CA2904447C - Therapy for complications of diabetes - Google Patents

Therapy for complications of diabetes Download PDF

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Publication number
CA2904447C
CA2904447C CA2904447A CA2904447A CA2904447C CA 2904447 C CA2904447 C CA 2904447C CA 2904447 A CA2904447 A CA 2904447A CA 2904447 A CA2904447 A CA 2904447A CA 2904447 C CA2904447 C CA 2904447C
Authority
CA
Canada
Prior art keywords
angiotensin
converting enzyme
enzyme inhibitor
receptor blocker
diabetic nephropathy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2904447A
Other languages
English (en)
French (fr)
Other versions
CA2904447A1 (en
Inventor
Robert L. Roden
Richard J. Gorczynski
Michael J. Gerber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Deutschland GmbH and Co KG
Original Assignee
AbbVie Deutschland GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AbbVie Deutschland GmbH and Co KG filed Critical AbbVie Deutschland GmbH and Co KG
Publication of CA2904447A1 publication Critical patent/CA2904447A1/en
Application granted granted Critical
Publication of CA2904447C publication Critical patent/CA2904447C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2904447A 2007-08-22 2008-08-22 Therapy for complications of diabetes Expired - Fee Related CA2904447C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95730007P 2007-08-22 2007-08-22
US60/957,300 2007-08-22
CA2697057A CA2697057A1 (en) 2007-08-22 2008-08-22 Therapy for complications of diabetes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2697057A Division CA2697057A1 (en) 2007-08-22 2008-08-22 Therapy for complications of diabetes

Publications (2)

Publication Number Publication Date
CA2904447A1 CA2904447A1 (en) 2009-02-26
CA2904447C true CA2904447C (en) 2017-01-03

Family

ID=40220116

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2904447A Expired - Fee Related CA2904447C (en) 2007-08-22 2008-08-22 Therapy for complications of diabetes
CA2697057A Abandoned CA2697057A1 (en) 2007-08-22 2008-08-22 Therapy for complications of diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2697057A Abandoned CA2697057A1 (en) 2007-08-22 2008-08-22 Therapy for complications of diabetes

Country Status (5)

Country Link
US (5) US20090054473A1 (enExample)
EP (2) EP2190433A2 (enExample)
JP (5) JP2010536880A (enExample)
CA (2) CA2904447C (enExample)
WO (1) WO2009026517A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070196510A1 (en) * 2006-02-17 2007-08-23 Gerber Michael J Method for treating resistant hypertension
JP2010535210A (ja) 2007-07-31 2010-11-18 ギリード・コロラド・インコーポレーテッド アンブリセンタンの代謝産物および誘導体
WO2009026517A2 (en) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapy for complications of diabetes
CN101632672B (zh) * 2008-07-24 2011-01-12 鲁南制药集团股份有限公司 一种用于治疗高血压的复方药物组合物
ES2562957T3 (es) * 2009-04-30 2016-03-09 Midwestern University Método y composición para el tratamiento de la cetoacidosis diabética
US9255931B2 (en) 2010-06-24 2016-02-09 Morehouse School Of Medicine Method and compositions for the treatment and detection of endothelin-1 related kidney diseases
EP2727587A1 (en) * 2012-10-30 2014-05-07 Pharnext Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
KR20160003128A (ko) 2013-04-30 2016-01-08 애브비 인코포레이티드 아트라센탄을 사용하는 지질 프로파일을 개선시키기 위한 방법
JO3624B1 (ar) * 2014-05-08 2020-08-27 Lilly Co Eli تركيبات إنسولين سريعة المفعول
WO2016073846A1 (en) * 2014-11-07 2016-05-12 Abbvie Inc. Methods of treating ckd using predictors of fluid retention
JO3749B1 (ar) * 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
US10369156B2 (en) * 2016-11-15 2019-08-06 The George Institute for Global Health Compositions for the treatment of hypertension
US12521380B2 (en) 2017-01-25 2026-01-13 The George Institute for Global Health Compositions for the treatment of hypertension
ES2940316T3 (es) 2017-01-25 2023-05-05 The George Inst For Global Health Composiciones para el tratamiento de la hipertensión
US11174247B2 (en) * 2017-02-27 2021-11-16 Idorsia Pharmaceuticals Ltd Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases
US20190260657A1 (en) * 2018-02-21 2019-08-22 Cisco Technology, Inc. In-band performance loss measurement in ipv6/srv6 software defined networks
ES2978951T3 (es) * 2018-05-03 2024-09-23 Univ Midwestern Composición que comprende centaquina o una sal de la misma para su uso en el tratamiento de un individuo que padece disminución aguda de la función renal
US20210186930A1 (en) * 2018-05-23 2021-06-24 University Of Miami Methods of Treating Renal Disease Associated With Chronic Kidney Disease Such as Alport Syndrome
KR20210038931A (ko) * 2018-07-26 2021-04-08 더 조지 인스티튜트 포 글로벌 헬스 고혈압 치료용 조성물
CA3158767A1 (en) * 2019-10-30 2021-05-06 Perfuse Therapeutics, Inc. Treatment of ocular diseases using endothelin receptor antagonists
CN116173014A (zh) 2019-12-17 2023-05-30 奇努克医疗公司 用阿曲生坦治疗IgA肾病的方法
WO2022009163A1 (en) 2020-07-10 2022-01-13 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease
MX2023012723A (es) 2021-04-30 2024-02-08 Perfuse Therapeutics Inc Composiciones farmacéuticas y sistemas de administración de medicamentos intravítreos para el tratamiento de enfermedades oculares.
CN116804048B (zh) * 2023-02-24 2024-11-15 中国农业大学 豌豆白蛋白分离肽、组合物及其用途

