WO2013061101A1 - Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens - Google Patents

Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens Download PDF

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Publication number
WO2013061101A1
WO2013061101A1 PCT/HU2012/000111 HU2012000111W WO2013061101A1 WO 2013061101 A1 WO2013061101 A1 WO 2013061101A1 HU 2012000111 W HU2012000111 W HU 2012000111W WO 2013061101 A1 WO2013061101 A1 WO 2013061101A1
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WO
WIPO (PCT)
Prior art keywords
primycin
component
components
combination
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2012/000111
Other languages
English (en)
French (fr)
Other versions
WO2013061101A9 (en
Inventor
Péter FEISZT
Levente EMŐDY
József Péter PALLOS
Ákos JUHÁSZ
Dénes SEFFER
Mária SEFFERNÉ SZALAI
Ágota PÉNZES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pannonpharma Gyogyszergyarto Zrt
Original Assignee
Pannonpharma Gyogyszergyarto Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pannonpharma Gyogyszergyarto Zrt filed Critical Pannonpharma Gyogyszergyarto Zrt
Priority to DK12788250.4T priority Critical patent/DK2771016T3/en
Priority to HRP20160833TT priority patent/HRP20160833T1/hr
Priority to US14/353,800 priority patent/US20140303105A1/en
Priority to IN3886CHN2014 priority patent/IN2014CN03886A/en
Priority to EP12788250.4A priority patent/EP2771016B1/en
Priority to SI201230625A priority patent/SI2771016T1/sl
Priority to CA2853407A priority patent/CA2853407C/en
Publication of WO2013061101A1 publication Critical patent/WO2013061101A1/en
Publication of WO2013061101A9 publication Critical patent/WO2013061101A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • Hungarian Patent No. 196309 describes synergistic effect of dual or triple combinations of primycin components Al, Bl and CI in various mass ratios. The antimicrobial effect of the individual primycin components is also described, which proves their independent applicability.
  • the invention covers pharmaceutical compositions containing primycin or a primycin component or a combination thereof for use in the treatment or prevention of infections caused by the bacterial strains defined above.
  • the invention also covers antibiotic compositions containing primycin or a primycin component or a combination thereof for use in the treatment or prevention of infections caused by the bacterial strains defined above.
  • the invention relates to combination of primycin components
  • compositions are prepared by mixing the active substance with non-reacted

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/HU2012/000111 2011-10-25 2012-10-25 Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens Ceased WO2013061101A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK12788250.4T DK2771016T3 (en) 2011-10-25 2012-10-25 Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens
HRP20160833TT HRP20160833T1 (hr) 2011-10-25 2012-10-25 Primicin i njegove komponente za uporabu u liječenju ili prevenciji infekcija uzrokovanih specifičnim patogenima
US14/353,800 US20140303105A1 (en) 2011-10-25 2012-10-25 Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens
IN3886CHN2014 IN2014CN03886A (enExample) 2011-10-25 2012-10-25
EP12788250.4A EP2771016B1 (en) 2011-10-25 2012-10-25 Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens
SI201230625A SI2771016T1 (sl) 2011-10-25 2012-10-25 Primicin in njegove komponente za uporabo pri zdravljenju ali preventivi okužb povzročenimi s specifičnimi patogeni
CA2853407A CA2853407C (en) 2011-10-25 2012-10-25 Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1100597A HU230455B1 (hu) 2011-10-25 2011-10-25 Primycin vagy primycin komponensek vagy ezek kombinációi mint speciális kórokozócsoportok által okozott fertőzések kezelésére vagy megelőzésére alkalmas gyógyszerhatóanyagok
HUP1100597 2011-10-25

Publications (2)

Publication Number Publication Date
WO2013061101A1 true WO2013061101A1 (en) 2013-05-02
WO2013061101A9 WO2013061101A9 (en) 2013-06-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2012/000111 Ceased WO2013061101A1 (en) 2011-10-25 2012-10-25 Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens

Country Status (10)

Country Link
US (1) US20140303105A1 (enExample)
EP (1) EP2771016B1 (enExample)
CA (1) CA2853407C (enExample)
DK (1) DK2771016T3 (enExample)
HR (1) HRP20160833T1 (enExample)
HU (1) HU230455B1 (enExample)
IN (1) IN2014CN03886A (enExample)
PL (1) PL2771016T3 (enExample)
SI (1) SI2771016T1 (enExample)
WO (1) WO2013061101A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112175027A (zh) * 2020-10-23 2021-01-05 中国医学科学院医药生物技术研究所 一种洋橄榄叶素衍生物及其制备方法和应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949077A (en) 1969-09-30 1976-04-06 Chinoin Gyogyszer-Es Vegyeszeti Termekek Gyara Rt Synergistic antibiotic compositions
US4404189A (en) 1981-01-21 1983-09-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Synergistic antimicrobial compositions
HU195514B (en) 1984-05-31 1988-05-30 Chinoin Gyogyszer Es Vegyeszet Process for the digestion of triamycine, an antibioticcomplex
HU196309B (hu) 1985-05-29 1988-11-28 Chinoin Gyogyszer Es Vegyeszet Eljárás primicin gyógyszerkészítmény előállítására
HU196425B (en) 1984-07-26 1988-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing components of primicin and pharmaceutical compositions containing them
HU196822B (en) 1984-07-03 1989-01-30 Chinoin Gyogyszer Es Vegyeszet Process for producing primicin salts
US4873348A (en) 1984-05-31 1989-10-10 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Oxypricin, a new antibiotic
WO2011051741A1 (en) * 2009-10-29 2011-05-05 Pannonpharma Gyógyszergyártó Kft. Process for producing primycin, primycin component(s), precursors and metabolites thereof via fementation by the use of bacterial species saccharomonospora azurea

