CA2915426A1 - Suppression of itch - Google Patents
Suppression of itch Download PDFInfo
- Publication number
- CA2915426A1 CA2915426A1 CA2915426A CA2915426A CA2915426A1 CA 2915426 A1 CA2915426 A1 CA 2915426A1 CA 2915426 A CA2915426 A CA 2915426A CA 2915426 A CA2915426 A CA 2915426A CA 2915426 A1 CA2915426 A1 CA 2915426A1
- Authority
- CA
- Canada
- Prior art keywords
- itch
- polypeptide
- protease
- pruriceptor
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 210000003901 trigeminal nerve Anatomy 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21072—IgA-specific serine endopeptidase (3.4.21.72)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24013—IgA-specific metalloendopeptidase (3.4.24.13)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1312295.7A GB201312295D0 (en) | 2013-07-09 | 2013-07-09 | Suppression of itch |
| GB1312295.7 | 2013-07-09 | ||
| PCT/GB2014/052101 WO2015004464A1 (en) | 2013-07-09 | 2014-07-09 | Suppression of itch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2915426A1 true CA2915426A1 (en) | 2015-01-15 |
Family
ID=49033545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2915426A Abandoned CA2915426A1 (en) | 2013-07-09 | 2014-07-09 | Suppression of itch |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160137999A1 (es) |
| EP (1) | EP3019241B1 (es) |
| JP (2) | JP6675306B2 (es) |
| KR (1) | KR102181505B1 (es) |
| CN (1) | CN105492074A (es) |
| AU (1) | AU2014288956B2 (es) |
| CA (1) | CA2915426A1 (es) |
| EA (1) | EA201690193A1 (es) |
| ES (1) | ES2682679T3 (es) |
| GB (1) | GB201312295D0 (es) |
| MX (1) | MX369006B (es) |
| SG (1) | SG11201510578PA (es) |
| UA (1) | UA118197C2 (es) |
| WO (1) | WO2015004464A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201814045A (zh) | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
| CN109790204A (zh) | 2016-09-29 | 2019-05-21 | 益普生生物制药有限公司 | 杂合神经毒素 |
| EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778634B2 (en) * | 2004-12-01 | 2014-07-15 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| GB0610867D0 (en) * | 2006-06-01 | 2006-07-12 | Syntaxin Ltd | Treatment of pain |
| GB0820970D0 (en) * | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| GB0903006D0 (en) * | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
| CN102574900A (zh) * | 2009-08-14 | 2012-07-11 | 阿勒根公司 | 使用阿片样物质再靶向内肽酶治疗癌症的方法 |
| AU2010353292A1 (en) * | 2009-12-16 | 2012-07-12 | Allergan, Inc. | Modified Clostridial toxins comprising an integrated protease cleavage site-binding domain |
| US9504671B2 (en) * | 2010-02-26 | 2016-11-29 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| SG184497A1 (en) * | 2010-04-12 | 2012-11-29 | Somalogic Inc | 5-position modified pyrimidines and their use |
| GB201108108D0 (en) * | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
-
2013
- 2013-07-09 GB GBGB1312295.7A patent/GB201312295D0/en not_active Ceased
-
2014
- 2014-07-09 EA EA201690193A patent/EA201690193A1/ru unknown
- 2014-07-09 CA CA2915426A patent/CA2915426A1/en not_active Abandoned
- 2014-07-09 CN CN201480039346.0A patent/CN105492074A/zh active Pending
- 2014-07-09 WO PCT/GB2014/052101 patent/WO2015004464A1/en active Application Filing
- 2014-07-09 AU AU2014288956A patent/AU2014288956B2/en not_active Ceased
- 2014-07-09 EP EP14739923.2A patent/EP3019241B1/en not_active Not-in-force
- 2014-07-09 MX MX2015017489A patent/MX369006B/es active IP Right Grant
- 2014-07-09 JP JP2016524895A patent/JP6675306B2/ja not_active Expired - Fee Related
- 2014-07-09 SG SG11201510578PA patent/SG11201510578PA/en unknown
- 2014-07-09 US US14/900,892 patent/US20160137999A1/en not_active Abandoned
- 2014-07-09 ES ES14739923.2T patent/ES2682679T3/es active Active
- 2014-07-09 KR KR1020167003023A patent/KR102181505B1/ko active IP Right Grant
- 2014-09-07 UA UAA201601114A patent/UA118197C2/uk unknown
-
2018
- 2018-04-27 US US15/964,969 patent/US20180298367A1/en not_active Abandoned
-
2019
- 2019-11-19 JP JP2019208885A patent/JP2020039349A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| UA118197C2 (uk) | 2018-12-10 |
| EP3019241A1 (en) | 2016-05-18 |
| GB201312295D0 (en) | 2013-08-21 |
| KR102181505B1 (ko) | 2020-11-23 |
| MX369006B (es) | 2019-10-24 |
| KR20160030392A (ko) | 2016-03-17 |
| SG11201510578PA (en) | 2016-01-28 |
| MX2015017489A (es) | 2016-07-28 |
| CN105492074A (zh) | 2016-04-13 |
| JP2020039349A (ja) | 2020-03-19 |
| EA201690193A1 (ru) | 2016-05-31 |
| ES2682679T3 (es) | 2018-09-21 |
| EP3019241B1 (en) | 2018-05-30 |
| US20180298367A1 (en) | 2018-10-18 |
| AU2014288956B2 (en) | 2019-10-24 |
| AU2014288956A1 (en) | 2016-02-11 |
| US20160137999A1 (en) | 2016-05-19 |
| JP2016528889A (ja) | 2016-09-23 |
| WO2015004464A1 (en) | 2015-01-15 |
| JP6675306B2 (ja) | 2020-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190423 |
|
| FZDE | Discontinued |
Effective date: 20220907 |
|
| FZDE | Discontinued |
Effective date: 20220907 |