CA2879908A1 - Therapeutic compounds - Google Patents

Therapeutic compounds Download PDF

Info

Publication number
CA2879908A1
CA2879908A1 CA2879908A CA2879908A CA2879908A1 CA 2879908 A1 CA2879908 A1 CA 2879908A1 CA 2879908 A CA2879908 A CA 2879908A CA 2879908 A CA2879908 A CA 2879908A CA 2879908 A1 CA2879908 A1 CA 2879908A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
cycloalkyl
halo
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2879908A
Other languages
English (en)
French (fr)
Inventor
Zhendong Jin
Lei Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation
Original Assignee
University of Iowa Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Iowa Research Foundation filed Critical University of Iowa Research Foundation
Publication of CA2879908A1 publication Critical patent/CA2879908A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2879908A 2012-07-25 2013-07-25 Therapeutic compounds Abandoned CA2879908A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261675665P 2012-07-25 2012-07-25
US61/675,665 2012-07-25
US201261720785P 2012-10-31 2012-10-31
US61/720,785 2012-10-31
PCT/US2013/052081 WO2014018765A1 (en) 2012-07-25 2013-07-25 Therapeutic compounds

Publications (1)

Publication Number Publication Date
CA2879908A1 true CA2879908A1 (en) 2014-01-30

Family

ID=49997838

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2879908A Abandoned CA2879908A1 (en) 2012-07-25 2013-07-25 Therapeutic compounds

Country Status (12)

Country Link
US (1) US9346781B2 (enExample)
EP (1) EP2877172A4 (enExample)
JP (1) JP6289463B2 (enExample)
KR (1) KR20150036742A (enExample)
CN (1) CN104812386A (enExample)
AU (1) AU2013295723A1 (enExample)
BR (1) BR112015001515A2 (enExample)
CA (1) CA2879908A1 (enExample)
IL (1) IL236873A0 (enExample)
IN (1) IN2015KN00386A (enExample)
MX (1) MX2015001134A (enExample)
WO (1) WO2014018765A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025231146A1 (en) * 2024-04-30 2025-11-06 University Of Iowa Research Foundation Synthetic superstolides and therapeutic use thereof

Also Published As

Publication number Publication date
US9346781B2 (en) 2016-05-24
IL236873A0 (en) 2015-03-31
EP2877172A4 (en) 2016-06-15
JP2015524809A (ja) 2015-08-27
EP2877172A1 (en) 2015-06-03
US20150210664A1 (en) 2015-07-30
MX2015001134A (es) 2015-10-12
WO2014018765A1 (en) 2014-01-30
AU2013295723A1 (en) 2015-02-26
JP6289463B2 (ja) 2018-03-07
KR20150036742A (ko) 2015-04-07
IN2015KN00386A (enExample) 2015-07-10
BR112015001515A2 (pt) 2017-07-04
CN104812386A (zh) 2015-07-29

Similar Documents

Publication Publication Date Title
JP2015083570A (ja) ベンゾインデンプロスタグランジンの合成のための中間体及びその製造法
WO2013072896A1 (en) Structural variants of mycolactones for use in modulating inflammation, immunity and pain
AU2014273108A1 (en) Methods of synthesis of ingenol and intermediates thereof
US9346781B2 (en) Therapeutic compounds
JP2009067794A (ja) 新規エストロゲン受容体リガンド
Żurawiński et al. Stereocontrolled synthesis of enantiopure anticancer cyclopentenone prostaglandin analogues:(−)-and (+)-TEI-9826
JP3986606B2 (ja) ビタミンｄ誘導体のａ環部分の合成に有用な合成中間体、その製造方法およびその使用方法
JP2011526297A (ja) シュワインフルチンアナログ
US20090137828A1 (en) Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol
Nagaiah et al. Enantioselective Synthesis of the Natural Product (S)‐Rugulactone
ES2946255B2 (es) Sila-analogos de compuestos de vitamina d, metodo de produccion de dichos compuestos y usos de los mismos
Rico et al. Novel stereocontrolled synthesis of the tricyclic lactone (1R, 3R, 6R, 9S)-6, 9-dimethyl-8-oxo-7-oxatricyclo [4.3. 0.03, 9] nonane
Delmain Studies of Cyclization Reactions for Oxa-Bridged Bicyclic Compounds Using Transition-Metal Catalysis
JP2004307420A (ja) 細胞死抑制作用を有する化合物、およびその製造方法
JP2004315373A (ja) 抗腫瘍活性および血管新生阻害活性を有する化合物、ならびにその製造方法
Yip Total Synthesis of Maltepolide E and Congeners Using Diene-Ene Ring-Closing Mathesis as the Key Step
WO2007011629A2 (en) Synthesis and complete stereochemical assignment of psymberin/irciniastatin for anti-tumor use
WO2023205908A1 (en) Synthetic process for production of lipoxin b4 and analogues thereof
JP4041928B2 (ja) ジエン化合物およびその製造方法
Yoo Total Synthesis of Spliceosome Modulator Pladienolide B and the Development of Enantioselective Iridium-Catalyzed Carbon-Carbon and Carbon-Nitrogen Bond Formations
Gorman Transition metal-mediated cyclizations and synthesis of annonaceous acetogenin analogs
TWI441632B (zh) 番荔枝皂素類似物及其合成方法與用途
Aav Synthesis of 9, 11-secosterols intermediates
Chen Total Synthesis of Thapsigargins
Zhegalova Cyclic enediynes and enyne-allenes containing additional functionalities: achieving control of the mechanism and reactivity

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20190725