CA2873610C - Method of identifying precursor ions - Google Patents

Method of identifying precursor ions Download PDF

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Publication number
CA2873610C
CA2873610C CA2873610A CA2873610A CA2873610C CA 2873610 C CA2873610 C CA 2873610C CA 2873610 A CA2873610 A CA 2873610A CA 2873610 A CA2873610 A CA 2873610A CA 2873610 C CA2873610 C CA 2873610C
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CA
Canada
Prior art keywords
mass
ions
fragment
precursor
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2873610A
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English (en)
French (fr)
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CA2873610A1 (en
Inventor
Jason Lee Wildgoose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
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Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2873610A1 publication Critical patent/CA2873610A1/en
Application granted granted Critical
Publication of CA2873610C publication Critical patent/CA2873610C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2873610A 2012-05-18 2013-05-09 Method of identifying precursor ions Active CA2873610C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1208961.1A GB201208961D0 (en) 2012-05-18 2012-05-18 2 dimensional MSMS
GB1208961.1 2012-05-18
US201261649998P 2012-05-22 2012-05-22
US61/649,998 2012-05-22
PCT/GB2013/051199 WO2013171459A2 (en) 2012-05-18 2013-05-09 Method of identifying precursor ions

Publications (2)

Publication Number Publication Date
CA2873610A1 CA2873610A1 (en) 2013-11-21
CA2873610C true CA2873610C (en) 2020-03-24

Family

ID=46546450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2873610A Active CA2873610C (en) 2012-05-18 2013-05-09 Method of identifying precursor ions

Country Status (6)

Country Link
US (2) US9460902B2 (enExample)
EP (2) EP3926659B1 (enExample)
JP (1) JP6309508B2 (enExample)
CA (1) CA2873610C (enExample)
GB (2) GB201208961D0 (enExample)
WO (1) WO2013171459A2 (enExample)

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WO2015159096A1 (en) 2014-04-17 2015-10-22 Micromass Uk Limited Hybrid acquisition method incorporating multiple dissociation techniques
GB201406981D0 (en) * 2014-04-17 2014-06-04 Micromass Ltd Hybrid acquisition method incorporating electron transfer dissociation triggered from fast sequential 2D MS/MS collision induced dissociation
DE112015002258B4 (de) * 2014-05-13 2023-09-21 Micromass Uk Limited Mehrdimensionale Ionentrennung
DE112015002566B4 (de) * 2014-05-30 2022-11-03 Micromass Uk Limited Kombinierte Tandem-Massenspektrometrie und Ionenbeweglichkeits-Massenspektrometrie
GB201410346D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Two dimensional msms acquisition modes
JP6515117B2 (ja) * 2014-06-11 2019-05-15 マイクロマス ユーケー リミテッド ２次元ｍｓ／ｍｓ取得モード
EP3155638B1 (en) * 2014-06-13 2023-09-20 Waters Technologies Corporation Analysis of complex biological matrices through targeting and advanced precursor and product ion alignment
CN106463339B (zh) * 2014-06-16 2018-06-15 株式会社岛津制作所 Ms/ms型质谱分析方法以及ms/ms型质谱分析装置
WO2016055888A1 (en) * 2014-10-08 2016-04-14 Dh Technologies Development Pte. Ltd. Improving ida spectral output for database searches
JP6698668B2 (ja) * 2015-02-05 2020-05-27 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 断片化エネルギーを切り替えながらの幅広い四重極ｒｆ窓の高速スキャニング
CN111710588B (zh) * 2015-04-23 2023-09-26 英国质谱公司 在离子阱中分离离子
CN109075012B (zh) 2016-04-14 2021-01-26 英国质谱公司 二维msms
WO2018020363A1 (en) 2016-07-25 2018-02-01 Dh Technologies Development Pte. Ltd. Systems and methods for identifying precursor and product ion pairs in scanning swath data
WO2018154400A1 (en) * 2017-02-22 2018-08-30 Dh Technologies Development Pte. Ltd. Physical isolation of adducts and other complicating factors in precursor ion selection for ida
GB2563565B (en) 2017-04-13 2022-05-11 Micromass Ltd Mass spectrometry with increased duty cycle
WO2020049694A1 (ja) * 2018-09-06 2020-03-12 株式会社島津製作所 四重極質量分析装置
US10832897B2 (en) * 2018-10-19 2020-11-10 Thermo Finnigan Llc Methods and devices for high-throughput data independent analysis for mass spectrometry using parallel arrays of cells
WO2020240506A1 (en) 2019-05-31 2020-12-03 Dh Technologies Development Pte. Ltd. Method for real time encoding of scanning swath data and probabilistic framework for precursor inference
JP7762203B2 (ja) 2020-11-19 2025-10-29 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析の堅牢性を強化するためにバンドパスフィルタリング衝突セルを使用して高強度イオンビームのｍｓ／ｍｓを実施する方法
US20240258091A1 (en) 2021-06-09 2024-08-01 Dh Technologies Development Pte. Ltd. Enhanced Q1 Mass Segregation in Scanning SWATH
WO2023002282A1 (en) 2021-07-23 2023-01-26 Dh Technologies Development Pte. Ltd. Preventing errors in processing and interpreting mass spectrometry results
CN117795643A (zh) 2021-08-05 2024-03-29 Dh科技发展私人贸易有限公司 Tof-ms中的空间电荷减少
US20240404813A1 (en) 2021-08-26 2024-12-05 Dh Technologies Development Pte. Ltd. Method for enhancing information in dda mass spectrometry
WO2023037248A1 (en) 2021-09-08 2023-03-16 Dh Technologies Development Pte. Ltd. Identification of changing pathways or disease indicators through cluster analysis
WO2023057925A1 (en) 2021-10-05 2023-04-13 Dh Technologies Development Pte. Ltd. Methods for enhancing complete data extraction of dia data
CN118556276A (zh) 2021-11-19 2024-08-27 Dh科技发展私人贸易有限公司 用于使用模拟检测系统进行降噪和离子速率估计的方法
EP4473537A1 (en) 2022-02-04 2024-12-11 DH Technologies Development Pte. Ltd. Compound identification using a mass spectrum
EP4508650A1 (en) 2022-04-12 2025-02-19 DH Technologies Development Pte. Ltd. Library search using deep learning based spectral compression
US20250191673A1 (en) 2022-04-12 2025-06-12 Dh Technologies Development Pte. Ltd. Scoring of Whole Protein MSMS Spectra Based on a Bond Relevance Score
US20250259697A1 (en) 2022-04-12 2025-08-14 Dh Technologies Development Pte. Ltd. Single Panel Representation of Multiple Charge Evidence Linked to a Bond in the Protein
WO2024075065A1 (en) 2022-10-06 2024-04-11 Dh Technologies Development Pte. Ltd. Creation of realistic ms/ms spectra for putative designer drugs
WO2024075058A1 (en) 2022-10-06 2024-04-11 Dh Technologies Development Pte. Ltd. Reducing data complexity for subsequent rt alignment
WO2024121697A1 (en) 2022-12-07 2024-06-13 Dh Technologies Development Pte. Ltd. De novo sequencing of dna
WO2024150129A1 (en) 2023-01-09 2024-07-18 Dh Technologies Development Pte. Ltd. Sequencing of morpholino oligomers using electron capture dissociation
WO2024194801A1 (en) * 2023-03-22 2024-09-26 Dh Technologies Development Pte. Ltd. Multidimensional variable scanning swath mass spectrometry

