CA2873891C - Pharmaceutical composition for the prophylaxis and treatment of psychological, behavioral and cognitive disorders - Google Patents
Pharmaceutical composition for the prophylaxis and treatment of psychological, behavioral and cognitive disorders Download PDFInfo
- Publication number
- CA2873891C CA2873891C CA2873891A CA2873891A CA2873891C CA 2873891 C CA2873891 C CA 2873891C CA 2873891 A CA2873891 A CA 2873891A CA 2873891 A CA2873891 A CA 2873891A CA 2873891 C CA2873891 C CA 2873891C
- Authority
- CA
- Canada
- Prior art keywords
- melatonin
- memantine
- pharmaceutical composition
- composition according
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012121410 | 2012-05-24 | ||
| RU2012121410/15A RU2488388C1 (ru) | 2012-05-24 | 2012-05-24 | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
| PCT/RU2012/000888 WO2013176567A1 (ru) | 2012-05-24 | 2012-10-31 | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2873891A1 CA2873891A1 (en) | 2013-11-28 |
| CA2873891C true CA2873891C (en) | 2016-02-16 |
Family
ID=49155569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2873891A Expired - Fee Related CA2873891C (en) | 2012-05-24 | 2012-10-31 | Pharmaceutical composition for the prophylaxis and treatment of psychological, behavioral and cognitive disorders |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20150157604A1 (esLanguage) |
| EP (1) | EP2857011A4 (esLanguage) |
| JP (1) | JP5864819B2 (esLanguage) |
| KR (1) | KR101581611B1 (esLanguage) |
| CN (1) | CN104334166A (esLanguage) |
| AU (1) | AU2012380583B2 (esLanguage) |
| CA (1) | CA2873891C (esLanguage) |
| EA (1) | EA201400973A1 (esLanguage) |
| HK (1) | HK1205467A1 (esLanguage) |
| IL (1) | IL235852A0 (esLanguage) |
| IN (1) | IN2014DN09940A (esLanguage) |
| RU (1) | RU2488388C1 (esLanguage) |
| UA (1) | UA112352C2 (esLanguage) |
| WO (1) | WO2013176567A1 (esLanguage) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2536270C1 (ru) * | 2013-10-21 | 2014-12-20 | Общество с ограниченной ответственностью ООО "ВАЛЕНТА ИНТЕЛЛЕКТ" | Комбинация для коррекции неврологического и психоэмоционального статуса при органических нарушениях цнс |
| DK3383482T3 (da) | 2015-11-24 | 2023-04-11 | Massachusetts Inst Technology | Systemer og fremgangsmåder til forebyggelse, mildnelse og/eller behandling af demens |
| RU2623865C1 (ru) * | 2016-06-29 | 2017-06-29 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Фармацевтическая композиция, содержащая комбинацию мемантина и мелатонина |
| RU2654713C1 (ru) * | 2016-06-29 | 2018-05-22 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Фармацевтическая композиция, содержащая комбинацию мемантина и мелатонина |
| EP3479822B1 (en) * | 2016-06-29 | 2023-06-07 | Ltd. "Valenta-Intellekt" | Pharmaceutical composition containing combination of memantine and melatonin |
| CN109922795B (zh) * | 2016-10-31 | 2021-10-08 | 纽里姆药物有限公司 | 褪黑素小片剂及其制备方法 |
| US10849856B2 (en) | 2016-10-31 | 2020-12-01 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
| JP7082334B2 (ja) | 2016-11-17 | 2022-06-08 | コグニート セラピューティクス,インク. | 視覚刺激を介した神経刺激のための方法およびシステム |
| US10960225B2 (en) * | 2017-10-10 | 2021-03-30 | Massachusetts Institute Of Technology | Systems and methods for preventing, mitigating, and/or treating dementia via visual stimulation that binds higher order brain regions, reduces neurodegeneration and neuroinflammation, and improves cognitive function |
| CN111565698A (zh) | 2017-10-10 | 2020-08-21 | 麻省理工学院 | 用于预防、减轻和/或治疗痴呆的系统和方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7305644A (esLanguage) | 1972-04-20 | 1973-10-23 | ||
| DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
| EP0392059B1 (de) | 1989-04-14 | 1993-09-15 | Merz & Co. GmbH & Co. | Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US6469044B1 (en) | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
| CA2292558C (en) * | 1997-06-30 | 2006-09-19 | Merz + Co. Gmbh & Co. | 1-amino-alkylcyclohexane nmda receptor antagonists |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| DK1562585T3 (da) | 2002-10-30 | 2011-03-14 | Asat Ag Applied Science & Tech | Daglige melatonindoseringsenheder |
| RU2268737C2 (ru) | 2004-02-16 | 2006-01-27 | Государственное учреждение институт клинической иммунологии СО РАМН | Способ лечения атопического дерматита |
| AU2005265031A1 (en) * | 2004-06-17 | 2006-01-26 | Forest Laboratories, Inc. | Modified release formulation of memantine |
