CA2888889A1 - Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e - Google Patents

Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e Download PDF

Info

Publication number
CA2888889A1
CA2888889A1 CA2888889A CA2888889A CA2888889A1 CA 2888889 A1 CA2888889 A1 CA 2888889A1 CA 2888889 A CA2888889 A CA 2888889A CA 2888889 A CA2888889 A CA 2888889A CA 2888889 A1 CA2888889 A1 CA 2888889A1
Authority
CA
Canada
Prior art keywords
aryl
compound
disease
amino
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2888889A
Other languages
English (en)
French (fr)
Inventor
Michael Patane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bantam Pharmaceutical LLC
Original Assignee
Egenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egenix Inc filed Critical Egenix Inc
Publication of CA2888889A1 publication Critical patent/CA2888889A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2888889A 2012-10-22 2013-10-22 Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e Abandoned CA2888889A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261716987P 2012-10-22 2012-10-22
US61/716,987 2012-10-22
US201261735458P 2012-12-10 2012-12-10
US61/735,458 2012-12-10
PCT/US2013/066041 WO2014066304A1 (en) 2012-10-22 2013-10-22 Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e

Publications (1)

Publication Number Publication Date
CA2888889A1 true CA2888889A1 (en) 2014-05-01

Family

ID=50545165

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2888889A Abandoned CA2888889A1 (en) 2012-10-22 2013-10-22 Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e

Country Status (7)

Country Link
US (1) US9409901B2 (enExample)
EP (1) EP2909203A4 (enExample)
JP (1) JP2015534990A (enExample)
AU (1) AU2013334860B2 (enExample)
CA (1) CA2888889A1 (enExample)
IL (1) IL238415B (enExample)
WO (1) WO2014066304A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6707630B2 (ja) * 2015-06-01 2020-06-10 バンタム、ファーマシューティカル、リミテッド、ライアビリティー、カンパニーBantam Pharmaceutical, Llc 置換ピラゾールおよびピロール化合物、および翻訳開始の阻害およびこれらに関連する疾患および障害の治療のためにこれらを用いる方法
MX2019006299A (es) * 2016-11-30 2019-11-12 Bantam Pharmaceutical Llc Compuestos de pirazola sustituida y metodos para usarlos para el tratamiento de enfermedades hiperproliferativas.
JP2020513403A (ja) 2016-11-30 2020-05-14 バンタム、ファーマシューティカル、リミテッド、ライアビリティー、カンパニーBantam Pharmaceutical, Llc 置換ピラゾールおよびピロール化合物の使用する方法ならびに過剰増殖性疾患の治療のための方法
AU2020343106B2 (en) * 2019-09-03 2025-04-10 Sovargen Co., Ltd. Composition for diagnosing or treating conditions associated with increased eIF4E activity comprising eIF4E inhibitor
WO2021067752A1 (en) * 2019-10-04 2021-04-08 Yale University Targeting cap-dependent translation to reduce seizures in mtor disorders
AR121506A1 (es) * 2020-03-03 2022-06-08 Pic Therapeutics Inc Inhibidores del eif4e y sus usos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472954A (en) 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
US5324718A (en) 1992-07-14 1994-06-28 Thorsteinn Loftsson Cyclodextrin/drug complexation
NZ550114A (en) * 2004-04-20 2011-02-25 Transtech Pharma Inc Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators
EP1868604B1 (en) * 2005-01-21 2014-08-13 President and Fellows of Harvard College Regulation of protein synthesis by inhibition of eif4e-eif4g interaction
GB0614068D0 (en) * 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
GB0614070D0 (en) * 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
KR20090082440A (ko) * 2006-10-31 2009-07-30 쉐링 코포레이션 단백질 키나제 억제제로서의 2-아미노티아졸-4-카복실산 아미드
KR20100042287A (ko) * 2007-07-31 2010-04-23 쉐링 코포레이션 항암요법으로서의 항-유사분열제 및 아우로라 키나제 억제제 조합물
CA2803880C (en) 2010-06-28 2018-09-25 President And Fellows Of Harvard College Compounds for the inhibition of cellular proliferation

Also Published As

Publication number Publication date
JP2015534990A (ja) 2015-12-07
EP2909203A4 (en) 2016-04-06
WO2014066304A1 (en) 2014-05-01
AU2013334860B2 (en) 2018-02-15
US9409901B2 (en) 2016-08-09
IL238415A0 (en) 2015-06-30
US20150274717A1 (en) 2015-10-01
EP2909203A1 (en) 2015-08-26
AU2013334860A1 (en) 2015-05-14
IL238415B (en) 2018-04-30

Similar Documents

Publication Publication Date Title
JP7416872B2 (ja) 癌の治療のための配合剤
AU2013334860B2 (en) Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E
CN111770914B (zh) 作为神经激肽-1受体拮抗剂的化合物及其用途
BRPI0711080A2 (pt) uso de um composto, composto, composição farmacêutica e processo para a preparação deste composto
EA025033B1 (ru) Диаминиевые соли фенотиазина и их применение
EP2891649B1 (en) Prolylhydroxylase inhibitors and methods of use
JP2022532379A (ja) 神経変性および代謝障害の処置のための化合物
US20180022735A1 (en) Modulators of the p70s6 kinase for use in the treatment of brain disorders and triple-negative breast cancer
WO2019036678A1 (en) MU OPIOID RECEIVER MODULATORS
WO2023078451A1 (zh) 用作cdk7激酶抑制剂的化合物及其应用
WO2014183673A1 (zh) 阿那格雷及其衍生物的抗肿瘤用途
US10098861B1 (en) Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof
AU2019273656B2 (en) Pharmaceutical compounds for use in treating Huntington's disease
CN114828856B (zh) 以稠合嘧啶化合物为有效成分的治疗剂
CN114901665B (zh) 三唑并三嗪衍生物在治疗疾病中的用途
HK40073574A (en) Therapeutic agent containing fused pyrimidine compound as active ingredient
TW202438074A (zh) 噁二唑衍生物化合物及包含其之醫藥組合物
HK40067960A (en) Therapeutic or prophylactic method for diabetes using combination medicine

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20191022