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949077A (en) 1969-09-30 1976-04-06 Chinoin Gyogyszer-Es Vegyeszeti Termekek Gyara Rt Synergistic antibiotic compositions
US4404189A (en) 1981-01-21 1983-09-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Synergistic antimicrobial compositions
HU195514B (en) 1984-05-31 1988-05-30 Chinoin Gyogyszer Es Vegyeszet Process for the digestion of triamycine, an antibioticcomplex
US4873348A (en) 1984-05-31 1989-10-10 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Oxypricin, a new antibiotic
HU196822B (en) 1984-07-03 1989-01-30 Chinoin Gyogyszer Es Vegyeszet Process for producing primicin salts
HU196425B (en) 1984-07-26 1988-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing components of primicin and pharmaceutical compositions containing them
HU196309B (hu) 1985-05-29 1988-11-28 Chinoin Gyogyszer Es Vegyeszet Eljárás primicin gyógyszerkészítmény előállítására
WO2011051741A1 (en) * 2009-10-29 2011-05-05 Pannonpharma Gyógyszergyártó Kft. Process for producing primycin, primycin component(s), precursors and metabolites thereof via fementation by the use of bacterial species saccharomonospora azurea

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
"Remington's Pharmaceutical Sciences manual", 1990, MACK PUBLISHING CO.
BRYSKIER A.: "Antimicrobials - antibacterials and antifungals", 2005, ASM PRESS WASHINGTON DC, pages: 1179 - 1180
FERRARA ET AL: "Treatment of hospital-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 30, no. 1, 8 June 2007 (2007-06-08), pages 19 - 24, XP022109120, ISSN: 0924-8579, DOI: 10.1016/J.IJANTIMICAG.2007.02.011 *
FRANK J; DEKANY GY; PELCZER I; APSIMON W J, TETRAHEDRON LETTERS, vol. 28, 1987, pages 2759 - 2762
HORVÁTH I; KRAMER M; BAUER PI, ARCH MICROBIOL., vol. 121, no. 2, 1979, pages 135 - 139
INOUE M ET AL: "Enhancement of antibacterial activity of beta-lactam antibiotics by [P2W18O62]<6->, [SiMo12O40]<4->, and [PTi2W10O40]<7-> against methicillin-resistant and vancomycin-resistant Staphylococcus aureus", JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER INC, US, vol. 100, no. 7, 1 July 2006 (2006-07-01), pages 1225 - 1233, XP027900264, ISSN: 0162-0134, [retrieved on 20060701] *
MASCITTI K B ET AL: "Preferred treatment and prevention strategies for recurrent community-associated methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: A survey of adult and pediatric providers", AMERICAN JOURNAL OF INFECTION CONTROL, C.V. MOSBY CO., ST. LOUIS, MO, US, vol. 38, no. 4, 1 May 2010 (2010-05-01), pages 324 - 328, XP027043064, ISSN: 0196-6553, [retrieved on 20100424] *
NOGRADI M., DRUGS OF TODAY, vol. 24, no. 8, 1988, pages 563 - 566
URI JV., ACTA MICROBIOL HUNG, vol. 33, no. 2, 1986, pages 141 - 146
URI JV; ACTOR P., J ANTIBIOT (TOKYO, vol. 32, no. 11, November 1979 (1979-11-01), pages 1207 - 1209
VALYI-NAGY T ET AL: "Primycin, a new antibiotic", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 174, no. 4441, 11 December 1954 (1954-12-11), pages 1105 - 1106, XP009165902, ISSN: 0028-0836 *
VALYI-NAGY T; KELENTEY B., ARCH INT PHARMACODYN THER, vol. 124, 1960, pages 466 - 481
VALYI-NAGY T; URI J; SZILDGYI 1., NATURE, vol. 174, 1954, pages 1105

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112175027A (zh) * 2020-10-23 2021-01-05 中国医学科学院医药生物技术研究所 一种洋橄榄叶素衍生物及其制备方法和应用

Also Published As

Publication number Publication date
US20140303105A1 (en) 2014-10-09
HRP20160833T1 (hr) 2016-09-23
EP2771016B1 (en) 2016-04-20
PL2771016T3 (pl) 2016-11-30
CA2853407C (en) 2019-08-27
DK2771016T3 (en) 2016-08-01
IN2014CN03886A (enExample) 2015-10-16
EP2771016A1 (en) 2014-09-03
CA2853407A1 (en) 2013-05-02
WO2013061101A9 (en) 2013-06-06
HUP1100597A2 (en) 2013-04-29
SI2771016T1 (sl) 2016-10-28
HU230455B1 (hu) 2016-07-28

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