CA2898294C - Heteroaromatic compounds as pi3 kinase modulators - Google Patents
Heteroaromatic compounds as pi3 kinase modulators Download PDFInfo
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- CA2898294C CA2898294C CA2898294A CA2898294A CA2898294C CA 2898294 C CA2898294 C CA 2898294C CA 2898294 A CA2898294 A CA 2898294A CA 2898294 A CA2898294 A CA 2898294A CA 2898294 C CA2898294 C CA 2898294C
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- Prior art keywords
- cancer
- alkylene
- cycloalkyl
- alkyl
- compound
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201361767721P | 2013-02-21 | 2013-02-21 | |
| US61/767,721 | 2013-02-21 | ||
| PCT/US2014/016643 WO2014130375A1 (en) | 2013-02-21 | 2014-02-15 | Heteroaromatic compounds as pi3 kinase modulators |
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| CA2898294A1 CA2898294A1 (en) | 2014-08-28 |
| CA2898294C true CA2898294C (en) | 2020-06-09 |
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| EP (1) | EP2958564B1 (OSRAM) |
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| AU (1) | AU2014219256B2 (OSRAM) |
| BR (1) | BR112015018318A2 (OSRAM) |
| CA (1) | CA2898294C (OSRAM) |
| ES (1) | ES2674705T3 (OSRAM) |
| MX (1) | MX2015010700A (OSRAM) |
| MY (1) | MY182036A (OSRAM) |
| RU (1) | RU2672910C9 (OSRAM) |
| SG (1) | SG11201505493QA (OSRAM) |
| TW (1) | TWI620749B (OSRAM) |
| WO (1) | WO2014130375A1 (OSRAM) |
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| TWI733713B (zh) | 2015-11-19 | 2021-07-21 | 美商纜圖藥品公司 | 用於治療神經促進性酪氨酸受體激酶相關之異常的化合物與組成物 |
| WO2018136202A2 (en) * | 2016-12-23 | 2018-07-26 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| WO2018169700A1 (en) * | 2017-03-14 | 2018-09-20 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| CN109867669B (zh) * | 2017-12-02 | 2021-02-26 | 广东东阳光药业有限公司 | 一种吡唑[1,5-a]吡啶化合物的晶型及其药物组合物和用途 |
| CN109867668B (zh) * | 2017-12-02 | 2021-03-26 | 广东东阳光药业有限公司 | 一种吡唑[1,5-a]吡啶化合物的晶型及其药物组合物和用途 |
| CN109867670B (zh) * | 2017-12-02 | 2020-07-07 | 广东东阳光药业有限公司 | 一种吡唑[1,5-a]吡啶化合物的单钠盐及其医药用途 |
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| US5578716A (en) | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
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| US6066625A (en) | 1998-02-03 | 2000-05-23 | Methylgene, Inc. | Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences |
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| KR20100107509A (ko) | 2001-09-14 | 2010-10-05 | 9222-9129 퀘벡 인코포레이티드 | 히스톤 데아세틸라아제의 억제제 |
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-
2014
- 2014-02-15 RU RU2015131467A patent/RU2672910C9/ru active
- 2014-02-15 US US14/181,670 patent/US9573953B2/en active Active
- 2014-02-15 AU AU2014219256A patent/AU2014219256B2/en active Active
- 2014-02-15 JP JP2015558892A patent/JP6389829B2/ja active Active
- 2014-02-15 MX MX2015010700A patent/MX2015010700A/es unknown
- 2014-02-15 ES ES14754663.4T patent/ES2674705T3/es active Active
- 2014-02-15 CA CA2898294A patent/CA2898294C/en active Active
- 2014-02-15 SG SG11201505493QA patent/SG11201505493QA/en unknown
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- 2014-02-15 MY MYPI2015702491A patent/MY182036A/en unknown
- 2014-02-15 EP EP14754663.4A patent/EP2958564B1/en active Active
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- 2014-02-15 KR KR1020157019069A patent/KR102148681B1/ko active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20150118102A (ko) | 2015-10-21 |
| US20140234254A1 (en) | 2014-08-21 |
| AU2014219256B2 (en) | 2017-02-16 |
| KR102148681B1 (ko) | 2020-08-27 |
| HK1218385A1 (en) | 2017-02-17 |
| TWI620749B (zh) | 2018-04-11 |
| WO2014130375A1 (en) | 2014-08-28 |
| MY182036A (en) | 2021-01-18 |
| ES2674705T3 (es) | 2018-07-03 |
| JP6389829B2 (ja) | 2018-09-12 |
| BR112015018318A2 (pt) | 2017-08-22 |
| EP2958564A4 (en) | 2016-10-26 |
| RU2015131467A (ru) | 2017-03-24 |
| EP2958564B1 (en) | 2018-05-09 |
| SG11201505493QA (en) | 2015-08-28 |
| JP2016509056A (ja) | 2016-03-24 |
| RU2672910C2 (ru) | 2018-11-21 |
| CA2898294A1 (en) | 2014-08-28 |
| TW201443049A (zh) | 2014-11-16 |
| AU2014219256A1 (en) | 2015-07-30 |
| EP2958564A1 (en) | 2015-12-30 |
| MX2015010700A (es) | 2017-01-23 |
| RU2672910C9 (ru) | 2019-06-04 |
| US9573953B2 (en) | 2017-02-21 |
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