JP2017504575A - 非熱プラズマを用いるｄｎａワクチンの経皮デリバリ - Google Patents

非熱プラズマを用いるｄｎａワクチンの経皮デリバリ Download PDF

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Publication number
JP2017504575A
JP2017504575A JP2016536112A JP2016536112A JP2017504575A JP 2017504575 A JP2017504575 A JP 2017504575A JP 2016536112 A JP2016536112 A JP 2016536112A JP 2016536112 A JP2016536112 A JP 2016536112A JP 2017504575 A JP2017504575 A JP 2017504575A
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Prior art keywords
plasma
skin
dna vaccine
dna
treatment
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Japanese (ja)
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JP2017504575A5 (enExample
Inventor
カルガットギ，サミーア
アントナカス，ダフネ・パパス
ツァイ，ツンチャン
グレイ，ロバート・エル
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EP Technologies LLC
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EP Technologies LLC
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Publication of JP2017504575A5 publication Critical patent/JP2017504575A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/47—Generating plasma using corona discharges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/10—Testing at atmospheric pressure
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/20—Non-thermal plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/32—Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/34—Skin treatments, e.g. disinfection or wound treatment

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2016536112A 2013-12-04 2014-12-04 非熱プラズマを用いるｄｎａワクチンの経皮デリバリ Withdrawn JP2017504575A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361911536P 2013-12-04 2013-12-04
US61/911,536 2013-12-04
PCT/US2014/068522 WO2015085043A1 (en) 2013-12-04 2014-12-04 Transdermal delivery of dna vaccines using non-thermal plasma

Publications (2)

Publication Number Publication Date
JP2017504575A true JP2017504575A (ja) 2017-02-09
JP2017504575A5 JP2017504575A5 (enExample) 2018-01-18

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JP2016536112A Withdrawn JP2017504575A (ja) 2013-12-04 2014-12-04 非熱プラズマを用いるｄｎａワクチンの経皮デリバリ

Country Status (10)

Country Link
US (1) US20150151135A1 (enExample)
EP (1) EP3077042A1 (enExample)
JP (1) JP2017504575A (enExample)
KR (1) KR20160093658A (enExample)
CN (1) CN105792885A (enExample)
AU (1) AU2014360491A1 (enExample)
CA (1) CA2932264A1 (enExample)
IL (1) IL245717A0 (enExample)
MX (1) MX2016007304A (enExample)
WO (1) WO2015085043A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023534149A (ja) * 2020-06-26 2023-08-08 イリノイ トゥール ワークス インコーポレイティド 大気プラズマ処理によって分子コードを材料上へとグラフトするシステム及び方法

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
US10892140B2 (en) * 2018-07-27 2021-01-12 Eagle Harbor Technologies, Inc. Nanosecond pulser bias compensation
US11490947B2 (en) 2015-05-15 2022-11-08 Clear Intradermal Technologies, Inc. Tattoo removal using a liquid-gas mixture with plasma gas bubbles
CA2986031C (en) 2015-05-15 2024-03-19 ClearIt, LLC Systems and methods for tattoo removal using cold plasma
DE102015111401B3 (de) * 2015-07-14 2016-09-01 Cinogy Gmbh Behandlungsgerät zur Behandlung mit einem dielektrisch behinderten Plasma
CN105193836A (zh) * 2015-09-11 2015-12-30 陶烈晖 外用补充核苷酸的方法和制剂
CN105472856A (zh) * 2015-12-21 2016-04-06 华中科技大学 一种六边形管式结构的低温等离子体发生器
US10765850B2 (en) 2016-05-12 2020-09-08 Gojo Industries, Inc. Methods and systems for trans-tissue substance delivery using plasmaporation
CN109477084A (zh) * 2016-07-19 2019-03-15 国立研究开发法人农业·食品产业技术综合研究机构 使用等离子体在植物细胞内导入物质的方法
CA3071408A1 (en) * 2016-08-01 2018-02-08 Drexel University Devices and methods for treatment of skin conditions
WO2018089577A1 (en) 2016-11-10 2018-05-17 EP Technologies LLC Methods and systems for generating plasma activated liquid
DE102017100192A1 (de) * 2017-01-06 2018-07-12 Cinogy Gmbh Permanente Wundauflage mit Plasmaelektrode
WO2019066113A1 (ko) * 2017-09-29 2019-04-04 한국기계연구원 플렉서블 활성종 발생기 및 이의 용도
CN108322983B (zh) * 2018-01-26 2024-05-31 中国科学院西安光学精密机械研究所 浮动电极增强介质阻挡放电弥散等离子体射流发生装置
CA3124411A1 (en) 2018-12-19 2020-06-25 ClearIt, LLC Systems and methods for tattoo removal using an applied electric field
CN110743099A (zh) * 2019-11-06 2020-02-04 中国科学技术大学 基于低温等离子体的皮下给药装置
CN111228471A (zh) * 2019-12-20 2020-06-05 中国科学院合肥物质科学研究院 一种基于低温等离子体肿瘤细胞疫苗的制备方法
IL314621A (en) 2020-03-19 2024-09-01 Caps Medical Ltd Treatment of internal spaces using a device for plasma production
EP4120941A2 (en) * 2020-03-19 2023-01-25 Caps Medical Ltd. Plasma system with directional features
CA3185220A1 (en) * 2020-07-24 2022-01-27 Theisen, Olaf Device for supporting a treatment using pulsed electric fields in order to heal wounds and/or for the inactivation of microorganisms, and method for the inactivation of microorganism
CN113633893B (zh) * 2021-08-20 2024-11-01 北京北卓医疗科技发展有限责任公司 等离子在制备改善或治疗脑梗死和脑水肿的药物中的用途
CN115282478B (zh) * 2022-08-08 2026-04-03 北京载愈生物科技有限公司 一种递送系统及递送方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2351018A1 (en) * 2001-07-09 2003-01-09 Universite De Sherbrooke Dna vaccine against staphylococcus aureus
US8455228B2 (en) * 2003-07-16 2013-06-04 University Of South Florida Method to facilitate directed delivery and electroporation using a charged stream
DE102008045830A1 (de) * 2008-09-05 2010-03-11 Cinogy Gmbh Verfahren zur Behandlung eines lebende Zellen enthaltenden biologischen Materials
DE102009028462A1 (de) * 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023534149A (ja) * 2020-06-26 2023-08-08 イリノイ トゥール ワークス インコーポレイティド 大気プラズマ処理によって分子コードを材料上へとグラフトするシステム及び方法
JP7717099B2 (ja) 2020-06-26 2025-08-01 イリノイ トゥール ワークス インコーポレイティド 大気プラズマ処理によって分子コードを材料上へとグラフトするシステム及び方法

Also Published As

Publication number Publication date
EP3077042A1 (en) 2016-10-12
IL245717A0 (en) 2016-07-31
CA2932264A1 (en) 2015-06-11
US20150151135A1 (en) 2015-06-04
MX2016007304A (es) 2017-03-03
WO2015085043A1 (en) 2015-06-11
AU2014360491A1 (en) 2016-07-21
CN105792885A (zh) 2016-07-20
KR20160093658A (ko) 2016-08-08

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