CA2898619C - Dosage forms and therapeutic uses of l-4-chlorokynurenine - Google Patents

Dosage forms and therapeutic uses of l-4-chlorokynurenine Download PDF

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Publication number
CA2898619C
CA2898619C CA2898619A CA2898619A CA2898619C CA 2898619 C CA2898619 C CA 2898619C CA 2898619 A CA2898619 A CA 2898619A CA 2898619 A CA2898619 A CA 2898619A CA 2898619 C CA2898619 C CA 2898619C
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CA
Canada
Prior art keywords
chlorokynurenine
administration
days
pharmaceutical composition
treating depression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2898619A
Other languages
English (en)
French (fr)
Other versions
CA2898619A1 (en
Inventor
H. Ralph Snodgrass
Allen E. Cato
Jack S. Hicklin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vistagen Therapeutics Inc
Original Assignee
Vistagen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vistagen Therapeutics Inc filed Critical Vistagen Therapeutics Inc
Priority to CA3128321A priority Critical patent/CA3128321C/en
Publication of CA2898619A1 publication Critical patent/CA2898619A1/en
Application granted granted Critical
Publication of CA2898619C publication Critical patent/CA2898619C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Lubricants (AREA)
  • Quinoline Compounds (AREA)
CA2898619A 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine Active CA2898619C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3128321A CA3128321C (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361849191P 2013-01-22 2013-01-22
US61/849,191 2013-01-22
PCT/US2014/012598 WO2014116739A1 (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses l-4-chlorokynurenine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3128321A Division CA3128321C (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine

Publications (2)

Publication Number Publication Date
CA2898619A1 CA2898619A1 (en) 2014-07-31
CA2898619C true CA2898619C (en) 2021-10-19

Family

ID=51228003

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2898619A Active CA2898619C (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine
CA3216579A Pending CA3216579A1 (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine
CA3128321A Active CA3128321C (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3216579A Pending CA3216579A1 (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine
CA3128321A Active CA3128321C (en) 2013-01-22 2014-01-22 Dosage forms and therapeutic uses of l-4-chlorokynurenine

Country Status (22)

Country Link
US (8) US9993450B2 (OSRAM)
EP (4) EP3228313B1 (OSRAM)
JP (5) JP6436913B2 (OSRAM)
KR (5) KR102335919B1 (OSRAM)
CN (4) CN112933073A (OSRAM)
AU (5) AU2014209466B2 (OSRAM)
BR (1) BR112015017535A2 (OSRAM)
CA (3) CA2898619C (OSRAM)
CY (1) CY1122403T1 (OSRAM)
DK (3) DK2948140T3 (OSRAM)
ES (3) ES2635353T3 (OSRAM)
HK (1) HK1217170A1 (OSRAM)
HR (2) HRP20240812T1 (OSRAM)
HU (1) HUE067381T2 (OSRAM)
IL (3) IL291831A (OSRAM)
MX (2) MX375318B (OSRAM)
PL (2) PL3228313T3 (OSRAM)
PT (3) PT2948140T (OSRAM)
RS (1) RS59687B1 (OSRAM)
SI (2) SI3228313T1 (OSRAM)
WO (1) WO2014116739A1 (OSRAM)
ZA (2) ZA201505569B (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3228313T1 (sl) 2013-01-22 2019-12-31 Vistagen Therapeutics, Inc. Odmerne oblike in terapevtske uporabe L-4-klorokinurenina
KR20240068766A (ko) * 2015-05-22 2024-05-17 비스타젠 쎄라퓨틱스, 인크. L-4-클로로키누레닌의 치료적 용도
CA2996308A1 (en) * 2015-09-08 2017-03-16 Cephalon, Inc. Prodrugs of chlorokynurenines
CN112236412B (zh) 2018-02-09 2024-01-30 维斯塔津治疗公司 4-氯代犬尿氨酸及中间体的合成
CN109223785A (zh) * 2018-10-29 2019-01-18 中国药科大学 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用
WO2022082100A1 (en) * 2020-10-16 2022-04-21 Vistagen Therapeutics, Inc. Cocrystals of l-4-chlorokynurenine, compositions and therapeutic uses thereof

