CA2872000A1 - Complement pathway modulators and uses thereof - Google Patents
Complement pathway modulators and uses thereof Download PDFInfo
- Publication number
- CA2872000A1 CA2872000A1 CA2872000A CA2872000A CA2872000A1 CA 2872000 A1 CA2872000 A1 CA 2872000A1 CA 2872000 A CA2872000 A CA 2872000A CA 2872000 A CA2872000 A CA 2872000A CA 2872000 A1 CA2872000 A1 CA 2872000A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- benzo
- indol
- carbonitrile
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/IB2013/053546 WO2013164802A1 (en) | 2012-05-04 | 2013-05-03 | Complement pathway modulators and uses thereof |
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| US10849883B2 (en) | 2016-02-01 | 2020-12-01 | Biocryst Pharmaceuticals, Inc. | Benzopyrazole compounds and analogues thereof |
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| JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| EP3089963A1 (en) * | 2013-10-30 | 2016-11-09 | Novartis AG | 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof |
| CN103755622A (zh) * | 2013-12-25 | 2014-04-30 | 华东理工大学 | 合成4,5,6,7-四氘代吲哚-3-乙酸的方法 |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| RU2018145364A (ru) * | 2016-06-27 | 2020-07-28 | Ачиллион Фармасьютикалс, Инк. | Хиназолиновые и индольные соединения для лечения медицинских нарушений |
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| TWI873092B (zh) * | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| WO2020041301A1 (en) | 2018-08-20 | 2020-02-27 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| WO2020051532A2 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| US11814363B2 (en) | 2018-09-06 | 2023-11-14 | Achillion Pharmaceuticals, Inc. | Morphic forms of danicopan |
| BR112021005506A2 (pt) | 2018-09-25 | 2021-06-15 | Achillion Pharmaceuticals, Inc. | formas mórficas de inibidores de fator complementar d |
| WO2021168320A1 (en) | 2020-02-20 | 2021-08-26 | Achillion Pharmaceuticals, Inc. | Heteroaryl compounds for treatment of complement factor d mediated disorders |
| CA3179686A1 (en) * | 2020-04-07 | 2021-10-14 | UCB Biopharma SRL | Difluorocyclohexyl derivatives as il-17 modulators |
| CN114057758A (zh) | 2020-08-07 | 2022-02-18 | 上海美悦生物科技发展有限公司 | 补体因子b抑制剂及其药物组合物、制备方法和用途 |
| EP4194449A4 (en) | 2020-08-07 | 2024-03-20 | Shanghai Meiyue Biotech Development Co., Ltd. | Heterocyclic compound, preparation method therefor and use thereof |
| WO2022066774A1 (en) | 2020-09-23 | 2022-03-31 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| US20240287034A1 (en) * | 2021-06-03 | 2024-08-29 | Chinook Therapeutics, Inc. | Substituted indole compounds and methods of use thereof |
| CA3242815A1 (en) | 2022-01-26 | 2023-08-03 | Shanghai Meiyue Biotech Development Co., Ltd. | Salt type and crystal form of complement factor b inhibitor, and preparation method therefor and application thereof |
| CN119137099A (zh) * | 2022-04-01 | 2024-12-13 | 诺华股份有限公司 | 补体因子b抑制剂及其用途 |
| EP4617266A1 (en) | 2022-11-11 | 2025-09-17 | Shanghai Yisheng Biopharmaceutical company Limited | Piperidine-substituted benzoic acid compound, and pharmaceutical composition and use thereof |
| JP2026502231A (ja) * | 2022-12-31 | 2026-01-21 | チューハイ ユナイテッド ラボラトリーズ シーオー．，エルティーディー． | 補体因子ｂ阻害剤、その医薬組成物および使用 |
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| IL325760A (en) | 2023-07-04 | 2026-03-01 | Sitala Bio Ltd | History of 2-(1H-indol-4-yl)methyl)-isoindoline as factor B inhibitors |
| WO2025008516A2 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Novel compounds |
| WO2025008517A1 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| CN119371402A (zh) | 2023-07-26 | 2025-01-28 | 上海美悦生物科技发展有限公司 | 螺环烯基类或氮杂烯基类化合物及其药物组合物、制备方法和用途 |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
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| CN100415723C (zh) * | 2000-01-17 | 2008-09-03 | 帝人株式会社 | 苯并咪唑衍生物 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10849883B2 (en) | 2016-02-01 | 2020-12-01 | Biocryst Pharmaceuticals, Inc. | Benzopyrazole compounds and analogues thereof |
| US11559515B2 (en) | 2016-02-01 | 2023-01-24 | Biocryst Pharmaceuticals, Inc. | Indole compounds and analogues thereof |
| US12485109B2 (en) | 2016-02-01 | 2025-12-02 | Biocryst Pharmaceuticals, Inc. | Pyrrolo 12.3-dipyrimidine compounds and analogues thereof |
Also Published As
| Publication number | Publication date |
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| AU2013255470A1 (en) | 2014-11-13 |
| EP2855456B1 (en) | 2017-03-29 |
| IL235362A0 (en) | 2014-12-31 |
| CR20140508A (es) | 2015-03-13 |
| HK1206017A1 (en) | 2015-12-31 |
| AU2013255470B2 (en) | 2015-09-17 |
| CL2014002919A1 (es) | 2015-07-03 |
| WO2013164802A1 (en) | 2013-11-07 |
| PH12014502462A1 (en) | 2014-12-22 |
| AP2014008040A0 (en) | 2014-10-31 |
| TW201348199A (zh) | 2013-12-01 |
| PL2855456T3 (pl) | 2017-09-29 |
| BR112014027359A2 (pt) | 2017-07-18 |
| CN104603127A (zh) | 2015-05-06 |
| JP6180514B2 (ja) | 2017-08-16 |
| EA201492023A1 (ru) | 2015-03-31 |
| PT2855456T (pt) | 2017-07-10 |
| KR20150003903A (ko) | 2015-01-09 |
| UY34781A (es) | 2013-12-31 |
| SG11201406973PA (en) | 2014-12-30 |
| AR090945A1 (es) | 2014-12-17 |
| CN104603127B (zh) | 2016-10-05 |
| TN2014000449A1 (en) | 2016-03-30 |
| JP2015515976A (ja) | 2015-06-04 |
| ES2630079T3 (es) | 2017-08-17 |
| MX2014013428A (es) | 2015-02-04 |
| PE20150623A1 (es) | 2015-05-17 |
| EA027113B1 (ru) | 2017-06-30 |
| EP2855456A1 (en) | 2015-04-08 |
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