CA2873610C - Method of identifying precursor ions - Google Patents

Method of identifying precursor ions Download PDF

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Publication number
CA2873610C
CA2873610C CA2873610A CA2873610A CA2873610C CA 2873610 C CA2873610 C CA 2873610C CA 2873610 A CA2873610 A CA 2873610A CA 2873610 A CA2873610 A CA 2873610A CA 2873610 C CA2873610 C CA 2873610C
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CA
Canada
Prior art keywords
mass
ions
fragment
precursor
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2873610A
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English (en)
French (fr)
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CA2873610A1 (en
Inventor
Jason Lee Wildgoose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
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Micromass UK Ltd
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Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2873610A1 publication Critical patent/CA2873610A1/en
Application granted granted Critical
Publication of CA2873610C publication Critical patent/CA2873610C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2873610A 2012-05-18 2013-05-09 Method of identifying precursor ions Active CA2873610C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1208961.1A GB201208961D0 (en) 2012-05-18 2012-05-18 2 dimensional MSMS
GB1208961.1 2012-05-18
US201261649998P 2012-05-22 2012-05-22
US61/649,998 2012-05-22
PCT/GB2013/051199 WO2013171459A2 (en) 2012-05-18 2013-05-09 Method of identifying precursor ions

Publications (2)

Publication Number Publication Date
CA2873610A1 CA2873610A1 (en) 2013-11-21
CA2873610C true CA2873610C (en) 2020-03-24

Family

ID=46546450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2873610A Active CA2873610C (en) 2012-05-18 2013-05-09 Method of identifying precursor ions

Country Status (6)

Country Link
US (2) US9460902B2 (https=)
EP (2) EP3926659B1 (https=)
JP (1) JP6309508B2 (https=)
CA (1) CA2873610C (https=)
GB (2) GB201208961D0 (https=)
WO (1) WO2013171459A2 (https=)

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DE112015001841B4 (de) 2014-04-17 2024-08-22 Micromass Uk Limited Hybrid-Erfassungsverfahren unter Einbeziehung mehrerer Dissoziationstechniken
WO2015173562A1 (en) * 2014-05-13 2015-11-19 Micromass Uk Limited Multi-dimensional ion separation
WO2015181563A1 (en) * 2014-05-30 2015-12-03 Micromass Uk Limited Combined tandem mass spectrometry and ion mobility mass spectrometry
DE112015002731B4 (de) 2014-06-11 2024-03-28 Micromass Uk Limited Zweidimensionale MS/MS-Erfassungsmodi
GB201410346D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Two dimensional msms acquisition modes
WO2015191999A1 (en) * 2014-06-13 2015-12-17 Waters Technologies Corporation Analysis of complex biological matrices through targeting and advanced precursor and product ion alignment
WO2015193946A1 (ja) * 2014-06-16 2015-12-23 株式会社島津製作所 Ｍｓ／ｍｓ型質量分析方法及びｍｓ／ｍｓ型質量分析装置
CA2964190A1 (en) * 2014-10-08 2016-04-14 Dh Technologies Development Pte. Ltd. Improving ida spectral output for database searches
CA2975963A1 (en) * 2015-02-05 2016-08-11 Dh Technologies Development Pte. Ltd. Rapid scanning of wide quadrupole rf windows while toggling fragmentation energy
EP3926340B1 (en) * 2015-04-23 2025-04-16 Micromass UK Limited Separating ions in an ion trap
CN109075012B (zh) 2016-04-14 2021-01-26 英国质谱公司 二维msms
CN109643635B (zh) 2016-07-25 2021-08-17 Dh科技发展私人贸易有限公司 用于在扫描swath数据中识别前体及产物离子对的系统及方法
JP7153658B2 (ja) * 2017-02-22 2022-10-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Ｉｄａのための前駆体イオン選択における付加物およびその他の悪化因子の物理的単離
GB2563565B (en) 2017-04-13 2022-05-11 Micromass Ltd Mass spectrometry with increased duty cycle
JPWO2020049694A1 (ja) * 2018-09-06 2021-08-12 株式会社島津製作所 四重極質量分析装置
US10832897B2 (en) * 2018-10-19 2020-11-10 Thermo Finnigan Llc Methods and devices for high-throughput data independent analysis for mass spectrometry using parallel arrays of cells
EP3977628A4 (en) 2019-05-31 2023-06-28 DH Technologies Development Pte. Ltd. Method for real time encoding of scanning swath data and probabilistic framework for precursor inference
JP7762203B2 (ja) 2020-11-19 2025-10-29 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析の堅牢性を強化するためにバンドパスフィルタリング衝突セルを使用して高強度イオンビームのｍｓ／ｍｓを実施する方法
WO2022259102A1 (en) 2021-06-09 2022-12-15 Dh Technologies Development Pte. Ltd. Enhanced q1 mass segregation in scanning swath
WO2023002282A1 (en) 2021-07-23 2023-01-26 Dh Technologies Development Pte. Ltd. Preventing errors in processing and interpreting mass spectrometry results
US20240312776A1 (en) 2021-08-05 2024-09-19 Dh Technologies Development Pte. Ltd. Space Charge Reduction in TOF-MS
WO2023026136A1 (en) 2021-08-26 2023-03-02 Dh Technologies Development Pte. Ltd. Method for enhancing information in dda mass spectrometry
US20250006307A1 (en) 2021-09-08 2025-01-02 Dh Technologies Development Pte. Ltd. Identification of Changing Pathways or Disease Indicators Through Cluster Analysis
WO2023057925A1 (en) 2021-10-05 2023-04-13 Dh Technologies Development Pte. Ltd. Methods for enhancing complete data extraction of dia data
EP4434073A1 (en) 2021-11-19 2024-09-25 DH Technologies Development Pte. Ltd. Method for noise reduction and ion rate estimation using an analog detection system
EP4473537A1 (en) 2022-02-04 2024-12-11 DH Technologies Development Pte. Ltd. Compound identification using a mass spectrum
EP4508646A1 (en) 2022-04-12 2025-02-19 DH Technologies Development Pte. Ltd. Scoring of whole protein msms spectra based on a bond relevance score
EP4508650A1 (en) 2022-04-12 2025-02-19 DH Technologies Development Pte. Ltd. Library search using deep learning based spectral compression
US20250259697A1 (en) 2022-04-12 2025-08-14 Dh Technologies Development Pte. Ltd. Single Panel Representation of Multiple Charge Evidence Linked to a Bond in the Protein
WO2024075065A1 (en) 2022-10-06 2024-04-11 Dh Technologies Development Pte. Ltd. Creation of realistic ms/ms spectra for putative designer drugs
WO2024075058A1 (en) 2022-10-06 2024-04-11 Dh Technologies Development Pte. Ltd. Reducing data complexity for subsequent rt alignment
WO2024121697A1 (en) 2022-12-07 2024-06-13 Dh Technologies Development Pte. Ltd. De novo sequencing of dna
WO2024150129A1 (en) 2023-01-09 2024-07-18 Dh Technologies Development Pte. Ltd. Sequencing of morpholino oligomers using electron capture dissociation
WO2024194801A1 (en) * 2023-03-22 2024-09-26 Dh Technologies Development Pte. Ltd. Multidimensional variable scanning swath mass spectrometry