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US5086072A (en) 1990-06-18 1992-02-04 The United States Of America As Represented By The Department Of Health And Human Services Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex
US5484814A (en) 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5360814A (en) 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5763393A (en) 1996-05-17 1998-06-09 Neurotherapeutics L.P. Neuroactive peptides
TW518218B (en) 1999-05-27 2003-01-21 Merck Patent Gmbh Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
WO2003015713A2 (en) 2001-08-20 2003-02-27 Maiken Nedergaard Treatment of glial tumors with glutamate antagonists
WO2004022069A1 (en) 2002-09-06 2004-03-18 Durect Corporation Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
KR20090004950A (ko) 2006-04-12 2009-01-12 프로비오드룩 아게 효소 억제제
EP1903028A1 (en) * 2006-09-22 2008-03-26 Werner Tschollar Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects
US8058243B2 (en) 2006-10-13 2011-11-15 Hsc Research And Development Limited Partnership Method for treating a brain cancer with ifenprodil
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
WO2009135091A1 (en) * 2008-04-30 2009-11-05 Medivation Technologies, Inc. Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions
US20110190347A1 (en) * 2008-08-21 2011-08-04 Richter Gedeon Nyrt. Methods for treating neuropathic pain
DK2421519T3 (en) 2009-04-23 2017-02-06 Univ Zuerich NMDA RECEPTOR BLOCKERS FOR THE TREATMENT OF SEAL CELL ANAEMS
CA2763551A1 (en) * 2009-06-17 2010-12-23 Targacept, Inc. Reversal of l-dopa-induced dyskinesia by neuronal nicotinic receptor ligands
JPWO2011019072A1 (ja) 2009-08-12 2013-01-17 ヒューマン・メタボローム・テクノロジーズ株式会社 うつ病のバイオマーカー、うつ病のバイオマーカーの測定法、コンピュータプログラム、及び記憶媒体
US8951968B2 (en) 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
EP2338873A1 (en) * 2009-12-22 2011-06-29 Gmeiner, Peter New aminotetraline derivatives
ES2560676T3 (es) 2010-06-15 2016-02-22 Grünenthal GmbH Combinación farmacéutica para el tratamiento del dolor
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
SI3228313T1 (sl) 2013-01-22 2019-12-31 Vistagen Therapeutics, Inc. Odmerne oblike in terapevtske uporabe L-4-klorokinurenina
EP2970080A4 (en) 2013-03-14 2017-01-18 Vistagen Therapeutics, Inc. Synthesis of chiral kynurenine compounds and intermediates
CN112321678A (zh) 2013-10-28 2021-02-05 诺雷克斯股份有限公司 Nmda受体调节剂及其前药、盐和用途
KR20240068766A (ko) 2015-05-22 2024-05-17 비스타젠 쎄라퓨틱스, 인크. L-4-클로로키누레닌의 치료적 용도

Also Published As

Publication number Publication date
RS59687B1 (sr) 2020-01-31
HRP20192189T1 (hr) 2020-02-21
US20190133984A1 (en) 2019-05-09
JP2020183400A (ja) 2020-11-12
JP2019023195A (ja) 2019-02-14
US10632091B2 (en) 2020-04-28
EP4385563A3 (en) 2024-08-21
KR20150109428A (ko) 2015-10-01
AU2018253600B2 (en) 2020-07-09
WO2014116739A1 (en) 2014-07-31
ZA201505569B (en) 2017-01-25
CA3128321A1 (en) 2014-07-31
JP2024069257A (ja) 2024-05-21
MX2020009966A (es) 2020-10-12
AU2020204420A1 (en) 2020-07-23
EP3228313A1 (en) 2017-10-11
DK2948140T3 (en) 2017-08-21
IL276126B (en) 2022-05-01
PL3228313T3 (pl) 2020-03-31
MX2015009277A (es) 2015-12-11
CA2898619A1 (en) 2014-07-31
EP2948140B1 (en) 2017-05-10
CY1122403T1 (el) 2021-01-27
ZA201607581B (en) 2019-04-24
IL240090A0 (en) 2015-09-24
US20220409564A1 (en) 2022-12-29
SI3228313T1 (sl) 2019-12-31
US20250161251A1 (en) 2025-05-22
ES2751138T3 (es) 2020-03-30
MX375318B (es) 2025-03-06
JP7021298B2 (ja) 2022-02-16
CA3216579A1 (en) 2014-07-31
EP2948140A4 (en) 2016-08-03
KR20210063449A (ko) 2021-06-01
KR20230003410A (ko) 2023-01-05
EP3228313B1 (en) 2019-09-11
US20180369180A1 (en) 2018-12-27
BR112015017535A2 (pt) 2020-02-04
AU2022221382B2 (en) 2024-09-19
AU2022221382A1 (en) 2022-09-15
SI3598971T1 (sl) 2024-10-30
DK3598971T3 (da) 2024-06-10
EP3598971B1 (en) 2024-03-20
KR102257284B1 (ko) 2021-05-28
PL3598971T3 (pl) 2024-09-09
AU2018253600A1 (en) 2018-11-22
ES2635353T3 (es) 2017-10-03
JP6436913B2 (ja) 2018-12-12
US20150359772A1 (en) 2015-12-17
EP2948140A1 (en) 2015-12-02
ES2980120T3 (es) 2024-09-30
US9993450B2 (en) 2018-06-12
KR20230098711A (ko) 2023-07-04
NZ710121A (en) 2021-01-29
EP3598971A1 (en) 2020-01-29
KR102335919B1 (ko) 2021-12-07
CN113116877A (zh) 2021-07-16
HRP20240812T1 (hr) 2024-09-27
CN112933073A (zh) 2021-06-11
US12036198B2 (en) 2024-07-16
EP4385563A2 (en) 2024-06-19
IL276126A (en) 2020-08-31
PT3598971T (pt) 2024-06-20
US9993453B2 (en) 2018-06-12
JP6804497B2 (ja) 2020-12-23
PT3228313T (pt) 2019-12-17
US10617663B2 (en) 2020-04-14
US20190125707A1 (en) 2019-05-02
CA3128321C (en) 2023-12-05
JP2022070894A (ja) 2022-05-13
KR20210149905A (ko) 2021-12-09
DK3228313T3 (da) 2019-11-25
IL240090B (en) 2020-08-31
US20180289649A1 (en) 2018-10-11
US20160158178A1 (en) 2016-06-09
US10980758B2 (en) 2021-04-20
JP2016505050A (ja) 2016-02-18
PT2948140T (pt) 2017-08-10
CN105073108A (zh) 2015-11-18
HUE067381T2 (hu) 2024-10-28
AU2014209466B2 (en) 2018-11-08
HK1217170A1 (zh) 2016-12-30
AU2024278564A1 (en) 2025-01-09
IL291831A (en) 2022-06-01
CN113209068A (zh) 2021-08-06
AU2014209466A1 (en) 2015-08-06

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Effective date: 20190121