005-12-05 | 2010-03-03 | Merck & Co Inc | METHOD FOR PREDICTING THE APPLICATION FOR TREATMENT BASED ON THE EXPRESSION PROFILES OF PROTEIN AND TRANSCRIPTION BIOMARKERS |
| AU2007211085A1 (en) | 2006-01-27 | 2007-08-09 | Tripath Imaging, Inc. | Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| BRPI0716944A2 (pt) | 2006-09-19 | 2013-09-17 | Novartis Ag | biomarcadores de modulaÇço alvo, eficÁcia, diagnàstico, e/ou prognàstico para inibidores de raf |
| AU2008288256A1 (en) | 2007-08-13 | 2009-02-19 | Almac Diagnostics Limited | A 3' -based sequencing approach for microarray manufacture |
| AU2008324782A1 (en) | 2007-11-09 | 2009-05-14 | Genentech, Inc. | Methods and compositions for diagnostic use in cancer patients |
| EP2297349A1 (en) | 2008-06-04 | 2011-03-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Diffuse large b-cell lymphoma markers and uses therefor |
| CA2726811C (en) | 2008-06-06 | 2019-11-26 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Survival predictor for diffuse large b cell lymphoma |
| AU2009270851A1 (en) | 2008-07-16 | 2010-01-21 | Dana-Farber Cancer Institute, Inc. | Signatures and PCDETERMINANTS associated with prostate cancer and methods of use thereof |
| ES2644723T3 (es) | 2008-07-23 | 2017-11-30 | F. Hoffmann-La Roche Ag | Identificación de sujetos susceptibles de tratamiento antiangiogénico |
| DK2368118T3 (da) | 2008-12-23 | 2013-11-25 | Merck Patent Gmbh | Biomarkører til inhibitorer med anti-angiogen aktivitet |
| WO2010088688A2 (en) | 2009-02-02 | 2010-08-05 | Biotheranostics, Inc. | Diagnosis of in situ and invasive breast cancer |
| NZ596054A (en) | 2009-05-01 | 2013-07-26 | Genomic Health Inc | Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy |
| US7615353B1 (en) * | 2009-07-06 | 2009-11-10 | Aveo Pharmaceuticals, Inc. | Tivozanib response prediction |
| WO2011033006A1 (en) | 2009-09-17 | 2011-03-24 | F. Hoffmann-La Roche Ag | Methods and compositions for diagnostics use in cancer patients |
| SG188397A1 (en) | 2010-09-15 | 2013-04-30 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| EP2659005A4 (en) * | 2010-12-28 | 2016-08-24 | Caris Mpi Inc | MOLECULAR PROFILING OF CANCER |
| US10260097B2 (en) * | 2011-06-02 | 2019-04-16 | Almac Diagnostics Limited | Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent |
| MX356802B (es) * | 2012-01-13 | 2018-06-13 | Genentech Inc | Marcadores biologicos para identificar pacientes para tratamiento con antagonistas de vegf. |
| SG11201504023SA (en) * | 2012-12-03 | 2015-06-29 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
-
2014
- 2014-05-28 GB GBGB1409479.1A patent/GB201409479D0/en not_active Ceased
-
2015
- 2015-02-09 EP EP15705693.8A patent/EP3102700A1/en not_active Withdrawn
- 2015-02-09 CA CA2938807A patent/CA2938807A1/en not_active Abandoned
- 2015-02-09 US US15/116,641 patent/US10280468B2/en not_active Expired - Fee Related
- 2015-02-09 KR KR1020167024823A patent/KR20160117606A/ko not_active Withdrawn
- 2015-02-09 CN CN201580016568.5A patent/CN106164296A/zh active Pending
- 2015-02-09 AU AU2015213844A patent/AU2015213844A1/en not_active Abandoned
- 2015-02-09 BR BR112016018044A patent/BR112016018044A2/pt not_active IP Right Cessation
- 2015-02-09 JP JP2016550631A patent/JP2017506506A/ja active Pending
- 2015-02-09 WO PCT/GB2015/050352 patent/WO2015118353A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017506506A (ja) | 2017-03-09 |
| US10280468B2 (en) | 2019-05-07 |
| US20170073761A1 (en) | 2017-03-16 |
| CN106164296A (zh) | 2016-11-23 |
| BR112016018044A2 (pt) | 2018-02-20 |
| AU2015213844A1 (en) | 2016-09-15 |
| WO2015118353A1 (en) | 2015-08-13 |
| GB201409479D0 (en) | 2014-07-09 |
| EP3102700A1 (en) | 2016-12-14 |
| KR20160117606A (ko) | 2016-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10280468B2 (en) | Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer | |
| US11091809B2 (en) | Molecular diagnostic test for cancer | |
| AU2012261820B2 (en) | Molecular diagnostic test for cancer | |
| US11254986B2 (en) | Gene signature for immune therapies in cancer | |
| EP2619574B1 (en) | Molecular test for predicting responsiveness to dna-damage therapeutic agents in individuals having cancer | |
| AU2012261820A1 (en) | Molecular diagnostic test for cancer | |
| US20160222459A1 (en) | Molecular diagnostic test for lung cancer | |
| US20160222460A1 (en) | Molecular diagnostic test for oesophageal cancer | |
| WO2017216559A1 (en) | Predicting responsiveness to therapy in prostate cancer | |
| US20170088902A1 (en) | Expression profiling for cancers treated with anti-angiogenic therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20200211 |
|
| FZDE | Discontinued |
Effective date: 20200211 |