CA2885899A1 - Apixaban liquid formulations - Google Patents
Apixaban liquid formulations Download PDFInfo
- Publication number
- CA2885899A1 CA2885899A1 CA2885899A CA2885899A CA2885899A1 CA 2885899 A1 CA2885899 A1 CA 2885899A1 CA 2885899 A CA2885899 A CA 2885899A CA 2885899 A CA2885899 A CA 2885899A CA 2885899 A1 CA2885899 A1 CA 2885899A1
- Authority
- CA
- Canada
- Prior art keywords
- vehicle
- apixaban
- administering
- formulation
- liquid formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- QNZCBYKSOIHPEH-UHFFFAOYSA-N Apixaban Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(CCCC3)=O)=C2C(C(N)=O)=N1 QNZCBYKSOIHPEH-UHFFFAOYSA-N 0.000 title claims abstract description 162
- 229960003886 apixaban Drugs 0.000 title claims abstract description 162
- 239000012669 liquid formulation Substances 0.000 title claims abstract description 104
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
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- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201261705943P | 2012-09-26 | 2012-09-26 | |
| US61/705,943 | 2012-09-26 | ||
| US201361773032P | 2013-03-05 | 2013-03-05 | |
| US61/773,032 | 2013-03-05 | ||
| PCT/US2013/062051 WO2014052678A1 (en) | 2012-09-26 | 2013-09-26 | Apixaban liquid formulations |
Publications (1)
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| CA2885899A1 true CA2885899A1 (en) | 2014-04-03 |
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| CA2885899A Abandoned CA2885899A1 (en) | 2012-09-26 | 2013-09-26 | Apixaban liquid formulations |
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| EP (1) | EP2900217A1 (enExample) |
| JP (1) | JP6248112B2 (enExample) |
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| EP2907507A1 (en) * | 2014-02-17 | 2015-08-19 | Sandoz Ag | Pharmaceutical composition comprising apixaban |
| WO2017221209A1 (en) | 2016-06-23 | 2017-12-28 | Lupin Limited | Pharmaceutical formulations of apixaban |
| WO2019204193A1 (en) | 2018-04-16 | 2019-10-24 | Bristol-Myers Squibb Company | Apixaban formulations |
| CA3109007A1 (en) | 2018-08-14 | 2020-02-20 | Jiangsu Hengrui Medicine Co., Ltd. | Injectable pharmaceutical composition and preparation method therefor |
| EP4640220A3 (en) | 2019-11-13 | 2026-01-28 | Unison Pharmaceuticals Pvt. Ltd. | Orally disintegrating pharmaceutical compositions of apixaban |
| WO2022123074A1 (en) | 2020-12-13 | 2022-06-16 | Dafechem Ltd | Liquid apixaban formulation in small dose volume |
| CN113384526A (zh) * | 2021-08-03 | 2021-09-14 | 合肥医工医药股份有限公司 | 一种稳定的阿哌沙班口服溶液制剂及其制备方法 |
| NL2029536B1 (en) | 2021-10-27 | 2023-05-26 | Pharma Data S A | Apixaban suspension and preparation method |
| AU2022374714B2 (en) | 2021-10-27 | 2024-05-23 | Pharma-Data Research And Development Single Member S.A. | Apixaban suspension and preparation method |
| US12194028B2 (en) | 2022-03-09 | 2025-01-14 | Slayback Pharma Llc | Stable pharmaceutical compositions of apixaban |
| WO2023218482A1 (en) * | 2022-05-09 | 2023-11-16 | Syri Research Private Limited | Liquid oral formulation of apixaban or pharmaceutically acceptable salt thereof |
| US12213972B2 (en) * | 2022-07-27 | 2025-02-04 | Slayback Pharma Llc | Stable pharmaceutical compositions of apixaban |
| US11833138B1 (en) | 2023-01-30 | 2023-12-05 | Tap Pharmaceuticals Ag | Liquid pharmaceutical formulations of apixaban |
