CA2895166C - Acetyl transferases and their use for producing carotenoids - Google Patents

Acetyl transferases and their use for producing carotenoids Download PDF

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Publication number
CA2895166C
CA2895166C CA2895166A CA2895166A CA2895166C CA 2895166 C CA2895166 C CA 2895166C CA 2895166 A CA2895166 A CA 2895166A CA 2895166 A CA2895166 A CA 2895166A CA 2895166 C CA2895166 C CA 2895166C
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CA
Canada
Prior art keywords
seq
polypeptide
atf1
nucleic acid
zeaxanthin
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CA2895166A
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English (en)
French (fr)
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CA2895166A1 (en
Inventor
Christopher M. Farrell
Peter HOUSTON
Lisa LAPRADE
Nathalie BALCH
Maria Elena Mayorga
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DSM IP Assets BV
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DSM IP Assets BV
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Publication of CA2895166A1 publication Critical patent/CA2895166A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01084—Alcohol O-acetyltransferase (2.3.1.84)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2895166A 2012-12-20 2013-08-28 Acetyl transferases and their use for producing carotenoids Active CA2895166C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12198373.8 2012-12-20
EP12198373 2012-12-20
US201361830234P 2013-06-03 2013-06-03
US61/830,234 2013-06-03
PCT/IB2013/058049 WO2014096992A1 (en) 2012-12-20 2013-08-28 Acetyl transferases and their use for producing carotenoids

Publications (2)

Publication Number Publication Date
CA2895166A1 CA2895166A1 (en) 2014-06-26
CA2895166C true CA2895166C (en) 2022-10-04

Family

ID=47429658

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2895166A Active CA2895166C (en) 2012-12-20 2013-08-28 Acetyl transferases and their use for producing carotenoids

Country Status (9)

