CA2909117A1 - The treatment of inflammatory disorders - Google Patents
The treatment of inflammatory disordersInfo
- Publication number
- CA2909117A1 CA2909117A1 CA2909117A CA2909117A CA2909117A1 CA 2909117 A1 CA2909117 A1 CA 2909117A1 CA 2909117 A CA2909117 A CA 2909117A CA 2909117 A CA2909117 A CA 2909117A CA 2909117 A1 CA2909117 A1 CA 2909117A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- disease
- use according
- nalidixic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000027866 inflammatory disease Diseases 0.000 title claims abstract description 15
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| GB201306413A GB201306413D0 (en) | 2013-04-09 | 2013-04-09 | The local treatment of ophthalmic diseases |
| GB1306411.8 | 2013-04-09 | ||
| GB201306411A GB201306411D0 (en) | 2013-04-09 | 2013-04-09 | Treatment of inflammatory conditions |
| PCT/GB2014/051109 WO2014167327A1 (en) | 2013-04-09 | 2014-04-09 | The treatment of inflammatory disorders |
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| CN108348516B (zh) * | 2015-10-29 | 2021-02-12 | 特一华制药株式会社 | 外用剂 |
| AU2017336765B2 (en) | 2016-09-28 | 2023-06-08 | Medicon Pharmaceuticals, Inc. | Compositions and methods for treating ophthalmic conditions |
| WO2020021035A1 (en) * | 2018-07-26 | 2020-01-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of antibiotics for the treatment of immunoglobulin a nephropathy |
| EP3921309A1 (en) * | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Quinolin-4-one and 4(1h)-cinnolinone compounds and methods of using same |
| WO2021050649A1 (en) * | 2019-09-11 | 2021-03-18 | Adverum Biotechnologies, Inc. | Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept |
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| DE19729879C2 (de) * | 1997-07-11 | 1999-07-08 | Mann Gerhard Chem Pharm Fab | Lagerstabile ophthalmische Zusammensetzungen, umfassend Diclofenac und Ofloxacin |
| DE19826050A1 (de) * | 1998-06-12 | 1999-12-16 | Bayer Ag | Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester |
| CN1090959C (zh) * | 1999-06-17 | 2002-09-18 | 卢世全 | 一种治疗咳喘病的中、西复方成药及制备方法 |
| US6552020B1 (en) * | 1999-07-30 | 2003-04-22 | Allergan, Inc. | Compositions including antibiotics and methods for using same |
| JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
| JP3648132B2 (ja) * | 2000-06-19 | 2005-05-18 | 大正薬品工業株式会社 | キノロン系抗菌薬液体製剤及びその包装体 |
| WO2003004098A1 (en) * | 2001-07-06 | 2003-01-16 | Sucampo Ag | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| AUPS017702A0 (en) * | 2002-01-25 | 2002-02-14 | Atopic Pty Ltd | Methods and compositions for the treatment of asthma and related disorders |
| RU2424792C2 (ru) * | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| PL2489659T3 (pl) * | 2004-06-24 | 2018-06-29 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą atp |
| JP2006028031A (ja) * | 2004-07-12 | 2006-02-02 | Ltt Bio-Pharma Co Ltd | 経粘膜吸収用薬物封入ナノ粒子 |
| WO2006039336A2 (en) * | 2004-10-01 | 2006-04-13 | Ramscor, Inc. | Conveniently implantable sustained release drug compositions |
| JP2009518312A (ja) * | 2005-12-02 | 2009-05-07 | ヘルス エンハンスメント プロダクツ インク | 疾患を治療するための植物浸出物の組成物および使用 |
| US20080138350A1 (en) * | 2006-10-20 | 2008-06-12 | Bennett Michael D | Process for use of fluoroquinolones to reduce or modulate inflammation due to eye disease or ophthalmic surgery |
| CN101129386A (zh) * | 2007-07-17 | 2008-02-27 | 长治市三宝生化药业有限公司 | 一种含环丙沙星和地塞米松的局部悬浮滴眼剂 |
| WO2009037855A1 (ja) * | 2007-09-21 | 2009-03-26 | Nihon Kodoiryo Kenkyukai Co., Ltd. | 口腔用及び皮膚用組成物 |
| GB0719518D0 (en) * | 2007-10-05 | 2007-11-14 | Therapeutics Ltd E | Therapy |
