CA2897925C - Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications - Google Patents
Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications Download PDFInfo
- Publication number
- CA2897925C CA2897925C CA2897925A CA2897925A CA2897925C CA 2897925 C CA2897925 C CA 2897925C CA 2897925 A CA2897925 A CA 2897925A CA 2897925 A CA2897925 A CA 2897925A CA 2897925 C CA2897925 C CA 2897925C
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- Prior art keywords
- zone
- insulin
- controller
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751942P | 2013-01-14 | 2013-01-14 | |
| US61/751,942 | 2013-01-14 | ||
| PCT/US2014/011378 WO2014110541A1 (en) | 2013-01-14 | 2014-01-14 | Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type i diabetes applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2897925A1 CA2897925A1 (en) | 2014-07-17 |
| CA2897925C true CA2897925C (en) | 2017-05-30 |
Family
ID=51165703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2897925A Active CA2897925C (en) | 2013-01-14 | 2014-01-14 | Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10507284B2 (https=) |
| EP (1) | EP2943150B1 (https=) |
| JP (1) | JP6810989B2 (https=) |
| KR (1) | KR102212020B1 (https=) |
| CN (1) | CN105050539B (https=) |
| AU (1) | AU2014205123B2 (https=) |
| CA (1) | CA2897925C (https=) |
| WO (1) | WO2014110541A1 (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8417311B2 (en) | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| WO2009049252A1 (en) | 2007-10-10 | 2009-04-16 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| ES2755497T3 (es) | 2010-10-31 | 2020-04-22 | Univ Boston | Sistema de control de glucosa en sangre |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
| MX373076B (es) | 2014-01-31 | 2020-07-06 | Univ Boston | Control de nivel de glucosa fuera de línea basado en periodos anteriores de control de nivel de glucosa en línea. |
| AU2015301146B2 (en) | 2014-08-06 | 2020-06-25 | Regents Of The University Of California | Moving-horizon state-initializer for control applications |
| DE102015000845A1 (de) * | 2015-01-27 | 2016-07-28 | W.O.M. World Of Medicine Gmbh | Verfahren und Vorrichtung zur Regelung der Temperatur des Gasstroms bei medizintechnischen Vorrichtungen |
| CN111905188B (zh) | 2015-02-18 | 2022-07-22 | 英赛罗公司 | 流体输送和输注装置及其使用方法 |
| DK3319511T3 (da) | 2015-08-07 | 2021-11-01 | Univ Boston | Glucosestyringssystem med automatisk tilpasning af glucosemål |
| WO2017070553A1 (en) | 2015-10-21 | 2017-04-27 | University Of Virginia Patent Foundation | System, method and computer readable medium for dynamical tracking of the risk for hypoglycemia in type 1 and type 2 diabetes |
| WO2017123805A1 (en) * | 2016-01-12 | 2017-07-20 | President And Fellows Of Harvard College | Predictive control model for the artificial pancreas using past predictions |
| US10275573B2 (en) | 2016-01-13 | 2019-04-30 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| HK1256995A1 (zh) | 2016-01-14 | 2019-10-11 | Bigfoot Biomedical, Inc. | 药物输送设备、系统和方法中的阻塞解决方案 |
| US10806859B2 (en) | 2016-01-14 | 2020-10-20 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
| RU2737326C2 (ru) | 2016-02-05 | 2020-11-27 | Энимас Корпорейшн | Средство наглядного представления и анализа для системы доставки лекарственных средств |
| WO2017192397A1 (en) | 2016-05-02 | 2017-11-09 | Dexcom, Inc. | System and method for providing alerts optimized for a user |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| WO2018009614A1 (en) | 2016-07-06 | 2018-01-11 | President And Fellows Of Harvard College | Event-triggered model predictive control for embedded artificial pancreas systems |
| WO2018058041A1 (en) | 2016-09-23 | 2018-03-29 | Insulet Corporation | Fluid delivery device with sensor |
| CA3037432A1 (en) | 2016-12-12 | 2018-06-21 | Bigfoot Biomedical, Inc. | Alarms and alerts for medication delivery devices and related systems and methods |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP4708311A2 (en) | 2017-01-13 | 2026-03-11 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10881793B2 (en) | 2017-01-13 | 2021-01-05 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568860B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10583250B2 (en) | 2017-01-13 | 2020-03-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US11497851B2 (en) | 2017-03-31 | 2022-11-15 | Lifescan Ip Holdings, Llc | Maintaining maximum dosing limits for closed loop insulin management systems |