Country Link
US (2) US10465174B2 (US07223432-20070529-C00017.png)
EP (1) EP2935571B1 (US07223432-20070529-C00017.png)
JP (2) JP6607567B2 (US07223432-20070529-C00017.png)
KR (1) KR102205236B1 (US07223432-20070529-C00017.png)
CN (1) CN105339490A (US07223432-20070529-C00017.png)
BR (1) BR112015014258B1 (US07223432-20070529-C00017.png)
CA (1) CA2895166C (US07223432-20070529-C00017.png)
EA (1) EA033724B1 (US07223432-20070529-C00017.png)
WO (1) WO2014096992A1 (US07223432-20070529-C00017.png)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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EA033724B1 (ru) 2012-12-20 2019-11-20 Dsm Ip Assets Bv Трансформированные микроорганизмы, обладающие ацетилтрансферазной активностью и способные продуцировать ацетилированные каротиноиды, и их применение
CN105316246B (zh) * 2014-06-03 2019-10-01 上海来益生物药物研究开发中心有限责任公司 β-胡萝卜素高产菌种及其应用
WO2016154314A1 (en) * 2015-03-23 2016-09-29 Arch Innotek, Llc Compositions and methods of biosynthesizing carotenoids and their derivatives
CN107418938B (zh) * 2016-05-24 2022-07-15 中国医学科学院药物研究所 10-去乙酰巴卡亭III 10β-O-乙酰转移酶突变体及其在催化合成紫杉醇及其类似物中的应用
CN111107834A (zh) * 2017-09-25 2020-05-05 帝斯曼知识产权资产管理有限公司 类视黄醇的生物合成
BR112020005769A2 (pt) 2017-09-25 2020-09-24 Dsm Ip Assets B.V. produção de ésteres retinílicos
CN111108194A (zh) 2017-09-25 2020-05-05 帝斯曼知识产权资产管理有限公司 视黄醇的生产
BR112020005770A2 (pt) 2017-09-25 2020-09-24 Dsm Ip Assets B.V. produção de trans-retinal
US20200239925A1 (en) * 2017-09-25 2020-07-30 Dsm Ip Assets B.V. Production of retinyl esters
CN108949599A (zh) * 2018-06-29 2018-12-07 华南理工大学 一种产β-紫罗兰酮基因工程菌及其构建方法与应用
DE112019005312T5 (de) * 2018-10-26 2021-09-16 Industry-Academic Cooperation Foundation Gyeongsang National University Verfahren zur biologischen herstellung einer acetinverbindung
CN113227365A (zh) * 2018-12-31 2021-08-06 帝斯曼知识产权资产管理有限公司 新型乙酰转移酶
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
BR112022000683A2 (pt) 2019-07-16 2022-03-03 Dsm Ip Assets Bv Novas betacaroteno oxidases
BR112022001412A2 (pt) 2019-08-01 2022-03-22 Dsm Ip Assets Bv Método de fermentação de betacaroteno
CN111454854B (zh) * 2020-05-02 2022-05-06 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
WO2022003130A2 (en) 2020-07-01 2022-01-06 Dsm Ip Assets B.V. Yeast expression system
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
KR20230095103A (ko) 2020-10-30 2023-06-28 디에스엠 아이피 어셋츠 비.브이. 동일 반응계내 2상 추출 시스템
WO2022090548A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. Fermentative production of isoprenoids
WO2022090547A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. Production of carotenoids by fermentation
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
WO2023067030A1 (en) 2021-10-19 2023-04-27 Dsm Ip Assets B.V. Retinoid production
KR102414136B1 (ko) * 2021-10-26 2022-06-27 서울대학교산학협력단 제아잔틴을 생산하는 재조합 야로위아 리폴리티카 및 제아잔틴 생산방법
WO2023148187A1 (en) 2022-02-02 2023-08-10 Dsm Ip Assets B.V. Yarrowia production process
CN115895922B (zh) * 2022-12-19 2024-04-02 云南大学 一株高产类胡萝卜素的禾本红酵母及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3363197B2 (ja) * 1992-06-18 2003-01-08 麒麟麦酒株式会社 アルコールアセチルトランスフェラーゼ遺伝子およびその利用
JP3363198B2 (ja) * 1993-02-26 2003-01-08 麒麟麦酒株式会社 エステル香味の低減した酒類の製造
DE19801120A1 (de) 1998-01-15 1999-07-22 Basf Ag Orotidin-5'-Phosphatdecarboxylase-Gen, Genkonstrukt enthaltend dieses Gen und seine Verwendung
EP1392824B1 (en) * 2001-06-06 2008-08-20 DSM IP Assets B.V. Improved isoprenoid production
US7572609B2 (en) 2004-08-19 2009-08-11 Dsm Ip Assets B.V. Production of isoprenoids
CN103589650A (zh) 2005-03-18 2014-02-19 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
WO2009006386A2 (en) * 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing isoprenyl alkanoates
EP2594645A3 (en) * 2007-09-21 2013-11-06 BASF Plant Science GmbH Plants with increased yield
US20100297722A1 (en) * 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
EA033724B1 (ru) 2012-12-20 2019-11-20 Dsm Ip Assets Bv Трансформированные микроорганизмы, обладающие ацетилтрансферазной активностью и способные продуцировать ацетилированные каротиноиды, и их применение

Also Published As

Publication number Publication date
CN105339490A (zh) 2016-02-17
BR112015014258B1 (pt) 2022-05-17
JP2016501543A (ja) 2016-01-21
KR20150096754A (ko) 2015-08-25
US10465174B2 (en) 2019-11-05
US20150322412A1 (en) 2015-11-12
EA033724B1 (ru) 2019-11-20
EA201500659A1 (ru) 2015-12-30
JP2018183139A (ja) 2018-11-22
WO2014096992A8 (en) 2015-12-23
CA2895166A1 (en) 2014-06-26
KR102205236B1 (ko) 2021-01-20
EP2935571B1 (en) 2018-03-07
WO2014096992A1 (en) 2014-06-26
JP6607567B2 (ja) 2019-11-20
US10865392B2 (en) 2020-12-15
US20200123507A1 (en) 2020-04-23
EP2935571A1 (en) 2015-10-28
BR112015014258A2 (US07223432-20070529-C00017.png) 2017-08-22

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