CA2873610C - Method of identifying precursor ions - Google Patents

Method of identifying precursor ions Download PDF

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Publication number
CA2873610C
CA2873610C CA2873610A CA2873610A CA2873610C CA 2873610 C CA2873610 C CA 2873610C CA 2873610 A CA2873610 A CA 2873610A CA 2873610 A CA2873610 A CA 2873610A CA 2873610 C CA2873610 C CA 2873610C
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CA
Canada
Prior art keywords
mass
ions
fragment
precursor
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2873610A
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English (en)
French (fr)
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CA2873610A1 (en
Inventor
Jason Lee Wildgoose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
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Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2873610A1 publication Critical patent/CA2873610A1/en
Application granted granted Critical
Publication of CA2873610C publication Critical patent/CA2873610C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2873610A 2012-05-18 2013-05-09 Method of identifying precursor ions Active CA2873610C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1208961.1A GB201208961D0 (en) 2012-05-18 2012-05-18 2 dimensional MSMS
GB1208961.1 2012-05-18
US201261649998P 2012-05-22 2012-05-22
US61/649,998 2012-05-22
PCT/GB2013/051199 WO2013171459A2 (en) 2012-05-18 2013-05-09 Method of identifying precursor ions

Publications (2)

Publication Number Publication Date
CA2873610A1 CA2873610A1 (en) 2013-11-21
CA2873610C true CA2873610C (en) 2020-03-24

Family

ID=46546450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2873610A Active CA2873610C (en) 2012-05-18 2013-05-09 Method of identifying precursor ions

Country Status (6)

Country Link
US (2) US9460902B2 (enExample)
EP (2) EP2850636B1 (enExample)
JP (1) JP6309508B2 (enExample)
CA (1) CA2873610C (enExample)
GB (2) GB201208961D0 (enExample)
WO (1) WO2013171459A2 (enExample)

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GB201406981D0 (en) * 2014-04-17 2014-06-04 Micromass Ltd Hybrid acquisition method incorporating electron transfer dissociation triggered from fast sequential 2D MS/MS collision induced dissociation
CN106463330B (zh) * 2014-05-13 2018-10-09 英国质谱公司 多维离子分离
CN106550609B (zh) * 2014-05-30 2020-06-05 英国质谱公司 组合式串级质谱法和离子迁移率质谱法
US11424113B2 (en) 2014-06-11 2022-08-23 Micromass Uk Limited Two dimensional MS/MS acquisition modes
GB201410346D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Two dimensional msms acquisition modes
EP3155638B1 (en) * 2014-06-13 2023-09-20 Waters Technologies Corporation Analysis of complex biological matrices through targeting and advanced precursor and product ion alignment
WO2015193946A1 (ja) * 2014-06-16 2015-12-23 株式会社島津製作所 Ｍｓ／ｍｓ型質量分析方法及びｍｓ／ｍｓ型質量分析装置
WO2016055888A1 (en) * 2014-10-08 2016-04-14 Dh Technologies Development Pte. Ltd. Improving ida spectral output for database searches
JP6698668B2 (ja) * 2015-02-05 2020-05-27 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 断片化エネルギーを切り替えながらの幅広い四重極ｒｆ窓の高速スキャニング
EP3286557B1 (en) * 2015-04-23 2021-09-01 Micromass UK Limited Separating ions in an ion trap
WO2017178835A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Two dimensional msms
US10651019B2 (en) * 2016-07-25 2020-05-12 Dh Technologies Development Pte. Ltd. Systems and methods for identifying precursor and product ion pairs in scanning SWATH data
JP7153658B2 (ja) * 2017-02-22 2022-10-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Ｉｄａのための前駆体イオン選択における付加物およびその他の悪化因子の物理的単離
GB2563565B (en) 2017-04-13 2022-05-11 Micromass Ltd Mass spectrometry with increased duty cycle
CN112640034B (zh) * 2018-09-06 2024-10-11 株式会社岛津制作所 四极质量分析装置
US10832897B2 (en) * 2018-10-19 2020-11-10 Thermo Finnigan Llc Methods and devices for high-throughput data independent analysis for mass spectrometry using parallel arrays of cells
JP2022534468A (ja) 2019-05-31 2022-08-01 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 走査型ｓｗａｔｈデータのリアルタイムエンコーディングおよび前駆体推測のための確率的フレームワークのための方法
EP4248482A2 (en) 2020-11-19 2023-09-27 DH Technologies Development Pte. Ltd. Method of performing ms/ms of high intensity ion beams using a bandpass filtering collision cell to enhance mass spectrometry robustness
CN117581330A (zh) 2021-06-09 2024-02-20 Dh科技发展私人贸易有限公司 扫描swath中增强的q1质量分离
US20250125133A1 (en) 2021-07-23 2025-04-17 Dh Technologies Development Pte. Ltd. Preventing Errors in Processing and Interpreting Mass Spectrometry Results
CN117795643A (zh) 2021-08-05 2024-03-29 Dh科技发展私人贸易有限公司 Tof-ms中的空间电荷减少
CN118043938A (zh) 2021-08-26 2024-05-14 Dh科技发展私人贸易有限公司 用于增强dda质谱法中的信息的方法
US20240355605A1 (en) * 2021-09-03 2024-10-24 Dh Technologies Development Pte. Ltd. Prediction of precursor charge state in dm-swath analysis
US20250006307A1 (en) 2021-09-08 2025-01-02 Dh Technologies Development Pte. Ltd. Identification of Changing Pathways or Disease Indicators Through Cluster Analysis
CN118525336A (zh) 2021-10-05 2024-08-20 Dh科技发展私人贸易有限公司 用于增强对dia数据的完整数据提取的方法
US20250014880A1 (en) 2021-11-19 2025-01-09 Dh Technologies Development Pte. Ltd. Method for Noise Reduction and Ion Rate Estimation Using an Analog Detection System
EP4473537A1 (en) 2022-02-04 2024-12-11 DH Technologies Development Pte. Ltd. Compound identification using a mass spectrum
WO2023199138A1 (en) 2022-04-12 2023-10-19 Dh Technologies Development Pte. Ltd. Scoring of whole protein msms spectra based on a bond relevance score
US20250259713A1 (en) 2022-04-12 2025-08-14 Dh Technologies Development Pte. Ltd. Library Search Using Deep Learning Based Spectral Compression
WO2023199137A1 (en) 2022-04-12 2023-10-19 Dh Technologies Development Pte. Ltd. Single panel representation of multiple charge evidence linked to a bond in the protein
US20260079140A1 (en) 2022-10-06 2026-03-19 Dh Technologies Development Pte. Ltd. Reducing Data Complexity for Subsequent RT Alignment
WO2024075065A1 (en) 2022-10-06 2024-04-11 Dh Technologies Development Pte. Ltd. Creation of realistic ms/ms spectra for putative designer drugs
US20260078445A1 (en) 2022-12-07 2026-03-19 Dh Technologies Development Pte. Ltd. De Novo Sequencing of DNA
EP4649518A1 (en) 2023-01-09 2025-11-19 DH Technologies Development Pte. Ltd. Sequencing of morpholino oligomers using electron capture dissociation
EP4684415A1 (en) * 2023-03-22 2026-01-28 DH Technologies Development Pte. Ltd. Multidimensional variable scanning swath mass spectrometry

