CA2927358C - Device for formulating particles at small volumes - Google Patents
Device for formulating particles at small volumes Download PDFInfo
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- CA2927358C CA2927358C CA2927358A CA2927358A CA2927358C CA 2927358 C CA2927358 C CA 2927358C CA 2927358 A CA2927358 A CA 2927358A CA 2927358 A CA2927358 A CA 2927358A CA 2927358 C CA2927358 C CA 2927358C
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
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- B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
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- B01F33/30—Micromixers
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- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
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- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Molecular Biology (AREA)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201361891758P | 2013-10-16 | 2013-10-16 | |
| US61/891,758 | 2013-10-16 | ||
| PCT/US2014/060961 WO2015057998A1 (en) | 2013-10-16 | 2014-10-16 | Device for formulating particles at small volumes |
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| CA2927358A1 CA2927358A1 (en) | 2015-04-23 |
| CA2927358C true CA2927358C (en) | 2021-12-21 |
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| CA2927358A Active CA2927358C (en) | 2013-10-16 | 2014-10-16 | Device for formulating particles at small volumes |
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| EP (1) | EP3057693A4 (cg-RX-API-DMAC7.html) |
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| CA (1) | CA2927358C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015057998A1 (cg-RX-API-DMAC7.html) |
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| EP4481401A3 (en) | 2015-02-24 | 2025-04-23 | The University of British Columbia | Continuous flow microfluidic system and method |
| EP3283059B1 (en) | 2015-04-13 | 2024-01-03 | CureVac Manufacturing GmbH | Method for producing rna compositions |
| WO2016176505A1 (en) | 2015-04-28 | 2016-11-03 | The University Of British Columbia | Disposable microfluidic cartridge |
| USD772427S1 (en) | 2015-04-28 | 2016-11-22 | University Of British Columbia | Microfluidic cartridge |
| USD771834S1 (en) | 2015-04-28 | 2016-11-15 | University Of British Columbia | Microfluidic cartridge |
| USD771833S1 (en) | 2015-04-28 | 2016-11-15 | University Of British Columbia | Microfluidic cartridge |
| WO2017048770A1 (en) * | 2015-09-15 | 2017-03-23 | Regulus Therapeutics, Inc. | Systems, compositions, and methods for formulating nucleic acid compositions |
| KR102361123B1 (ko) * | 2016-01-06 | 2022-02-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 분기 혼합기들 및 그 사용 및 제조 방법 |
| WO2018006166A1 (en) | 2016-07-06 | 2018-01-11 | Precision Nanosystems Inc | Smart microfluidic mixing instrument and cartridges |
| US20210284998A1 (en) * | 2016-10-03 | 2021-09-16 | Precision Nanosystems Inc. | Compositions for Transfecting Resistant Cell Types |
| EP3554478B1 (en) * | 2016-12-16 | 2022-01-26 | Delphi Scientific, LLC | Layered particles and processes thereof |
| US20190298857A1 (en) * | 2018-01-09 | 2019-10-03 | Trucode Gene Repair, Inc. | Polymer-based nanoparticles, related formulations methods, and apparatus |
| CN112105389B (zh) * | 2018-04-29 | 2024-10-18 | 环球生命科学解决方案加拿大有限公司 | 用于转染抵抗细胞类型的组合物 |
| WO2020081933A1 (en) * | 2018-10-19 | 2020-04-23 | Translate Bio, Inc. | Pumpless encapsulation of messenger rna |
| EP3956459A4 (en) * | 2019-04-15 | 2023-01-11 | Precision Nanosystems Inc | NONVIRAL MODIFICATION OF T LYMPHOCYTE GENE EXPRESSION |
| CA3165471A1 (en) * | 2019-12-23 | 2021-07-01 | Nutcracker Therapeutics, Inc. | Microfluidic apparatus and methods of use thereof |
| EP4132478A1 (en) | 2020-04-09 | 2023-02-15 | Finncure Oy | Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses |
| US12194157B2 (en) | 2020-04-09 | 2025-01-14 | Finncure Oy | Carrier for targeted delivery to a host |
| DE102020214601A1 (de) * | 2020-11-19 | 2022-05-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren und Vorrichtung zur Herstellung einer Flüssigkeit enthaltend Liposomen und hergestellte Flüssigkeit |
| WO2022109721A1 (en) | 2020-11-30 | 2022-06-02 | Precision Nanosystems Inc. | Non aggregating microfluidic mixer and methods therefor |
| CN114247398A (zh) * | 2021-12-17 | 2022-03-29 | 沈磊 | 一种脂质纳米颗粒制备系统及设备 |
| WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
| CN120390635A (zh) | 2022-12-12 | 2025-07-29 | 环球生命科学解决方案加拿大有限公司 | 脂质纳米颗粒冻干方法和组合物 |
| AU2023457883A1 (en) | 2023-06-28 | 2025-12-18 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticle formulations for cell therapy and related methods |
| WO2025049579A1 (en) | 2023-08-31 | 2025-03-06 | Global Life Sciences Solutions Canada Ulc | Intranasal formulation for pulmonary delivery of nanoparticles, compositions, uses, and manufacturing methods thereof |
| WO2025219528A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Non-destructive plasmid delivery to immune cells |
| WO2025219491A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Method and composition for hdr template dna delivery |
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| EP2496700B1 (en) * | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
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| EP3057693A4 (en) | 2017-08-09 |
| EP3057693A1 (en) | 2016-08-24 |
| CN105813721B (zh) | 2019-11-05 |
| US10159652B2 (en) | 2018-12-25 |
| WO2015057998A1 (en) | 2015-04-23 |
| JP2017500279A (ja) | 2017-01-05 |
| US20190076372A1 (en) | 2019-03-14 |
| JP6640079B2 (ja) | 2020-02-05 |
| CA2927358A1 (en) | 2015-04-23 |
| US20160235688A1 (en) | 2016-08-18 |
| CN105813721A (zh) | 2016-07-27 |
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