AU2013334860B2 - Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E - Google Patents
Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E Download PDFInfo
- Publication number
- AU2013334860B2 AU2013334860B2 AU2013334860A AU2013334860A AU2013334860B2 AU 2013334860 B2 AU2013334860 B2 AU 2013334860B2 AU 2013334860 A AU2013334860 A AU 2013334860A AU 2013334860 A AU2013334860 A AU 2013334860A AU 2013334860 B2 AU2013334860 B2 AU 2013334860B2
- Authority
- AU
- Australia
- Prior art keywords
- pct
- disease
- compound
- disorder
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 Cc(c1c2ccc(I)c1)n[n]2-c1nc(*)c(*)[s]1 Chemical compound Cc(c1c2ccc(I)c1)n[n]2-c1nc(*)c(*)[s]1 0.000 description 8
- FFDGPVCHZBVARC-UHFFFAOYSA-N CN(C)CC(O)=O Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 1
- QHTUMQYGZQYEOZ-UHFFFAOYSA-N CN1CCN(CCO)CC1 Chemical compound CN1CCN(CCO)CC1 QHTUMQYGZQYEOZ-UHFFFAOYSA-N 0.000 description 1
- BMXHPMQKEMARLG-UHFFFAOYSA-N [O-][N+](c1ccccc1-c(ccc(-c1nc(-c(cc2)cc(Cl)c2Cl)c[s]1)c1)c1C(O)=O)=O Chemical compound [O-][N+](c1ccccc1-c(ccc(-c1nc(-c(cc2)cc(Cl)c2Cl)c[s]1)c1)c1C(O)=O)=O BMXHPMQKEMARLG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716987P | 2012-10-22 | 2012-10-22 | |
| US61/716,987 | 2012-10-22 | ||
| US201261735458P | 2012-12-10 | 2012-12-10 | |
| US61/735,458 | 2012-12-10 | ||
| PCT/US2013/066041 WO2014066304A1 (en) | 2012-10-22 | 2013-10-22 | Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013334860A1 AU2013334860A1 (en) | 2015-05-14 |
| AU2013334860B2 true AU2013334860B2 (en) | 2018-02-15 |
Family
ID=50545165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013334860A Ceased AU2013334860B2 (en) | 2012-10-22 | 2013-10-22 | Compositions and methods for treating or preventing diseases or disorders associated with misregulated elF4E |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9409901B2 (enExample) |
| EP (1) | EP2909203A4 (enExample) |
| JP (1) | JP2015534990A (enExample) |
| AU (1) | AU2013334860B2 (enExample) |
| CA (1) | CA2888889A1 (enExample) |
| IL (1) | IL238415B (enExample) |
| WO (1) | WO2014066304A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6707630B2 (ja) * | 2015-06-01 | 2020-06-10 | バンタム、ファーマシューティカル、リミテッド、ライアビリティー、カンパニーＢａｎｔａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌ， Ｌｌｃ | 置換ピラゾールおよびピロール化合物、および翻訳開始の阻害およびこれらに関連する疾患および障害の治療のためにこれらを用いる方法 |
| MX2019006299A (es) * | 2016-11-30 | 2019-11-12 | Bantam Pharmaceutical Llc | Compuestos de pirazola sustituida y metodos para usarlos para el tratamiento de enfermedades hiperproliferativas. |
| JP2020513403A (ja) | 2016-11-30 | 2020-05-14 | バンタム、ファーマシューティカル、リミテッド、ライアビリティー、カンパニーＢａｎｔａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌ， Ｌｌｃ | 置換ピラゾールおよびピロール化合物の使用する方法ならびに過剰増殖性疾患の治療のための方法 |
| AU2020343106B2 (en) * | 2019-09-03 | 2025-04-10 | Sovargen Co., Ltd. | Composition for diagnosing or treating conditions associated with increased eIF4E activity comprising eIF4E inhibitor |
| WO2021067752A1 (en) * | 2019-10-04 | 2021-04-08 | Yale University | Targeting cap-dependent translation to reduce seizures in mtor disorders |
| AR121506A1 (es) * | 2020-03-03 | 2022-06-08 | Pic Therapeutics Inc | Inhibidores del eif4e y sus usos |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006793A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2008006790A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2012006068A2 (en) * | 2010-06-28 | 2012-01-12 | President And Fellows Of Harvard College | Compounds for the inhibition of cellular proliferation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| US5324718A (en) | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
| NZ550114A (en) * | 2004-04-20 | 2011-02-25 | Transtech Pharma Inc | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
| EP1868604B1 (en) * | 2005-01-21 | 2014-08-13 | President and Fellows of Harvard College | Regulation of protein synthesis by inhibition of eif4e-eif4g interaction |
| KR20090082440A (ko) * | 2006-10-31 | 2009-07-30 | 쉐링 코포레이션 | 단백질 키나제 억제제로서의 2-아미노티아졸-4-카복실산 아미드 |
| KR20100042287A (ko) * | 2007-07-31 | 2010-04-23 | 쉐링 코포레이션 | 항암요법으로서의 항-유사분열제 및 아우로라 키나제 억제제 조합물 |
-
2013
- 2013-10-22 US US14/437,251 patent/US9409901B2/en not_active Expired - Fee Related
- 2013-10-22 WO PCT/US2013/066041 patent/WO2014066304A1/en not_active Ceased
- 2013-10-22 AU AU2013334860A patent/AU2013334860B2/en not_active Ceased
- 2013-10-22 CA CA2888889A patent/CA2888889A1/en not_active Abandoned
- 2013-10-22 EP EP13849178.2A patent/EP2909203A4/en not_active Withdrawn
- 2013-10-22 JP JP2015538124A patent/JP2015534990A/ja active Pending
-
2015
- 2015-04-21 IL IL238415A patent/IL238415B/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006793A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2008006790A1 (en) * | 2006-07-14 | 2008-01-17 | Glaxo Group Limited | Indole compounds |
| WO2012006068A2 (en) * | 2010-06-28 | 2012-01-12 | President And Fellows Of Harvard College | Compounds for the inhibition of cellular proliferation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015534990A (ja) | 2015-12-07 |
| EP2909203A4 (en) | 2016-04-06 |
| WO2014066304A1 (en) | 2014-05-01 |
| US9409901B2 (en) | 2016-08-09 |
| IL238415A0 (en) | 2015-06-30 |
| CA2888889A1 (en) | 2014-05-01 |
| US20150274717A1 (en) | 2015-10-01 |
| EP2909203A1 (en) | 2015-08-26 |
| AU2013334860A1 (en) | 2015-05-14 |
| IL238415B (en) | 2018-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: BANTAM PHARMACEUTICAL, LLC Free format text: FORMER APPLICANT(S): EGENIX, INC. |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |