CA2928259C - Fluid control and processing system - Google Patents
Fluid control and processing system Download PDFInfo
- Publication number
- CA2928259C CA2928259C CA2928259A CA2928259A CA2928259C CA 2928259 C CA2928259 C CA 2928259C CA 2928259 A CA2928259 A CA 2928259A CA 2928259 A CA2928259 A CA 2928259A CA 2928259 C CA2928259 C CA 2928259C
- Authority
- CA
- Canada
- Prior art keywords
- fluid
- chamber
- valve
- fluid displacement
- processing region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 225
- 238000012545 processing Methods 0.000 title claims abstract description 121
- 238000006073 displacement reaction Methods 0.000 claims abstract description 66
- 238000004891 communication Methods 0.000 claims abstract description 43
- 238000006243 chemical reaction Methods 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 22
- 239000002699 waste material Substances 0.000 claims description 22
- 230000002934 lysing effect Effects 0.000 claims description 5
- 230000009089 cytolysis Effects 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 239000012491 analyte Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 60
- 239000000203 mixture Substances 0.000 description 15
- 239000006166 lysate Substances 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- -1 polypropylene Polymers 0.000 description 6
- 238000001914 filtration Methods 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
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- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
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- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
- G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2983994A CA2983994C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/648,570 US6374684B1 (en) | 2000-08-25 | 2000-08-25 | Fluid control and processing system |
| US09/648,570 | 2000-08-25 | ||
| CA2814576A CA2814576C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2814576A Division CA2814576C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2983994A Division CA2983994C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2928259A1 CA2928259A1 (en) | 2002-03-07 |
| CA2928259C true CA2928259C (en) | 2017-12-12 |
Family
ID=24601335
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2928259A Expired - Lifetime CA2928259C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA2814576A Expired - Lifetime CA2814576C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA2419862A Expired - Lifetime CA2419862C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA2983994A Expired - Lifetime CA2983994C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA3014112A Expired - Lifetime CA3014112C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2814576A Expired - Lifetime CA2814576C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA2419862A Expired - Lifetime CA2419862C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA2983994A Expired - Lifetime CA2983994C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
| CA3014112A Expired - Lifetime CA3014112C (en) | 2000-08-25 | 2001-07-26 | Fluid control and processing system |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6374684B1 (enExample) |
| EP (3) | EP3153837B1 (enExample) |
| JP (9) | JP4663959B2 (enExample) |
| AT (1) | ATE408129T1 (enExample) |
| AU (2) | AU7907001A (enExample) |
| CA (5) | CA2928259C (enExample) |
| DE (1) | DE60135766D1 (enExample) |
| DK (2) | DK1325298T3 (enExample) |
| ES (3) | ES2313972T3 (enExample) |
| WO (1) | WO2002018902A1 (enExample) |
Families Citing this family (164)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048386B2 (en) * | 2002-02-25 | 2011-11-01 | Cepheid | Fluid processing and control |
| WO2003033740A2 (en) * | 2001-07-10 | 2003-04-24 | Massachusetts Institute Of Technology | Apparatus and method for isolating a nucleic acid |
| DE10209732A1 (de) * | 2002-03-06 | 2003-10-09 | Endress & Hauser Gmbh & Co Kg | Schutzgehäuse für ein Feldgerät |
| DE10228917A1 (de) * | 2002-06-24 | 2004-01-22 | Epigenomics Ag | Vorrichtung zur Handhabung von Flüssigkeiten in einer Mehrzahl von Kanälen |
| JP2005532072A (ja) * | 2002-07-10 | 2005-10-27 | マサチューセッツ・インスティテュート・オブ・テクノロジー | サンプルから核酸を単離するための装置および方法 |
| US20040101444A1 (en) * | 2002-07-15 | 2004-05-27 | Xeotron Corporation | Apparatus and method for fluid delivery to a hybridization station |
| US20040038385A1 (en) * | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
| ES2402092T3 (es) * | 2002-09-11 | 2013-04-26 | Temple University - Of The Commonwealth System Of Higher Education | Sistema automatizado para separaciones electroforéticas de alta capacidad de producción |
| WO2004083806A2 (en) | 2003-01-22 | 2004-09-30 | University Of South Florida | Autonomous genosensor apparatus and methods for use |
