CA2885234C - Flow cytometer nozzle tip - Google Patents

Flow cytometer nozzle tip Download PDF

Info

Publication number
CA2885234C
CA2885234C CA2885234A CA2885234A CA2885234C CA 2885234 C CA2885234 C CA 2885234C CA 2885234 A CA2885234 A CA 2885234A CA 2885234 A CA2885234 A CA 2885234A CA 2885234 C CA2885234 C CA 2885234C
Authority
CA
Canada
Prior art keywords
nozzle tip
nozzle
flow cytometer
angle
chamfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2885234A
Other languages
English (en)
French (fr)
Other versions
CA2885234A1 (en
Inventor
Kris BUCHANAN
Kenneth Michael Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inguran LLC
Original Assignee
Inguran LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2013/031787 external-priority patent/WO2014046733A1/en
Application filed by Inguran LLC filed Critical Inguran LLC
Publication of CA2885234A1 publication Critical patent/CA2885234A1/en
Application granted granted Critical
Publication of CA2885234C publication Critical patent/CA2885234C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/02Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
CA2885234A 2012-09-19 2013-09-19 Flow cytometer nozzle tip Active CA2885234C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261703102P 2012-09-19 2012-09-19
US61/703,102 2012-09-19
USPCT/US2013/031787 2013-03-14
PCT/US2013/031787 WO2014046733A1 (en) 2012-09-19 2013-03-14 Nozzle assembly for a flow cytometer system and methods of manufacture
US201361842310P 2013-07-02 2013-07-02
US61/842,310 2013-07-02
PCT/US2013/060730 WO2014047358A1 (en) 2012-09-19 2013-09-19 Flow cytometer nozzle tip

Publications (2)

Publication Number Publication Date
CA2885234A1 CA2885234A1 (en) 2014-03-27
CA2885234C true CA2885234C (en) 2019-08-06

Family

ID=50274164

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2885234A Active CA2885234C (en) 2012-09-19 2013-09-19 Flow cytometer nozzle tip

Country Status (12)

Country Link
US (1) US9222872B2 (OSRAM)
EP (2) EP2898057B1 (OSRAM)
JP (1) JP2015531878A (OSRAM)
CN (1) CN104662145B (OSRAM)
AU (1) AU2013318001B2 (OSRAM)
BR (1) BR112015006181B1 (OSRAM)
CA (1) CA2885234C (OSRAM)
DK (1) DK2898057T3 (OSRAM)
ES (1) ES2928128T3 (OSRAM)
IN (1) IN2015KN00621A (OSRAM)
NZ (1) NZ630368A (OSRAM)
WO (1) WO2014047358A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10870175B2 (en) 2013-09-18 2020-12-22 Cytonome/St, Llc Microfluidic flow-through elements and methods of manufacture of same
US10504758B2 (en) * 2014-02-14 2019-12-10 Taiwan Semiconductor Manufacturing Company Ltd. Nozzle having real time inspection functions
JP6102783B2 (ja) * 2014-02-14 2017-03-29 ソニー株式会社 粒子分取装置、粒子分取方法及びプログラム
HK1254621B (en) * 2015-06-16 2020-06-19 Adige S.P.A. Machine for the laser working of profiles and method for carrying out an inclined cutting operation on a profile by means of this machine
WO2017003725A1 (en) * 2015-06-29 2017-01-05 Doak R Bruce Nozzle apparatus and two-photon laser lithography for fabrication of xfel sample injectors
JP6455470B2 (ja) * 2016-03-15 2019-01-23 オムロン株式会社 粒子センサ、及びそれを備えた電子機器
KR102501627B1 (ko) * 2016-04-15 2023-02-21 벡톤 디킨슨 앤드 컴퍼니 밀폐형 액적 분류기 및 이의 사용 방법
US10267723B1 (en) * 2018-01-23 2019-04-23 Cbrn International, Ltd. Bioaerosol particle detector
MX2020008681A (es) * 2018-02-20 2020-12-07 Spraying Systems Co Boquilla de rociamiento fluídico de cuerpo dividido.
EP3785017B1 (en) * 2018-04-27 2025-09-10 Becton, Dickinson And Company Collection systems for flow cytometrically sorted samples and methods of using the same
CN119269374A (zh) 2018-04-27 2025-01-07 贝克顿·迪金森公司 具有气溶胶含量受控的封闭式液滴分选仪的流式细胞仪及其使用方法
US11035776B2 (en) 2018-10-30 2021-06-15 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
CN111521549B (zh) * 2020-05-13 2021-01-01 洹仪科技(上海)有限公司 一种颗粒分选装置及方法
CN112924364B (zh) * 2021-01-22 2024-07-23 贝克曼库尔特生物科技(苏州)有限公司 喷嘴、载体、喷嘴组件及样本处理仪

