CA2897618A1 - Process for making benzoxazepin compounds - Google Patents

Process for making benzoxazepin compounds Download PDF

Info

Publication number
CA2897618A1
CA2897618A1 CA2897618A CA2897618A CA2897618A1 CA 2897618 A1 CA2897618 A1 CA 2897618A1 CA 2897618 A CA2897618 A CA 2897618A CA 2897618 A CA2897618 A CA 2897618A CA 2897618 A1 CA2897618 A1 CA 2897618A1
Authority
CA
Canada
Prior art keywords
reacting
bromo
acid
cl2pd
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2897618A
Other languages
English (en)
French (fr)
Inventor
Remy Angelaud
Danial BEAUDRY
Diane CARRERA
Sushant Malhotra
Travis Remarchuk
Fredric ST-JEAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CA2948763A priority Critical patent/CA2948763C/en
Priority to CA2948765A priority patent/CA2948765A1/en
Publication of CA2897618A1 publication Critical patent/CA2897618A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2897618A 2013-03-13 2014-03-12 Process for making benzoxazepin compounds Abandoned CA2897618A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2948763A CA2948763C (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA2948765A CA2948765A1 (en) 2013-03-13 2014-03-12 Intermediate (4-bromo-2-fluorophenyl)-1h-imidazoyl derivatives for use in a process to synthesize benzoxazepin compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361779619P 2013-03-13 2013-03-13
US61/779,619 2013-03-13
PCT/EP2014/054786 WO2014140073A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA2948763A Division CA2948763C (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA2948765A Division CA2948765A1 (en) 2013-03-13 2014-03-12 Intermediate (4-bromo-2-fluorophenyl)-1h-imidazoyl derivatives for use in a process to synthesize benzoxazepin compounds

Publications (1)

Publication Number Publication Date
CA2897618A1 true CA2897618A1 (en) 2014-09-18

Family

ID=50241450

Family Applications (6)

Application Number Title Priority Date Filing Date
CA2897618A Abandoned CA2897618A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA2948763A Expired - Fee Related CA2948763C (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA3005103A Abandoned CA3005103A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA3005118A Abandoned CA3005118A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA2948765A Abandoned CA2948765A1 (en) 2013-03-13 2014-03-12 Intermediate (4-bromo-2-fluorophenyl)-1h-imidazoyl derivatives for use in a process to synthesize benzoxazepin compounds
CA3005112A Abandoned CA3005112A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds

Family Applications After (5)

Application Number Title Priority Date Filing Date
CA2948763A Expired - Fee Related CA2948763C (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA3005103A Abandoned CA3005103A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA3005118A Abandoned CA3005118A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds
CA2948765A Abandoned CA2948765A1 (en) 2013-03-13 2014-03-12 Intermediate (4-bromo-2-fluorophenyl)-1h-imidazoyl derivatives for use in a process to synthesize benzoxazepin compounds
CA3005112A Abandoned CA3005112A1 (en) 2013-03-13 2014-03-12 Process for making benzoxazepin compounds

Country Status (15)