| EP1841460A2 (en) * | 2004-06-18 | 2007-10-10 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| CN101374525A (zh) * | 2004-09-23 | 2009-02-25 | 莫茨药物股份两合公司 | 美金刚治疗儿童行为障碍 |
| MY148806A (en) * | 2005-04-04 | 2013-05-31 | Takeda Pharmaceutical | Prophylactic or therapeutic agent for nocturnal conduct disorder associated with dementia |
| CN1709230A (zh) * | 2005-07-05 | 2005-12-21 | 北京阜康仁生物制药科技有限公司 | 盐酸美金刚分散片及其制备方法 |
| RU2294741C1 (ru) | 2005-08-08 | 2007-03-10 | Рина Михайловна Заславская | Способ лечения больных ишемической болезнью сердца, стабильной стенокардией в сочетании с артериальной гипертонией |
| KR20090024140A (ko) * | 2006-05-22 | 2009-03-06 | 반다 파마슈티칼즈, 인코퍼레이티드. | 우울증 질환에 대한 치료 |
| MX2008014843A (es) * | 2006-05-22 | 2008-12-05 | Vanda Pharmaceuticals Inc | Tratamiento de trastornos depresivos. |
| CA2654523A1 (en) * | 2006-07-05 | 2008-01-10 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical compositions of memantine |
| WO2008005534A2 (en) * | 2006-07-06 | 2008-01-10 | Forest Laboratories, Inc. | Orally dissolving formulations of memantine |
| GB0623897D0 (en) * | 2006-11-30 | 2007-01-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutical composition of memantine |
| US20080167363A1 (en) * | 2006-12-28 | 2008-07-10 | Braincells, Inc | Modulation of Neurogenesis By Melatoninergic Agents |
| RU2326660C1 (ru) | 2007-03-14 | 2008-06-20 | Закрытое акционерное общество "Биологические исследования и системы" | Пероральный лекарственный препарат мемантин (варианты) и способ его получения (варианты) |
| AU2008239683B2 (en) | 2007-04-11 | 2014-03-27 | Pharmaceuticals Productions Inc | Melatonin tablet and methods of preparation and use |
| BRPI0811052A2 (pt) | 2007-04-12 | 2015-01-27 | Univ Minnesota | Composições de proteção de isquemia/reperfusão e métodos de uso. |
| US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| CA2751667C (en) * | 2009-02-06 | 2016-12-13 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| RU2394571C1 (ru) | 2009-05-14 | 2010-07-20 | Государственное бюджетное учреждение здравоохранения города Москвы "Городская клиническая больница № 24" Департамента здравоохранения города Москвы | Способ лечения воспалительных заболеваний кишечника |
| RU2418586C2 (ru) | 2009-06-11 | 2011-05-20 | Государственное образовательное учреждение высшего профессионального образования "Новосибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО НГМУ Росздрава) | Способ коррекции нарушений в репродуктивных органах, вызванных высокой температурой |
| RU2428183C1 (ru) | 2010-07-01 | 2011-09-10 | Рина Михайловна Заславская | Адаптоген для метеочувствительных больных стенокардией и артериальной гипертензией и применение мелатонина в качестве адаптогена |
-
2012
- 2012-05-24 RU RU2012121410/15A patent/RU2488388C1/ru not_active IP Right Cessation
- 2012-10-31 AU AU2012380583A patent/AU2012380583B2/en not_active Revoked
- 2012-10-31 US US14/400,526 patent/US20150157604A1/en not_active Abandoned
- 2012-10-31 EA EA201400973A patent/EA201400973A1/ru unknown
- 2012-10-31 IN IN9940DEN2014 patent/IN2014DN09940A/en unknown
- 2012-10-31 CA CA2873891A patent/CA2873891C/en not_active Expired - Fee Related
- 2012-10-31 JP JP2015513964A patent/JP5864819B2/ja not_active Expired - Fee Related
- 2012-10-31 EP EP12877152.4A patent/EP2857011A4/en not_active Withdrawn
- 2012-10-31 CN CN201280073167.XA patent/CN104334166A/zh not_active Withdrawn
- 2012-10-31 WO PCT/RU2012/000888 patent/WO2013176567A1/ru not_active Ceased
- 2012-10-31 HK HK15106114.1A patent/HK1205467A1/xx unknown
- 2012-10-31 UA UAA201412436A patent/UA112352C2/uk unknown
- 2012-10-31 KR KR1020147032836A patent/KR101581611B1/ko not_active Ceased
-
2014
- 2014-11-23 IL IL235852A patent/IL235852A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150157604A1 (en) | 2015-06-11 |
| JP2015517569A (ja) | 2015-06-22 |
| JP5864819B2 (ja) | 2016-02-17 |
| CN104334166A (zh) | 2015-02-04 |
| WO2013176567A1 (ru) | 2013-11-28 |
| IL235852A0 (en) | 2015-01-29 |
| EP2857011A1 (en) | 2015-04-08 |
| EA201400973A1 (ru) | 2015-02-27 |
| IN2014DN09940A (esLanguage) | 2015-08-14 |
| UA112352C2 (uk) | 2016-08-25 |
| AU2012380583B2 (en) | 2015-01-22 |
| AU2012380583A1 (en) | 2014-12-18 |
| KR20150005999A (ko) | 2015-01-15 |
| KR101581611B1 (ko) | 2015-12-31 |
| EP2857011A4 (en) | 2015-12-02 |
| RU2488388C1 (ru) | 2013-07-27 |
| CA2873891A1 (en) | 2013-11-28 |
| HK1205467A1 (en) | 2015-12-18 |
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