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3672324A (en) 1970-12-28 1972-06-27 Armco Steel Corp Releasable melting means for movable fluid nozzle extension
US3893766A (en) 1973-06-14 1975-07-08 Coulter Electronics Apparatus for orienting generally flat particles for slit-scan photometry
US4362246A (en) 1980-07-14 1982-12-07 Adair Edwin Lloyd Method of treating collected mammal semen and separating sperm into X Y components
US4361400A (en) * 1980-11-26 1982-11-30 The United States Of America As Represented By The United States Department Of Energy Fluidic assembly for an ultra-high-speed chromosome flow sorter
US4660971A (en) 1984-05-03 1987-04-28 Becton, Dickinson And Company Optical features of flow cytometry apparatus
NO156916C (no) 1985-07-10 1987-12-16 Harald B Steen Stroemningskammer for vaeskestroemsfotometer.
US4813609A (en) 1987-02-09 1989-03-21 French Floyd R Spray nozzle
US5346990A (en) 1987-04-08 1994-09-13 Cytogam, Inc. Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
JPS63262565A (ja) 1987-04-20 1988-10-28 Hitachi Ltd フロ−セル
US4798008A (en) 1987-05-04 1989-01-17 Belanger, Inc. Nozzle construction
US4848670A (en) 1987-05-27 1989-07-18 Belanger, Inc. Nozzle construction
US4988619A (en) 1987-11-30 1991-01-29 United States Department Of Energy Flow cytometry apparatus
JPH02118852A (ja) 1988-10-28 1990-05-07 Nec Eng Ltd 高級言語のデバッグの簡易化方式
DK0471758T3 (OSRAM) 1989-05-10 1997-03-10 Us Agriculture
JP2808321B2 (ja) 1989-09-19 1998-10-08 東亜医用電子株式会社 細胞分析方法及び装置
JP3075370B2 (ja) 1991-07-26 2000-08-14 シスメックス株式会社 粒子分析用のサンプル扁平流形成装置
US5466572A (en) 1992-09-03 1995-11-14 Systemix, Inc. High speed flow cytometric separation of viable cells
US5311290A (en) 1992-09-30 1994-05-10 Pulp And Paper Research Institute Of Canada Imaging apparatus and method of fiber analysis
US5371585A (en) 1992-11-10 1994-12-06 Pacific Scientific Company Particle detecting instrument with sapphire detecting cell defining a rectangular flow path
JP3052665B2 (ja) 1993-01-26 2000-06-19 株式会社日立製作所 フローセル装置
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
US5601234A (en) 1994-08-01 1997-02-11 Abbott Laboratories Fluid nozzle and method of introducing a fluid
US5700692A (en) 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
US5602349A (en) 1994-10-14 1997-02-11 The University Of Washington Sample introduction system for a flow cytometer
US5602039A (en) 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
EP0786078B1 (en) 1994-10-14 2004-01-07 University of Washington System and method for high speed flow cytometer droplet formation
US6861265B1 (en) 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
US5985216A (en) 1997-07-24 1999-11-16 The United States Of America, As Represented By The Secretary Of Agriculture Flow cytometry nozzle for high efficiency cell sorting
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6746873B1 (en) 1998-02-20 2004-06-08 Xy, Inc. Vibratory system for a sorting flow cytometer
FR2777351B1 (fr) 1998-04-08 2000-06-23 Hycel Diagnostics Procede et dispositif de mesure de particules en suspension dans un liquide
US6267301B1 (en) 1999-06-11 2001-07-31 Spraying Systems Co. Air atomizing nozzle assembly with improved air cap
US6372506B1 (en) 1999-07-02 2002-04-16 Becton, Dickinson And Company Apparatus and method for verifying drop delay in a flow cytometer
US7024316B1 (en) 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US6491190B1 (en) 1999-11-22 2002-12-10 Bruce E. Dunworth Permeable refractory nozzle and manufacturing method
US6263745B1 (en) 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
MXPA02010971A (es) * 2000-05-09 2003-07-14 Xy Inc Poblaciones de espermatozoides que portan cromosoma x y que porta cromosoma y de alta pureza.
EP1370365A2 (en) * 2000-11-10 2003-12-17 Therics, Inc. A wetting-resistant nozzle for dispensing small volumes of liquid and a method for manufacturing a wetting-resistant nozzle
US20030042326A1 (en) * 2000-12-22 2003-03-06 Kimberly-Clark Worldwide, Inc. Apparatus and method to selectively microemulsify water and other normally immiscible fluids into the fuel of continuous combustors at the point of injection
WO2002092247A1 (en) * 2001-05-17 2002-11-21 Cytomation, Inc. Flow cytometer with active automated optical alignment system
US6550691B2 (en) 2001-05-22 2003-04-22 Steve Pence Reagent dispenser head
CA2534394C (en) * 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
DE10257518A1 (de) 2002-12-10 2004-07-08 Dieter Wildfang Gmbh Sanitäres Einbauteil
WO2004088283A2 (en) 2003-03-28 2004-10-14 Monsanto Technology Llc Apparatus and methods for providing sex-sorted animal sperm
US20060263829A1 (en) 2003-05-15 2006-11-23 Evans Kenneth M Efficient haploid cell sorting flow cytometer systems
JP4057539B2 (ja) * 2004-01-09 2008-03-05 浜松ホトニクス株式会社 シースフローセルキュベット及びその製造方法
DE602005017748D1 (de) 2004-02-26 2009-12-31 Pursuit Dynamics Plc Verbesserungen eines verfahrens und einer vorrichtung zur erzeugung eines nebels
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
ITMI20050749A1 (it) 2005-04-27 2006-10-28 De Longhi Spa Dispositivo per la formazione di sciuma in una bevanda a base di latte
US20070269348A1 (en) 2006-05-19 2007-11-22 Cytopeia Incorporated Enhanced droplet flow cytometer system and method
WO2008061058A2 (en) 2006-11-10 2008-05-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
WO2009151624A1 (en) * 2008-06-13 2009-12-17 Xy, Inc. Lubricious microfluidic flow path system
US20100009333A1 (en) * 2008-07-08 2010-01-14 Beckman Coulter, Inc. Methods for Acoustic Particle Focusing in Biological Sample Analyzers
US8557587B2 (en) 2009-01-07 2013-10-15 Xy, Llc Self-tuning, biologically modeled sorter
FR2956207B1 (fr) * 2010-02-10 2012-05-04 Horiba Abx Sas Dispositif et procede de mesures multiparametriques de microparticules dans un fluide
JP5437148B2 (ja) 2010-04-23 2014-03-12 ベイバイオサイエンス株式会社 フローサイトメータおよびセルソータ
CA2826544C (en) 2011-02-04 2020-06-30 Cytonome/St, Llc Particle sorting apparatus and method
CN103013811A (zh) * 2011-09-20 2013-04-03 北京富通华投资有限公司 精子分选仪
CA3234097A1 (en) 2012-09-19 2014-03-27 Inguran, Llc Nozzle assembly for a flow cytometer system and methods of manufacture