| ES2220227B1 (es) | 2003-05-30 | 2006-02-16 | INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" | Metodo y aparato para la deteccion de sustancias o analitos a partir del analisis de una o varias muestras. |
| GB0319671D0 (en) | 2003-08-21 | 2003-09-24 | Secr Defence | Apparatus for processing a fluid sample |
| US7541166B2 (en) * | 2003-09-19 | 2009-06-02 | Microfluidic Systems, Inc. | Sonication to selectively lyse different cell types |
| WO2005028635A2 (en) * | 2003-09-19 | 2005-03-31 | Microfluidic Systems Inc. | Microfluidic differential extraction cartridge |
| US7032605B1 (en) | 2003-10-15 | 2006-04-25 | Douglas B. Dority | Dual piston rotary valve |
| WO2005055804A2 (en) * | 2003-12-02 | 2005-06-23 | Musc Foundation For Research Development | Methods and compositions for diagnosing epithelial cell cancer |
| WO2005084254A2 (en) * | 2004-02-27 | 2005-09-15 | Musc Foundation For Research Development | Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription |
| US20050244837A1 (en) * | 2004-04-28 | 2005-11-03 | Cepheid | Method and device for sample preparation control |
| WO2006017150A2 (en) | 2004-07-09 | 2006-02-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Educatiion | Identification of markers in lung and breast cancer |
| EP1807211A1 (en) * | 2004-09-09 | 2007-07-18 | Microfluidic Systems Inc. | A handheld and portable microfluidic device to automatically prepare nucleic acids for analysis |
| EP1799858A4 (en) * | 2004-09-20 | 2009-03-04 | Univ Pittsburgh | MULTI MODE MULTIPLEX FIRE PROCEDURES |
| US20080193961A1 (en) * | 2004-09-29 | 2008-08-14 | Easley Christopher J | Localized Control of Thermal Properties on Microdevices and Applications Thereof |
| US8056881B2 (en) | 2004-10-13 | 2011-11-15 | University Of Virginia Patent Foundation | Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof |
| JP4999103B2 (ja) * | 2004-10-27 | 2012-08-15 | セフィード | 閉鎖系の多段階核酸増幅反応 |
| US7785868B2 (en) * | 2004-12-02 | 2010-08-31 | Microfluidic Systems, Inc. | Apparatus to automatically lyse a sample |
| WO2006069305A2 (en) * | 2004-12-22 | 2006-06-29 | University Of Virginia Patent Foundation | The use of microwaves for thermal and non-thermal applications in micro and nanoscale devices |
| DE102005008224B3 (de) * | 2005-02-23 | 2006-06-14 | Directif Gmbh | Vorrichtung und Verfahren zur automatischen Betätigung einer mikrofluidischen Einrichtung |
| US8343755B2 (en) * | 2005-08-01 | 2013-01-01 | University Of Virginia Patent Foundation | Microdevices for chemical sensing and chemical actuation |
| EP1938425A4 (en) * | 2005-08-23 | 2010-09-15 | Univ Virginia | PASSIVE COMPONENTS FOR MICROFLUIDIC FLOW PROFILE FORMATION AND METHOD THEREOF |
| US20110033922A1 (en) * | 2005-10-04 | 2011-02-10 | Landers James P | Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof |
| WO2007047336A2 (en) * | 2005-10-12 | 2007-04-26 | University Of Virginia Patent Foundation | Integrated microfluidic analysis systems |
| CN100478671C (zh) * | 2005-10-25 | 2009-04-15 | 艾康生物技术(杭州)有限公司 | 用于液体样本的检测装置和方法 |
| CN101498655B (zh) * | 2005-10-25 | 2012-05-30 | 阿莱瑞士股份有限公司 | 用于液体样本的检测装置 |
| US8900828B2 (en) * | 2006-05-01 | 2014-12-02 | Cepheid | Methods and apparatus for sequential amplification reactions |
| US20100216657A1 (en) * | 2006-05-16 | 2010-08-26 | Arcxis Biotechnologies, Inc. | Pcr-free sample preparation and detection systems for high speed biologic analysis and identification |
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| KR101563687B1 (ko) | 2008-09-02 | 2015-11-09 | 삼성전자주식회사 | 표적 분자 분리를 위한 미세유동 카트리지, 분리장치, 및 이를 이용한 표적 분자 분리 방법 |
| DE102008042581B4 (de) | 2008-10-02 | 2012-02-02 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Mikrofluidische Extraktions- und Reaktionsvorrichtung |
| FR2938063B1 (fr) | 2008-11-05 | 2014-09-19 | Commissariat Energie Atomique | Dispositif de preparation et/ou de traitement d'un echantillon biologique |
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| EP3597671B1 (en) | 2010-05-17 | 2022-09-21 | EMD Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
| EP2420846B1 (en) * | 2010-08-20 | 2020-09-23 | ABB Schweiz AG | Chemical analysis apparatus |
| CN102087295B (zh) * | 2011-01-24 | 2013-04-03 | 杭州安旭科技有限公司 | 一种快速检测装置 |
| WO2012122458A2 (en) * | 2011-03-10 | 2012-09-13 | Biodetection Instruments, Llc | A cartridge based system and method for detecting an analyte in a sample |
| US9737891B2 (en) | 2011-06-01 | 2017-08-22 | Streck, Inc. | Rapid thermocycler system for rapid amplification of nucleic acids and related methods |
| US11485968B2 (en) | 2012-02-13 | 2022-11-01 | Neumodx Molecular, Inc. | Microfluidic cartridge for processing and detecting nucleic acids |
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