RU2651023C2 - Фармацевтическая комбинация, включающая ингибитор фосфатидилинозитол 3-киназы и ингибитор ароматазы - Google Patents
Фармацевтическая комбинация, включающая ингибитор фосфатидилинозитол 3-киназы и ингибитор ароматазы Download PDFInfo
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- RU2651023C2 RU2651023C2 RU2015111171A RU2015111171A RU2651023C2 RU 2651023 C2 RU2651023 C2 RU 2651023C2 RU 2015111171 A RU2015111171 A RU 2015111171A RU 2015111171 A RU2015111171 A RU 2015111171A RU 2651023 C2 RU2651023 C2 RU 2651023C2
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201261703533P | 2012-09-20 | 2012-09-20 | |
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| US201261708070P | 2012-10-01 | 2012-10-01 | |
| US61/708,070 | 2012-10-01 | ||
| PCT/US2013/060292 WO2014047109A1 (en) | 2012-09-20 | 2013-09-18 | Pharmaceutical combination comprising a phosphatidylinositol 3-kinase inhibitor|and an aromatase inhibitor |
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| RU2015111171A RU2015111171A (ru) | 2016-11-10 |
| RU2651023C2 true RU2651023C2 (ru) | 2018-04-18 |
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| CN118593514B (zh) * | 2024-05-09 | 2025-05-27 | 西南医科大学附属医院 | 芳香化酶抑制剂在制备治疗黑色素瘤药物中的应用 |
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Non-Patent Citations (3)
| Title |
|---|
| SABNIS G. et al. Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway Improves Response of Long-term Estrogen-Deprived Breast Cancer Xenografts to Antiestrogens // Clinical cancer research. Vol.13, No.9, P.2751-2757. * |
| ХАРКЕВИЧ Д.А. Фармакология. Изд. 3-е. М.:"Медицина". 1987. MILLER T.W. et al. Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer // J Clin Oncol. 2011, Vol.29(33), P.4452-4461. * |
| ХАРКЕВИЧ Д.А. Фармакология. Изд. 3-е. М.:"Медицина". 1987. MILLER T.W. et al. Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer // J Clin Oncol. 2011, Vol.29(33), P.4452-4461. SABNIS G. et al. Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway Improves Response of Long-term Estrogen-Deprived Breast Cancer Xenografts to Antiestrogens // Clinical cancer research. Vol.13, No.9, P.2751-2757. * |
Also Published As
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| BR112015004152A2 (pt) | 2017-07-04 |
| ES2686689T3 (es) | 2018-10-19 |
| HUE040520T2 (hu) | 2019-03-28 |
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| MX356278B (es) | 2018-05-22 |
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| JP2015532927A (ja) | 2015-11-16 |
| US20150231124A1 (en) | 2015-08-20 |
| CA2880506A1 (en) | 2014-03-27 |
| CN104661681B (zh) | 2018-07-03 |
| EP2897644A1 (en) | 2015-07-29 |
| US9532982B2 (en) | 2017-01-03 |
| KR20150056778A (ko) | 2015-05-27 |
| RU2015111171A (ru) | 2016-11-10 |
| AU2013318205A1 (en) | 2015-02-26 |
| PL2897644T3 (pl) | 2018-11-30 |
| KR102220965B1 (ko) | 2021-02-26 |
| CN104661681A (zh) | 2015-05-27 |
| MX2015003657A (es) | 2015-06-05 |
| AU2013318205B2 (en) | 2016-05-19 |
| SI2897644T1 (sl) | 2018-10-30 |
| CA2880506C (en) | 2021-04-20 |
| LT2897644T (lt) | 2018-09-25 |
| DK2897644T3 (en) | 2018-09-10 |
| HRP20181413T1 (hr) | 2018-10-19 |
| CY1120984T1 (el) | 2019-12-11 |
| WO2014047109A1 (en) | 2014-03-27 |
| JP6212563B2 (ja) | 2017-10-11 |
| PT2897644T (pt) | 2018-10-16 |
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