CA2869295A1 - Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies - Google Patents
Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies Download PDFInfo
- Publication number
- CA2869295A1 CA2869295A1 CA2869295A CA2869295A CA2869295A1 CA 2869295 A1 CA2869295 A1 CA 2869295A1 CA 2869295 A CA2869295 A CA 2869295A CA 2869295 A CA2869295 A CA 2869295A CA 2869295 A1 CA2869295 A1 CA 2869295A1
- Authority
- CA
- Canada
- Prior art keywords
- methylation
- dna
- cell
- cells
- cpg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Molecular Biology (AREA)
- Data Mining & Analysis (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioethics (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Software Systems (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161489883P | 2011-05-25 | 2011-05-25 | |
US61/489,883 | 2011-05-25 | ||
US201161509644P | 2011-07-20 | 2011-07-20 | |
US61/509,644 | 2011-07-20 | ||
US201261585892P | 2012-01-12 | 2012-01-12 | |
US61/585,892 | 2012-01-12 | ||
US201261619663P | 2012-04-03 | 2012-04-03 | |
US61/619,663 | 2012-04-03 | ||
PCT/US2012/039699 WO2012162660A2 (en) | 2011-05-25 | 2012-05-25 | Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2869295A1 true CA2869295A1 (en) | 2012-11-29 |
Family
ID=47218125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2869295A Abandoned CA2869295A1 (en) | 2011-05-25 | 2012-05-25 | Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2714933A4 (de) |
CA (1) | CA2869295A1 (de) |
WO (1) | WO2012162660A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9561006B2 (en) * | 2008-10-15 | 2017-02-07 | The United States Of America As Represented By The Secretary Of The Navy | Bayesian modeling of pre-transplant variables accurately predicts kidney graft survival |
EP3382033B1 (de) * | 2017-03-30 | 2020-08-05 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Verfahren zur bestimmung von blutkörperchenzahlen auf der basis der dns methylierung |
DE102017125013B4 (de) | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten |
DE102017125019B4 (de) | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | PDCD1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere PD1+ Zellen |
DE102017125150B4 (de) | 2017-10-26 | 2019-10-10 | Epiontis Gmbh | Endosialin (CD248) als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere naïver CD8+ T-Zellen |
DE102017125335B4 (de) | 2017-10-27 | 2019-10-17 | Epiontis Gmbh | Amplikon-Region als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere nicht-klassischer Monozyten |
DE102017126248B4 (de) | 2017-11-09 | 2019-10-17 | Epiontis Gmbh | ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs) |
DE102018112644B4 (de) | 2018-05-25 | 2020-06-10 | Epiontis Gmbh | CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen |
WO2020007951A1 (en) | 2018-07-05 | 2020-01-09 | Epiontis Gmbh | Epigenetic method to detect and distinguish ipex and ipex-like syndromes, in particular in newborns |
DE102020108560B4 (de) | 2020-03-27 | 2022-03-03 | Precision For Medicine Gmbh | CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen |
DE102020111423B4 (de) | 2020-04-27 | 2022-03-03 | Precision For Medicine Gmbh | MYH11/NDE1 Region als epigenetischer Marker für die Identifizierung von Endothel-Vorläuferzellen (EPCs) |
KR20230119130A (ko) | 2020-12-14 | 2023-08-16 | 리제너론 파마슈티칼스 인코포레이티드 | 인히빈 서브유닛 베타 e(inhbe) 억제제로 대사 장애 및 심혈관 질환을 치료하는 방법 |
CN114703284A (zh) * | 2022-04-15 | 2022-07-05 | 北京莱盟君泰国际医疗技术开发有限公司 | 一种血液游离dna甲基化定量检测方法及其应用 |
WO2024073508A2 (en) * | 2022-09-27 | 2024-04-04 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell dna |
CN116312794B (zh) * | 2023-01-09 | 2023-11-14 | 哈尔滨医科大学 | 一种融合单细胞分析方法的甲基化样本聚类方法 |
CN116949156B (zh) * | 2023-09-19 | 2023-12-08 | 美迪西普亚医药科技(上海)有限公司 | 一种基于核酸变体的通用型检测人t细胞的分析方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1826279T3 (pl) * | 2006-02-28 | 2011-11-30 | Univ Berlin Charite | Wykrywanie i kontrola jakości regulatorowych limfocytów T dzięki analizie metylacji DNA genu FoxP3 |
-
2012
- 2012-05-25 EP EP12789375.8A patent/EP2714933A4/de not_active Withdrawn
- 2012-05-25 WO PCT/US2012/039699 patent/WO2012162660A2/en unknown
- 2012-05-25 CA CA2869295A patent/CA2869295A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2714933A4 (de) | 2014-12-31 |
WO2012162660A2 (en) | 2012-11-29 |
WO2012162660A3 (en) | 2013-03-28 |
EP2714933A2 (de) | 2014-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20170524 |
|
FZDE | Discontinued |
Effective date: 20210831 |