CA2927358C - Device for formulating particles at small volumes - Google Patents
Device for formulating particles at small volumes Download PDFInfo
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- CA2927358C CA2927358C CA2927358A CA2927358A CA2927358C CA 2927358 C CA2927358 C CA 2927358C CA 2927358 A CA2927358 A CA 2927358A CA 2927358 A CA2927358 A CA 2927358A CA 2927358 C CA2927358 C CA 2927358C
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Classifications
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- B01F23/40—Mixing liquids with liquids; Emulsifying
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- B01F23/40—Mixing liquids with liquids; Emulsifying
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
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- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891758P | 2013-10-16 | 2013-10-16 | |
| US61/891,758 | 2013-10-16 | ||
| PCT/US2014/060961 WO2015057998A1 (en) | 2013-10-16 | 2014-10-16 | Device for formulating particles at small volumes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2927358A1 CA2927358A1 (en) | 2015-04-23 |
| CA2927358C true CA2927358C (en) | 2021-12-21 |
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|---|---|---|---|
| CA2927358A Active CA2927358C (en) | 2013-10-16 | 2014-10-16 | Device for formulating particles at small volumes |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10159652B2 (enExample) |
| EP (1) | EP3057693A4 (enExample) |
| JP (1) | JP6640079B2 (enExample) |
| CN (1) | CN105813721B (enExample) |
| CA (1) | CA2927358C (enExample) |
| WO (1) | WO2015057998A1 (enExample) |
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| JP6764870B2 (ja) | 2015-02-24 | 2020-10-07 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 連続フローマイクロ流体システム |
| WO2016165825A1 (en) | 2015-04-13 | 2016-10-20 | Curevac Ag | Method for producing rna compositions |
| JP2018525209A (ja) | 2015-04-28 | 2018-09-06 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 使い捨てマイクロ流体カートリッジ |
| USD771833S1 (en) | 2015-04-28 | 2016-11-15 | University Of British Columbia | Microfluidic cartridge |
| USD771834S1 (en) | 2015-04-28 | 2016-11-15 | University Of British Columbia | Microfluidic cartridge |
| USD772427S1 (en) | 2015-04-28 | 2016-11-22 | University Of British Columbia | Microfluidic cartridge |
| WO2017048770A1 (en) * | 2015-09-15 | 2017-03-23 | Regulus Therapeutics, Inc. | Systems, compositions, and methods for formulating nucleic acid compositions |
| JP7349788B2 (ja) * | 2016-01-06 | 2023-09-25 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 分岐ミキサー並びにその使用及び製造方法 |
| CA3027643C (en) | 2016-07-06 | 2021-01-19 | Precision Nanosystems Inc | Smart microfluidic mixing instrument and cartridges |
| WO2018064755A1 (en) * | 2016-10-03 | 2018-04-12 | Precision Nanosystems Inc. | Compositions for transfecting resistant cell types |
| US11938456B2 (en) | 2016-12-16 | 2024-03-26 | Delphi Scientific, Llc | Layered particles and processes thereof |
| WO2019139997A1 (en) * | 2018-01-09 | 2019-07-18 | Trucode Gene Repair, Inc. | Polymer-based nanoparticles, related formulation methods, and apparatus |
| CA3097203C (en) * | 2018-04-29 | 2023-09-05 | Precision Nanosystems Inc. | Compositions for transfecting resistant cell types |
| AU2019362031A1 (en) * | 2018-10-19 | 2021-04-08 | Translate Bio, Inc. | Pumpless encapsulation of messenger RNA |
| AU2020260280B2 (en) * | 2019-04-15 | 2023-06-29 | Global Life Sciences Solutions Canada Ulc | Nonviral modification of t cell gene expression |
| TWI851862B (zh) * | 2019-12-23 | 2024-08-11 | 美商胡桃夾子治療公司 | 微流體裝置及其使用方法 |
| AU2021252164A1 (en) | 2020-04-09 | 2022-12-15 | Finncure Oy | Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses |
| US12194157B2 (en) | 2020-04-09 | 2025-01-14 | Finncure Oy | Carrier for targeted delivery to a host |
| DE102020214601A1 (de) * | 2020-11-19 | 2022-05-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren und Vorrichtung zur Herstellung einer Flüssigkeit enthaltend Liposomen und hergestellte Flüssigkeit |
| CN116887910A (zh) | 2020-11-30 | 2023-10-13 | 精密纳米系统无限责任公司 | 非聚集微流体混合器和用于其的方法 |
| CN114247398A (zh) * | 2021-12-17 | 2022-03-29 | 沈磊 | 一种脂质纳米颗粒制备系统及设备 |
| WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
| KR20250120406A (ko) | 2022-12-12 | 2025-08-08 | 글로벌 라이프 사이언시즈 솔루션즈 캐나다 유엘씨 | 지질 나노입자 동결건조 방법 및 조성물 |
| WO2025005990A1 (en) | 2023-06-28 | 2025-01-02 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticle formulations for cell therapy and related methods |
| WO2025049579A1 (en) | 2023-08-31 | 2025-03-06 | Global Life Sciences Solutions Canada Ulc | Intranasal formulation for pulmonary delivery of nanoparticles, compositions, uses, and manufacturing methods thereof |
| WO2025219528A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Non-destructive plasmid delivery to immune cells |
| WO2025219491A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Method and composition for hdr template dna delivery |
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| US20130323269A1 (en) | 2010-07-30 | 2013-12-05 | Muthiah Manoharan | Methods and compositions for delivery of active agents |
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2014
- 2014-10-16 CA CA2927358A patent/CA2927358C/en active Active
- 2014-10-16 WO PCT/US2014/060961 patent/WO2015057998A1/en not_active Ceased
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- 2014-10-16 EP EP14853947.1A patent/EP3057693A4/en active Pending
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2018
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| US20160235688A1 (en) | 2016-08-18 |
| WO2015057998A1 (en) | 2015-04-23 |
| US10159652B2 (en) | 2018-12-25 |
| US20190076372A1 (en) | 2019-03-14 |
| JP2017500279A (ja) | 2017-01-05 |
| CN105813721B (zh) | 2019-11-05 |
| EP3057693A4 (en) | 2017-08-09 |
| JP6640079B2 (ja) | 2020-02-05 |
| EP3057693A1 (en) | 2016-08-24 |
| CA2927358A1 (en) | 2015-04-23 |
| CN105813721A (zh) | 2016-07-27 |
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