CA2858720A1 - Nicotinic receptor targeted compounds and compositions - Google Patents

Nicotinic receptor targeted compounds and compositions Download PDF

Info

Publication number
CA2858720A1
CA2858720A1 CA2858720A CA2858720A CA2858720A1 CA 2858720 A1 CA2858720 A1 CA 2858720A1 CA 2858720 A CA2858720 A CA 2858720A CA 2858720 A CA2858720 A CA 2858720A CA 2858720 A1 CA2858720 A1 CA 2858720A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
formula
alkoxy
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2858720A
Other languages
English (en)
French (fr)
Inventor
William Reade Kem
Ferenc Soti
Hong Xing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida Research Foundation Inc
Original Assignee
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida Research Foundation Inc filed Critical University of Florida Research Foundation Inc
Publication of CA2858720A1 publication Critical patent/CA2858720A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2858720A 2011-12-12 2012-12-11 Nicotinic receptor targeted compounds and compositions Abandoned CA2858720A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161569539P 2011-12-12 2011-12-12
US61/569,539 2011-12-12
PCT/US2012/068943 WO2013090260A1 (en) 2011-12-12 2012-12-11 Nicotinic receptor targeted compounds and compositions

Publications (1)

Publication Number Publication Date
CA2858720A1 true CA2858720A1 (en) 2013-06-20

Family

ID=48613106

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2858720A Abandoned CA2858720A1 (en) 2011-12-12 2012-12-11 Nicotinic receptor targeted compounds and compositions

Country Status (6)

Country Link
US (1) US9150558B2 (https=)
EP (1) EP2791135B8 (https=)
JP (1) JP2015504861A (https=)
AU (1) AU2012352510A1 (https=)
CA (1) CA2858720A1 (https=)
WO (1) WO2013090260A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2813451A1 (en) * 2010-11-18 2012-05-24 Dignity Health Methods of diagnosing and treating neurodegenerative diseases
CN105985410B (zh) * 2015-02-16 2019-11-29 海南大学 芋螺肽、其药物组合物及用途
JP6590226B2 (ja) * 2016-05-11 2019-10-16 株式会社シード探索研究所 オキサアジリジン化合物およびその製造方法
WO2018064529A1 (en) 2016-09-29 2018-04-05 The Uab Research Foundation Methods and compositions for increasing mucus clearance
WO2021113311A1 (en) * 2019-12-02 2021-06-10 Bcell Solutions, Inc. Treatment of cancer using acetylcholine modulation and immunotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE116317T1 (de) * 1990-07-23 1995-01-15 Pfizer Chinuclidinderivate.
KR100342275B1 (ko) * 1993-10-21 2002-12-05 지.디. 썰 엘엘씨 산화질소신타제저해제로서유용한아미디노유도체
AU7723300A (en) 1999-09-27 2001-04-30 Georgetown University Novel tropane analogs
US7244745B2 (en) * 2002-08-30 2007-07-17 Memory Pharmaceuticals Corp. Heterocyclic compounds, methods for the preparation thereof, and uses thereof
EP1891036A4 (en) * 2005-06-07 2010-08-04 Univ Florida SELECTIVE LIGANDS FOR ALPHA-7 NICOTINE RECEPTORS
GB0702265D0 (en) 2007-02-06 2007-03-14 Eisai London Res Lab Ltd 7-Azaindole derivatives

Also Published As

Publication number Publication date
EP2791135B8 (en) 2018-07-18
US9150558B2 (en) 2015-10-06
AU2012352510A1 (en) 2014-07-17
US20140343042A1 (en) 2014-11-20
JP2015504861A (ja) 2015-02-16
EP2791135A4 (en) 2015-10-14
WO2013090260A1 (en) 2013-06-20
EP2791135A1 (en) 2014-10-22
EP2791135B1 (en) 2018-06-06

Similar Documents

Publication Publication Date Title
JP6880260B2 (ja) ムスカリン受容体アゴニスト
JP6847093B2 (ja) ムスカリン様アゴニスト
JP6876675B2 (ja) ムスカリンアゴニスト
JP5883399B2 (ja) ｍＧｌｕＲ４アロステリック増強剤としてのピラゾロピリジン、ピラゾロピラジン、ピラゾロピリミジン、ピラゾロチオフェンおよびピラゾロチアゾール化合物、組成物、および神経機能不全を治療する方法
US8592458B2 (en) Alpha7 nicotinic receptor selective ligands
TW200948364A (en) Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
TW200911254A (en) Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators-842
RU2434851C1 (ru) Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
JP2018508562A (ja) ムスカリンｍ１受容体及び／またはｍ４受容体のアゴニストとしてのスピロ環状化合物
KR20150082616A (ko) 디히드로피라졸 gpr40 조절제
JP2021527112A (ja) ニューロキニン−１受容体アンタゴニストとしての化合物およびその使用
TW201632516A (zh) 細胞壞死抑制劑與相關方法
EP2791135B1 (en) Anabasine derivatives targeting the nicotinic acetylcholine receptors
JP6786566B2 (ja) ヘテロアリール化合物及びその使用方法
JP2022504762A (ja) Ｌｒｒｋ２の野生型および変異型の分解誘導剤
US10214536B2 (en) Amlexanox analogs
JP2007538084A (ja) チエノピリジノン化合物及び治療方法
US20190202827A1 (en) Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof
EA037264B1 (ru) Гетероциклическое сульфонамидное производное и содержащее его лекарственное средство
US20170313686A1 (en) Compounds and their use as bace inhibitors
WO2025209533A1 (zh) 一种pan-RAS抑制剂化合物
US9085539B2 (en) Cyclic N,N′-diarylthiourea—androgen receptor antagonist, anti breast cancer composition and use thereof
JP2017095411A (ja) ピラゾール誘導体の塩の結晶
US20250195699A1 (en) Radiolabeled Mu Opioid Antagonist and Methods of Making and Using the Same
US10377763B2 (en) Morphinan derivative and medical usage thereof

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20171212