CA2884848C - Composes de benzamide et heterobenzamide - Google Patents
Composes de benzamide et heterobenzamide Download PDFInfo
- Publication number
- CA2884848C CA2884848C CA2884848A CA2884848A CA2884848C CA 2884848 C CA2884848 C CA 2884848C CA 2884848 A CA2884848 A CA 2884848A CA 2884848 A CA2884848 A CA 2884848A CA 2884848 C CA2884848 C CA 2884848C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- methyl
- optionally substituted
- halo
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261707447P | 2012-09-28 | 2012-09-28 | |
US61/707,447 | 2012-09-28 | ||
PCT/IB2013/058580 WO2014049488A1 (fr) | 2012-09-28 | 2013-09-16 | Composés de benzamide et hétérobenzamide |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2884848A1 CA2884848A1 (fr) | 2014-04-03 |
CA2884848C true CA2884848C (fr) | 2017-08-22 |
Family
ID=49681084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2884848A Expired - Fee Related CA2884848C (fr) | 2012-09-28 | 2013-09-16 | Composes de benzamide et heterobenzamide |
Country Status (5)
Country | Link |
---|---|
US (2) | US20150239842A1 (fr) |
EP (1) | EP2900653A1 (fr) |
JP (1) | JP6254169B2 (fr) |
CA (1) | CA2884848C (fr) |
WO (1) | WO2014049488A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
CA2862289C (fr) | 2012-02-10 | 2019-11-26 | Constellation Pharmaceuticals, Inc. | Modulateurs d'enzymes de modification par methylation, leurs compositions et utilisations |
UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
EP2970305B1 (fr) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées |
EP3033334A1 (fr) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Dérivés d'indole utilisés en tant que modulateurs d'enzymes de modification du méthyle, compositions et utilisations associées |
GB201316600D0 (en) * | 2013-09-18 | 2013-10-30 | Redx Pharma Ltd | Agricultural chemicals |
US9738630B2 (en) * | 2013-11-19 | 2017-08-22 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
WO2015110999A1 (fr) * | 2014-01-24 | 2015-07-30 | Piramal Enterprises Limited | Inhibiteurs de ezh2 et leurs utilisations |
CN105037360B (zh) * | 2014-04-28 | 2016-08-17 | 四川大学 | 吡啶酮衍生物及其制备方法和用途 |
US20170305943A1 (en) * | 2014-05-21 | 2017-10-26 | Taxis Pharmaceuticals, Inc. | Compounds for the treatment of bacterial infections |
CR20160574A (es) | 2014-06-17 | 2017-02-23 | Pfizer | Compuestos de dihidroisoquinolinona sustituida |
WO2015193768A1 (fr) * | 2014-06-17 | 2015-12-23 | Pfizer Inc. | Lactames à fusion aryle à utiliser en tant que modulateurs ezh2 |
TW201636344A (zh) | 2014-12-05 | 2016-10-16 | 美國禮來大藥廠 | Ezh2抑制劑 |
UY36422A (es) | 2014-12-09 | 2016-06-30 | Evotec Ag | Benzamidas sustituidas con 1,3-tiazol-2-ilo |
US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
US20180271857A1 (en) | 2014-12-23 | 2018-09-27 | University Of Copenhagen | Treatment of cancer by inhibiting ezh2 activity |
TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ezh2抑制劑 |
WO2017040190A1 (fr) | 2015-08-28 | 2017-03-09 | Constellation Pharmaceuticals, Inc. | Formes cristallines de (r)-n-((4-méthoxy-6-méthyl-2-oxo-1,2-dihydropyridin-3-yl)méthyl)-2-méthyl-1-(1-(1-(2,2,2-trifluoroéthyl)pipéridin-4-yl)éthyl)-1h-indole-3-carboxamide |
CN106496130B (zh) * | 2016-09-09 | 2019-09-20 | 苏州大学 | 一种甲基酮衍生物及其制备方法与应用 |
EP3529242A1 (fr) | 2016-10-19 | 2019-08-28 | Constellation Pharmaceuticals, Inc. | Synthèse d'inhibiteurs d'ezh2 |
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
US11529344B2 (en) | 2017-11-14 | 2022-12-20 | Pfizer Inc. | EZH2 inhibitor combination therapies |
DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
JP2021531340A (ja) | 2018-07-09 | 2021-11-18 | フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles | 眼障害を治療するためのprc2サブユニットの阻害 |
CN111683936B (zh) * | 2018-07-27 | 2021-08-20 | 苏州信诺维医药科技股份有限公司 | 多取代苯环化合物、制备方法及其用途 |
EP3950676A4 (fr) * | 2019-03-25 | 2022-08-10 | Shanghai Synergy Pharmaceutical Sciences Co., Ltd | Procédé de préparation de composé amide et son application dans le domaine de la médecine |
AU2021322253A1 (en) * | 2020-08-06 | 2023-02-23 | Chdi Foundation, Inc. | Heterobiaryl compounds and imaging agents for imaging Huntingtin protein |
EP4230625A1 (fr) * | 2020-10-13 | 2023-08-23 | Evopoint Biosciences Co., Ltd. | Forme cristalline d'un composé maléate à cycle benzénique multi-substitué, son procédé de préparation et son utilisation |
CN115093400B (zh) * | 2021-09-18 | 2023-09-05 | 北京华森英诺生物科技有限公司 | AhR抑制剂及其用途和制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
WO2000035298A1 (fr) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing-gum contenant des agents medicamenteux actifs |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
CA2525437C (fr) | 2003-05-12 | 2009-04-28 | Pfizer Products Inc. | Inhibiteurs benzamidiques du recepteur p2x<sb>7</sb> |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
WO2012005805A1 (fr) * | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Aza-indazoles |
BR112012028556A2 (pt) | 2010-05-07 | 2014-04-01 | Glaxosmithkline Llc | Indóis |
US8846935B2 (en) * | 2010-05-07 | 2014-09-30 | Glaxosmithkline Llc | Indazoles |
JO3438B1 (ar) * | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
TWI598336B (zh) * | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
ES2718900T3 (es) * | 2012-03-12 | 2019-07-05 | Epizyme Inc | Inhibidores de EZH2 humana y métodos de uso de los mismos |
WO2013173441A2 (fr) * | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Inhibiteurs d'homologue d'activateur de zeste 2 |
-
2013
- 2013-09-16 JP JP2015533726A patent/JP6254169B2/ja not_active Expired - Fee Related
- 2013-09-16 CA CA2884848A patent/CA2884848C/fr not_active Expired - Fee Related
- 2013-09-16 US US14/430,799 patent/US20150239842A1/en not_active Abandoned
- 2013-09-16 EP EP13798742.6A patent/EP2900653A1/fr not_active Withdrawn
- 2013-09-16 WO PCT/IB2013/058580 patent/WO2014049488A1/fr active Application Filing
-
2017
- 2017-02-06 US US15/425,732 patent/US20170152239A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2015531366A (ja) | 2015-11-02 |
US20170152239A1 (en) | 2017-06-01 |
JP6254169B2 (ja) | 2017-12-27 |
WO2014049488A1 (fr) | 2014-04-03 |
EP2900653A1 (fr) | 2015-08-05 |
CA2884848A1 (fr) | 2014-04-03 |
US20150239842A1 (en) | 2015-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20150312 |
|
EEER | Examination request |
Effective date: 20150312 |
|
MKLA | Lapsed |
Effective date: 20190916 |