| WO2024160789A1 (en) | 2023-01-30 | 2024-08-08 | Tap Pharmaceuticals Ag | Liquid pharmaceutical formulations of apixaban |
| EP4450064A1 (en) | 2023-04-14 | 2024-10-23 | Novick BioSciences Private Limited | Apixaban compositions |
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| US5763449A (en) * | 1996-08-07 | 1998-06-09 | Ascent Pediatrics, Inc. | Pleasant-tasting aqueous liquid composition of a bitter-tasting drug |
| KR100558239B1 (ko) | 1999-12-23 | 2006-03-10 | 화이자 프로덕츠 인크. | 증가된 약물 농도를 제공하는 제약학적 조성물 |
| MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| BRPI0212726B8 (pt) * | 2001-09-21 | 2021-05-25 | Bristol Myers Squibb Co | compostos contendo lactamas, e derivados dos mesmos, composição farmacêutica que os compreende e seus usos |
| TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| US7101572B2 (en) * | 2001-12-07 | 2006-09-05 | Unilab Pharmatech, Ltd. | Taste masked aqueous liquid pharmaceutical composition |
| WO2006093493A1 (en) * | 2005-02-25 | 2006-09-08 | Biomarin Pharmaceutical Inc. | Room temperature stable aqueous liquid pharmaceutical composition |
| US20070191306A1 (en) * | 2005-08-17 | 2007-08-16 | Bristol-Myers Squibb Company | FACTOR Xa INHIBITOR FORMULATION AND METHOD |
| WO2009090558A2 (en) * | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| EP3100728B1 (en) * | 2009-05-13 | 2019-11-20 | Cydex Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same |
| SMT202000093T1 (it) | 2009-06-16 | 2020-03-13 | Pfizer | Forme di dosaggio di apixaban |
| PL2538925T3 (pl) * | 2010-02-25 | 2016-06-30 | Pfizer | Formulacje apiksabanu |
| EP2484775A1 (de) * | 2011-02-07 | 2012-08-08 | Siemens Healthcare Diagnostics Products GmbH | Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren |
| RU2638155C1 (ru) * | 2016-02-29 | 2017-12-12 | Общество С Ограниченной Ответственностью "Сай Фарма" | Производные бензо[d]изоксазола и их применение |
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2016
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| AU2013323435B2 (en) | 2017-10-19 |
| PH12015500590A1 (en) | 2015-05-25 |
| MY179191A (en) | 2020-10-30 |
| RU2015115127A (ru) | 2016-11-20 |
| WO2014052678A1 (en) | 2014-04-03 |
| KR20150058243A (ko) | 2015-05-28 |
| AU2013323435C1 (en) | 2018-04-12 |
| HK1212900A1 (zh) | 2016-06-24 |
| NZ630763A (en) | 2017-01-27 |
| KR102035373B1 (ko) | 2019-10-22 |
| US10016362B2 (en) | 2018-07-10 |
| JP6248112B2 (ja) | 2017-12-13 |
| SG11201501743UA (en) | 2015-04-29 |
| SG10201702048VA (en) | 2017-04-27 |
| MX2015003393A (es) | 2015-09-25 |
| MX358097B (es) | 2018-08-06 |
| RU2660358C2 (ru) | 2018-07-05 |
| US20150224053A1 (en) | 2015-08-13 |
| JP2015531377A (ja) | 2015-11-02 |
| CN104736142B (zh) | 2020-03-03 |
| AU2013323435A1 (en) | 2014-04-03 |
| CN104736142A (zh) | 2015-06-24 |
| IL237804A0 (en) | 2015-05-31 |
| AU2013323435A8 (en) | 2015-04-23 |
| EP2900217A1 (en) | 2015-08-05 |
| US9452134B2 (en) | 2016-09-27 |
| PH12015500590B1 (en) | 2019-08-23 |
| IN2015DN01902A (enExample) | 2015-08-07 |
| BR112015005995A2 (pt) | 2017-07-04 |
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|---|---|---|---|
| EEER | Examination request |
Effective date: 20180918 |
|
| FZDE | Discontinued |
Effective date: 20210831 |
|
| FZDE | Discontinued |
Effective date: 20210831 |