| CA2711957C (en) * | 2007-10-11 | 2019-03-19 | The Regents Of The University Of California | Use of inhibitors of n-acylethanolamine-hydrolyzing acid amidase as anti-inflamatory medicaments |
| MX342183B (es) * | 2008-09-09 | 2016-09-20 | Allergan Inc | Suspension oftalmica para uso ocular. |
| CA2739893C (en) * | 2008-10-07 | 2016-10-04 | Mpex Pharmaceuticals, Inc. | Inhalation of levofloxacin for reducing lung inflammation |
| EP2467138A4 (en) * | 2009-08-19 | 2013-11-06 | Mpex Pharmaceuticals Inc | USE OF AEROSOLIZED ANTIBIOTICS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE |
| EP2515907A1 (en) * | 2009-12-22 | 2012-10-31 | Deutsches Krebsforschungszentrum | Fluoroquinolones for the treatment and/or prophylaxis of inflammatory diseases |
| MX346312B (es) * | 2011-04-05 | 2017-03-15 | Optosolve Res & Dev Ltd | Tratamientos oftalmicos. |
-
2014
- 2014-04-09 WO PCT/GB2014/051109 patent/WO2014167327A1/en not_active Ceased
- 2014-04-09 CA CA2909117A patent/CA2909117A1/en not_active Abandoned
- 2014-04-09 WO PCT/GB2014/051108 patent/WO2014167326A1/en not_active Ceased
- 2014-04-09 RU RU2015145134A patent/RU2015145134A/ru not_active Application Discontinuation
- 2014-04-09 AU AU2014252807A patent/AU2014252807A1/en not_active Abandoned
- 2014-04-09 US US14/783,038 patent/US20160051526A1/en not_active Abandoned
- 2014-04-09 CA CA2909111A patent/CA2909111A1/en not_active Abandoned
- 2014-04-09 GB GB1406390.3A patent/GB2516137B/en active Active
- 2014-04-09 CN CN201480030407.7A patent/CN105431172A/zh active Pending
- 2014-04-09 US US14/782,975 patent/US20160068527A1/en not_active Abandoned
- 2014-04-09 CN CN201480030418.5A patent/CN105555364A/zh active Pending
- 2014-04-09 EP EP14717821.4A patent/EP2983713A1/en not_active Withdrawn
- 2014-04-09 RU RU2015145135A patent/RU2015145135A/ru not_active Application Discontinuation
- 2014-04-09 HK HK16109376.7A patent/HK1221190A1/zh unknown
- 2014-04-09 HK HK16109377.6A patent/HK1221166A1/zh unknown
- 2014-04-09 JP JP2016507058A patent/JP2016516761A/ja active Pending
- 2014-04-09 JP JP2016507059A patent/JP2016516762A/ja active Pending
- 2014-04-09 GB GB1406396.0A patent/GB2516138C/en active Active
- 2014-04-09 EP EP14717820.6A patent/EP2983788A1/en not_active Withdrawn
- 2014-04-09 AU AU2014252808A patent/AU2014252808A1/en not_active Abandoned
-
2015
- 2015-10-15 ZA ZA201507718A patent/ZA201507718B/en unknown
- 2015-10-15 ZA ZA2015/07724A patent/ZA201507724B/en unknown
Also Published As
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|---|---|
| RU2015145134A3 (enExample) | 2018-03-16 |
| GB2516138A (en) | 2015-01-14 |
| HK1221166A1 (zh) | 2017-05-26 |
| GB201406390D0 (en) | 2014-05-21 |
| RU2015145135A (ru) | 2017-05-12 |
| WO2014167327A1 (en) | 2014-10-16 |
| CA2909111A1 (en) | 2014-10-16 |
| US20160051526A1 (en) | 2016-02-25 |
| JP2016516762A (ja) | 2016-06-09 |
| ZA201507724B (en) | 2019-02-27 |
| CN105555364A (zh) | 2016-05-04 |
| GB2516138B (en) | 2015-11-25 |
| HK1221190A1 (zh) | 2017-05-26 |
| EP2983713A1 (en) | 2016-02-17 |
| JP2016516761A (ja) | 2016-06-09 |
| EP2983788A1 (en) | 2016-02-17 |
| RU2015145134A (ru) | 2017-05-16 |
| US20160068527A1 (en) | 2016-03-10 |
| AU2014252808A1 (en) | 2015-11-12 |
| CN105431172A (zh) | 2016-03-23 |
| GB2516138C (en) | 2015-12-09 |
| ZA201507718B (en) | 2019-11-27 |
| GB2516137A (en) | 2015-01-14 |
| WO2014167326A1 (en) | 2014-10-16 |
| GB2516137B (en) | 2016-02-17 |
| GB201406396D0 (en) | 2014-05-21 |
| AU2014252807A1 (en) | 2015-11-12 |
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