CN105792885A - 使用非热等离子体经皮递送dna疫苗 - Google Patents

使用非热等离子体经皮递送dna疫苗 Download PDF

Info

Publication number
CN105792885A
CN105792885A CN201480066524.9A CN201480066524A CN105792885A CN 105792885 A CN105792885 A CN 105792885A CN 201480066524 A CN201480066524 A CN 201480066524A CN 105792885 A CN105792885 A CN 105792885A
Authority
CN
China
Prior art keywords
plasma
skin
dna
tissue
pores
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480066524.9A
Other languages
English (en)
Chinese (zh)
Inventor
萨米尔·格尔格特吉
达芙妮·P·安托纳卡斯
蔡宗展
罗伯特·L·格雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ep Science And Technology Ltd
Original Assignee
Ep Science And Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ep Science And Technology Ltd filed Critical Ep Science And Technology Ltd
Publication of CN105792885A publication Critical patent/CN105792885A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/47—Generating plasma using corona discharges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/10—Testing at atmospheric pressure
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/20—Non-thermal plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/32—Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/34—Skin treatments, e.g. disinfection or wound treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201480066524.9A 2013-12-04 2014-12-04 使用非热等离子体经皮递送dna疫苗 Pending CN105792885A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361911536P 2013-12-04 2013-12-04
US61/911,536 2013-12-04
PCT/US2014/068522 WO2015085043A1 (en) 2013-12-04 2014-12-04 Transdermal delivery of dna vaccines using non-thermal plasma

Publications (1)

Publication Number Publication Date
CN105792885A true CN105792885A (zh) 2016-07-20

Family

ID=52232437

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480066524.9A Pending CN105792885A (zh) 2013-12-04 2014-12-04 使用非热等离子体经皮递送dna疫苗

Country Status (10)

Country Link
US (1) US20150151135A1 (enExample)
EP (1) EP3077042A1 (enExample)
JP (1) JP2017504575A (enExample)
KR (1) KR20160093658A (enExample)
CN (1) CN105792885A (enExample)
AU (1) AU2014360491A1 (enExample)
CA (1) CA2932264A1 (enExample)
IL (1) IL245717A0 (enExample)
MX (1) MX2016007304A (enExample)
WO (1) WO2015085043A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108322983A (zh) * 2018-01-26 2018-07-24 中国科学院西安光学精密机械研究所 浮动电极增强介质阻挡放电弥散等离子体射流发生装置
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CN110743099A (zh) * 2019-11-06 2020-02-04 中国科学技术大学 基于低温等离子体的皮下给药装置

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10892140B2 (en) * 2018-07-27 2021-01-12 Eagle Harbor Technologies, Inc. Nanosecond pulser bias compensation
CA2986031C (en) 2015-05-15 2024-03-19 ClearIt, LLC Systems and methods for tattoo removal using cold plasma
US11490947B2 (en) 2015-05-15 2022-11-08 Clear Intradermal Technologies, Inc. Tattoo removal using a liquid-gas mixture with plasma gas bubbles
DE102015111401B3 (de) 2015-07-14 2016-09-01 Cinogy Gmbh Behandlungsgerät zur Behandlung mit einem dielektrisch behinderten Plasma
CN105193836A (zh) * 2015-09-11 2015-12-30 陶烈晖 外用补充核苷酸的方法和制剂
CN105472856A (zh) * 2015-12-21 2016-04-06 华中科技大学 一种六边形管式结构的低温等离子体发生器
US10765850B2 (en) 2016-05-12 2020-09-08 Gojo Industries, Inc. Methods and systems for trans-tissue substance delivery using plasmaporation
CN109922748A (zh) * 2016-08-01 2019-06-21 德雷塞尔大学 用于处理皮肤病况的装置和方法
US10692704B2 (en) 2016-11-10 2020-06-23 Gojo Industries Inc. Methods and systems for generating plasma activated liquid
DE102017100192A1 (de) * 2017-01-06 2018-07-12 Cinogy Gmbh Permanente Wundauflage mit Plasmaelektrode
WO2019066113A1 (ko) * 2017-09-29 2019-04-04 한국기계연구원 플렉서블 활성종 발생기 및 이의 용도
CA3124411A1 (en) 2018-12-19 2020-06-25 ClearIt, LLC Systems and methods for tattoo removal using an applied electric field
CN111228471A (zh) * 2019-12-20 2020-06-05 中国科学院合肥物质科学研究院 一种基于低温等离子体肿瘤细胞疫苗的制备方法
US20230126911A1 (en) * 2020-03-19 2023-04-27 Caps Medical Ltd. Plasma system with a plurality of plasma generating sites
US20210402430A1 (en) * 2020-06-26 2021-12-30 Illinois Tool Works Inc. Systems and methods for grafting a molecular code onto a material by an atmospheric plasma treatment
CN113633893B (zh) * 2021-08-20 2024-11-01 北京北卓医疗科技发展有限责任公司 等离子在制备改善或治疗脑梗死和脑水肿的药物中的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030087864A1 (en) * 2001-07-09 2003-05-08 Brian Talbot DNA vaccine against staphylococcus aureus
US20090004717A1 (en) * 2003-07-16 2009-01-01 University Of South Florida Device and Method to Facilitate Directed Delivery and Electroporation Using a Charged Stream
US20120107896A1 (en) * 2008-09-05 2012-05-03 Dirk Wandke Method for Treating a Biological Material Comprising Living Cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009028462A1 (de) * 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030087864A1 (en) * 2001-07-09 2003-05-08 Brian Talbot DNA vaccine against staphylococcus aureus
US20090004717A1 (en) * 2003-07-16 2009-01-01 University Of South Florida Device and Method to Facilitate Directed Delivery and Electroporation Using a Charged Stream
US20120107896A1 (en) * 2008-09-05 2012-05-03 Dirk Wandke Method for Treating a Biological Material Comprising Living Cells

