KR20170052520A - 고효능 판크레아틴 약학적 조성물 - Google Patents
고효능 판크레아틴 약학적 조성물 Download PDFInfo
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- KR20170052520A KR20170052520A KR1020167001052A KR20167001052A KR20170052520A KR 20170052520 A KR20170052520 A KR 20170052520A KR 1020167001052 A KR1020167001052 A KR 1020167001052A KR 20167001052 A KR20167001052 A KR 20167001052A KR 20170052520 A KR20170052520 A KR 20170052520A
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- Prior art keywords
- pancreatin
- solvent
- lipase
- buffer
- mixture
- Prior art date
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 108010020708 plasmepsin Proteins 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
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- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 229940034796 ultresa Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
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- 239000011719 vitamin A Substances 0.000 description 1
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- 239000011710 vitamin D Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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- 238000007805 zymography Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/94—Pancreatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900092P | 2013-11-05 | 2013-11-05 | |
| US61/900,092 | 2013-11-05 | ||
| PCT/US2014/063984 WO2015069677A1 (en) | 2013-11-05 | 2014-11-05 | High potency pancreatin pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20170052520A true KR20170052520A (ko) | 2017-05-12 |
Family
ID=53042009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167001052A Withdrawn KR20170052520A (ko) | 2013-11-05 | 2014-11-05 | 고효능 판크레아틴 약학적 조성물 |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP3003360B1 (enExample) |
| JP (1) | JP2017500885A (enExample) |
| KR (1) | KR20170052520A (enExample) |
| CN (1) | CN106659773A (enExample) |
| AU (1) | AU2014346930A1 (enExample) |
| BR (1) | BR112016000658A2 (enExample) |
| CA (1) | CA2915671A1 (enExample) |
| ES (1) | ES2834483T3 (enExample) |
| HK (1) | HK1222325A1 (enExample) |
| IL (3) | IL243435B (enExample) |
| MX (1) | MX2016000480A (enExample) |
| RU (1) | RU2015155470A (enExample) |
| WO (1) | WO2015069677A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| PT2079445E (pt) | 2007-02-20 | 2016-02-29 | Allergan Pharmaceuticals Internat Ltd | Composições de enzimas digestivas estáveis |
| WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
| EA029101B1 (ru) | 2010-10-01 | 2018-02-28 | Апталис Фарма Лимитид | Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием |
| CA2843556A1 (en) | 2011-08-08 | 2013-02-14 | Aptalis Pharma Ltd. | Method for dissolution testing of solid compositions containing digestive enzymes |
| CA2919114A1 (en) | 2013-07-22 | 2015-02-12 | Aptalis Pharma Ltd. | High potency pancreatin pharmaceutical compositions |
| EP3639846B1 (en) | 2013-08-09 | 2022-09-28 | Allergan Pharmaceuticals International Limited | Digestive enzyme composition suitable for enteral administration |
| EP3157568A1 (en) * | 2014-06-19 | 2017-04-26 | Aptalis Pharma Limited | Methods for removing viral contaminants from pancreatic extracts |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2751330A (en) * | 1952-08-27 | 1956-06-19 | Armour & Co | Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material |
| GB928654A (en) | 1960-10-25 | 1963-06-12 | Philips Nv | Improvements in or relating to the production of pancreatin |
| US3168448A (en) | 1963-01-07 | 1965-02-02 | Wilson & Co Inc | Process of preparing a lipolytic enzyme composition |
| DE2460334C3 (de) * | 1974-12-20 | 1979-09-06 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas |
| DE3377506D1 (en) * | 1982-12-30 | 1988-09-01 | Nordmark Arzneimittel Gmbh | Process for obtaining pancreatin |
