CA2915671A1 - High potency pancreatin pharmaceutical compositions - Google Patents

High potency pancreatin pharmaceutical compositions Download PDF

Info

Publication number
CA2915671A1
CA2915671A1 CA2915671A CA2915671A CA2915671A1 CA 2915671 A1 CA2915671 A1 CA 2915671A1 CA 2915671 A CA2915671 A CA 2915671A CA 2915671 A CA2915671 A CA 2915671A CA 2915671 A1 CA2915671 A1 CA 2915671A1
Authority
CA
Canada
Prior art keywords
pancreatin
solvent
mixture
mpa
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2915671A
Other languages
English (en)
French (fr)
Inventor
Stephen Perrett
Robert Becker
Luigi Boltri
Luigi Ghidorsi
Paola ARZUFFI
Vincenza Pironti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Allergan Pharmaceuticals International Ltd
Aptalis Pharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53042009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2915671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Pharmaceuticals International Ltd, Aptalis Pharma SRL filed Critical Allergan Pharmaceuticals International Ltd
Publication of CA2915671A1 publication Critical patent/CA2915671A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/94—Pancreatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2915671A 2013-11-05 2014-11-05 High potency pancreatin pharmaceutical compositions Pending CA2915671A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361900092P 2013-11-05 2013-11-05
US61/900,092 2013-11-05
PCT/US2014/063984 WO2015069677A1 (en) 2013-11-05 2014-11-05 High potency pancreatin pharmaceutical compositions

Publications (1)

Publication Number Publication Date
CA2915671A1 true CA2915671A1 (en) 2015-05-14

Family

ID=53042009

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2915671A Pending CA2915671A1 (en) 2013-11-05 2014-11-05 High potency pancreatin pharmaceutical compositions

Country Status (13)

Country Link
EP (2) EP3003360B1 (enExample)
JP (1) JP2017500885A (enExample)
KR (1) KR20170052520A (enExample)
CN (1) CN106659773A (enExample)
AU (1) AU2014346930A1 (enExample)
BR (1) BR112016000658A2 (enExample)
CA (1) CA2915671A1 (enExample)
ES (1) ES2834483T3 (enExample)
HK (1) HK1222325A1 (enExample)
IL (3) IL243435B (enExample)
MX (1) MX2016000480A (enExample)
RU (1) RU2015155470A (enExample)
WO (1) WO2015069677A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
PT2079445E (pt) 2007-02-20 2016-02-29 Allergan Pharmaceuticals Internat Ltd Composições de enzimas digestivas estáveis
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
EA029101B1 (ru) 2010-10-01 2018-02-28 Апталис Фарма Лимитид Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием
CA2843556A1 (en) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
CA2919114A1 (en) 2013-07-22 2015-02-12 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions
EP3639846B1 (en) 2013-08-09 2022-09-28 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
EP3157568A1 (en) * 2014-06-19 2017-04-26 Aptalis Pharma Limited Methods for removing viral contaminants from pancreatic extracts

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751330A (en) * 1952-08-27 1956-06-19 Armour & Co Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material
GB928654A (en) 1960-10-25 1963-06-12 Philips Nv Improvements in or relating to the production of pancreatin
US3168448A (en) 1963-01-07 1965-02-02 Wilson & Co Inc Process of preparing a lipolytic enzyme composition
DE2460334C3 (de) * 1974-12-20 1979-09-06 Hoechst Ag, 6000 Frankfurt Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas
DE3377506D1 (en) * 1982-12-30 1988-09-01 Nordmark Arzneimittel Gmbh Process for obtaining pancreatin
FR2603804B1 (fr) * 1986-09-17 1989-10-27 Jouveinal Sa Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique
DE3927286C2 (de) * 1989-08-18 1997-07-24 Roehm Gmbh Wäßrige Enzym-Flüssigformulierungen
DE69634248T2 (de) 1995-05-31 2006-01-12 Medzyme N.V. Zusammensetzungen zur verbesserung der verdaulichkeit und ausnutzung von nähestoffen
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
DE19724845A1 (de) * 1996-08-28 1998-03-05 Solvay Pharm Gmbh Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
US20010046493A1 (en) 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
CA2419572A1 (en) * 2003-02-18 2004-08-18 Axcan Pharma Inc. High dosage protease formulation
US20060198838A1 (en) * 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
DK1809320T3 (da) * 2004-10-14 2010-11-15 Cystic Fibrosis Foundation The Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens
PL2278002T3 (pl) 2005-07-29 2017-12-29 Abbott Laboratories Gmbh Pankreatyna o zmniejszonej zawartości wirusowej
PT2079445E (pt) * 2007-02-20 2016-02-29 Allergan Pharmaceuticals Internat Ltd Composições de enzimas digestivas estáveis
KR20130050923A (ko) * 2010-03-19 2013-05-16 앱탈리스 파마 캐나다 아이엔씨. 위 내성 효소 제약 조성물
CN102946872A (zh) * 2010-05-03 2013-02-27 阿普塔利斯制药有限公司 包含含有胰酶的消化酶混合物的微丸组合物
EA029101B1 (ru) * 2010-10-01 2018-02-28 Апталис Фарма Лимитид Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием
CN103060297B (zh) * 2012-12-28 2014-06-25 青岛九龙生物医药有限公司 一种分离纯化胰蛋白酶的方法
CN103060296B (zh) * 2012-12-30 2014-05-21 青岛九龙生物医药有限公司 从动物胰脏中提取胰蛋白酶的方法
CA2919114A1 (en) 2013-07-22 2015-02-12 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions

Also Published As

Publication number Publication date
IL274583A (en) 2020-06-30
EP3003360B1 (en) 2020-10-07
ES2834483T3 (es) 2021-06-17
EP3003360A4 (en) 2017-04-26
KR20170052520A (ko) 2017-05-12
CN106659773A (zh) 2017-05-10
AU2014346930A1 (en) 2016-01-07
EP3003360A1 (en) 2016-04-13
MX2016000480A (es) 2016-10-21
RU2015155470A3 (enExample) 2018-09-10
IL274583B (en) 2022-06-01
IL243435B (en) 2020-06-30
IL243435A0 (en) 2016-03-31
JP2017500885A (ja) 2017-01-12
EP3613429A1 (en) 2020-02-26
BR112016000658A2 (pt) 2018-03-20
WO2015069677A1 (en) 2015-05-14
RU2015155470A (ru) 2017-08-21
HK1222325A1 (zh) 2017-06-30
IL284419A (en) 2021-07-29

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