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CN108322983A (zh) * 2018-01-26 2018-07-24 中国科学院西安光学精密机械研究所 浮动电极增强介质阻挡放电弥散等离子体射流发生装置
CN108322983B (zh) * 2018-01-26 2024-05-31 中国科学院西安光学精密机械研究所 浮动电极增强介质阻挡放电弥散等离子体射流发生装置
CN110743099A (zh) * 2019-11-06 2020-02-04 中国科学技术大学 基于低温等离子体的皮下给药装置

Also Published As

Publication number Publication date
EP3077042A1 (en) 2016-10-12
AU2014360491A1 (en) 2016-07-21
WO2015085043A1 (en) 2015-06-11
CA2932264A1 (en) 2015-06-11
KR20160093658A (ko) 2016-08-08
US20150151135A1 (en) 2015-06-04
MX2016007304A (es) 2017-03-03
JP2017504575A (ja) 2017-02-09
IL245717A0 (en) 2016-07-31

Similar Documents

Publication Publication Date Title
CN105792885A (zh) 使用非热等离子体经皮递送dna疫苗
JP2017506094A (ja) 分子、薬物、ワクチンなどの細胞内および細胞間送達のための方法および機器
US8455228B2 (en) Method to facilitate directed delivery and electroporation using a charged stream
US20160220670A1 (en) Boosting the efficacy of dna-based vaccines with non-thermal dbd plasma
US7171264B1 (en) Intradermal delivery of active agents by needle-free injection and electroporation
JP4499295B2 (ja) 細胞内への巨大分子の送達
US20170246440A1 (en) Apparatuses and methods for plasmaporation using microneedles
WO2017147362A1 (en) Methods and systems for controlling or tuning the electric field generated in skin or tissue during cold plasma skin treatments
CN105658200A (zh) 跨组织层递送分子的方法和装置
WO2014106258A1 (en) Cold plasma electroporation of medication and associated methods
JPH11506630A (ja) 薬剤及び遺伝子のエレクトロポレーションを利用した治療方法
EP4157226B1 (en) Devices and systems for facilitating tissue delivery of drug
Sreedevi et al. Cold atmospheric plasma mediated cell membrane permeation and gene delivery-empirical interventions and pertinence
KR102601524B1 (ko) 미세전극을 사용한 조직 전기이동을 위한 소자
US20210353939A1 (en) Multiple Tissue Layer Electroporation Applicator and Device
Regnier et al. Parameters controlling topical delivery of oligonucleotides by electroporation
EP2156860A1 (en) Method for producing insulated electrodes for applying electric fields into conductive material
Connolly et al. Plasma facilitated delivery of DNA to skin
Hui et al. Enhancing transdermal drug delivery with electroporation
Kim et al. A Polymeric Electroporation Microneedle Array for Minimally Invasive and Highly Localized Electrogenetherapy and Electrochemotherapy
SE0951039A1 (sv) Elektroporeringsanordning

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160720

WD01 Invention patent application deemed withdrawn after publication