CA2885487C - Therapeutics using adipose cells and cell secretions - Google Patents

Therapeutics using adipose cells and cell secretions Download PDF

Info

Publication number
CA2885487C
CA2885487C CA2885487A CA2885487A CA2885487C CA 2885487 C CA2885487 C CA 2885487C CA 2885487 A CA2885487 A CA 2885487A CA 2885487 A CA2885487 A CA 2885487A CA 2885487 C CA2885487 C CA 2885487C
Authority
CA
Canada
Prior art keywords
adipose tissue
cells
secretions
derived
cell suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2885487A
Other languages
English (en)
French (fr)
Other versions
CA2885487A1 (en
Inventor
Graham Vesey
Rebecca Anne WEBSTER
Richard Lilischkis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Ideas Pty Ltd
Original Assignee
Cell Ideas Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2011903938A external-priority patent/AU2011903938A0/en
Application filed by Cell Ideas Pty Ltd filed Critical Cell Ideas Pty Ltd
Publication of CA2885487A1 publication Critical patent/CA2885487A1/en
Application granted granted Critical
Publication of CA2885487C publication Critical patent/CA2885487C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653Adipocytes; Adipose tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0667Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
CA2885487A 2011-09-23 2012-09-21 Therapeutics using adipose cells and cell secretions Active CA2885487C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
AU2011903938A AU2011903938A0 (en) 2011-09-23 Therapeutic methods and compositions
AU2011903938 2011-09-23
AU2012901350A AU2012901350A0 (en) 2012-04-04 Therapeutic methods and compositions
AU2012901350 2012-04-04
AU2012903646 2012-08-23
AU2012903646A AU2012903646A0 (en) 2012-08-23 Therapeutic methods and compositions
PCT/AU2012/001140 WO2013040649A1 (en) 2011-09-23 2012-09-21 Therapeutics using adipose cells and cell secretions

Publications (2)

Publication Number Publication Date
CA2885487A1 CA2885487A1 (en) 2013-03-28
CA2885487C true CA2885487C (en) 2021-11-16

Family

ID=47913679

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2885487A Active CA2885487C (en) 2011-09-23 2012-09-21 Therapeutics using adipose cells and cell secretions

Country Status (9)

Country Link
US (3) US10111909B2 (da)
EP (3) EP3868871A1 (da)
JP (5) JP6162123B2 (da)
AU (1) AU2012313352B2 (da)
CA (1) CA2885487C (da)
DK (2) DK3546569T3 (da)
ES (2) ES2880084T3 (da)
SG (2) SG10201606745XA (da)
WO (1) WO2013040649A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US20140286911A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
JP2023002772A (ja) * 2011-09-23 2023-01-10 レジニアス リミテッド 脂肪細胞および細胞分泌物を使用する治療
DK3546569T3 (da) * 2011-09-23 2021-07-12 Cell Ideas Pty Ltd Terapeutiske midler med anvendelse af fedtceller og cellesekreter
AU2013204930C1 (en) * 2012-09-26 2015-01-22 Cell Ideas Pty Ltd Therapeutics using multiple injections of cells
WO2014078705A1 (en) 2012-11-15 2014-05-22 Allosource Minced cartilage systems and methods
JP6286445B2 (ja) 2012-12-24 2018-02-28 セル・アイディアズ・ピーティーワイ・リミテッド がんの治療のためのワクチン及びワクチン有効性を増強するための組成物
EP2958523B1 (en) 2013-02-22 2020-04-22 AlloSource Cartilage mosaic compositions and methods
US9168140B2 (en) 2013-03-15 2015-10-27 Allosource Perforated osteochondral allograft compositions
US10206954B2 (en) * 2013-06-19 2019-02-19 Spinalcyte, Llc Adipose cells for chondrocyte applications
WO2015048842A1 (en) 2013-10-04 2015-04-09 Cell Ideas Pty Ltd Biomarkers for cell therapy
WO2016094932A1 (en) 2014-12-19 2016-06-23 Cell Ideas Pty Ltd Improved cell therapies
US20180236003A1 (en) 2015-09-08 2018-08-23 Cell Ideas Pty Ltd Cell Expansion Methods and Therapeutic Compositions
CN108289915A (zh) * 2015-11-24 2018-07-17 日本乐敦制药株式会社 包含脂肪组织来源基质细胞的肝病治疗剂及其制造方法
EP3624815A4 (en) 2017-05-15 2021-01-20 Stem Cell Medicine Ltd. TREATMENT OF MULTIPLE SCLEROSIS WITH LONG-ACTING GLATIRAMER AND ADAPTIVE STEM CELLS
IL269893B2 (en) 2017-05-15 2023-10-01 Stem Cell Medicine Ltd Treatment of multiple sclerosis using stem cells derived from adipose tissue
AU2017434946A1 (en) * 2017-10-02 2019-11-28 Hirotaro Fukuoka Pharmaceutical composition to be used for modification of scalp or skin, healing of wound or modification of hair
JP2021528489A (ja) * 2018-06-15 2021-10-21 パルド ルイス マリニャス 皮膚科用医薬組成物及びその使用
JP7429032B2 (ja) * 2019-12-24 2024-02-07 学校法人順天堂 間質性肺炎モデル非ヒト動物の作製方法
JP6826744B1 (ja) * 2020-07-17 2021-02-10 医療法人Yanaga CLinic 成熟脂肪細胞含有組成物の製造方法
CN114452303A (zh) * 2020-11-10 2022-05-10 上海萨美细胞技术有限公司 无细胞脂肪提取液对关节炎的治疗用途
IT202100003062A1 (it) * 2021-02-11 2022-08-11 Gaia Margiotta "processo di crioconservazione di tessuto adiposo"
CN115521908A (zh) * 2022-10-24 2022-12-27 潍坊天创生物科技有限公司 一种脂肪间充质干细胞的体外培养及外泌体的分离纯化方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037175A (en) 1996-03-12 2000-03-14 The University Of South Florida Method and media for enhancing cryopreservation of cells
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
CZ2004695A3 (cs) * 2001-11-09 2005-06-15 Artecel Sciences, Inc. Způsoby a kompozice pro použití buněk stromatu pro podporu embryonálních a dospělých kmenových buněk
EP2305276A3 (en) * 2001-12-07 2011-09-21 Cytori Therapeutics, Inc. Processed lipoaspirate cells for use in therapy
EP2450433A3 (en) * 2003-10-08 2012-08-08 Vet-Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
US8715733B2 (en) * 2004-07-23 2014-05-06 DePuy Synthes Products, LLC Enhanced adipose tissue
JP5240715B2 (ja) * 2006-08-08 2013-07-17 国立大学法人名古屋大学 脂肪組織由来多分化能幹細胞を含有する細胞製剤
US8835170B2 (en) * 2006-10-06 2014-09-16 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
WO2009115581A2 (en) 2008-03-19 2009-09-24 Cryo-Save Ag Improved cryopreservation of adipose tissue for the isolation of mesenchymal stem cells
WO2009152084A2 (en) 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
AU2009201915C1 (en) 2008-08-22 2015-02-26 Regeneus Ltd Therapeutic methods
US20120020937A1 (en) * 2009-04-28 2012-01-26 Anterogen Co., Ltd. Autologous and allogenic adipose-derived stromal stem cell composition for treating fistulas
WO2011047345A2 (en) 2009-10-15 2011-04-21 Tai June Yoo Methods of treating diseases of conditions using mesenchymal stem cells
DK3156060T3 (da) * 2011-03-15 2019-11-25 Cell Ideas Pty Ltd Farmaceutiske sammensætninger og topisk anvendelse deraf
DK3546569T3 (da) 2011-09-23 2021-07-12 Cell Ideas Pty Ltd Terapeutiske midler med anvendelse af fedtceller og cellesekreter

