CA2937418A1 - Compositions and methods for treating intracerebral hemorrhage - Google Patents

Compositions and methods for treating intracerebral hemorrhage Download PDF

Info

Publication number
CA2937418A1
CA2937418A1 CA2937418A CA2937418A CA2937418A1 CA 2937418 A1 CA2937418 A1 CA 2937418A1 CA 2937418 A CA2937418 A CA 2937418A CA 2937418 A CA2937418 A CA 2937418A CA 2937418 A1 CA2937418 A1 CA 2937418A1
Authority
CA
Canada
Prior art keywords
ich
less
subject
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2937418A
Other languages
English (en)
French (fr)
Inventor
Steven ARKIN
Joachim Fruebis
Marcus E. Carr
Sunita HETT
Reema JASUJA
Debra D. Pittman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2937418A1 publication Critical patent/CA2937418A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2937418A 2014-01-24 2015-01-15 Compositions and methods for treating intracerebral hemorrhage Abandoned CA2937418A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461931071P 2014-01-24 2014-01-24
US61/931,071 2014-01-24
PCT/IB2015/050313 WO2015110939A1 (en) 2014-01-24 2015-01-15 Compositions and methods for treating intracerebral hemorrhage

Publications (1)

Publication Number Publication Date
CA2937418A1 true CA2937418A1 (en) 2015-07-30

Family

ID=52630418

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2937418A Abandoned CA2937418A1 (en) 2014-01-24 2015-01-15 Compositions and methods for treating intracerebral hemorrhage

Country Status (18)

Country Link
US (2) US20160375109A1 (OSRAM)
EP (1) EP3096779B1 (OSRAM)
JP (1) JP6624787B2 (OSRAM)
KR (3) KR20160093731A (OSRAM)
CN (2) CN105934250A (OSRAM)
AU (1) AU2015208819B2 (OSRAM)
BR (1) BR112016014617A2 (OSRAM)
CA (1) CA2937418A1 (OSRAM)
DK (1) DK3096779T3 (OSRAM)
ES (1) ES2772802T3 (OSRAM)
HU (1) HUE047588T4 (OSRAM)
IL (1) IL246637A0 (OSRAM)
MX (1) MX375355B (OSRAM)
PL (1) PL3096779T3 (OSRAM)
PT (1) PT3096779T (OSRAM)
RU (1) RU2016126423A (OSRAM)
SI (1) SI3096779T1 (OSRAM)
WO (1) WO2015110939A1 (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150103205A (ko) 2013-01-31 2015-09-09 화이자 인코포레이티드 인자 Xa 억제를 길항하기 위한 조성물 및 방법
SG11201601221XA (en) 2013-09-24 2016-04-28 Pfizer Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2570330A1 (en) * 2004-06-21 2005-12-29 Novo Nordisk Health Care A/S Use of factor viia or factor viia equivalents for preventing or attenuating haemorrhage growth, and/or oedema generation following intracerebral haemorrhage (ich)
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
CN101918025A (zh) * 2008-01-18 2010-12-15 诺沃-诺迪斯克保健股份有限公司 因子Ⅶa或因子Ⅶa等同物用于防止或减弱选择的脑内出血患者亚群在脑内出血(ICH)后出血增多和/或水肿形成的用途
JP6163304B2 (ja) * 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
WO2011020866A2 (en) * 2009-08-20 2011-02-24 Csl Behring Gmbh Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
US9371522B2 (en) * 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
SG11201500579SA (en) * 2012-07-25 2015-02-27 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof
KR20150103205A (ko) * 2013-01-31 2015-09-09 화이자 인코포레이티드 인자 Xa 억제를 길항하기 위한 조성물 및 방법

Also Published As

Publication number Publication date
PT3096779T (pt) 2020-02-21
CN105934250A (zh) 2016-09-07
IL246637A0 (en) 2016-08-31
JP6624787B2 (ja) 2019-12-25
ES2772802T3 (es) 2020-07-08
SI3096779T1 (sl) 2020-03-31
RU2016126423A (ru) 2018-03-01
KR20210008177A (ko) 2021-01-20
PL3096779T3 (pl) 2020-05-18
EP3096779B1 (en) 2019-12-18
DK3096779T3 (da) 2020-02-24
CN112156176A (zh) 2021-01-01
RU2016126423A3 (OSRAM) 2018-03-01
US20190231856A1 (en) 2019-08-01
BR112016014617A2 (pt) 2017-09-19
US20160375109A1 (en) 2016-12-29
WO2015110939A1 (en) 2015-07-30
KR20180014221A (ko) 2018-02-07
MX2016009665A (es) 2016-11-14
KR20160093731A (ko) 2016-08-08
AU2015208819A1 (en) 2016-06-30
EP3096779A1 (en) 2016-11-30
HUE047588T4 (hu) 2020-06-29
JP2015147764A (ja) 2015-08-20
HUE047588T2 (hu) 2020-04-28
AU2015208819B2 (en) 2020-01-23
MX375355B (es) 2025-03-04

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160720

FZDE Discontinued

Effective date: 20230329