CA2880506C - Pharmaceutical combination comprising a phosphatidylinositol 3-kinase inhibitor and an aromatase inhibitor - Google Patents
Pharmaceutical combination comprising a phosphatidylinositol 3-kinase inhibitor and an aromatase inhibitor Download PDFInfo
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- CA2880506C CA2880506C CA2880506A CA2880506A CA2880506C CA 2880506 C CA2880506 C CA 2880506C CA 2880506 A CA2880506 A CA 2880506A CA 2880506 A CA2880506 A CA 2880506A CA 2880506 C CA2880506 C CA 2880506C
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- cancer
- pharmaceutically acceptable
- acceptable salt
- combination
- treatment
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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- Hematology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| US201261703533P | 2012-09-20 | 2012-09-20 | |
| US61/703,533 | 2012-09-20 | ||
| US201261708070P | 2012-10-01 | 2012-10-01 | |
| US61/708,070 | 2012-10-01 | ||
| PCT/US2013/060292 WO2014047109A1 (en) | 2012-09-20 | 2013-09-18 | Pharmaceutical combination comprising a phosphatidylinositol 3-kinase inhibitor|and an aromatase inhibitor |
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| CA2880506A1 CA2880506A1 (en) | 2014-03-27 |
| CA2880506C true CA2880506C (en) | 2021-04-20 |
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| CA2880506A Active CA2880506C (en) | 2012-09-20 | 2013-09-18 | Pharmaceutical combination comprising a phosphatidylinositol 3-kinase inhibitor and an aromatase inhibitor |
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| EP3140427B1 (en) * | 2014-05-09 | 2020-10-14 | Memorial Sloan Kettering Cancer Center | Biomarkers for response to pi3k inhibitors |
| CN118593514B (zh) * | 2024-05-09 | 2025-05-27 | 西南医科大学附属医院 | 芳香化酶抑制剂在制备治疗黑色素瘤药物中的应用 |
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| PE20091523A1 (es) * | 2007-12-20 | 2009-10-29 | Novartis Ag | Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k) |
| JP2011525535A (ja) * | 2008-06-24 | 2011-09-22 | 武田薬品工業株式会社 | ＰＩ３Ｋ／ｍＴＯＲ阻害剤 |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| US8293753B2 (en) * | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
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| ES2686689T3 (es) | 2018-10-19 |
| HUE040520T2 (hu) | 2019-03-28 |
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| IN2015DN00735A (enExample) | 2015-07-10 |
| JP2015532927A (ja) | 2015-11-16 |
| US20150231124A1 (en) | 2015-08-20 |
| CA2880506A1 (en) | 2014-03-27 |
| CN104661681B (zh) | 2018-07-03 |
| EP2897644A1 (en) | 2015-07-29 |
| US9532982B2 (en) | 2017-01-03 |
| KR20150056778A (ko) | 2015-05-27 |
| RU2015111171A (ru) | 2016-11-10 |
| AU2013318205A1 (en) | 2015-02-26 |
| PL2897644T3 (pl) | 2018-11-30 |
| KR102220965B1 (ko) | 2021-02-26 |
| CN104661681A (zh) | 2015-05-27 |
| MX2015003657A (es) | 2015-06-05 |
| AU2013318205B2 (en) | 2016-05-19 |
| SI2897644T1 (sl) | 2018-10-30 |
| LT2897644T (lt) | 2018-09-25 |
| DK2897644T3 (en) | 2018-09-10 |
| HRP20181413T1 (hr) | 2018-10-19 |
| CY1120984T1 (el) | 2019-12-11 |
| WO2014047109A1 (en) | 2014-03-27 |
| JP6212563B2 (ja) | 2017-10-11 |
| PT2897644T (pt) | 2018-10-16 |
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