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CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6992283B2 (en) 2003-06-06 2006-01-31 Micromass Uk Limited Mass spectrometer
DE102004049918B4 (de) * 2003-10-14 2010-11-25 Micromass Uk Ltd. Verfahren zur Massenspektrometrie
WO2006133192A2 (en) * 2005-06-03 2006-12-14 Waters Investments Limited Generation and use of a catalog of polypeptide-related information for chemical analyses
WO2006133191A2 (en) * 2005-06-03 2006-12-14 Waters Investments Limited Methods and apparatus for performing retention-time matching
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
JP5262010B2 (ja) * 2007-08-01 2013-08-14 株式会社日立製作所 質量分析計及び質量分析方法
JP5111123B2 (ja) * 2008-01-16 2012-12-26 株式会社日立製作所 質量分析計及び質量分析方法
JP5251232B2 (ja) * 2008-04-25 2013-07-31 株式会社島津製作所 質量分析データ処理方法及び質量分析装置
WO2009146345A1 (en) * 2008-05-29 2009-12-03 Waters Technologies Corporation Techniques for performing retention-time matching of precursor and product ions and for constructing precursor and product ion spectra
WO2010089798A1 (ja) * 2009-02-05 2010-08-12 株式会社島津製作所 Ｍｓ／ｍｓ型質量分析装置
CA2762364A1 (en) * 2009-05-27 2010-12-02 Dh Technologies Development Pte. Ltd. Linear ion trap for msms
GB0909289D0 (en) * 2009-05-29 2009-07-15 Micromass Ltd Method of processing mass spectral data
GB0915474D0 (en) * 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
JP5454484B2 (ja) * 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
GB201208961D0 (en) * 2012-05-18 2012-07-04 Micromass Ltd 2 dimensional MSMS
US10615014B2 (en) * 2013-11-12 2020-04-07 Micromass Uk Limited Data dependent MS/MS analysis

Also Published As

Publication number Publication date
EP2850636B1 (en) 2021-09-01
GB2504373A (en) 2014-01-29
US9460902B2 (en) 2016-10-04
EP3926659A1 (en) 2021-12-22
JP2015523550A (ja) 2015-08-13
WO2013171459A2 (en) 2013-11-21
CA2873610A1 (en) 2013-11-21
GB2504373B (en) 2017-01-25
GB201208961D0 (en) 2012-07-04
EP3926659B1 (en) 2025-07-30
US10068754B2 (en) 2018-09-04
US20150136969A1 (en) 2015-05-21
GB201308297D0 (en) 2013-06-12
WO2013171459A3 (en) 2014-06-26
EP2850636A2 (en) 2015-03-25
JP6309508B2 (ja) 2018-04-11
US20170125224A1 (en) 2017-05-04

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