CN106659773A - 高效的胰酶药物组合物 - Google Patents
高效的胰酶药物组合物 Download PDFInfo
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- CN106659773A CN106659773A CN201480040273.7A CN201480040273A CN106659773A CN 106659773 A CN106659773 A CN 106659773A CN 201480040273 A CN201480040273 A CN 201480040273A CN 106659773 A CN106659773 A CN 106659773A
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- Prior art keywords
- pancreatin
- solvent
- methods according
- lipase
- mixture
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- 239000003760 tallow Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940032021 tetramune Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 238000007805 zymography Methods 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/94—Pancreatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900092P | 2013-11-05 | 2013-11-05 | |
| US61/900,092 | 2013-11-05 | ||
| PCT/US2014/063984 WO2015069677A1 (en) | 2013-11-05 | 2014-11-05 | High potency pancreatin pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106659773A true CN106659773A (zh) | 2017-05-10 |
Family
ID=53042009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480040273.7A Pending CN106659773A (zh) | 2013-11-05 | 2014-11-05 | 高效的胰酶药物组合物 |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP3613429A1 (enExample) |
| JP (1) | JP2017500885A (enExample) |
| KR (1) | KR20170052520A (enExample) |
| CN (1) | CN106659773A (enExample) |
| AU (1) | AU2014346930A1 (enExample) |
| BR (1) | BR112016000658A2 (enExample) |
| CA (1) | CA2915671A1 (enExample) |
| ES (1) | ES2834483T3 (enExample) |
| HK (1) | HK1222325A1 (enExample) |
| IL (3) | IL243435B (enExample) |
| MX (1) | MX2016000480A (enExample) |
| RU (1) | RU2015155470A (enExample) |
| WO (1) | WO2015069677A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| EP2079445B1 (en) | 2007-02-20 | 2015-11-04 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
| WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
| EP2621476B8 (en) | 2010-10-01 | 2020-12-23 | Société des Produits Nestlé S.A. | Enteric coated, low-strength pancrelipase formulations |
| RU2602183C2 (ru) | 2011-08-08 | 2016-11-10 | Апталис Фарма Лтд. | Способ проведения теста на растворение твердых композиций, содержащих пищеварительные ферменты |
| US10184121B2 (en) | 2013-06-28 | 2019-01-22 | Allergan Pharmaceuticals International Limited | Methods for removing viral contaminants from pancreatic extracts |
| ES2743212T5 (es) | 2013-07-22 | 2023-04-25 | Allergan Pharmaceuticals Int Ltd | Métodos para preparar pancreatina |
| WO2015020943A2 (en) | 2013-08-09 | 2015-02-12 | Aptalis Pharma Ltd. | Digestive enzyme composition suitable for enteral administration |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1487837A (zh) * | 2001-01-19 | 2004-04-07 | ������ҩ������˾ | 新的微生物酶混合物 |
| CN102883712A (zh) * | 2010-03-19 | 2013-01-16 | 加拿大阿普塔利斯制药公司 | 耐胃液酶药物组合物 |
| CN102946872A (zh) * | 2010-05-03 | 2013-02-27 | 阿普塔利斯制药有限公司 | 包含含有胰酶的消化酶混合物的微丸组合物 |
| CN103060296A (zh) * | 2012-12-30 | 2013-04-24 | 青岛九龙生物医药有限公司 | 从动物胰脏中提取胰蛋白酶的方法 |
| CN103060297A (zh) * | 2012-12-28 | 2013-04-24 | 青岛九龙生物医药有限公司 | 一种分离纯化胰蛋白酶的方法 |
| CN105392496A (zh) * | 2013-07-22 | 2016-03-09 | 阿普塔利斯制药有限公司 | 高效的胰酶药物组合物 |
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| US2751330A (en) * | 1952-08-27 | 1956-06-19 | Armour & Co | Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material |
| GB928654A (en) | 1960-10-25 | 1963-06-12 | Philips Nv | Improvements in or relating to the production of pancreatin |
| US3168448A (en) | 1963-01-07 | 1965-02-02 | Wilson & Co Inc | Process of preparing a lipolytic enzyme composition |
| DE2460334C3 (de) * | 1974-12-20 | 1979-09-06 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas |
| DE3377506D1 (en) * | 1982-12-30 | 1988-09-01 | Nordmark Arzneimittel Gmbh | Process for obtaining pancreatin |
| FR2603804B1 (fr) * | 1986-09-17 | 1989-10-27 | Jouveinal Sa | Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique |
| DE3927286C2 (de) * | 1989-08-18 | 1997-07-24 | Roehm Gmbh | Wäßrige Enzym-Flüssigformulierungen |
