CA2932264A1 - Transdermal delivery of dna vaccines using non-thermal plasma - Google Patents

Transdermal delivery of dna vaccines using non-thermal plasma Download PDF

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Publication number
CA2932264A1
CA2932264A1 CA2932264A CA2932264A CA2932264A1 CA 2932264 A1 CA2932264 A1 CA 2932264A1 CA 2932264 A CA2932264 A CA 2932264A CA 2932264 A CA2932264 A CA 2932264A CA 2932264 A1 CA2932264 A1 CA 2932264A1
Authority
CA
Canada
Prior art keywords
plasma
skin
pores
dna
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2932264A
Other languages
English (en)
French (fr)
Inventor
Sameer Kalghatgi
Daphne Pappas Antonakas
Tsung-Chan TSAI
Robert L. Gray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EP Technologies LLC
Original Assignee
EP Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EP Technologies LLC filed Critical EP Technologies LLC
Publication of CA2932264A1 publication Critical patent/CA2932264A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/47—Generating plasma using corona discharges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/10—Testing at atmospheric pressure
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/20—Non-thermal plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/32—Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/34—Skin treatments, e.g. disinfection or wound treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2932264A 2013-12-04 2014-12-04 Transdermal delivery of dna vaccines using non-thermal plasma Abandoned CA2932264A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361911536P 2013-12-04 2013-12-04
US61/911,536 2013-12-04
PCT/US2014/068522 WO2015085043A1 (en) 2013-12-04 2014-12-04 Transdermal delivery of dna vaccines using non-thermal plasma

Publications (1)

Publication Number Publication Date
CA2932264A1 true CA2932264A1 (en) 2015-06-11

Family

ID=52232437

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2932264A Abandoned CA2932264A1 (en) 2013-12-04 2014-12-04 Transdermal delivery of dna vaccines using non-thermal plasma

Country Status (10)

Country Link
US (1) US20150151135A1 (enExample)
EP (1) EP3077042A1 (enExample)
JP (1) JP2017504575A (enExample)
KR (1) KR20160093658A (enExample)
CN (1) CN105792885A (enExample)
AU (1) AU2014360491A1 (enExample)
CA (1) CA2932264A1 (enExample)
IL (1) IL245717A0 (enExample)
MX (1) MX2016007304A (enExample)
WO (1) WO2015085043A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10892140B2 (en) * 2018-07-27 2021-01-12 Eagle Harbor Technologies, Inc. Nanosecond pulser bias compensation
AU2016263428B2 (en) 2015-05-15 2021-04-22 Clear Intradermal Technologies, Inc. Systems and methods for tattoo removal using cold plasma
US11490947B2 (en) 2015-05-15 2022-11-08 Clear Intradermal Technologies, Inc. Tattoo removal using a liquid-gas mixture with plasma gas bubbles
DE102015111401B3 (de) * 2015-07-14 2016-09-01 Cinogy Gmbh Behandlungsgerät zur Behandlung mit einem dielektrisch behinderten Plasma
CN105193836A (zh) * 2015-09-11 2015-12-30 陶烈晖 外用补充核苷酸的方法和制剂
CN105472856A (zh) * 2015-12-21 2016-04-06 华中科技大学 一种六边形管式结构的低温等离子体发生器
WO2017197071A1 (en) 2016-05-12 2017-11-16 EP Technologies LLC Methods and systems for trans-tissue substance delivery using plasmaporation
AU2017298742A1 (en) * 2016-07-19 2019-01-31 National Agriculture And Food Research Organization Method for introducing substance into plant cell using plasma
AU2017306078B2 (en) * 2016-08-01 2023-03-09 Drexel University Devices and methods for treatment of skin conditions
WO2018089577A1 (en) 2016-11-10 2018-05-17 EP Technologies LLC Methods and systems for generating plasma activated liquid
DE102017100192A1 (de) * 2017-01-06 2018-07-12 Cinogy Gmbh Permanente Wundauflage mit Plasmaelektrode
US11540380B2 (en) * 2017-09-29 2022-12-27 Korea Institute Of Materials Science Flexible active species generator and use thereof
CN108322983B (zh) * 2018-01-26 2024-05-31 中国科学院西安光学精密机械研究所 浮动电极增强介质阻挡放电弥散等离子体射流发生装置
AU2019402973B2 (en) 2018-12-19 2024-10-24 Clear Intradermal Technologies, Inc. Systems and methods for tattoo removal using an applied electric field
CN110743099A (zh) * 2019-11-06 2020-02-04 中国科学技术大学 基于低温等离子体的皮下给药装置
CN111228471A (zh) * 2019-12-20 2020-06-05 中国科学院合肥物质科学研究院 一种基于低温等离子体肿瘤细胞疫苗的制备方法
EP4120942A1 (en) * 2020-03-19 2023-01-25 Caps Medical Ltd. Plasma system with a plurality of plasma generating sites
US20210402430A1 (en) * 2020-06-26 2021-12-30 Illinois Tool Works Inc. Systems and methods for grafting a molecular code onto a material by an atmospheric plasma treatment
CN113633893B (zh) * 2021-08-20 2024-11-01 北京北卓医疗科技发展有限责任公司 等离子在制备改善或治疗脑梗死和脑水肿的药物中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2351018A1 (en) * 2001-07-09 2003-01-09 Universite De Sherbrooke Dna vaccine against staphylococcus aureus
US8455228B2 (en) * 2003-07-16 2013-06-04 University Of South Florida Method to facilitate directed delivery and electroporation using a charged stream
DE102008045830A1 (de) * 2008-09-05 2010-03-11 Cinogy Gmbh Verfahren zur Behandlung eines lebende Zellen enthaltenden biologischen Materials
DE102009028462A1 (de) * 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas

Also Published As

Publication number Publication date
IL245717A0 (en) 2016-07-31
KR20160093658A (ko) 2016-08-08
US20150151135A1 (en) 2015-06-04
CN105792885A (zh) 2016-07-20
JP2017504575A (ja) 2017-02-09
WO2015085043A1 (en) 2015-06-11
EP3077042A1 (en) 2016-10-12
MX2016007304A (es) 2017-03-03
AU2014360491A1 (en) 2016-07-21

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20191204