CA2916033C - Stabilized pharmaceutical dosage forms comprising atrasentan - Google Patents
Stabilized pharmaceutical dosage forms comprising atrasentan Download PDFInfo
- Publication number
- CA2916033C CA2916033C CA2916033A CA2916033A CA2916033C CA 2916033 C CA2916033 C CA 2916033C CA 2916033 A CA2916033 A CA 2916033A CA 2916033 A CA2916033 A CA 2916033A CA 2916033 C CA2916033 C CA 2916033C
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- weight percent
- atrasentan
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002552 dosage form Substances 0.000 title claims abstract description 518
- MOTJMGVDPWRKOC-QPVYNBJUSA-N atrasentan Chemical compound C1([C@H]2[C@@H]([C@H](CN2CC(=O)N(CCCC)CCCC)C=2C=C3OCOC3=CC=2)C(O)=O)=CC=C(OC)C=C1 MOTJMGVDPWRKOC-QPVYNBJUSA-N 0.000 title claims description 606
- 229950010993 atrasentan Drugs 0.000 title claims description 589
- 150000003839 salts Chemical class 0.000 claims abstract description 311
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 3
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
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| US201361843799P | 2013-07-08 | 2013-07-08 | |
| US61/843,799 | 2013-07-08 | ||
| PCT/US2014/045581 WO2015006219A1 (en) | 2013-07-08 | 2014-07-07 | Stabilized pharmaceutical dosage forms comprising atrasentan |
Publications (2)
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| CA2916033A1 CA2916033A1 (en) | 2015-01-15 |
| CA2916033C true CA2916033C (en) | 2022-08-23 |
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| CA2916033A Active CA2916033C (en) | 2013-07-08 | 2014-07-07 | Stabilized pharmaceutical dosage forms comprising atrasentan |
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| PE20160221A1 (es) * | 2013-07-08 | 2016-05-22 | Abbvie Inc | Formas de dosificacion farmaceuticas estabilizadas que comprenden atrasentan |
| US10929741B2 (en) | 2018-06-18 | 2021-02-23 | University Of Florida Research Foundation, Incorporated | Cross-registration for unclonable chipless RFID tags |
| AU2020404984A1 (en) * | 2019-12-17 | 2022-07-14 | Chinook Therapeutics, Inc. | Methods of treating IgA nephropathy with atrasentan |
| IL297208A (en) * | 2020-04-10 | 2022-12-01 | Chinook Therapeutics Inc | Treatment methods for diabetic kidney disease |
| PH12023550025A1 (en) | 2020-07-10 | 2024-03-11 | Astrazeneca Ab | Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease |
| US12156914B2 (en) * | 2022-06-30 | 2024-12-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising bupropion and cysteine |
| IL320469A (en) | 2022-10-28 | 2025-06-01 | Chinook Therapeutics Inc | Treatment of IGA nephropathy with an endothelin receptor antagonist and an APRIL-binding antibody |
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| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
| US6946481B1 (en) | 1994-08-19 | 2005-09-20 | Abbott Laboratories | Endothelin antagonists |
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| US20030092757A1 (en) | 2001-04-11 | 2003-05-15 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
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| US7297709B2 (en) | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| WO2006034084A1 (en) | 2004-09-17 | 2006-03-30 | Abbott Laboratories | Crystalline form 2 of atrasentan hydrochloride |
| WO2006034094A1 (en) * | 2004-09-17 | 2006-03-30 | Abbott Laboratories | Crystalline form 1 of atrasentan hxdrochloride |
| US9051301B2 (en) | 2004-09-17 | 2015-06-09 | Abbvie Inc. | Crystalline form of a drug |
| US20060135596A1 (en) | 2004-09-17 | 2006-06-22 | Zhang Geoff G | Amorphous form of a drug |
| EP2001446A2 (en) * | 2006-03-13 | 2008-12-17 | Encysive Pharmaceuticals, Inc | Formulations of sitaxsentan sodium |
| US20080132710A1 (en) | 2006-12-04 | 2008-06-05 | Abbott Laboratories | Atrasentan hydrochloride crystalline form 2 |
| US20100184026A1 (en) | 2009-01-22 | 2010-07-22 | Abbott Laboratories | Companion Diagnostic Assays For Endothelin Receptor Antagonists |
| JP5779591B2 (ja) * | 2009-12-22 | 2015-09-16 | アッヴィ・インコーポレイテッド | Ａｂｔ−２６３カプセル剤 |
| KR20110119108A (ko) | 2010-04-26 | 2011-11-02 | 울산대학교 산학협력단 | 포도씨 프로안토시아니딘 추출물을 유효성분으로 함유하는 폐 섬유화증 치료 및 예방용 약학조성물 |
| CN102114005B (zh) * | 2010-12-06 | 2012-12-12 | 武汉武药科技有限公司 | 一种波生坦胶囊及其制备方法 |
| PE20160221A1 (es) * | 2013-07-08 | 2016-05-22 | Abbvie Inc | Formas de dosificacion farmaceuticas estabilizadas que comprenden atrasentan |
| US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
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- 2014-07-07 RU RU2016103764A patent/RU2016103764A/ru not_active Application Discontinuation
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- 2014-07-07 WO PCT/US2014/045581 patent/WO2015006219A1/en not_active Ceased
- 2014-07-07 AU AU2014287496A patent/AU2014287496A1/en not_active Abandoned
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- 2014-07-07 MX MX2016000188A patent/MX2016000188A/es unknown
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Also Published As
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| US10016393B2 (en) | 2018-07-10 |
| US9364458B2 (en) | 2016-06-14 |
| WO2015006219A1 (en) | 2015-01-15 |
| PH12016500042A1 (en) | 2016-03-28 |
| CL2016000027A1 (es) | 2016-07-22 |
| CR20160037A (es) | 2016-04-05 |
| CL2016000788A1 (es) | 2016-11-11 |
| RU2016103764A3 (enExample) | 2018-05-31 |
| IL243242B (en) | 2020-11-30 |
| US20160250186A1 (en) | 2016-09-01 |
| SG11201600107RA (en) | 2016-02-26 |
| CA2916033A1 (en) | 2015-01-15 |
| EP3019158A1 (en) | 2016-05-18 |
| RU2016103764A (ru) | 2017-08-11 |
| DOP2016000003A (es) | 2016-02-15 |
| CN105517541A (zh) | 2016-04-20 |
| US20150011602A1 (en) | 2015-01-08 |
| HK1223825A1 (zh) | 2017-08-11 |
| AU2014287496A1 (en) | 2016-01-07 |
| KR20160029125A (ko) | 2016-03-14 |
| JP2016530238A (ja) | 2016-09-29 |
| MX2016000188A (es) | 2016-03-09 |
| IL243242A0 (en) | 2016-02-29 |
| SG10201700596PA (en) | 2017-02-27 |
| ECSP16005195A (es) | 2017-02-24 |
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