| US6051220A (en) | 1995-05-31 | 2000-04-18 | Medzyme N.V. And Simon Lodewijk Scharpe | Composition to improve digestibility and utilization of nutrients |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| DE19724845A1 (de) * | 1996-08-28 | 1998-03-05 | Solvay Pharm Gmbh | Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen |
| US20010046493A1 (en) | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| CA2419572A1 (en) * | 2003-02-18 | 2004-08-18 | Axcan Pharma Inc. | High dosage protease formulation |
| US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
| HUE031245T2 (en) | 2004-10-14 | 2017-06-28 | Lilly Co Eli | Preparations containing lipase, protease and amylase for the treatment of pancreatic insufficiency |
| MX2008000850A (es) | 2005-07-29 | 2008-03-18 | Solvay Pharm Gmbh | Procedimientos para la fabricacion de polvo de pancreatina esterilizada. |
| EP2079445B1 (en) * | 2007-02-20 | 2015-11-04 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
| EP2621476B8 (en) * | 2010-10-01 | 2020-12-23 | Société des Produits Nestlé S.A. | Enteric coated, low-strength pancrelipase formulations |
-
2014
- 2014-11-05 MX MX2016000480A patent/MX2016000480A/es unknown
- 2014-11-05 CA CA2915671A patent/CA2915671A1/en active Pending
- 2014-11-05 AU AU2014346930A patent/AU2014346930A1/en not_active Abandoned
- 2014-11-05 CN CN201480040273.7A patent/CN106659773A/zh active Pending
- 2014-11-05 BR BR112016000658A patent/BR112016000658A2/pt not_active Application Discontinuation
- 2014-11-05 EP EP19201877.8A patent/EP3613429A1/en not_active Withdrawn
- 2014-11-05 RU RU2015155470A patent/RU2015155470A/ru not_active Application Discontinuation
- 2014-11-05 HK HK16110490.6A patent/HK1222325A1/zh unknown
- 2014-11-05 WO PCT/US2014/063984 patent/WO2015069677A1/en not_active Ceased
- 2014-11-05 EP EP14859866.7A patent/EP3003360B1/en not_active Revoked
- 2014-11-05 ES ES14859866T patent/ES2834483T3/es active Active
- 2014-11-05 JP JP2016552457A patent/JP2017500885A/ja active Pending
- 2014-11-05 KR KR1020167001052A patent/KR20170052520A/ko not_active Withdrawn
-
2015
- 2015-12-31 IL IL243435A patent/IL243435B/en active IP Right Grant
-
2020
- 2020-05-11 IL IL274583A patent/IL274583B/en unknown
-
2021
- 2021-06-27 IL IL284419A patent/IL284419A/en unknown
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| CN102883712A (zh) * | 2010-03-19 | 2013-01-16 | 加拿大阿普塔利斯制药公司 | 耐胃液酶药物组合物 |
| CN102946872A (zh) * | 2010-05-03 | 2013-02-27 | 阿普塔利斯制药有限公司 | 包含含有胰酶的消化酶混合物的微丸组合物 |
| CN103060297A (zh) * | 2012-12-28 | 2013-04-24 | 青岛九龙生物医药有限公司 | 一种分离纯化胰蛋白酶的方法 |
| CN103060296A (zh) * | 2012-12-30 | 2013-04-24 | 青岛九龙生物医药有限公司 | 从动物胰脏中提取胰蛋白酶的方法 |
| CN105392496A (zh) * | 2013-07-22 | 2016-03-09 | 阿普塔利斯制药有限公司 | 高效的胰酶药物组合物 |
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112016000658A2 (pt) | 2018-03-20 |
| JP2017500885A (ja) | 2017-01-12 |
| MX2016000480A (es) | 2016-10-21 |
| EP3613429A1 (en) | 2020-02-26 |
| IL274583B (en) | 2022-06-01 |
| CA2915671A1 (en) | 2015-05-14 |
| IL274583A (en) | 2020-06-30 |
| IL243435B (en) | 2020-06-30 |
| IL243435A0 (en) | 2016-03-31 |
| EP3003360A4 (en) | 2017-04-26 |
| EP3003360A1 (en) | 2016-04-13 |
| WO2015069677A1 (en) | 2015-05-14 |
| KR20170052520A (ko) | 2017-05-12 |
| EP3003360B1 (en) | 2020-10-07 |
| ES2834483T3 (es) | 2021-06-17 |
| HK1222325A1 (zh) | 2017-06-30 |
| RU2015155470A3 (enExample) | 2018-09-10 |
| AU2014346930A1 (en) | 2016-01-07 |
| RU2015155470A (ru) | 2017-08-21 |
| IL284419A (en) | 2021-07-29 |
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| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Perrett Stephen Inventor after: Robert Bacal Inventor after: Luigi Boltry Inventor after: GHIDORSI LUIGI Inventor after: Paula Arzufi Inventor after: Vincenza Pironti Inventor before: Perrett Stephen Inventor before: Robert Bacal Inventor before: Luigi Boltry Inventor before: GHIDORSI LUIGI Inventor before: Paula Arzufi Inventor before: Vincenza Pironti Inventor before: Michael Throtha Inventor before: William Ward |
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Address after: Irish Dublin Applicant after: APTALIS PHARMA LTD. Address before: Vic County, Ireland Applicant before: APTALIS PHARMA LTD. |