Also Published As

Publication number Publication date
AU2013318001B2 (en) 2016-06-16
US9222872B2 (en) 2015-12-29
DK2898057T3 (da) 2022-10-10
US20140078502A1 (en) 2014-03-20
EP2898057A4 (en) 2016-05-18
BR112015006181B1 (pt) 2021-01-05
JP2015531878A (ja) 2015-11-05
NZ630368A (en) 2016-06-24
EP2898057B1 (en) 2022-07-06
CN104662145B (zh) 2016-11-09
IN2015KN00621A (OSRAM) 2015-07-17
EP2898057A1 (en) 2015-07-29
CN104662145A (zh) 2015-05-27
ES2928128T3 (es) 2022-11-15
EP4163618A1 (en) 2023-04-12
AU2013318001A1 (en) 2015-04-02
CA2885234A1 (en) 2014-03-27
WO2014047358A1 (en) 2014-03-27

Similar Documents

Publication Publication Date Title
CA2885234C (en) Flow cytometer nozzle tip
EP3555589B1 (en) Method and apparatus for bulk microparticle sorting using a microfulidic channel
KR100909862B1 (ko) 개선된 플로우 사이토미터 노즐 및 플로우 사이토미터 샘플처리 방법
CA2885170C (en) Nozzle assembly for a flow cytometer system and methods of manufacture
CA2534394C (en) High resolution flow cytometer
CN105073262B (zh) 用于高通过量精子分选的设备和方法
EP2671065B1 (en) Particle sorting apparatus and method
DK2304020T3 (en) Method and apparatus for sorting cells
US11668640B2 (en) Nozzle assembly for a flow cytometry system and methods of manufacture
CN214844688U (zh) 用于样本处理仪的透明管组件和流式池及样本处理仪
US20230384201A1 (en) Nozzle assembly for a flow cytometry system and methods of manufacture
HK1189655A (en) Methods, systems, and apparatus for performing flow cytometry

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150316