| US11147920B2 (en) | 2017-04-18 | 2021-10-19 | Lifescan Ip Holdings, Llc | Diabetes management system with automatic basal and manual bolus insulin control |
| CA3198598A1 (en) | 2017-05-05 | 2018-11-08 | Eli Lilly And Company | Closed loop control of physiological glucose |
| US12161463B2 (en) | 2017-06-09 | 2024-12-10 | President And Fellows Of Harvard College | Prevention of post-bariatric hypoglycemia using a novel glucose prediction algorithm and mini-dose stable glucagon |
| EP3438858A1 (en) | 2017-08-02 | 2019-02-06 | Diabeloop | Closed-loop blood glucose control systems and methods |
| WO2019125932A1 (en) | 2017-12-21 | 2019-06-27 | Eli Lilly And Company | Closed loop control of physiological glucose |
| CA3089642A1 (en) | 2018-02-09 | 2019-08-15 | Dexcom, Inc. | System and method for decision support |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| US11147919B2 (en) | 2018-04-23 | 2021-10-19 | Medtronic Minimed, Inc. | Methodology to recommend and implement adjustments to a fluid infusion device of a medication delivery system |
| US11158413B2 (en) | 2018-04-23 | 2021-10-26 | Medtronic Minimed, Inc. | Personalized closed loop medication delivery system that utilizes a digital twin of the patient |
| EP3788628B1 (en) | 2018-05-04 | 2024-12-11 | Insulet Corporation | Safety constraints for a control algorithm-based drug delivery system |
| US12562251B1 (en) | 2018-05-09 | 2026-02-24 | Bigfoot Biomedical, Inc. | Computing architecture for assuring the provenance of medication therapy related parameters, and related systems, methods and devices |
| US12128212B2 (en) | 2018-06-19 | 2024-10-29 | President And Fellows Of Harvard College | Adaptive zone model predictive control with a glucose and velocity dependent dynamic cost function for an artificial pancreas |
| CN112313754A (zh) | 2018-06-22 | 2021-02-02 | 伊莱利利公司 | 胰岛素和普兰林肽输送系统、方法和设备 |
| US11547799B2 (en) | 2018-09-20 | 2023-01-10 | Medtronic Minimed, Inc. | Patient day planning systems and methods |
| US11628251B2 (en) | 2018-09-28 | 2023-04-18 | Insulet Corporation | Activity mode for artificial pancreas system |
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| US11986629B2 (en) | 2019-06-11 | 2024-05-21 | Medtronic Minimed, Inc. | Personalized closed loop optimization systems and methods |
| US11957876B2 (en) | 2019-07-16 | 2024-04-16 | Beta Bionics, Inc. | Glucose control system with automated backup therapy protocol generation |
| MX2022000670A (es) | 2019-07-16 | 2022-05-20 | Beta Bionics Inc | Sistema de control de glucosa en sangre. |
| DE112020003406T5 (de) | 2019-07-16 | 2022-06-23 | Beta Bionics, Inc. | Blutzuckerkontrollsystem |
| US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
| US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
| WO2021113647A1 (en) | 2019-12-06 | 2021-06-10 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
| US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
| JP7512395B2 (ja) | 2020-01-06 | 2024-07-08 | インスレット コーポレイション | 持続する残差に基づく食事および／または運動行為の予測 |
| US12370307B2 (en) | 2020-02-03 | 2025-07-29 | Insulet Corporation | Use of fuzzy logic in predicting user behavior affecting blood glucose concentration in a closed loop control system of an automated insulin delivery device |
| US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
| US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
| US11986630B2 (en) | 2020-02-12 | 2024-05-21 | Insulet Corporation | Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk |
| US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
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| US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
| CN111710009B (zh) * | 2020-05-29 | 2023-06-23 | 北京百度网讯科技有限公司 | 人流密度的生成方法、装置、电子设备以及存储介质 |
| WO2022020197A1 (en) | 2020-07-22 | 2022-01-27 | Insulet Corporation | Open-loop insulin delivery basal parameters based on insulin delivery records |
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| KR102521085B1 (ko) * | 2020-10-30 | 2023-04-12 | 이오플로우(주) | 인슐린 패치를 포함하는 인공췌장 제어 방법 및 그 장치 |
| US11160925B1 (en) | 2021-01-29 | 2021-11-02 | Insulet Corporation | Automatic drug delivery system for delivery of a GLP-1 therapeutic |
| US20220273874A1 (en) * | 2021-02-24 | 2022-09-01 | University Of Virginia Patent Foundation | Method and system of fully-automated artificial pancreas control for counteracting postprandial hyperglycemia |
