CA2859777C - Serine protease inhibitor (serpin) peptides and methods thereof - Google Patents

Serine protease inhibitor (serpin) peptides and methods thereof Download PDF

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Publication number
CA2859777C
CA2859777C CA2859777A CA2859777A CA2859777C CA 2859777 C CA2859777 C CA 2859777C CA 2859777 A CA2859777 A CA 2859777A CA 2859777 A CA2859777 A CA 2859777A CA 2859777 C CA2859777 C CA 2859777C
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Canada
Prior art keywords
peptide
peptides
amino acid
composition
seq
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Active
Application number
CA2859777A
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English (en)
French (fr)
Other versions
CA2859777A1 (en
Inventor
Soren Mogelsvang
Cohava Gelber
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SERPIN PHARMA LLC
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SERPIN PHARMA LLC
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Priority to CA3077804A priority Critical patent/CA3077804C/en
Publication of CA2859777A1 publication Critical patent/CA2859777A1/en
Application granted granted Critical
Publication of CA2859777C publication Critical patent/CA2859777C/en
Active legal-status Critical Current
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins
    • C07K14/8125Alpha-1-antitrypsin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2859777A 2012-01-09 2013-01-07 Serine protease inhibitor (serpin) peptides and methods thereof Active CA2859777C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3077804A CA3077804C (en) 2012-01-09 2013-01-07 Peptides and methods of using same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261584517P 2012-01-09 2012-01-09
US61/584,517 2012-01-09
US201261699571P 2012-09-11 2012-09-11
US61/699,571 2012-09-11
PCT/US2013/020498 WO2013106273A2 (en) 2012-01-09 2013-01-07 Peptides and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3077804A Division CA3077804C (en) 2012-01-09 2013-01-07 Peptides and methods of using same

Publications (2)

Publication Number Publication Date
CA2859777A1 CA2859777A1 (en) 2013-07-18
CA2859777C true CA2859777C (en) 2020-06-30

Family

ID=47595077

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3077804A Active CA3077804C (en) 2012-01-09 2013-01-07 Peptides and methods of using same
CA2859777A Active CA2859777C (en) 2012-01-09 2013-01-07 Serine protease inhibitor (serpin) peptides and methods thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3077804A Active CA3077804C (en) 2012-01-09 2013-01-07 Peptides and methods of using same

Country Status (10)

Country Link
US (6) US9951104B2 (enExample)
EP (2) EP3381461B1 (enExample)
JP (1) JP6416627B2 (enExample)
AU (3) AU2013208293B2 (enExample)
CA (2) CA3077804C (enExample)
DK (2) DK3381461T3 (enExample)
ES (2) ES2676028T3 (enExample)
IL (1) IL233481A0 (enExample)
MX (1) MX365403B (enExample)
WO (1) WO2013106273A2 (enExample)

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CA3077804C (en) 2012-01-09 2023-07-25 Serpin Pharma, Llc Peptides and methods of using same
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US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11020462B2 (en) * 2015-08-28 2021-06-01 Serpin Pharma Methods for treatment of diseases
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN112020555B (zh) * 2018-05-02 2024-06-21 国立大学法人新潟大学 肽及其应用
EP4003391A4 (en) 2020-07-06 2023-02-22 Serpin Pharma, LLC PEPTIDES AND THEIR METHODS OF USE

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Also Published As

Publication number Publication date
US10899797B2 (en) 2021-01-26
ES2676028T3 (es) 2018-07-16
CA3077804C (en) 2023-07-25
AU2017258892B2 (en) 2019-11-14
DK2802338T3 (en) 2018-06-14
AU2013208293A1 (en) 2014-06-26
WO2013106273A3 (en) 2013-12-19
US8975224B2 (en) 2015-03-10
US20140378372A1 (en) 2014-12-25
MX365403B (es) 2019-05-31
WO2013106273A2 (en) 2013-07-18
JP2015504073A (ja) 2015-02-05
AU2019253814B2 (en) 2022-03-10
AU2013208293B2 (en) 2017-08-10
ES2871544T3 (es) 2021-10-29
JP6416627B2 (ja) 2018-10-31
CA2859777A1 (en) 2013-07-18
AU2013208293A2 (en) 2016-01-28
US20170029465A9 (en) 2017-02-02
US9951104B2 (en) 2018-04-24
CA3077804A1 (en) 2013-07-18
US20200017550A1 (en) 2020-01-16
US20150133375A1 (en) 2015-05-14
US20250346632A1 (en) 2025-11-13
EP2802338A2 (en) 2014-11-19
AU2019253814A1 (en) 2019-11-14
BR112014016734A2 (pt) 2020-10-27
US10214562B2 (en) 2019-02-26
EP3381461B1 (en) 2021-03-10
US12291581B2 (en) 2025-05-06
AU2017258892A1 (en) 2017-11-30
US20130274187A1 (en) 2013-10-17
HK1203161A1 (en) 2015-10-23
MX2014007799A (es) 2014-10-24
DK3381461T3 (da) 2021-05-17
US20210188912A1 (en) 2021-06-24
EP2802338B1 (en) 2018-03-07
EP3381461A1 (en) 2018-10-03
IL233481A0 (en) 2014-08-31

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