CA2931294C - Virus de la vaccine de recombinaison dependant de la proteine kinase activee par mitogene (md-rvv), et son utilisation - Google Patents

Virus de la vaccine de recombinaison dependant de la proteine kinase activee par mitogene (md-rvv), et son utilisation Download PDF

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CA2931294C
CA2931294C CA2931294A CA2931294A CA2931294C CA 2931294 C CA2931294 C CA 2931294C CA 2931294 A CA2931294 A CA 2931294A CA 2931294 A CA2931294 A CA 2931294A CA 2931294 C CA2931294 C CA 2931294C
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vgf
cells
vaccinia virus
cancer
virus
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CA2931294A1 (fr
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Takafumi Nakamura
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Tottori University NUC
KM Biologics Co Ltd
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KM Biologics Co Ltd
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    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24171—Demonstrated in vivo effect

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne un virus de la vaccine qui croît spécifiquement dans des cellules cancéreuses et les détruit. Elle concerne en outre l'utilisation dudit virus dans le traitement du cancer. Un virus de la vaccine dépendant de la protéine kinase activée par mitogène, auquel manque un facteur de croissance (VGF) du virus de la vaccine et la fonction O1L, se développe spécifiquement dans des cellules cancéreuses mais pas dans des cellules saines, et présente des propriétés oncolytiques pouvant détruire spécifiquement les cellules cancéreuses.
CA2931294A 2013-11-21 2014-11-20 Virus de la vaccine de recombinaison dependant de la proteine kinase activee par mitogene (md-rvv), et son utilisation Active CA2931294C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-241299 2013-11-21
JP2013241299 2013-11-21
PCT/JP2014/081484 WO2015076422A1 (fr) 2013-11-21 2014-11-20 Virus de la vaccine de recombinaison dépendant de la protéine kinase activée par mitogène (md-rvv), et son utilisation

Publications (2)

Publication Number Publication Date
CA2931294A1 CA2931294A1 (fr) 2015-05-28
CA2931294C true CA2931294C (fr) 2022-05-31

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CA2931294A Active CA2931294C (fr) 2013-11-21 2014-11-20 Virus de la vaccine de recombinaison dependant de la proteine kinase activee par mitogene (md-rvv), et son utilisation

Country Status (8)

Country Link
US (1) US9809803B2 (fr)
EP (1) EP3072966B1 (fr)
JP (1) JP6378200B2 (fr)
KR (1) KR102197374B1 (fr)
CN (2) CN105765062B (fr)
CA (1) CA2931294C (fr)
DK (1) DK3072966T3 (fr)
WO (1) WO2015076422A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017014296A1 (fr) * 2015-07-22 2017-01-26 国立大学法人鳥取大学 Facteur de régulation d'un hôte pour améliorer la prolifération et la propagation de virus de la vaccine
US10888594B2 (en) 2016-05-30 2021-01-12 National University Corporation Tottori University Genetically engineered vaccinia viruses
WO2017209053A1 (fr) * 2016-05-30 2017-12-07 アステラス製薬株式会社 Nouveau virus de la vaccine génétiquement modifié
US20190336552A1 (en) * 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
WO2018012570A1 (fr) * 2016-07-13 2018-01-18 国立大学法人鳥取大学 Procédé de fabrication de virus vaccinal exprimant un gène étranger
JP7274138B2 (ja) * 2017-11-30 2023-05-16 アステラス製薬株式会社 Ｓｃｒ欠失ワクシニアウイルス
JP7034818B2 (ja) * 2018-04-19 2022-03-14 Ｋｍバイオロジクス株式会社 増殖性ヘルパーワクシニアウイルスを使用するポックスウイルスの製造方法
JP7484717B2 (ja) 2018-09-26 2024-05-16 アステラス製薬株式会社 腫瘍溶解性ワクシニアウイルスと免疫チェックポイント阻害剤との併用によるがん療法並びにこれに用いるための医薬組成物及び組合せ医薬
CN109750056A (zh) * 2019-01-07 2019-05-14 西安医学院 去除天坛株vgf基因的打靶质粒及其制备方法
US11529402B2 (en) 2019-01-14 2022-12-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
WO2020165730A1 (fr) 2019-02-14 2020-08-20 Ignite Immunotherapy, Inc. Virus de la vaccine recombinant et ses procédés d'utilisation
CN113840914A (zh) 2019-05-14 2021-12-24 国立大学法人鸟取大学 诱导细胞融合的痘苗病毒及其应用
JPWO2021029385A1 (fr) * 2019-08-09 2021-02-18
JP2022547234A (ja) 2019-08-29 2022-11-10 アステラス製薬株式会社 遺伝子操作された腫瘍溶解性ワクシニアウイルスおよびその使用方法
CA3163805A1 (fr) 2019-12-12 2021-06-17 Ignite Immunotherapy, Inc. Virus de la vaccine oncolytique a variants et ses methodes d'utilisation
US20230201283A1 (en) 2020-01-09 2023-06-29 Pfizer Inc. Recombinant vaccinia virus
KR20230023032A (ko) 2020-07-14 2023-02-16 화이자 인코포레이티드 재조합 백시니아 바이러스
US20230355691A1 (en) 2020-11-17 2023-11-09 National University Corporation Tottori University Novel recombinant vaccinia virus and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2375189C (fr) 1999-05-28 2010-02-09 The Government Of The United States Of America Vecteur du virus de la vaccine combinant deletion du facteur de croissance et deletion de thymidine kinase
US7638132B2 (en) 2003-12-05 2009-12-29 National University Corporation Hokkaido University Highly safe smallpox vaccine virus and vaccinia virus vector
US20130071430A1 (en) 2010-04-09 2013-03-21 The University Of Tokyo Microrna-controlled recombinant vaccinia virus and use thereof
CN103189506A (zh) * 2010-10-22 2013-07-03 国立大学法人北海道大学 包含痘苗病毒载体和仙台病毒载体的初免-加强疫苗用病毒载体
CA2836299A1 (fr) * 2011-04-15 2012-10-18 Genelux Corporation Souches clonales de virus attenues de la vaccine et leurs procedes d'utilisation
FI20115914L (fi) 2011-09-16 2013-03-17 Oncos Therapeutics Ltd Muunnettu onkolyyttinen virus
JP5935130B2 (ja) 2012-05-20 2016-06-15 香蘭産業株式会社 イネ科植物灰の製造方法

Also Published As

Publication number Publication date
EP3072966A4 (fr) 2017-04-19
DK3072966T3 (da) 2020-03-23
KR102197374B1 (ko) 2020-12-31
KR20160079901A (ko) 2016-07-06
CN105765062A (zh) 2016-07-13
CA2931294A1 (fr) 2015-05-28
US20160281066A1 (en) 2016-09-29
JP6378200B2 (ja) 2018-08-22
US9809803B2 (en) 2017-11-07
EP3072966A1 (fr) 2016-09-28
WO2015076422A1 (fr) 2015-05-28
EP3072966B1 (fr) 2020-01-08
CN105765062B (zh) 2020-12-11
JPWO2015076422A1 (ja) 2017-03-16
CN110527670A (zh) 2019-12-03

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