| FR2603804B1 (fr) * | 1986-09-17 | 1989-10-27 | Jouveinal Sa | Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique |
| DE3927286C2 (de) * | 1989-08-18 | 1997-07-24 | Roehm Gmbh | Wäßrige Enzym-Flüssigformulierungen |
| DE69634248T2 (de) | 1995-05-31 | 2006-01-12 | Medzyme N.V. | Zusammensetzungen zur verbesserung der verdaulichkeit und ausnutzung von nähestoffen |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| DE19724845A1 (de) * | 1996-08-28 | 1998-03-05 | Solvay Pharm Gmbh | Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen |
| US20010046493A1 (en) | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CA2419572A1 (en) * | 2003-02-18 | 2004-08-18 | Axcan Pharma Inc. | High dosage protease formulation |
| US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
| DK1809320T3 (da) * | 2004-10-14 | 2010-11-15 | Cystic Fibrosis Foundation The | Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens |
| PL2278002T3 (pl) | 2005-07-29 | 2017-12-29 | Abbott Laboratories Gmbh | Pankreatyna o zmniejszonej zawartości wirusowej |
| PT2079445E (pt) * | 2007-02-20 | 2016-02-29 | Allergan Pharmaceuticals Internat Ltd | Composições de enzimas digestivas estáveis |
| KR20130050923A (ko) * | 2010-03-19 | 2013-05-16 | 앱탈리스 파마 캐나다 아이엔씨. | 위 내성 효소 제약 조성물 |
| CN102946872A (zh) * | 2010-05-03 | 2013-02-27 | 阿普塔利斯制药有限公司 | 包含含有胰酶的消化酶混合物的微丸组合物 |
| EA029101B1 (ru) * | 2010-10-01 | 2018-02-28 | Апталис Фарма Лимитид | Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием |
| CN103060297B (zh) * | 2012-12-28 | 2014-06-25 | 青岛九龙生物医药有限公司 | 一种分离纯化胰蛋白酶的方法 |
| CN103060296B (zh) * | 2012-12-30 | 2014-05-21 | 青岛九龙生物医药有限公司 | 从动物胰脏中提取胰蛋白酶的方法 |
| CA2919114A1 (en) | 2013-07-22 | 2015-02-12 | Aptalis Pharma Ltd. | High potency pancreatin pharmaceutical compositions |
-
2014
- 2014-11-05 EP EP14859866.7A patent/EP3003360B1/en not_active Revoked
- 2014-11-05 RU RU2015155470A patent/RU2015155470A/ru not_active Application Discontinuation
- 2014-11-05 HK HK16110490.6A patent/HK1222325A1/zh unknown
- 2014-11-05 MX MX2016000480A patent/MX2016000480A/es unknown
- 2014-11-05 EP EP19201877.8A patent/EP3613429A1/en not_active Withdrawn
- 2014-11-05 BR BR112016000658A patent/BR112016000658A2/pt not_active Application Discontinuation
- 2014-11-05 KR KR1020167001052A patent/KR20170052520A/ko not_active Withdrawn
- 2014-11-05 CN CN201480040273.7A patent/CN106659773A/zh active Pending
- 2014-11-05 CA CA2915671A patent/CA2915671A1/en active Pending
- 2014-11-05 JP JP2016552457A patent/JP2017500885A/ja active Pending
- 2014-11-05 ES ES14859866T patent/ES2834483T3/es active Active
- 2014-11-05 WO PCT/US2014/063984 patent/WO2015069677A1/en not_active Ceased
- 2014-11-05 AU AU2014346930A patent/AU2014346930A1/en not_active Abandoned
-
2015
- 2015-12-31 IL IL243435A patent/IL243435B/en active IP Right Grant
-
2020
- 2020-05-11 IL IL274583A patent/IL274583B/en unknown
-
2021
- 2021-06-27 IL IL284419A patent/IL284419A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL274583A (en) | 2020-06-30 |
| EP3003360B1 (en) | 2020-10-07 |
| ES2834483T3 (es) | 2021-06-17 |
| EP3003360A4 (en) | 2017-04-26 |
| CN106659773A (zh) | 2017-05-10 |
| AU2014346930A1 (en) | 2016-01-07 |
| CA2915671A1 (en) | 2015-05-14 |
| EP3003360A1 (en) | 2016-04-13 |
| MX2016000480A (es) | 2016-10-21 |
| RU2015155470A3 (enExample) | 2018-09-10 |
| IL274583B (en) | 2022-06-01 |
| IL243435B (en) | 2020-06-30 |
| IL243435A0 (en) | 2016-03-31 |
| JP2017500885A (ja) | 2017-01-12 |
| EP3613429A1 (en) | 2020-02-26 |
| BR112016000658A2 (pt) | 2018-03-20 |
| WO2015069677A1 (en) | 2015-05-14 |
| RU2015155470A (ru) | 2017-08-21 |
| HK1222325A1 (zh) | 2017-06-30 |
| IL284419A (en) | 2021-07-29 |
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| PA0105 | International application |
Patent event date: 20160114 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |