CA2937417C - Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate - Google Patents
Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate Download PDFInfo
- Publication number
- CA2937417C CA2937417C CA2937417A CA2937417A CA2937417C CA 2937417 C CA2937417 C CA 2937417C CA 2937417 A CA2937417 A CA 2937417A CA 2937417 A CA2937417 A CA 2937417A CA 2937417 C CA2937417 C CA 2937417C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- trazodone
- alcohol
- hydrochloride
- free base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La présente invention concerne un procédé amélioré pour la préparation de trazodone et son sel de chlorhydrate sensiblement pur. Le procédé comprend la réaction du composé II (comme décrit) avec le composé III (comme décrit) facultativement en présence d'une base inorganique, et d'un catalyseur ; dans lequel, dans ledit procédé la trazodone base libre et/ou son sel de chlorhydrate sont isolés par précipitation à une température plus basse. Le procédé amélioré pour la préparation de chlorhydrate de trazodone (composé I) permet d'obtenir le produit avec une quantité totale de substances alkylantes (comme spécifié dans la description) en tant qu'impureté inférieure à 10 ppm. Le procédé amélioré pour la préparation de chlorhydrate de trazodone (composé I) permet d'obtenir le produit avec une quantité totale de 1-(3-chlorophényl)-4-(3-chloropropyl)pipérazine en tant qu'impureté inférieure à 2,5 ppm.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN203/MUM/2014 | 2014-01-21 | ||
IN203MU2014 IN2014MU00203A (fr) | 2014-01-21 | 2014-12-12 | |
PCT/IB2014/066841 WO2015110883A1 (fr) | 2014-01-21 | 2014-12-12 | Procédé amélioré pour la préparation de trazodone et son sel de chlorhydrate |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2937417A1 CA2937417A1 (fr) | 2015-07-30 |
CA2937417C true CA2937417C (fr) | 2022-04-12 |
Family
ID=53680891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2937417A Active CA2937417C (fr) | 2014-01-21 | 2014-12-12 | Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3097099A4 (fr) |
JP (1) | JP2017505302A (fr) |
CA (1) | CA2937417C (fr) |
IL (1) | IL246835A0 (fr) |
IN (1) | IN2014MU00203A (fr) |
WO (1) | WO2015110883A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL234822B1 (pl) | 2017-03-14 | 2020-04-30 | Politechnika Krakowska Im Tadeusza Kosciuszki | Sposób otrzymywania trazodonu |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
US4252806A (en) * | 1979-09-24 | 1981-02-24 | Mead Johnson & Company | Triazoloquinolones |
HU201324B (en) * | 1988-07-29 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on |
ITMI20071603A1 (it) * | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
US20090209550A1 (en) * | 2008-02-20 | 2009-08-20 | Auspex Pharmaceuticals, Inc. | Substituted triazolopyridines |
-
2014
- 2014-12-12 WO PCT/IB2014/066841 patent/WO2015110883A1/fr active Application Filing
- 2014-12-12 JP JP2016547540A patent/JP2017505302A/ja active Pending
- 2014-12-12 EP EP14879353.2A patent/EP3097099A4/fr not_active Ceased
- 2014-12-12 CA CA2937417A patent/CA2937417C/fr active Active
- 2014-12-12 IN IN203MU2014 patent/IN2014MU00203A/en unknown
-
2016
- 2016-07-19 IL IL246835A patent/IL246835A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2017505302A (ja) | 2017-02-16 |
WO2015110883A1 (fr) | 2015-07-30 |
IL246835A0 (en) | 2016-08-31 |
CA2937417A1 (fr) | 2015-07-30 |
EP3097099A4 (fr) | 2017-08-23 |
EP3097099A1 (fr) | 2016-11-30 |
IN2014MU00203A (fr) | 2015-09-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20191206 |