CA2911567C - Implant et methode de production d'un implant par decellularisation d'untissu sous perfusion en pression negative - Google Patents
Implant et methode de production d'un implant par decellularisation d'untissu sous perfusion en pression negative Download PDFInfo
- Publication number
- CA2911567C CA2911567C CA2911567A CA2911567A CA2911567C CA 2911567 C CA2911567 C CA 2911567C CA 2911567 A CA2911567 A CA 2911567A CA 2911567 A CA2911567 A CA 2911567A CA 2911567 C CA2911567 C CA 2911567C
- Authority
- CA
- Canada
- Prior art keywords
- implant
- tissue
- producing
- negative pressure
- under negative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3662—Ligaments, tendons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Rehabilitation Therapy (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La présente invention concerne un procédé de production d'un implant à partir de tissu interstitiel, conjonctif ou de support, le procédé comprenant au moins une étape de perfusion du tissu avec au moins un milieu de décellularisation sous pression négative appliquée pendant sensiblement toute la période de perfusion.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1310773.5A GB201310773D0 (en) | 2013-06-17 | 2013-06-17 | Implant and method of producing an implant |
GB1310773.5 | 2013-06-17 | ||
PCT/GB2014/051845 WO2014202958A1 (fr) | 2013-06-17 | 2014-06-16 | Implant et procédé de production d'un implant |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2911567A1 CA2911567A1 (fr) | 2014-12-24 |
CA2911567C true CA2911567C (fr) | 2018-10-23 |
Family
ID=48914690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2911567A Active CA2911567C (fr) | 2013-06-17 | 2014-06-16 | Implant et methode de production d'un implant par decellularisation d'untissu sous perfusion en pression negative |
Country Status (11)
Country | Link |
---|---|
US (1) | US9950095B2 (fr) |
EP (1) | EP3010558B1 (fr) |
JP (1) | JP6505088B2 (fr) |
KR (3) | KR102128863B1 (fr) |
CN (1) | CN105392506B (fr) |
AU (1) | AU2014283031B2 (fr) |
CA (1) | CA2911567C (fr) |
ES (1) | ES2821763T3 (fr) |
GB (1) | GB201310773D0 (fr) |
HK (1) | HK1219239A1 (fr) |
WO (1) | WO2014202958A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9999707B2 (en) * | 2014-03-04 | 2018-06-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Method for decellularization of tissue |
GB201409858D0 (en) * | 2014-06-03 | 2014-07-16 | Ucl Business Plc | Human liver scaffolds |
WO2017136950A1 (fr) * | 2016-02-12 | 2017-08-17 | University Of Ottawa | Structures de parois cellulaires décellularisées provenant de plantes et de champignons et leur utilisation comme matériaux d'échafaudage |
GB2549110A (en) * | 2016-04-05 | 2017-10-11 | Northwick Park Inst For Medical Res Ltd | Tissue scaffolds |
GB2554635A (en) | 2016-08-03 | 2018-04-11 | Northwick Park Institute For Medical Res Ltd | Bioreactors and methods for processing biological material |
WO2019154991A1 (fr) | 2018-02-09 | 2019-08-15 | Motherson Innovations Company Ltd. | Appareil d'impression 3d monté sur robot |
EP3941497A4 (fr) * | 2019-03-21 | 2022-12-21 | Miromatrix Medical Inc. | Décellularisation améliorée d'organes isolés |