Country Link
US (1) US9303043B2 (enExample)
EP (3) EP2970329A1 (enExample)
JP (6) JP6363120B2 (enExample)
KR (3) KR20180070715A (enExample)
CN (2) CN105377856B (enExample)
AR (1) AR095365A1 (enExample)
AU (3) AU2014230812B2 (enExample)
BR (1) BR112015020716A2 (enExample)
CA (6) CA2897618A1 (enExample)
IL (1) IL240793A0 (enExample)
MX (1) MX2015011438A (enExample)
NZ (1) NZ711192A (enExample)
RU (2) RU2018109979A (enExample)
SG (2) SG10201706760YA (enExample)
WO (1) WO2014140073A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266903B2 (en) * 2013-12-16 2016-02-23 Genentech, Inc. Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
CN111909173B (zh) * 2015-07-02 2025-03-04 豪夫迈·罗氏有限公司 苯并氧氮杂䓬噁唑烷酮化合物及其使用方法
JP6522807B2 (ja) 2015-07-02 2019-05-29 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ベンゾオキサゼピンオキサゾリジノン化合物及び使用方法
CN105906635A (zh) * 2016-06-08 2016-08-31 上海大学 全氟烷基苯并氮杂*并喹喔啉衍生物及其合成方法
EP3492452B1 (en) * 2016-07-29 2022-08-31 Japan Tobacco Inc. Production method for pyrazole-amide compound
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
PL3851441T3 (pl) 2016-12-15 2023-11-06 F. Hoffmann-La Roche Ag Proces otrzymywania (S)-2-((2-((S)-4-(difluorometylo)-2-oksooksazolidyn-3-ylo)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oksazepin-9-ylo)amino)propanamidu
CN108752237A (zh) * 2018-07-05 2018-11-06 四川青木制药有限公司 一种对氨基苯甲脒盐酸盐的新制备方法
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274327B1 (en) 1992-04-13 2001-08-14 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
GB9208135D0 (en) 1992-04-13 1992-05-27 Ludwig Inst Cancer Res Polypeptides having kinase activity,their preparation and use
US5846824A (en) 1994-02-07 1998-12-08 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
ES2205944T3 (es) * 1998-10-23 2004-05-01 Dow Agrosciences Llc Compuestos de 3-(fenil sustituido)-5-(ciclopropil sustituido)-1,2,4-triazol.
HUP0400164A2 (hu) 2001-07-12 2004-07-28 Avecia Ltd. Mikrokapszulázott katalizátor, eljárás előállítására és alkalmazása
CA2463441A1 (en) * 2001-10-12 2003-05-08 Bayer Pharmaceuticals Corporation Phenyl substituted 5-membered nitrogen containing heterocycles for the treatment of obesity
EP1945222B1 (en) 2005-11-02 2012-12-26 Bayer Pharma Aktiengesellschaft Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
EA016527B1 (ru) * 2006-10-23 2012-05-30 ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. Триазолопиридазиновые модуляторы протеинкиназ
BRPI0717320A2 (pt) * 2006-10-23 2013-10-22 Sgx Pharmaceuticals Inc Triazóis bicíclicos como moduladores de proteína cinase
CA2675755C (en) * 2007-01-19 2015-10-06 Xcovery, Inc. Pyridine and pyridazine derivatives as kinase inhibitors
WO2009055730A1 (en) * 2007-10-25 2009-04-30 Genentech, Inc. Process for making thienopyrimidine compounds
CN102015693B (zh) * 2008-02-21 2014-10-29 默沙东公司 作为erk抑制剂的化合物
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
US8263633B2 (en) 2009-09-28 2012-09-11 F. Hoffman-La Roche Ag Benzoxepin PI3K inhibitor compounds and methods of use
TWI423980B (zh) * 2009-09-28 2014-01-21 Hoffmann La Roche 苯并氧氮呯ｐｉ３ｋ抑制劑化合物及使用方法
CA2778684A1 (en) * 2009-10-29 2011-05-05 Schering Corporation Bridged bicyclic piperidine derivatives and methods of use thereof
CN102558167A (zh) * 2010-12-29 2012-07-11 中国医学科学院药物研究所 Gk和ppar双重激动活性的噻唑烷二酮衍生物
KR20140032383A (ko) 2011-03-21 2014-03-14 에프. 호프만-라 로슈 아게 Pi3k p110 델타에 대하여 선택적인 벤즈옥사제핀 화합물 및 이의 사용 방법
NO3175985T3 (enExample) * 2011-07-01 2018-04-28
CN104379163A (zh) 2012-06-08 2015-02-25 霍夫曼-拉罗奇有限公司 用于治疗癌症的磷酸肌醇3激酶抑制剂化合物和化疗剂的突变选择性及组合

Also Published As

Publication number Publication date
JP2016512209A (ja) 2016-04-25
AU2014230812A1 (en) 2015-09-03
CA2948763A1 (en) 2014-09-18
JP2020114814A (ja) 2020-07-30
CN105377856B (zh) 2018-05-22
RU2015138488A (ru) 2017-04-20
CA2948765A1 (en) 2014-09-18
JP2019089762A (ja) 2019-06-13
SG10201706760YA (en) 2017-10-30
RU2018109979A (ru) 2019-02-28
CN108929333A (zh) 2018-12-04
EP3404032A2 (en) 2018-11-21
AR095365A1 (es) 2015-10-14
AU2014230812B2 (en) 2016-04-07
CA3005118A1 (en) 2014-09-18
CA2948763C (en) 2018-04-24
WO2014140073A1 (en) 2014-09-18
EP3404032A3 (en) 2019-03-13
KR20170070270A (ko) 2017-06-21
CA3005112A1 (en) 2014-09-18
AU2014230812A8 (en) 2015-09-10
EP3404032C0 (en) 2025-07-02
NZ711192A (en) 2019-04-26
KR20180070715A (ko) 2018-06-26
EP3845540B1 (en) 2026-07-22
JP6442005B2 (ja) 2018-12-19
CA3005103A1 (en) 2014-09-18
US20140275523A1 (en) 2014-09-18
JP2018008959A (ja) 2018-01-18
AU2018201393A1 (en) 2018-03-15
EP2970329A1 (en) 2016-01-20
US9303043B2 (en) 2016-04-05
KR101871133B1 (ko) 2018-06-25
HK1215433A1 (zh) 2016-08-26
MX2015011438A (es) 2016-02-03
RU2649976C2 (ru) 2018-04-06
JP2019031493A (ja) 2019-02-28
EP3845540A1 (en) 2021-07-07
AU2016204432B2 (en) 2017-12-07
IL240793A0 (en) 2015-10-29
JP2018150298A (ja) 2018-09-27
JP6363120B2 (ja) 2018-07-25
AU2016204432A1 (en) 2016-07-21
KR101821468B1 (ko) 2018-01-23
CN105377856A (zh) 2016-03-02
JP6663459B2 (ja) 2020-03-11
EP3404032B1 (en) 2025-07-02
BR112015020716A2 (pt) 2017-07-18
KR20150119033A (ko) 2015-10-23
SG11201507394RA (en) 2015-10-29

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150709

FZDE Discontinued

Effective date: 20200312