CA2918277C - Indole-3-carbinol derivatives - Google Patents

Indole-3-carbinol derivatives Download PDF

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Publication number
CA2918277C
CA2918277C CA2918277A CA2918277A CA2918277C CA 2918277 C CA2918277 C CA 2918277C CA 2918277 A CA2918277 A CA 2918277A CA 2918277 A CA2918277 A CA 2918277A CA 2918277 C CA2918277 C CA 2918277C
Authority
CA
Canada
Prior art keywords
compound
indole
formula
carboxylic acid
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2918277A
Other languages
English (en)
French (fr)
Other versions
CA2918277A1 (en
Inventor
Rajiv Indravadan Modi
Chandan Hardhan Singh
Niravkumar Sureshbhai SAGAR
Sunilkumar Ramsuratbhai TIVARI
Bipin Dhanajibhai GADHIYA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cadila Pharmaceuticals Ltd
Original Assignee
Cadila Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd filed Critical Cadila Pharmaceuticals Ltd
Publication of CA2918277A1 publication Critical patent/CA2918277A1/en
Application granted granted Critical
Publication of CA2918277C publication Critical patent/CA2918277C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CA2918277A 2013-07-16 2014-07-11 Indole-3-carbinol derivatives Active CA2918277C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2370/MUM/2013 2013-07-16
PCT/IB2014/063031 WO2015008202A1 (en) 2013-07-16 2014-07-11 Indole-3-carbinol derivatives
IN2370MU2013 IN2013MU02370A (https=) 2013-07-16 2014-07-11

Publications (2)

Publication Number Publication Date
CA2918277A1 CA2918277A1 (en) 2015-01-22
CA2918277C true CA2918277C (en) 2021-02-16

Family

ID=52345790

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2918277A Active CA2918277C (en) 2013-07-16 2014-07-11 Indole-3-carbinol derivatives

Country Status (9)

Country Link
US (1) US9708258B2 (https=)
EP (1) EP3022177B1 (https=)
JP (1) JP6293271B2 (https=)
AU (1) AU2014291683B2 (https=)
CA (1) CA2918277C (https=)
EA (1) EA030692B1 (https=)
ES (1) ES2671998T3 (https=)
IN (1) IN2013MU02370A (https=)
WO (1) WO2015008202A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906086A (zh) * 2015-06-24 2015-09-16 安徽四正医药科技有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗肾小球肾炎药物的应用
US20210315909A1 (en) 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
CN113260363A (zh) * 2018-09-27 2021-08-13 阿瑞斯医疗有限公司 格拉普兰特(grapiprant)单位剂型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002060382A (ja) * 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
GB0614068D0 (en) * 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
WO2008144263A1 (en) 2007-05-18 2008-11-27 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents

Also Published As

Publication number Publication date
EP3022177B1 (en) 2018-03-28
WO2015008202A1 (en) 2015-01-22
AU2014291683A1 (en) 2016-02-18
EP3022177A1 (en) 2016-05-25
ES2671998T3 (es) 2018-06-12
CA2918277A1 (en) 2015-01-22
JP2016527226A (ja) 2016-09-08
EA201690236A1 (ru) 2016-07-29
US9708258B2 (en) 2017-07-18
US20160159740A1 (en) 2016-06-09
AU2014291683B2 (en) 2017-11-02
EA030692B1 (ru) 2018-09-28
IN2013MU02370A (https=) 2015-06-19
JP6293271B2 (ja) 2018-03-14

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