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ285522B6 (cs) * 1993-06-24 1999-08-11 Eli Lilly And Company Farmaceutický prostředek pro snížení koncentrace glukosy v krvi
EP0647449A1 (en) * 1993-06-24 1995-04-12 Takeda Chemical Industries, Ltd. Sustained-release preparation of anti-endothelin substance
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
US6946481B1 (en) * 1994-08-19 2005-09-20 Abbott Laboratories Endothelin antagonists
US7365093B2 (en) * 1994-08-19 2008-04-29 Abbott Laboratories Endothelin antagonists
DK0776324T3 (da) 1994-08-19 2002-10-07 Abbott Lab Endothelin-antagonister
US6162927A (en) * 1994-08-19 2000-12-19 Abbott Laboratories Endothelin antagonists
US7208517B1 (en) * 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
BR9707509A (pt) 1996-02-13 1999-07-27 Abbott Lab Composto composto farmacêutica e processos para antagonizar endotelina para tratar hipertensão insuficiência cardiaca congestiva congestiva restenose emseguida a lessão arterial isquemia cerebral ou miocárdica ou aterosclerose angina coronariana vasosespasmo cerebral insuficiência renal aguda e crônica ulceração gástrica nefrotoxicidade induzida por ciclosporina toxicidade induzida por endotoxina asma distúrbio da lipoproteina relacionados com lpl doenças proliferatives hipertensão pulmonar aguda ou cronica agregação plaquetaria tombose cardiotoxiadade mediada por il-2 noncicepção colite disturbio da permeabulidade vascilar lesão por reperfusão-isquemia doença deraynaud e enxaqueca e para a preparar um composto.
US6420412B2 (en) * 1996-03-29 2002-07-16 Smithkline Beecham Corporation Eprosartan dihydate and a process for its production and formulation
US6121416A (en) * 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
HUP0003484A3 (en) 1997-08-04 2002-02-28 Abbott Lab Pyrrolidine-3-crboxylic acid derivatives and their use as endothelin antagonists
US7445792B2 (en) * 2003-03-10 2008-11-04 Abbott Laboratories Medical device having a hydration inhibitor
US8257725B2 (en) * 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
CN1187050C (zh) 1997-09-26 2005-02-02 克诺尔有限公司 内皮素拮抗剂和血管紧张肽原酶-血管紧张肽系统抑制剂的联合体系
DE19743143A1 (de) 1997-09-30 1999-04-01 Knoll Ag Pharmazeutische Kombinationspräparate
DE19743142A1 (de) 1997-09-30 1999-04-01 Knoll Ag Pharmazeutische Kombinationspräparate
DE19743140A1 (de) 1997-09-30 1999-04-01 Knoll Ag Pharmazeutische Kombinationspräparate
DE19744799A1 (de) 1997-10-10 1999-04-15 Knoll Ag Pharmazeutische Kombinationspräparate
DE19754082A1 (de) 1997-12-05 1999-06-10 Knoll Ag Methode zur Bekämpfung der Fettleibigkeit
JP2002524546A (ja) 1998-09-14 2002-08-06 アボット・ラボラトリーズ 立体選択性ニトロ化合物の製造方法
US8257724B2 (en) * 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6238708B1 (en) * 1999-02-23 2001-05-29 The Iams Company Composition and process for controlling glucose metabolism in companion animals by dietary starch
US6559188B1 (en) * 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
