AU2013334860B2 - Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E - Google Patents
Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E Download PDFInfo
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- AU2013334860B2 AU2013334860B2 AU2013334860A AU2013334860A AU2013334860B2 AU 2013334860 B2 AU2013334860 B2 AU 2013334860B2 AU 2013334860 A AU2013334860 A AU 2013334860A AU 2013334860 A AU2013334860 A AU 2013334860A AU 2013334860 B2 AU2013334860 B2 AU 2013334860B2
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- alkyl
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- 201000006361 tethered spinal cord syndrome Diseases 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- 229960003433 thalidomide Drugs 0.000 description 1
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- 201000002510 thyroid cancer Diseases 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
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- 125000004306 triazinyl group Chemical group 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716987P | 2012-10-22 | 2012-10-22 | |
| US61/716,987 | 2012-10-22 | ||
| US201261735458P | 2012-12-10 | 2012-12-10 | |
| US61/735,458 | 2012-12-10 | ||
| PCT/US2013/066041 WO2014066304A1 (en) | 2012-10-22 | 2013-10-22 | Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013334860A1 AU2013334860A1 (en) | 2015-05-14 |
| AU2013334860B2 true AU2013334860B2 (en) | 2018-02-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013334860A Ceased AU2013334860B2 (en) | 2012-10-22 | 2013-10-22 | Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E |
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| Country | Link |
|---|---|
| US (1) | US9409901B2 (enExample) |
| EP (1) | EP2909203A4 (enExample) |
| JP (1) | JP2015534990A (enExample) |
| AU (1) | AU2013334860B2 (enExample) |
| CA (1) | CA2888889A1 (enExample) |
| IL (1) | IL238415B (enExample) |
| WO (1) | WO2014066304A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108349962A (zh) * | 2015-06-01 | 2018-07-31 | 班塔姆制药有限责任公司 | 取代的吡唑和吡咯化合物以及使用其用于抑制翻译起始和治疗与其相关的疾病和病症的方法 |
| CN110769823A (zh) | 2016-11-30 | 2020-02-07 | 班塔姆制药有限责任公司 | 使用被取代的吡唑和吡咯化合物以及治疗过度增生性疾病的方法 |
| MX2019006299A (es) * | 2016-11-30 | 2019-11-12 | Bantam Pharmaceutical Llc | Compuestos de pirazola sustituida y metodos para usarlos para el tratamiento de enfermedades hiperproliferativas. |
| CN114340678A (zh) * | 2019-09-03 | 2022-04-12 | 索瓦尔基因股份有限公司 | 用于诊断或治疗与elf4e活性增加相关的病症的包含elf4e抑制剂的组合物 |
| WO2021067752A1 (en) * | 2019-10-04 | 2021-04-08 | Yale University | Targeting cap-dependent translation to reduce seizures in mtor disorders |
| US11753403B2 (en) * | 2020-03-03 | 2023-09-12 | PIC Therapeutics, Inc. | EIF4E inhibitors and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006790A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2008006793A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2012006068A2 (en) * | 2010-06-28 | 2012-01-12 | President And Fellows Of Harvard College | Compounds for the inhibition of cellular proliferation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324718A (en) | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| NZ550114A (en) * | 2004-04-20 | 2011-02-25 | Transtech Pharma Inc | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
| WO2006078942A2 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Regulation of protein synthesis by inhibition of eif4e-eif4g interaction |
| EP2078004B1 (en) * | 2006-10-31 | 2015-02-25 | Merck Sharp & Dohme Corp. | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors |
| AU2008282885A1 (en) * | 2007-07-31 | 2009-02-05 | Schering Corporation | Anti-mitotic agent and aurora kinase inhibitor combination as anti-cancer treatment |
-
2013
- 2013-10-22 CA CA2888889A patent/CA2888889A1/en not_active Abandoned
- 2013-10-22 US US14/437,251 patent/US9409901B2/en not_active Expired - Fee Related
- 2013-10-22 EP EP13849178.2A patent/EP2909203A4/en not_active Withdrawn
- 2013-10-22 AU AU2013334860A patent/AU2013334860B2/en not_active Ceased
- 2013-10-22 JP JP2015538124A patent/JP2015534990A/ja active Pending
- 2013-10-22 WO PCT/US2013/066041 patent/WO2014066304A1/en not_active Ceased
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2015
- 2015-04-21 IL IL238415A patent/IL238415B/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006790A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2008006793A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2012006068A2 (en) * | 2010-06-28 | 2012-01-12 | President And Fellows Of Harvard College | Compounds for the inhibition of cellular proliferation |
Also Published As
| Publication number | Publication date |
|---|---|
| US9409901B2 (en) | 2016-08-09 |
| AU2013334860A1 (en) | 2015-05-14 |
| EP2909203A1 (en) | 2015-08-26 |
| EP2909203A4 (en) | 2016-04-06 |
| IL238415B (en) | 2018-04-30 |
| WO2014066304A1 (en) | 2014-05-01 |
| IL238415A0 (en) | 2015-06-30 |
| JP2015534990A (ja) | 2015-12-07 |
| US20150274717A1 (en) | 2015-10-01 |
| CA2888889A1 (en) | 2014-05-01 |
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| PC1 | Assignment before grant (sect. 113) |
Owner name: BANTAM PHARMACEUTICAL, LLC Free format text: FORMER APPLICANT(S): EGENIX, INC. |
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| FGA | Letters patent sealed or granted (standard patent) | ||
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