CA2853407C - Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens - Google Patents
Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens Download PDFInfo
- Publication number
- CA2853407C CA2853407C CA2853407A CA2853407A CA2853407C CA 2853407 C CA2853407 C CA 2853407C CA 2853407 A CA2853407 A CA 2853407A CA 2853407 A CA2853407 A CA 2853407A CA 2853407 C CA2853407 C CA 2853407C
- Authority
- CA
- Canada
- Prior art keywords
- primycin
- resistant
- component
- components
- vancomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- NYWSLZMTZNODJM-MCGDBQAWSA-N 2-[5-[(4e,20e)-35-butyl-19-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-10,12,14,16,18,22,26,30,34-nonahydroxy-3,5,21,33-tetramethyl-36-oxo-1-oxacyclohexatriaconta-4,20-dien-2-yl]-4-hydroxyhexyl]guanidine Chemical compound OC1CC(O)CC(O)CC(O)CC(O)CCCC\C(C)=C\C(C)C(C(C)C(O)CCCN=C(N)N)OC(=O)C(CCCC)C(O)C(C)CCC(O)CCCC(O)CCCC(O)\C(C)=C\C1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NYWSLZMTZNODJM-MCGDBQAWSA-N 0.000 title claims abstract description 167
- 229950010664 primycin Drugs 0.000 title claims abstract description 165
- NYWSLZMTZNODJM-SDUQVVOESA-N primycin Natural products CCCC[C@H]1[C@H](O)[C@H](C)CC[C@@H](O)CCC[C@@H](O)CCC[C@@H](O)C(=C[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@H](O)CCCCC(=C[C@@H](C)[C@@H](OC1=O)[C@H](C)[C@H](O)CCCNC(=N)N)C)C NYWSLZMTZNODJM-SDUQVVOESA-N 0.000 title claims abstract description 165
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- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 description 1
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- 241000186547 Sporosarcina Species 0.000 description 1
- 241000186652 Sporosarcina ureae Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
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- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241001134658 Streptococcus mitis Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 241001133165 Thermopolyspora Species 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- OZKXLOZHHUHGNV-UHFFFAOYSA-N Viomycin Natural products NCCCC(N)CC(=O)NC1CNC(=O)C(=CNC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC1=O)C2CC(O)NC(=N)N2 OZKXLOZHHUHGNV-UHFFFAOYSA-N 0.000 description 1
- 108010015940 Viomycin Proteins 0.000 description 1
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- 230000000996 additive effect Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
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- 238000012512 characterization method Methods 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
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- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
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- 229960002950 novobiocin Drugs 0.000 description 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068917 polyethylene glycols Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960005456 sisomicin Drugs 0.000 description 1
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1100597A HU230455B1 (hu) | 2011-10-25 | 2011-10-25 | Primycin vagy primycin komponensek vagy ezek kombinációi mint speciális kórokozócsoportok által okozott fertőzések kezelésére vagy megelőzésére alkalmas gyógyszerhatóanyagok |
| HUP1100597 | 2011-10-25 | ||
| PCT/HU2012/000111 WO2013061101A1 (en) | 2011-10-25 | 2012-10-25 | Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2853407A1 CA2853407A1 (en) | 2013-05-02 |
| CA2853407C true CA2853407C (en) | 2019-08-27 |
Family
ID=89990487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2853407A Expired - Fee Related CA2853407C (en) | 2011-10-25 | 2012-10-25 | Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140303105A1 (enExample) |
| EP (1) | EP2771016B1 (enExample) |
| CA (1) | CA2853407C (enExample) |
| DK (1) | DK2771016T3 (enExample) |
| HR (1) | HRP20160833T1 (enExample) |
| HU (1) | HU230455B1 (enExample) |
| IN (1) | IN2014CN03886A (enExample) |
| PL (1) | PL2771016T3 (enExample) |
| SI (1) | SI2771016T1 (enExample) |
| WO (1) | WO2013061101A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112175027B (zh) * | 2020-10-23 | 2021-10-22 | 中国医学科学院医药生物技术研究所 | 一种洋橄榄叶素衍生物的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756856A (fr) | 1969-09-30 | 1971-03-01 | Chinoin Gyogyszer Es Vegyeszet | Compositions antibiotiques nouvelles possedant un effet therapeutique accru et leur preparation |
| US4404189A (en) | 1981-01-21 | 1983-09-13 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Synergistic antimicrobial compositions |
| HU195514B (en) | 1984-05-31 | 1988-05-30 | Chinoin Gyogyszer Es Vegyeszet | Process for the digestion of triamycine, an antibioticcomplex |
| CA1274508A (en) | 1984-05-31 | 1990-09-25 | Imre Szilagyi | Primycin components and process for the separation of the antibiotic complex |
| HU196425B (en) | 1984-07-26 | 1988-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing components of primicin and pharmaceutical compositions containing them |
| HU196822B (en) | 1984-07-03 | 1989-01-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing primicin salts |
| HU196309B (hu) | 1985-05-29 | 1988-11-28 | Chinoin Gyogyszer Es Vegyeszet | Eljárás primicin gyógyszerkészítmény előállítására |
| HU229804B1 (en) * | 2009-10-29 | 2014-07-28 | Pannonpharma Gyogyszergyarto Kft | Method of production of primycin, primycin components, and/or precursors and metabolites of primycin via fementation by the use of bacterial species saccharomonospora azurea |
-
2011
- 2011-10-25 HU HU1100597A patent/HU230455B1/hu unknown
-
2012
- 2012-10-25 IN IN3886CHN2014 patent/IN2014CN03886A/en unknown
- 2012-10-25 US US14/353,800 patent/US20140303105A1/en not_active Abandoned
- 2012-10-25 EP EP12788250.4A patent/EP2771016B1/en not_active Not-in-force
- 2012-10-25 DK DK12788250.4T patent/DK2771016T3/en active
- 2012-10-25 HR HRP20160833TT patent/HRP20160833T1/hr unknown
- 2012-10-25 WO PCT/HU2012/000111 patent/WO2013061101A1/en not_active Ceased
- 2012-10-25 PL PL12788250.4T patent/PL2771016T3/pl unknown
- 2012-10-25 CA CA2853407A patent/CA2853407C/en not_active Expired - Fee Related
- 2012-10-25 SI SI201230625A patent/SI2771016T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20140303105A1 (en) | 2014-10-09 |
| SI2771016T1 (sl) | 2016-10-28 |
| PL2771016T3 (pl) | 2016-11-30 |
| EP2771016B1 (en) | 2016-04-20 |
| HU230455B1 (hu) | 2016-07-28 |
| EP2771016A1 (en) | 2014-09-03 |
| WO2013061101A9 (en) | 2013-06-06 |
| DK2771016T3 (en) | 2016-08-01 |
| CA2853407A1 (en) | 2013-05-02 |
| WO2013061101A1 (en) | 2013-05-02 |
| HUP1100597A2 (en) | 2013-04-29 |
| HRP20160833T1 (hr) | 2016-09-23 |
| IN2014CN03886A (enExample) | 2015-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170920 |
|
| MKLA | Lapsed |
Effective date: 20211025 |