CA2878792A1 - Inhibition of enzymes - Google Patents

Inhibition of enzymes Download PDF

Info

Publication number
CA2878792A1
CA2878792A1 CA2878792A CA2878792A CA2878792A1 CA 2878792 A1 CA2878792 A1 CA 2878792A1 CA 2878792 A CA2878792 A CA 2878792A CA 2878792 A CA2878792 A CA 2878792A CA 2878792 A1 CA2878792 A1 CA 2878792A1
Authority
CA
Canada
Prior art keywords
phenyl
pyridin
trifluoromethyl
triazolo
pyrazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2878792A
Other languages
English (en)
French (fr)
Inventor
Carmelida CAPALDI
Robert Andrew HEALD
Nicholas Charles Ray
Jonathan Mark Sutton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of CA2878792A1 publication Critical patent/CA2878792A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2878792A 2012-07-12 2013-07-10 Inhibition of enzymes Abandoned CA2878792A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12176079.7 2012-07-12
EP12176079 2012-07-12
EP13158756 2013-03-12
EP13158756.0 2013-03-12
PCT/EP2013/064603 WO2014009425A1 (en) 2012-07-12 2013-07-10 Inhibition of enzymes

Publications (1)

Publication Number Publication Date
CA2878792A1 true CA2878792A1 (en) 2014-01-16

Family

ID=48953361

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878792A Abandoned CA2878792A1 (en) 2012-07-12 2013-07-10 Inhibition of enzymes

Country Status (10)

Country Link
US (1) US9199984B2 (enEXAMPLES)
EP (1) EP2872509B1 (enEXAMPLES)
KR (1) KR20150031318A (enEXAMPLES)
CN (1) CN104428300B (enEXAMPLES)
AR (1) AR091737A1 (enEXAMPLES)
BR (1) BR112015000507A2 (enEXAMPLES)
CA (1) CA2878792A1 (enEXAMPLES)
IN (1) IN2015DN00202A (enEXAMPLES)
RU (1) RU2638537C2 (enEXAMPLES)
WO (1) WO2014009425A1 (enEXAMPLES)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160097227A (ko) 2013-12-16 2016-08-17 키에시 파르마슈티시 엣스. 피. 에이. 인간 호중구 엘라스타제 억제제로서 테트라하이드로트리아졸로피리미딘 유도체
US9487528B2 (en) 2014-06-09 2016-11-08 Chiesi Farmaceutici S.P.A. Compounds
US9475779B2 (en) 2014-07-31 2016-10-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9440930B2 (en) 2014-07-31 2016-09-13 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9657015B2 (en) 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9409870B2 (en) * 2014-12-15 2016-08-09 Chiesi Farmaceutici S.P.A. Compounds
AR108608A1 (es) * 2016-05-31 2018-09-05 Chiesi Farm Spa Derivados de pirazolil carbonilo inhibidores de ahr
AR108609A1 (es) * 2016-05-31 2018-09-05 Chiesi Farm Spa Derivados de imidazolona y pirazolona como inhibidores de la elastasa de neutrófilos humana (hne)
WO2017207430A1 (en) 2016-05-31 2017-12-07 Chiesi Farmaceutici S.P.A. Imidazolone compounds as human neutrophil elastase inhibitors
CN120578329A (zh) 2017-02-27 2025-09-02 格扎·巴林特 具有能实现所显示信息和/或数据的同时多功能操作的显示器的智能设备
CN118496198A (zh) 2019-07-23 2024-08-16 拜耳公司 作为农药的新的杂芳基-三唑化合物
MY208580A (en) 2019-07-23 2025-05-16 Bayer Ag Novel heteroaryl-triazole compounds as pesticides
AU2020349353A1 (en) 2019-09-17 2022-04-14 Duke University Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
AU2020363864A1 (en) 2019-10-09 2022-04-21 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
PH12022550862A1 (en) 2019-10-09 2023-04-24 Bayer Ag Novel heteroaryl-triazole compounds as pesticides
KR20220097434A (ko) * 2019-11-01 2022-07-07 브리스톨-마이어스 스큅 컴퍼니 톨 수용체 억제제로서의 치환된 피라졸 화합물
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
AU2021256835A1 (en) 2020-04-16 2022-10-13 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
JP2023542789A (ja) * 2020-09-28 2023-10-12 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド ピラゾール化合物並びにその調製方法及び使用
CN113480486B (zh) * 2021-07-30 2022-05-24 赣南师范大学 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用
EP4419102A1 (en) 2021-10-20 2024-08-28 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259504A (en) 1979-08-27 1981-03-31 American Cyanamid Company Substituted 1H-1,2,4-triazoles
US4451471A (en) 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
US4576958A (en) 1984-01-23 1986-03-18 E. I. Du Pont De Nemours And Company Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
ES2184633B1 (es) 2001-08-07 2004-08-01 J. URIACH & CIA, S.A. Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida.
US6693116B2 (en) * 2001-10-08 2004-02-17 Hoffmann-La Roche Inc. Adenosine receptor ligands
MX2007004179A (es) 2004-10-07 2007-06-07 Warner Lambert Co Derivados de triazolpiridina como agentes antibacterianos.
US7902374B2 (en) 2005-05-06 2011-03-08 Universal Display Corporation Stability OLED materials and devices
US20080125587A1 (en) 2006-05-25 2008-05-29 Chimmanamada Dinesh U Synthesis of triazole compounds that modulate HSP90 activity
AR069206A1 (es) * 2007-11-06 2010-01-06 Astrazeneca Ab Derivados de 2-pirazinona, proceso para preparalos, composiciones farmaceuticas que los comprenden, proceso de preparacion de las mismas y usos en el tratamiento de trastornos osteoarticularesy del aparato respiratorio, entre otros.
PE20091953A1 (es) 2008-05-08 2010-01-09 Du Pont Azoles sustituidos como fungicidas
CN102131805A (zh) * 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
WO2009155389A1 (en) * 2008-06-20 2009-12-23 Bristol-Myers Squibb Company Triazolopyridine compounds useful as kinase inhibitors
DE102009004197A1 (de) * 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
CN102639505A (zh) * 2009-10-02 2012-08-15 阿斯利康(瑞典)有限公司 用作嗜中性白细胞弹性蛋白酶抑制剂的吡啶-2-酮化合物

Also Published As

Publication number Publication date
EP2872509B1 (en) 2016-09-14
US9199984B2 (en) 2015-12-01
KR20150031318A (ko) 2015-03-23
HK1207078A1 (en) 2016-01-22
CN104428300B (zh) 2016-11-09
RU2638537C2 (ru) 2017-12-14
AR091737A1 (es) 2015-02-25
EP2872509A1 (en) 2015-05-20
US20140018345A1 (en) 2014-01-16
CN104428300A (zh) 2015-03-18
RU2015104644A (ru) 2016-08-27
WO2014009425A1 (en) 2014-01-16
BR112015000507A2 (pt) 2017-06-27
IN2015DN00202A (enEXAMPLES) 2015-06-12

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20190710