CA2910328C - Skin substitutes and methods for hair follicle neogenesis - Google Patents

Skin substitutes and methods for hair follicle neogenesis Download PDF

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Publication number
CA2910328C
CA2910328C CA2910328A CA2910328A CA2910328C CA 2910328 C CA2910328 C CA 2910328C CA 2910328 A CA2910328 A CA 2910328A CA 2910328 A CA2910328 A CA 2910328A CA 2910328 C CA2910328 C CA 2910328C
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Canada
Prior art keywords
cells
skin
dermal
hair
human
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Active
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CA2910328A
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English (en)
French (fr)
Other versions
CA2910328A1 (en
Inventor
Rajesh Thangapazham
Thomas N. Darling
Shaowei Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Original Assignee
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
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Publication of CA2910328A1 publication Critical patent/CA2910328A1/en
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Publication of CA2910328C publication Critical patent/CA2910328C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2910328A 2013-05-03 2014-05-01 Skin substitutes and methods for hair follicle neogenesis Active CA2910328C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361819332P 2013-05-03 2013-05-03
US61/819,332 2013-05-03
PCT/US2014/036351 WO2014179559A1 (en) 2013-05-03 2014-05-01 Skin substitutes and methods for hair follicle neogenesis

Publications (2)

Publication Number Publication Date
CA2910328A1 CA2910328A1 (en) 2014-11-06
CA2910328C true CA2910328C (en) 2019-10-22

Family

ID=50896543

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2910328A Active CA2910328C (en) 2013-05-03 2014-05-01 Skin substitutes and methods for hair follicle neogenesis

Country Status (6)

Country Link
US (1) US10478526B2 (https=)
EP (1) EP2991692B1 (https=)
JP (1) JP6469655B2 (https=)
AU (2) AU2014259787B2 (https=)
CA (1) CA2910328C (https=)
WO (1) WO2014179559A1 (https=)

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EP3117263B1 (en) * 2014-03-14 2018-05-09 Sony Interactive Entertainment Inc. Methods and systems tracking head mounted display (hmd) and calibrations for hmd headband adjustments
AU2015287978B2 (en) 2014-07-09 2021-04-29 Sanford-Burnham Medical Research Institute Methods and compositions to modulate hair growth
WO2016115034A1 (en) * 2015-01-12 2016-07-21 Wake Forest University Health Sciences Multi-layer skin substitute products and methods of making and using the same
EP3072535B1 (fr) * 2015-03-26 2017-03-01 Université de Bordeaux Procédé de reconstruction de peau
US10865373B2 (en) 2015-10-30 2020-12-15 National University Corporation Yokohama National University Regenerated hair follicle primordium aggregation manufacturing method, hair follicle tissue-containing sheet, and method for manufacturing hair follicle tissue-containing sheet
DE102015119877B4 (de) * 2015-11-17 2017-09-21 Technische Universität Berlin Verfahren zur Herstellung eines Hautäquivalents sowie dessen Verwendung für in vitro Tests und in vivo Transplantate
WO2017145162A1 (en) 2016-02-23 2017-08-31 Chaya Brodie Generation of cancer stem cells and use thereof
JP7044330B2 (ja) * 2016-06-17 2022-03-30 国立大学法人横浜国立大学 毛髪再生用細胞包埋ビーズ及びその製造方法、並びに毛髪再生用キット
JPWO2017221870A1 (ja) * 2016-06-21 2019-04-11 株式会社オーガンテクノロジーズ 毛包、皮脂腺、および毛穴を有する人工皮膚の製造方法
JP2019535705A (ja) * 2016-11-10 2019-12-12 オルガノボ インコーポレイテッド バイオプリントされた毛包およびその使用
WO2019215557A1 (en) * 2018-05-07 2019-11-14 Reelabs Pvt. Ltd. The method of autologous primary hair follicles preparation in 3d culture
JP7142840B2 (ja) * 2018-05-16 2022-09-28 国立大学法人横浜国立大学 細胞含有ハイドロゲル体及びその製造方法
JP7702229B2 (ja) * 2018-11-19 2025-07-03 株式会社 資生堂 毛包を有するヒト皮膚組織を再構成するための組成物、ヒト皮膚組織モデル動物およびその製造方法
EP3967749A4 (en) * 2019-05-07 2023-05-03 National University Corporation Yokohama National University HAIR FOLLICLE PLANTS AND PROCEDURES FOR THEIR MANUFACTURE
KR102224079B1 (ko) * 2020-08-31 2021-03-05 한국화학연구원 산업부생가스로부터 일산화탄소 회수 시스템 및 회수 방법
US20240240143A1 (en) * 2021-05-27 2024-07-18 The University Of Hong Kong Bioengineered dermal papilla and hair follicles and related products, methods and applications

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US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
GB8604360D0 (en) 1986-02-21 1986-03-26 Univ Dundee Stimulation of hair growth
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
FI924773L (fi) 1990-04-24 1992-10-21 Mark Eisenberg Kompositionssubstituter av levande hud
US5693332C1 (en) 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
SE9701162D0 (sv) 1997-03-27 1997-03-27 Karolinska Innovations Ab New use II
US5968546A (en) 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US5989837A (en) 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
EP2295540A1 (en) 1998-11-19 2011-03-16 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using them
WO2001074164A1 (en) 2000-03-31 2001-10-11 The General Hospital Corporation Methods of modulating hair growth
DE60126815T2 (de) 2000-12-08 2007-11-15 Xgene Corp., San Carlos Herstellung von geschichteten und nach zelltyp geordneten geweben in vitro
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
WO2003055990A2 (en) 2001-12-21 2003-07-10 Pharmagap Inc. Method for culturing and expansion of mammalian undifferentiated epidermal keratinocytes exhibiting stem cell characteristics
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Also Published As

Publication number Publication date
US20160184481A1 (en) 2016-06-30
US10478526B2 (en) 2019-11-19
WO2014179559A1 (en) 2014-11-06
AU2018201536B2 (en) 2019-08-22
CA2910328A1 (en) 2014-11-06
AU2014259787A1 (en) 2015-11-12
AU2014259787B2 (en) 2018-03-08
JP6469655B2 (ja) 2019-02-13
AU2018201536A1 (en) 2018-03-22
EP2991692A1 (en) 2016-03-09
JP2016522682A (ja) 2016-08-04
EP2991692B1 (en) 2019-08-21

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