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CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6992283B2 (en) 2003-06-06 2006-01-31 Micromass Uk Limited Mass spectrometer
JP4928724B2 (ja) * 2003-10-14 2012-05-09 マイクロマス ユーケー リミテッド 質量分析計
US8105838B2 (en) 2005-06-03 2012-01-31 Waters Technologies Corporation Generation and use of a catalog of polypeptide-related information for chemical analyses
WO2006133191A2 (en) * 2005-06-03 2006-12-14 Waters Investments Limited Methods and apparatus for performing retention-time matching
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
JP5262010B2 (ja) * 2007-08-01 2013-08-14 株式会社日立製作所 質量分析計及び質量分析方法
JP5111123B2 (ja) * 2008-01-16 2012-12-26 株式会社日立製作所 質量分析計及び質量分析方法
JP5251232B2 (ja) * 2008-04-25 2013-07-31 株式会社島津製作所 質量分析データ処理方法及び質量分析装置
WO2009146345A1 (en) * 2008-05-29 2009-12-03 Waters Technologies Corporation Techniques for performing retention-time matching of precursor and product ions and for constructing precursor and product ion spectra
CN102308361B (zh) * 2009-02-05 2014-01-29 株式会社岛津制作所 Ms/ms型质谱分析装置
EP2436025A1 (en) * 2009-05-27 2012-04-04 DH Technologies Development Pte. Ltd. Linear ion trap for msms
GB0909289D0 (en) * 2009-05-29 2009-07-15 Micromass Ltd Method of processing mass spectral data
GB0915474D0 (en) * 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
JP5454484B2 (ja) * 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
GB201208961D0 (en) * 2012-05-18 2012-07-04 Micromass Ltd 2 dimensional MSMS
EP3069374A1 (en) * 2013-11-12 2016-09-21 Micromass UK Limited Data dependent ms/ms analysis

Also Published As

Publication number Publication date
US9460902B2 (en) 2016-10-04
WO2013171459A2 (en) 2013-11-21
GB2504373B (en) 2017-01-25
GB2504373A (en) 2014-01-29
EP3926659A1 (en) 2021-12-22
EP2850636A2 (en) 2015-03-25
JP6309508B2 (ja) 2018-04-11
US20150136969A1 (en) 2015-05-21
EP3926659B1 (en) 2025-07-30
WO2013171459A3 (en) 2014-06-26
CA2873610A1 (en) 2013-11-21
EP2850636B1 (en) 2021-09-01
GB201208961D0 (en) 2012-07-04
GB201308297D0 (en) 2013-06-12
US10068754B2 (en) 2018-09-04
JP2015523550A (ja) 2015-08-13
US20170125224A1 (en) 2017-05-04

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