| EP4305636A1 (en) | 2021-03-10 | 2024-01-17 | Insulet Corporation | A medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions |
| US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
| US12465686B2 (en) | 2021-03-25 | 2025-11-11 | Beta Bionics, Inc. | Emergency medicament dose control |
| US12592306B2 (en) | 2021-04-28 | 2026-03-31 | Insulet Corporation | Devices and methods for initialization of drug delivery devices using measured analyte sensor information |
| US12496398B2 (en) | 2021-05-28 | 2025-12-16 | Insulet Corporation | Threshold based automatic glucose control response |
| US12406760B2 (en) | 2021-06-07 | 2025-09-02 | Insulet Corporation | Exercise safety prediction based on physiological conditions |
| US12514980B2 (en) | 2021-06-30 | 2026-01-06 | Insulet Corporation | Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase |
| US12521486B2 (en) | 2021-07-16 | 2026-01-13 | Insulet Corporation | Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems |
| WO2023049900A1 (en) | 2021-09-27 | 2023-03-30 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
| US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
| EP4243030A1 (en) | 2022-03-09 | 2023-09-13 | Insulet Corporation | Adjusting medicament delivery parameters in an open loop medicament delivery mode |
| CN120457493A (zh) | 2023-01-06 | 2025-08-08 | 英赛罗公司 | 自动或手动启动的随餐推注输送及随后的自动安全约束放宽 |
| CN119480135B (zh) * | 2024-11-08 | 2025-10-10 | 北京理工大学 | 基于未知外源输入估计的餐后长时间窗血糖态势预测方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6740072B2 (en) * | 2001-09-07 | 2004-05-25 | Medtronic Minimed, Inc. | System and method for providing closed loop infusion formulation delivery |
| US8152789B2 (en) * | 2001-10-23 | 2012-04-10 | Medtronic Minimed, Inc. | System and method for providing closed loop infusion formulation delivery |
| US7591801B2 (en) * | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| WO2006124716A2 (en) * | 2005-05-13 | 2006-11-23 | Trustees Of Boston University | Fully automated control system for type 1 diabetes |
| US9056165B2 (en) * | 2006-09-06 | 2015-06-16 | Medtronic Minimed, Inc. | Intelligent therapy recommendation algorithm and method of using the same |
| US20080234943A1 (en) * | 2007-03-20 | 2008-09-25 | Pinaki Ray | Computer program for diabetes management |
| WO2008135329A1 (en) * | 2007-05-03 | 2008-11-13 | Novo Nordisk A/S | Safety system for insulin delivery advisory algoritms |
| DK2171625T3 (en) * | 2007-06-21 | 2018-11-19 | Hoffmann La Roche | METHOD AND DEVICE FOR PREVENTING HYPOGLYCYMA |
| US8088098B2 (en) | 2007-06-25 | 2012-01-03 | Medingo, Ltd. | Tailored basal insulin delivery system and method |
| CA3037726C (en) | 2008-09-15 | 2021-11-16 | Deka Products Limited Partnership | Systems and methods for fluid delivery |
| EP2413781B1 (en) * | 2009-03-31 | 2019-07-24 | Abbott Diabetes Care Inc. | Overnight closed-loop insulin delivery with model predictive control and glucose measurement error model |
| WO2012051344A2 (en) * | 2010-10-12 | 2012-04-19 | Regents Of The University Of California, The | Maintaining multiple defined physiological zones using model predictive control |
| US9486578B2 (en) * | 2012-12-07 | 2016-11-08 | Animas Corporation | Method and system for tuning a closed-loop controller for an artificial pancreas |
-
2014
- 2014-01-14 KR KR1020157021677A patent/KR102212020B1/ko active Active
- 2014-01-14 US US14/154,241 patent/US10507284B2/en active Active
- 2014-01-14 WO PCT/US2014/011378 patent/WO2014110541A1/en not_active Ceased
- 2014-01-14 EP EP14738072.9A patent/EP2943150B1/en active Active
- 2014-01-14 CA CA2897925A patent/CA2897925C/en active Active
- 2014-01-14 AU AU2014205123A patent/AU2014205123B2/en active Active
- 2014-01-14 JP JP2015552873A patent/JP6810989B2/ja active Active
- 2014-01-14 CN CN201480015278.4A patent/CN105050539B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6810989B2 (ja) | 2021-01-13 |
| KR102212020B1 (ko) | 2021-02-05 |
| EP2943150B1 (en) | 2018-12-05 |
| AU2014205123B2 (en) | 2018-08-16 |
| WO2014110541A1 (en) | 2014-07-17 |
| US10507284B2 (en) | 2019-12-17 |
| CN105050539A (zh) | 2015-11-11 |
| CA2897925A1 (en) | 2014-07-17 |
| AU2014205123A1 (en) | 2015-07-30 |
| EP2943150A1 (en) | 2015-11-18 |
| JP2016504119A (ja) | 2016-02-12 |
| EP2943150A4 (en) | 2016-10-26 |
| CN105050539B (zh) | 2018-05-18 |
| KR20150108860A (ko) | 2015-09-30 |
| US20140200559A1 (en) | 2014-07-17 |
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