Also Published As

Publication number Publication date
JP2022033865A (ja) 2022-03-02
EP3546569B1 (en) 2021-06-16
US10660921B2 (en) 2020-05-26
DK2744892T3 (da) 2019-04-23
JP2014527821A (ja) 2014-10-23
ES2721180T3 (es) 2019-07-29
AU2012313352A1 (en) 2013-05-02
EP3868871A1 (en) 2021-08-25
CA2885487A1 (en) 2013-03-28
JP2021155461A (ja) 2021-10-07
AU2012313352A9 (en) 2013-09-26
US20190015455A1 (en) 2019-01-17
JP2019142971A (ja) 2019-08-29
US20140234272A1 (en) 2014-08-21
JP7022863B2 (ja) 2022-02-18
AU2012313352B2 (en) 2015-07-02
SG10201606745XA (en) 2016-10-28
DK3546569T3 (da) 2021-07-12
US20200261510A1 (en) 2020-08-20
EP2744892A1 (en) 2014-06-25
JP6912512B2 (ja) 2021-08-04
SG2014013676A (en) 2014-05-29
JP6162123B2 (ja) 2017-07-12
ES2880084T3 (es) 2021-11-23
JP2017193566A (ja) 2017-10-26
EP3546569A1 (en) 2019-10-02
EP2744892B1 (en) 2019-03-20
WO2013040649A1 (en) 2013-03-28
US10111909B2 (en) 2018-10-30
JP6839038B2 (ja) 2021-03-03
EP2744892A4 (en) 2015-05-20

Similar Documents

Publication Publication Date Title
US10660921B2 (en) Therapeutics using adipose cells and cell secretions
AU2020257078B2 (en) Stem cells and secretions for treatment of inflammatory conditions
AU2013203073B2 (en) Stem cell secretions for topical treatment of skin conditions
AU2013203072B2 (en) Therapeutic methods and compositions comprising cells and secretions
JP2023002772A (ja) 脂肪細胞および細胞分泌物を使用する治療
US11020436B2 (en) Multipotent and immunocompatible stem cell concentrate
AU2013204930C1 (en) Therapeutics using multiple injections of cells
AU2014200367A1 (en) Therapeutics using multiple injections of cells

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170801