TWI306760B (en) 2000-08-07 2009-03-01 Abbott Lab Use of an endothelin et-a receptor antagonist and orally delivered pharmaceutical composition comprising the same
US20020055457A1 (en) * 2000-08-07 2002-05-09 Janus Todd J. Methods of treating cancer and the pain associated therewith using endothelin antagonists
WO2002017912A1 (en) 2000-08-31 2002-03-07 Abbott Laboratories Endothelin antagonists
CN1514727A (zh) 2001-04-11 2004-07-21 ���Ͽع����޹�˾ 在前列腺癌患者中与健康相关的生活质量和与健康相关的质量-调节时间对疾病的进展的有利调节
US20030022811A1 (en) * 2001-04-11 2003-01-30 Amitabh Singh Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer
US20030092757A1 (en) * 2001-04-11 2003-05-15 Amitabh Singh Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer
CN1304415C (zh) * 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物
WO2003080038A1 (en) * 2002-03-22 2003-10-02 Kissei Pharmaceutical Co., Ltd. Preventive or therapeutic agent for kidney disease
GB0212412D0 (en) * 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
CL2004000545A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul
NZ549784A (en) * 2004-02-11 2008-06-30 Fibrogen Inc Inhibitors of CTGF the manufacture of a medicament for the treatment of diabetic nephropathy
CA2558020A1 (en) * 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
CA2559747C (en) * 2004-03-19 2013-12-31 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
WO2006034084A1 (en) 2004-09-17 2006-03-30 Abbott Laboratories Crystalline form 2 of atrasentan hydrochloride
US9051301B2 (en) * 2004-09-17 2015-06-09 Abbvie Inc. Crystalline form of a drug
WO2006034085A1 (en) 2004-09-17 2006-03-30 Abbott Laboratories Crystalline form of atrasentan hydrochloride
US20060189675A1 (en) * 2004-09-17 2006-08-24 Steve King Crystalline form of a drug
WO2006126695A1 (ja) * 2005-05-23 2006-11-30 Japan Tobacco Inc. ピラゾール化合物及びそれらピラゾール化合物を含んでなる糖尿病治療薬
US20080132710A1 (en) * 2006-12-04 2008-06-05 Abbott Laboratories Atrasentan hydrochloride crystalline form 2
WO2009026517A2 (en) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapy for complications of diabetes
US20100184026A1 (en) * 2009-01-22 2010-07-22 Abbott Laboratories Companion Diagnostic Assays For Endothelin Receptor Antagonists

Also Published As

Publication number Publication date
WO2009026517A3 (en) 2009-05-28
JP2014001234A (ja) 2014-01-09
US20150051234A1 (en) 2015-02-19
JP2015028062A (ja) 2015-02-12
US20170079978A1 (en) 2017-03-23
US9592231B2 (en) 2017-03-14
EP2545920A1 (en) 2013-01-16
WO2009026517A2 (en) 2009-02-26
JP2010536880A (ja) 2010-12-02
CA2904447A1 (en) 2009-02-26
EP2190433A2 (en) 2010-06-02
US20090054473A1 (en) 2009-02-26
US20140073574A1 (en) 2014-03-13
US20130178424A1 (en) 2013-07-11
JP2017145251A (ja) 2017-08-24
US8623819B2 (en) 2014-01-07
CA2697057A1 (en) 2009-02-26
US8865650B2 (en) 2014-10-21
JP2016053057A (ja) 2016-04-14

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