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CA2340150C (en) 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6992283B2 (en) 2003-06-06 2006-01-31 Micromass Uk Limited Mass spectrometer
DE102004049918B4 (de) * 2003-10-14 2010-11-25 Micromass Uk Ltd. Verfahren zur Massenspektrometrie
JP4932834B2 (ja) * 2005-06-03 2012-05-16 ウオーターズ・テクノロジーズ・コーポレイシヨン 保持時間整合を行うための方法および装置
WO2006133192A2 (en) * 2005-06-03 2006-12-14 Waters Investments Limited Generation and use of a catalog of polypeptide-related information for chemical analyses
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
JP5262010B2 (ja) * 2007-08-01 2013-08-14 株式会社日立製作所 質量分析計及び質量分析方法
JP5111123B2 (ja) * 2008-01-16 2012-12-26 株式会社日立製作所 質量分析計及び質量分析方法
JP5251232B2 (ja) * 2008-04-25 2013-07-31 株式会社島津製作所 質量分析データ処理方法及び質量分析装置
JP2011522257A (ja) * 2008-05-29 2011-07-28 ウオーターズ・テクノロジーズ・コーポレイシヨン 前駆体および生成物イオンの保持時間一致を実行し、前駆体および生成物イオンスペクトルを構成する技術
WO2010089798A1 (ja) * 2009-02-05 2010-08-12 株式会社島津製作所 Ｍｓ／ｍｓ型質量分析装置
US20100301205A1 (en) * 2009-05-27 2010-12-02 Bruce Thomson Linear ion trap for msms
GB0909289D0 (en) * 2009-05-29 2009-07-15 Micromass Ltd Method of processing mass spectral data
GB0915474D0 (en) * 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
JP5454484B2 (ja) * 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
GB201208961D0 (en) * 2012-05-18 2012-07-04 Micromass Ltd 2 dimensional MSMS
WO2015071651A1 (en) * 2013-11-12 2015-05-21 Micromass Uk Limited Data dependent ms/ms analysis

Also Published As

Publication number Publication date
JP6309508B2 (ja) 2018-04-11
WO2013171459A2 (en) 2013-11-21
WO2013171459A3 (en) 2014-06-26
EP3926659B1 (en) 2025-07-30
GB201208961D0 (en) 2012-07-04
US20170125224A1 (en) 2017-05-04
US20150136969A1 (en) 2015-05-21
GB201308297D0 (en) 2013-06-12
GB2504373A (en) 2014-01-29
US10068754B2 (en) 2018-09-04
CA2873610A1 (en) 2013-11-21
JP2015523550A (ja) 2015-08-13
EP2850636B1 (en) 2021-09-01
EP2850636A2 (en) 2015-03-25
EP3926659A1 (en) 2021-12-22
US9460902B2 (en) 2016-10-04
GB2504373B (en) 2017-01-25

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