CA2908815A1 - Drug combinations to treat cancer - Google Patents
Drug combinations to treat cancerInfo
- Publication number
- CA2908815A1 CA2908815A1 CA2908815A CA2908815A CA2908815A1 CA 2908815 A1 CA2908815 A1 CA 2908815A1 CA 2908815 A CA2908815 A CA 2908815A CA 2908815 A CA2908815 A CA 2908815A CA 2908815 A1 CA2908815 A1 CA 2908815A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- administered
- dose
- fasting
- once daily
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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Landscapes
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| PCT/US2014/033008 WO2014165779A1 (en) | 2013-04-04 | 2014-04-04 | Drug combinations to treat cancer |
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| CA2908815A1 true CA2908815A1 (en) | 2014-10-09 |
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| EP (1) | EP2983639A1 (enExample) |
| JP (1) | JP2016515628A (enExample) |
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| CA (1) | CA2908815A1 (enExample) |
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| NZ779754A (en) | 2009-01-16 | 2023-04-28 | Exelixis Inc | Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl] oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| MX352926B (es) | 2010-09-27 | 2017-12-14 | Exelixis Inc | Inhibidores dobles de met y factor de crecimiento endotelial vascular (vegf) para el tratamiento de cancer de prostata resistente a la castracion y metastasis osteoblasticas en los huesos. |
| AR085155A1 (es) | 2011-02-10 | 2013-09-11 | Exelixis Inc | Procesos para preparar compuestos de quinolina y composiciones farmaceuticas que contienen dichos compuestos |
| WO2013166296A1 (en) | 2012-05-02 | 2013-11-07 | Exelixis, Inc. | A dual met - vegf modulator for treating osteolytic bone metastases |
| GEP20196995B (en) | 2013-03-15 | 2019-07-25 | Inc Exelixis | Metabolites of n-(4-{[6,7-bis (methyloxy)quinolin-4-yl] oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide |
| EP2981263B1 (en) | 2013-04-04 | 2022-06-29 | Exelixis, Inc. | Cabozantinib dosage form and use in the treatment of cancer |
| WO2015123639A1 (en) | 2014-02-14 | 2015-08-20 | Exelixis, Inc. | Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use |
| US10159666B2 (en) | 2014-03-17 | 2018-12-25 | Exelixis, Inc. | Dosing of cabozantinib formulations |
| CN106715397B (zh) | 2014-07-31 | 2021-07-23 | 埃克塞里艾克西斯公司 | 制备氟-18标记的卡博替尼及其类似物的方法 |
| AU2015301097B2 (en) | 2014-08-05 | 2021-03-04 | Exelixis, Inc. | Drug combinations to treat multiple myeloma |
| CA3020749A1 (en) | 2016-04-15 | 2017-10-19 | Exelixis, Inc. | Method of treating renal cell carcinoma using n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluoropheny)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate |
| MA47310A (fr) * | 2017-01-20 | 2019-11-27 | Exelixis Inc | Combinaisons de cabozantinib et d'atzolizumab pour traiter le cancer |
| WO2019143908A1 (en) * | 2018-01-19 | 2019-07-25 | Indiana University Research And Technology Corporation | Therapeutic targeting of receptor tyrosine kinase inhibitor-induced androgen receptor phosphorylation in cancer |
| HRP20251184T1 (hr) | 2018-01-26 | 2025-12-05 | Exelixis, Inc. | Spojevi za liječenje poremećaja ovisnih o kinazi |
| AU2019285066B2 (en) | 2018-06-15 | 2024-06-13 | Handa Pharmaceuticals, Inc. | Kinase inhibitor salts and compositions thereof |
| WO2020059744A1 (ja) * | 2018-09-18 | 2020-03-26 | 大鵬薬品工業株式会社 | アシルチオウレア化合物とアビラテロンの併用療法 |
| CN120417903A (zh) | 2023-01-31 | 2025-08-01 | 汉达癌症医药责任有限公司 | 改良的卡博替尼组合物及其使用方法 |
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| SI2392564T1 (sl) * | 2003-09-26 | 2014-02-28 | Exelixis, Inc. | c-Met modulatorji in postopki uporabe |
| AU2005270068B2 (en) * | 2004-07-02 | 2012-04-19 | Exelixis, Inc. | C-Met modulators and method of use |
| CN104306977A (zh) * | 2006-08-25 | 2015-01-28 | 库伽尔生物科技公司 | 治疗癌症的方法和组合物 |
| WO2008083319A1 (en) | 2006-12-29 | 2008-07-10 | Il Yang Pharmaceutical Company, Ltd. | Solid state forms of enantiopure ilaprazole |
| NZ779754A (en) * | 2009-01-16 | 2023-04-28 | Exelixis Inc | Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl] oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer |
| AU2010274012A1 (en) * | 2009-07-17 | 2012-02-09 | Exelixis, Inc. | Crystalline forms of N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy] -quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide |
| UA108618C2 (uk) * | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| MX352926B (es) * | 2010-09-27 | 2017-12-14 | Exelixis Inc | Inhibidores dobles de met y factor de crecimiento endotelial vascular (vegf) para el tratamiento de cancer de prostata resistente a la castracion y metastasis osteoblasticas en los huesos. |
| CN103664778B (zh) * | 2013-11-27 | 2017-04-05 | 苏州摩尔医药有限公司 | 一种抗肿瘤治疗药物卡博替尼的合成方法 |
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- 2014-04-04 CA CA2908815A patent/CA2908815A1/en not_active Abandoned
- 2014-04-04 BR BR112015025408A patent/BR112015025408A8/pt not_active IP Right Cessation
- 2014-04-04 US US14/782,493 patent/US20160082019A1/en not_active Abandoned
- 2014-04-04 HK HK16109729.1A patent/HK1221424A1/zh unknown
- 2014-04-04 AU AU2014248001A patent/AU2014248001A1/en not_active Abandoned
- 2014-04-04 WO PCT/US2014/033008 patent/WO2014165779A1/en not_active Ceased
- 2014-04-04 CN CN201480029297.2A patent/CN108472242A/zh active Pending
- 2014-04-04 KR KR1020157030445A patent/KR20150138268A/ko not_active Withdrawn
- 2014-04-04 JP JP2016506653A patent/JP2016515628A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150138268A (ko) | 2015-12-09 |
| AU2014248001A1 (en) | 2015-11-19 |
| JP2016515628A (ja) | 2016-05-30 |
| EP2983639A1 (en) | 2016-02-17 |
| WO2014165779A1 (en) | 2014-10-09 |
| MX2015014046A (es) | 2016-05-16 |
| BR112015025408A8 (pt) | 2018-07-10 |
| CN108472242A (zh) | 2018-08-31 |
| BR112015025408A2 (pt) | 2017-07-18 |
| HK1221424A1 (zh) | 2017-06-02 |
| US20160082019A1 (en) | 2016-03-24 |
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