CA2885234C - Flow cytometer nozzle tip - Google Patents
Flow cytometer nozzle tip Download PDFInfo
- Publication number
- CA2885234C CA2885234C CA2885234A CA2885234A CA2885234C CA 2885234 C CA2885234 C CA 2885234C CA 2885234 A CA2885234 A CA 2885234A CA 2885234 A CA2885234 A CA 2885234A CA 2885234 C CA2885234 C CA 2885234C
- Authority
- CA
- Canada
- Prior art keywords
- nozzle tip
- nozzle
- flow cytometer
- angle
- chamfer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012530 fluid Substances 0.000 claims abstract description 133
- 239000002245 particle Substances 0.000 claims abstract description 53
- 238000004891 communication Methods 0.000 claims abstract description 35
- 230000004044 response Effects 0.000 claims abstract description 21
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 17
- 238000002347 injection Methods 0.000 claims description 32
- 239000007924 injection Substances 0.000 claims description 32
- 230000007704 transition Effects 0.000 claims description 10
- 230000007246 mechanism Effects 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 description 54
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- 238000010168 coupling process Methods 0.000 description 10
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- 210000001766 X chromosome Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 210000002593 Y chromosome Anatomy 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
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- 238000000926 separation method Methods 0.000 description 2
- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001274197 Scatophagus argus Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
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- 239000012620 biological material Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703102P | 2012-09-19 | 2012-09-19 | |
| US61/703,102 | 2012-09-19 | ||
| USPCT/US2013/031787 | 2013-03-14 | ||
| PCT/US2013/031787 WO2014046733A1 (en) | 2012-09-19 | 2013-03-14 | Nozzle assembly for a flow cytometer system and methods of manufacture |
| US201361842310P | 2013-07-02 | 2013-07-02 | |
| US61/842,310 | 2013-07-02 | ||
| PCT/US2013/060730 WO2014047358A1 (en) | 2012-09-19 | 2013-09-19 | Flow cytometer nozzle tip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2885234A1 CA2885234A1 (en) | 2014-03-27 |
| CA2885234C true CA2885234C (en) | 2019-08-06 |
Family
ID=50274164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2885234A Active CA2885234C (en) | 2012-09-19 | 2013-09-19 | Flow cytometer nozzle tip |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9222872B2 (OSRAM) |
| EP (2) | EP2898057B1 (OSRAM) |
| JP (1) | JP2015531878A (OSRAM) |
| CN (1) | CN104662145B (OSRAM) |
| AU (1) | AU2013318001B2 (OSRAM) |
| BR (1) | BR112015006181B1 (OSRAM) |
| CA (1) | CA2885234C (OSRAM) |
| DK (1) | DK2898057T3 (OSRAM) |
| ES (1) | ES2928128T3 (OSRAM) |
| IN (1) | IN2015KN00621A (OSRAM) |
| NZ (1) | NZ630368A (OSRAM) |
| WO (1) | WO2014047358A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10870175B2 (en) | 2013-09-18 | 2020-12-22 | Cytonome/St, Llc | Microfluidic flow-through elements and methods of manufacture of same |
| US10504758B2 (en) * | 2014-02-14 | 2019-12-10 | Taiwan Semiconductor Manufacturing Company Ltd. | Nozzle having real time inspection functions |
| JP6102783B2 (ja) * | 2014-02-14 | 2017-03-29 | ソニー株式会社 | 粒子分取装置、粒子分取方法及びプログラム |
| HK1254621B (en) * | 2015-06-16 | 2020-06-19 | Adige S.P.A. | Machine for the laser working of profiles and method for carrying out an inclined cutting operation on a profile by means of this machine |
| WO2017003725A1 (en) * | 2015-06-29 | 2017-01-05 | Doak R Bruce | Nozzle apparatus and two-photon laser lithography for fabrication of xfel sample injectors |
| JP6455470B2 (ja) * | 2016-03-15 | 2019-01-23 | オムロン株式会社 | 粒子センサ、及びそれを備えた電子機器 |
| KR102501627B1 (ko) * | 2016-04-15 | 2023-02-21 | 벡톤 디킨슨 앤드 컴퍼니 | 밀폐형 액적 분류기 및 이의 사용 방법 |
| US10267723B1 (en) * | 2018-01-23 | 2019-04-23 | Cbrn International, Ltd. | Bioaerosol particle detector |
| MX2020008681A (es) * | 2018-02-20 | 2020-12-07 | Spraying Systems Co | Boquilla de rociamiento fluídico de cuerpo dividido. |
| EP3785017B1 (en) * | 2018-04-27 | 2025-09-10 | Becton, Dickinson And Company | Collection systems for flow cytometrically sorted samples and methods of using the same |