CN111084904B (zh) * | 2019-12-31 | 2022-02-11 | 中南大学湘雅医院 | 一种组织工程支架的脱细胞方法 |
CN111643735B (zh) * | 2020-06-10 | 2022-05-13 | 中南大学湘雅二医院 | 脱细胞异种小血管的制备方法 |
CN111905148A (zh) * | 2020-07-22 | 2020-11-10 | 扬州大学 | 一种真空辅助快速制备无免疫原性兔脱细胞气管基质方法 |
CN112190758A (zh) * | 2020-09-17 | 2021-01-08 | 扬州大学 | 一种快速制备脱细胞气管支架的方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5556379A (en) * | 1994-08-19 | 1996-09-17 | Lifenet Research Foundation | Process for cleaning large bone grafts and bone grafts produced thereby |
US8043854B2 (en) * | 2003-05-15 | 2011-10-25 | Waseda University | Method of decellularizing tissues |
PL1928519T3 (pl) * | 2005-08-26 | 2012-08-31 | Univ Minnesota | Decelularyzacja i recelularyzacja narządów i tkanek |
KR100816395B1 (ko) * | 2006-09-21 | 2008-03-27 | (주)필미아젠 | 세포 유래 세포외기질막의 제조방법 |
KR20110102923A (ko) * | 2008-12-31 | 2011-09-19 | 케이씨아이 라이센싱 인코포레이티드 | 조직 성장을 자극하기 위해 유체 흐름을 유도하는 시스템 |
CA2818514A1 (fr) * | 2009-11-17 | 2011-05-26 | Harvard Bioscience, Inc. | Bioreacteurs, systemes, et procedes de production et/ou d'analyse d'organes |
JP2011127586A (ja) * | 2009-11-19 | 2011-06-30 | Sanden Corp | 遠心式送風機の多翼ファン |
CA2835862A1 (fr) * | 2011-05-27 | 2012-12-06 | Cormatrix Cardiovascular, Inc. | Conduit de valve de materiau de matrice extracellulaire et ses procedes de fabrication |
CN103987392A (zh) * | 2011-09-02 | 2014-08-13 | Adeka株式会社 | 脱细胞化组织制品的制备方法、及具备脱细胞化组织制品的移植片 |
US9290738B2 (en) * | 2012-06-13 | 2016-03-22 | Miromatrix Medical Inc. | Methods of decellularizing bone |
-
2013
- 2013-06-17 GB GBGB1310773.5A patent/GB201310773D0/en not_active Ceased
-
2014
- 2014-06-16 KR KR1020187026894A patent/KR102128863B1/ko active IP Right Grant
- 2014-06-16 EP EP14737308.8A patent/EP3010558B1/fr active Active
- 2014-06-16 KR KR1020177036136A patent/KR20170142211A/ko active Application Filing
- 2014-06-16 WO PCT/GB2014/051845 patent/WO2014202958A1/fr active Application Filing
- 2014-06-16 US US14/892,529 patent/US9950095B2/en active Active
- 2014-06-16 CN CN201480032234.2A patent/CN105392506B/zh active Active
- 2014-06-16 AU AU2014283031A patent/AU2014283031B2/en active Active
- 2014-06-16 ES ES14737308T patent/ES2821763T3/es active Active
- 2014-06-16 KR KR1020167001191A patent/KR20160021256A/ko active Search and Examination
- 2014-06-16 JP JP2016518589A patent/JP6505088B2/ja active Active
- 2014-06-16 CA CA2911567A patent/CA2911567C/fr active Active
-
2016
- 2016-06-22 HK HK16107247.8A patent/HK1219239A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2911567A1 (fr) | 2014-12-24 |
HK1219239A1 (zh) | 2017-03-31 |
JP2016521611A (ja) | 2016-07-25 |
AU2014283031B2 (en) | 2016-09-15 |
US9950095B2 (en) | 2018-04-24 |
KR20180105274A (ko) | 2018-09-27 |
GB201310773D0 (en) | 2013-07-31 |
ES2821763T3 (es) | 2021-04-27 |
EP3010558B1 (fr) | 2020-04-29 |
KR102128863B1 (ko) | 2020-07-01 |
KR20160021256A (ko) | 2016-02-24 |
JP6505088B2 (ja) | 2019-04-24 |
CN105392506B (zh) | 2018-02-02 |
CN105392506A (zh) | 2016-03-09 |
KR20170142211A (ko) | 2017-12-27 |
US20160095956A1 (en) | 2016-04-07 |
AU2014283031A1 (en) | 2016-01-21 |
WO2014202958A1 (fr) | 2014-12-24 |
EP3010558A1 (fr) | 2016-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20151106 |