| CN119269374A (zh) | 2018-04-27 | 2025-01-07 | 贝克顿·迪金森公司 | 具有气溶胶含量受控的封闭式液滴分选仪的流式细胞仪及其使用方法 |
| US11035776B2 (en) | 2018-10-30 | 2021-06-15 | Becton, Dickinson And Company | Particle sorting module with alignment window, systems and methods of use thereof |
| CN111521549B (zh) * | 2020-05-13 | 2021-01-01 | 洹仪科技(上海)有限公司 | 一种颗粒分选装置及方法 |
| CN112924364B (zh) * | 2021-01-22 | 2024-07-23 | 贝克曼库尔特生物科技(苏州)有限公司 | 喷嘴、载体、喷嘴组件及样本处理仪 |
Family Cites Families (60)
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| US3672324A (en) | 1970-12-28 | 1972-06-27 | Armco Steel Corp | Releasable melting means for movable fluid nozzle extension |
| US3893766A (en) | 1973-06-14 | 1975-07-08 | Coulter Electronics | Apparatus for orienting generally flat particles for slit-scan photometry |
| US4362246A (en) | 1980-07-14 | 1982-12-07 | Adair Edwin Lloyd | Method of treating collected mammal semen and separating sperm into X Y components |
| US4361400A (en) * | 1980-11-26 | 1982-11-30 | The United States Of America As Represented By The United States Department Of Energy | Fluidic assembly for an ultra-high-speed chromosome flow sorter |
| US4660971A (en) | 1984-05-03 | 1987-04-28 | Becton, Dickinson And Company | Optical features of flow cytometry apparatus |
| NO156916C (no) | 1985-07-10 | 1987-12-16 | Harald B Steen | Stroemningskammer for vaeskestroemsfotometer. |
| US4813609A (en) | 1987-02-09 | 1989-03-21 | French Floyd R | Spray nozzle |
| US5346990A (en) | 1987-04-08 | 1994-09-13 | Cytogam, Inc. | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex |
| JPS63262565A (ja) | 1987-04-20 | 1988-10-28 | Hitachi Ltd | フロ−セル |
| US4798008A (en) | 1987-05-04 | 1989-01-17 | Belanger, Inc. | Nozzle construction |
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| US4988619A (en) | 1987-11-30 | 1991-01-29 | United States Department Of Energy | Flow cytometry apparatus |
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| DK0471758T3 (OSRAM) | 1989-05-10 | 1997-03-10 | Us Agriculture | |
| JP2808321B2 (ja) | 1989-09-19 | 1998-10-08 | 東亜医用電子株式会社 | 細胞分析方法及び装置 |
| JP3075370B2 (ja) | 1991-07-26 | 2000-08-14 | シスメックス株式会社 | 粒子分析用のサンプル扁平流形成装置 |
| US5466572A (en) | 1992-09-03 | 1995-11-14 | Systemix, Inc. | High speed flow cytometric separation of viable cells |
| US5311290A (en) | 1992-09-30 | 1994-05-10 | Pulp And Paper Research Institute Of Canada | Imaging apparatus and method of fiber analysis |
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| CA2826544C (en) | 2011-02-04 | 2020-06-30 | Cytonome/St, Llc | Particle sorting apparatus and method |
| CN103013811A (zh) * | 2011-09-20 | 2013-04-03 | 北京富通华投资有限公司 | 精子分选仪 |
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-
2013
- 2013-09-19 IN IN621KON2015 patent/IN2015KN00621A/en unknown
- 2013-09-19 NZ NZ630368A patent/NZ630368A/en unknown
- 2013-09-19 DK DK13838116.5T patent/DK2898057T3/da active
- 2013-09-19 BR BR112015006181-8A patent/BR112015006181B1/pt active IP Right Grant
- 2013-09-19 EP EP13838116.5A patent/EP2898057B1/en active Active
- 2013-09-19 WO PCT/US2013/060730 patent/WO2014047358A1/en not_active Ceased
- 2013-09-19 EP EP22175379.1A patent/EP4163618A1/en active Pending
- 2013-09-19 CN CN201380048073.1A patent/CN104662145B/zh active Active
- 2013-09-19 US US14/032,086 patent/US9222872B2/en active Active
- 2013-09-19 ES ES13838116T patent/ES2928128T3/es active Active
- 2013-09-19 AU AU2013318001A patent/AU2013318001B2/en active Active
- 2013-09-19 JP JP2015532183A patent/JP2015531878A/ja active Pending
- 2013-09-19 CA CA2885234A patent/CA2885234C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013318001B2 (en) | 2016-06-16 |
| US9222872B2 (en) | 2015-12-29 |
| DK2898057T3 (da) | 2022-10-10 |
| US20140078502A1 (en) | 2014-03-20 |
| EP2898057A4 (en) | 2016-05-18 |
| BR112015006181B1 (pt) | 2021-01-05 |
| JP2015531878A (ja) | 2015-11-05 |
| NZ630368A (en) | 2016-06-24 |
| EP2898057B1 (en) | 2022-07-06 |
| CN104662145B (zh) | 2016-11-09 |
| IN2015KN00621A (OSRAM) | 2015-07-17 |
| EP2898057A1 (en) | 2015-07-29 |
| CN104662145A (zh) | 2015-05-27 |
| ES2928128T3 (es) | 2022-11-15 |
| EP4163618A1 (en) | 2023-04-12 |
| AU2013318001A1 (en) | 2015-04-02 |
| CA2885234A1 (en) | 2014-03-27 |
| WO2014047358A1 (en) | 2014-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150316 |